BG62068B2 - Хирудинмутеини и техни полиалкиленгликолови конюгати - Google Patents
Хирудинмутеини и техни полиалкиленгликолови конюгати Download PDFInfo
- Publication number
- BG62068B2 BG62068B2 BG98604A BG9860494A BG62068B2 BG 62068 B2 BG62068 B2 BG 62068B2 BG 98604 A BG98604 A BG 98604A BG 9860494 A BG9860494 A BG 9860494A BG 62068 B2 BG62068 B2 BG 62068B2
- Authority
- BG
- Bulgaria
- Prior art keywords
- glu
- gly
- gin
- asn
- thr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
- Y10S530/858—Proteins from animals other than mammals or birds insects; venom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyethers (AREA)
- Steroid Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3939800 | 1989-12-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
BG62068B2 true BG62068B2 (bg) | 1999-01-29 |
Family
ID=6394620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG98604A BG62068B2 (bg) | 1989-12-01 | 1994-02-28 | Хирудинмутеини и техни полиалкиленгликолови конюгати |
Country Status (9)
Country | Link |
---|---|
US (1) | US5663141A (ja) |
EP (1) | EP0502962B1 (ja) |
JP (1) | JP3187044B2 (ja) |
AT (1) | ATE135374T1 (ja) |
BG (1) | BG62068B2 (ja) |
CA (1) | CA2067224C (ja) |
DE (1) | DE59010205D1 (ja) |
ES (1) | ES2084149T3 (ja) |
WO (1) | WO1991008229A1 (ja) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
DE4117784A1 (de) * | 1991-05-31 | 1992-12-03 | Basf Ag | Herstellung von protein-polyalkylenglykolkonjugaten |
FR2687681B1 (fr) * | 1992-02-20 | 1995-10-13 | Transgene Sa | Conjugues polyethyleneglycol-hirudine, leur procede de preparation et leur emploi pour le traitement des thromboses. |
US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
EP0663009A1 (en) * | 1993-08-04 | 1995-07-19 | Novartis AG | High molecular weight desulphatohirudin |
DE4437502A1 (de) * | 1993-12-02 | 1995-06-08 | Basf Ag | Hirudin-Konjugate aus Hirudin und lipophilen Verbindungen |
DE4404168A1 (de) * | 1994-02-10 | 1995-08-17 | Hoechst Ag | Hirudinderivate und Verfahren zu deren Herstellung |
DE19533817C2 (de) * | 1995-09-13 | 1999-12-09 | Max Planck Gesellschaft | Komplex-gebundene Hemmstoffe aktivierbarer Stoffwechselenzyme als molekulare Marker zur Diagnostik und Therapieüberwachung |
DE19915862A1 (de) * | 1999-04-08 | 2000-10-12 | Max Planck Gesellschaft | Verwendung von molekulargewichtserweitertem Hirudin als Antikoagulans bei der extrakorporalen Nierenersatztherapie |
US20040228852A1 (en) * | 1999-04-08 | 2004-11-18 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V | Use of increased molecular-weight hirudin as an anticoagulant in extracorporeal kidney replace therapy |
US6809076B2 (en) * | 2000-03-20 | 2004-10-26 | Abbott Gmbh & Co. Kg | Use of anticoagulant agents in the extracorporeal treatment of blood |
AU2001248355A1 (en) * | 2000-03-20 | 2001-10-03 | Knoll Gmbh | The use of anticoagulant agents in the extracorporeal treatment of blood |
DE10102878A1 (de) * | 2001-01-23 | 2002-08-01 | Haemosys Gmbh | Oligo- oder Polyalkylengekoppelte Thrombininhibitoren |
DE10162521A1 (de) * | 2001-12-19 | 2003-07-17 | Goetz Nowak | Verwendung von molekulargewichtserweiterten Substanzen in der Tumortherapie |
USRE46830E1 (en) | 2004-10-19 | 2018-05-08 | Polypeptide Laboratories Holding (Ppl) Ab | Method for solid phase peptide synthesis |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19775033I2 (de) * | 1985-04-11 | 2011-01-20 | Bayer Schering Pharma Ag | Hirudin-Derivat. |
JP2514950B2 (ja) * | 1986-03-10 | 1996-07-10 | エフ・ホフマン―ラ ロシユ アーゲー | 化学修飾蛋白質,その製造法および中間体 |
FR2628429B1 (fr) * | 1988-03-08 | 1990-12-28 | Transgene Sa | Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir |
AU614121B2 (en) * | 1988-05-04 | 1991-08-22 | Novartis Ag | Improvements in the production of polypeptides |
DE3819079A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Hirudin-derivate mit verzoegerter wirkung |
CA2000887A1 (en) * | 1988-11-01 | 1990-05-01 | Cecilia S.L. Ku | Thromboresistant materials and methods for making same |
-
1990
- 1990-11-22 WO PCT/EP1990/001998 patent/WO1991008229A1/de active IP Right Grant
- 1990-11-22 JP JP50120591A patent/JP3187044B2/ja not_active Expired - Lifetime
- 1990-11-22 AT AT91900751T patent/ATE135374T1/de not_active IP Right Cessation
- 1990-11-22 EP EP91900751A patent/EP0502962B1/de not_active Expired - Lifetime
- 1990-11-22 CA CA002067224A patent/CA2067224C/en not_active Expired - Lifetime
- 1990-11-22 ES ES91900751T patent/ES2084149T3/es not_active Expired - Lifetime
- 1990-11-22 DE DE59010205T patent/DE59010205D1/de not_active Expired - Lifetime
- 1990-11-22 US US07/859,453 patent/US5663141A/en not_active Expired - Lifetime
-
1994
- 1994-02-28 BG BG98604A patent/BG62068B2/bg unknown
Also Published As
Publication number | Publication date |
---|---|
CA2067224A1 (en) | 1991-06-02 |
CA2067224C (en) | 2001-02-13 |
JP3187044B2 (ja) | 2001-07-11 |
ES2084149T3 (es) | 1996-05-01 |
EP0502962A1 (de) | 1992-09-16 |
ATE135374T1 (de) | 1996-03-15 |
WO1991008229A1 (de) | 1991-06-13 |
DE59010205D1 (de) | 1996-04-18 |
JPH05503092A (ja) | 1993-05-27 |
EP0502962B1 (de) | 1996-03-13 |
US5663141A (en) | 1997-09-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR100658961B1 (ko) | 공유적으로 가교결합된 인슐린 이량체, 이를 포함하는 약제학적 조성물 및 진단 키트, 및 이의 제조방법 | |
BG62068B2 (bg) | Хирудинмутеини и техни полиалкиленгликолови конюгати | |
US5314872A (en) | Glucan sulfate, stabilized fibroblast growth factor composition | |
US5312736A (en) | Anticoagulant analogues of the tissue factor extrinsic pathway inhibitor (EPI) with reduced affinity for heparin | |
FI102843B (fi) | Menetelmä oleellisesti puhdistettujen insuliinijohdannaisten valmistam iseksi | |
US5977310A (en) | Peg-modified HGF | |
US4990455A (en) | Novel human TNF polypeptide mutants and DNA's encoding said mutants | |
AU617291B2 (en) | Method of chain combination | |
BG100420A (bg) | Ацилиран инсулин | |
JPH08506095A (ja) | 改変インシュリン様成長因子 | |
EP1575490A2 (en) | Modified glucagon-like peptide-1 analogs | |
KR20000016402A (ko) | 렙틴(ob단백질)의 프레그먼트 | |
US7144989B2 (en) | Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof | |
JPH06502407A (ja) | 血小板凝集阻害剤 | |
US5095004A (en) | Fluorine containing atrial natriuretic peptides | |
JP2669510B2 (ja) | ヒルジンのアミノ酸配列に基づくトロンビン阻害剤 | |
US5120715A (en) | Method for purifying fibroblast growth factor protein | |
Tokunaga et al. | Synthesis and expression of a human growth hormone (somatotropin) gene mutated to change cysteine‐165 to alanine | |
JPH08511157A (ja) | Xaファクター阻害活性を有する新規ポリペプチド | |
US5376635A (en) | Fluorine containing atrial natriuretic peptides | |
HU200939B (en) | Process for stabilizing htnf obtained by recombinant dna technique | |
EP0900235B1 (en) | Fragments of cr1 and their use | |
WO2005085283A1 (ja) | 修飾インターロイキン−11及びそれを含有する医薬組成物 | |
JPS63316798A (ja) | 新規なペプチド及びこれを有効成分とする創傷治療剤 | |
JPH0817712B2 (ja) | 新規ヒトtnfポリペプチド変異体 |