BG61816B1 - Нови стероидни естери - Google Patents

Нови стероидни естери Download PDF

Info

Publication number
BG61816B1
BG61816B1 BG98011A BG9801193A BG61816B1 BG 61816 B1 BG61816 B1 BG 61816B1 BG 98011 A BG98011 A BG 98011A BG 9801193 A BG9801193 A BG 9801193A BG 61816 B1 BG61816 B1 BG 61816B1
Authority
BG
Bulgaria
Prior art keywords
compound
dione
formula
difluoro
ene
Prior art date
Application number
BG98011A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG98011A (bg
Inventor
Bengt Axelsson
Ralph Brattsand
Leif Kaellstroem
Arne Thalen
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of BG98011A publication Critical patent/BG98011A/bg
Publication of BG61816B1 publication Critical patent/BG61816B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
BG98011A 1991-02-04 1993-08-02 Нови стероидни естери BG61816B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9100342A SE9100342D0 (sv) 1991-02-04 1991-02-04 Novel steroid esters
PCT/SE1992/000056 WO1992013873A1 (en) 1991-02-04 1992-01-29 Novel steroid esters

Publications (2)

Publication Number Publication Date
BG98011A BG98011A (bg) 1994-04-29
BG61816B1 true BG61816B1 (bg) 1998-06-30

Family

ID=20381807

Family Applications (1)

Application Number Title Priority Date Filing Date
BG98011A BG61816B1 (bg) 1991-02-04 1993-08-02 Нови стероидни естери

Country Status (38)

Country Link
US (1) US5614514A (fi)
EP (1) EP0572451B1 (fi)
JP (1) JP2947933B2 (fi)
KR (1) KR100205835B1 (fi)
CN (3) CN1039329C (fi)
AP (1) AP365A (fi)
AT (1) ATE164589T1 (fi)
BG (1) BG61816B1 (fi)
CA (1) CA2100453A1 (fi)
CZ (1) CZ282057B6 (fi)
DE (1) DE69224982T2 (fi)
DK (1) DK0572451T3 (fi)
DZ (1) DZ1554A1 (fi)
EE (1) EE03110B1 (fi)
ES (1) ES2114931T3 (fi)
FI (1) FI933451A (fi)
HK (1) HK1004335A1 (fi)
HU (1) HU221168B1 (fi)
IE (1) IE920167A1 (fi)
IL (1) IL100542A (fi)
IS (1) IS1653B (fi)
MA (1) MA22407A1 (fi)
MX (1) MX9200374A (fi)
MY (1) MY111502A (fi)
NO (1) NO304074B1 (fi)
NZ (1) NZ241211A (fi)
PL (1) PL170383B1 (fi)
PT (1) PT100087B (fi)
RO (1) RO111272B1 (fi)
RU (1) RU2112775C1 (fi)
SE (1) SE9100342D0 (fi)
SK (1) SK281802B6 (fi)
TN (1) TNSN92008A1 (fi)
TW (1) TW287166B (fi)
UA (1) UA43825C2 (fi)
WO (1) WO1992013873A1 (fi)
YU (1) YU48893B (fi)
ZA (1) ZA92234B (fi)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
WO1994015947A1 (en) * 1993-01-08 1994-07-21 Astra Aktiebolag Novel colon- or ileum-specific steroid derivatives
US5983956A (en) 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
US5980949A (en) * 1994-10-03 1999-11-09 Astra Aktiebolag Formulation for inhalation
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700133D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
AU775500B2 (en) 1999-05-27 2004-08-05 Euro-Celtique S.A. Preparations for the application of anti-infective and/or anti-inflammatory agents
US7300667B1 (en) 1999-05-27 2007-11-27 Euro-Celtique, S.A. Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
WO2003070745A2 (en) 2002-02-20 2003-08-28 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids
US20050009798A1 (en) 2002-02-20 2005-01-13 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists
RU2330858C2 (ru) 2002-07-08 2008-08-10 Глаксомитклайн Истраживацки Центар Загреб Д.О.О. Новые соединения, составы и способы лечения воспалительных заболеваний и состояний
RS20050006A (en) 2002-07-08 2007-09-21 Glaxo Smith Kline Istraživački Centar Zagreb D.O.O., Novel compounds,compositions as carriers for steroid/non- steroid anti-inflammatory,antineoplastic and antiviral active molecules
AU2003265576A1 (en) * 2002-08-23 2004-03-11 The Mclean Hospital Corporation Corticosteroid conjugates and uses thereof
WO2004033478A2 (en) * 2002-10-08 2004-04-22 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
HRP20030604A2 (en) 2003-07-25 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromenes, preparation thereof andtheir antiinflammatory action
HRP20030603A2 (en) 2003-07-25 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromene compounds of antiinflammatory action
WO2005016352A1 (en) * 2003-08-05 2005-02-24 Sepracor Inc. AMINO ACID AND PEPTIDE-MODIFIED FORMS OF GLUCOCORTICOIDS IN COMBINATION WITH ß2 ADRENERGIC AGONISTS
MX2007005073A (es) 2004-10-27 2007-06-25 Glaxosmithkline Zagreb Conjugados con actividad antiinflamtoria.
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US8737506B1 (en) 2010-12-29 2014-05-27 Sprint Communications Company L.P. Determination of transmit diversity transmission delays
US8437713B1 (en) 2011-02-16 2013-05-07 Sprint Communications Company L.P. Wireless transmit diversity control by location of a wireless communication device
US8565686B2 (en) 2011-06-30 2013-10-22 Sprint Communications Company L.P. Power status multipath search window sizing for wireless communications
DK2797601T3 (en) 2012-02-10 2018-06-14 Taiwan Liposome Co Ltd PHARMACEUTICAL COMPOSITIONS FOR REDUCING COMPLICATIONS BY Ocular steroid
JP5965187B2 (ja) * 2012-03-30 2016-08-03 小林製薬株式会社 油性軟膏剤
CN109985048B (zh) * 2017-12-29 2021-06-29 广州市赛普特医药科技股份有限公司 2β,3α,5α-三羟基雄甾-6-酮用于炎症反应的治疗

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
US3197469A (en) * 1958-08-06 1965-07-27 Pharmaceutical Res Products In 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3357974A (en) * 1965-12-28 1967-12-12 Merck & Co Inc Processes for preparing 16alpha, 17alpha-acetals and ketals of 16alpha, 17alpha, 21-trihydroxy-delta4-pregnene-3, 20-diones
US3758686A (en) * 1971-12-07 1973-09-11 American Cyanamid Co Method of using steroid acetonides
SE378109B (fi) * 1972-05-19 1975-08-18 Bofors Ab
US3796701A (en) * 1973-02-26 1974-03-12 Squibb & Sons Inc 5alpha,9-oxazino steroids and 9-carboxamido steroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4304727A (en) * 1980-12-05 1981-12-08 The Upjohn Company 9α-Debromination
JPS58176485A (ja) * 1982-04-08 1983-10-15 Nippon Denso Co Ltd 可変容量圧縮機
US4749649A (en) * 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen
JPS6067496A (ja) * 1983-09-26 1985-04-17 Ota Seiyaku Kk フルオシノロン１６，１７−アセトニド２１−ブチレ−トおよびその製造法
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters

Also Published As

Publication number Publication date
UA43825C2 (uk) 2002-01-15
KR100205835B1 (ko) 1999-07-01
NO932762D0 (no) 1993-08-02
AU661472B2 (en) 1995-07-27
SK281802B6 (sk) 2001-08-06
CN1039329C (zh) 1998-07-29
FI933451A0 (fi) 1993-08-03
ATE164589T1 (de) 1998-04-15
NO932762L (no) 1993-08-02
CN1064078A (zh) 1992-09-02
JP2947933B2 (ja) 1999-09-13
IL100542A0 (en) 1992-09-06
CZ149593A3 (en) 1994-03-16
MY111502A (en) 2000-07-31
RO111272B1 (ro) 1996-08-30
JPH06505233A (ja) 1994-06-16
HU9302243D0 (en) 1993-10-28
CN1076607C (zh) 2001-12-26
EP0572451A1 (en) 1993-12-08
AU1235892A (en) 1992-09-07
NZ241211A (en) 1993-08-26
CN1158726A (zh) 1997-09-10
MA22407A1 (fr) 1992-10-01
YU6492A (sh) 1994-12-28
US5614514A (en) 1997-03-25
PT100087B (pt) 1999-09-30
HUT64972A (en) 1994-03-28
HK1004335A1 (en) 1998-11-20
DZ1554A1 (fr) 2002-02-17
BG98011A (bg) 1994-04-29
SK79793A3 (en) 1994-03-09
IE920167A1 (en) 1992-08-12
PT100087A (pt) 1993-05-31
WO1992013873A1 (en) 1992-08-20
DK0572451T3 (da) 1998-10-19
PL170383B1 (pl) 1996-12-31
TW287166B (fi) 1996-10-01
IS1653B (is) 1997-06-20
SE9100342D0 (sv) 1991-02-04
CZ282057B6 (cs) 1997-05-14
DE69224982T2 (de) 1998-07-30
IS3809A (is) 1992-08-05
FI933451A (fi) 1993-08-03
EP0572451B1 (en) 1998-04-01
ZA92234B (en) 1992-10-28
CN1076606C (zh) 2001-12-26
ES2114931T3 (es) 1998-06-16
IL100542A (en) 1997-02-18
AP365A (en) 1994-10-21
CA2100453A1 (en) 1992-08-05
CN1155418A (zh) 1997-07-30
AP9200354A0 (en) 1992-01-31
NO304074B1 (no) 1998-10-19
YU48893B (sh) 2002-10-18
TNSN92008A1 (fr) 1993-06-08
MX9200374A (es) 1992-08-01
HU221168B1 (en) 2002-08-28
EE03110B1 (et) 1998-08-17
DE69224982D1 (de) 1998-05-07
RU2112775C1 (ru) 1998-06-10

Similar Documents

Publication Publication Date Title
BG61816B1 (bg) Нови стероидни естери
KR930000045B1 (ko) 스테로이드 에스테르류를 함유하는 리포솜의 제조 방법
EP0570454B1 (en) Novel steroids
US5888995A (en) Steroid esters
AU661472C (en) Novel steroid esters
SI9210064A (sl) Nove antiinflamatorno in antialergijsko aktivne spojine, glukokortikosteroidi ter postopki za njihovo pripravo
AU661471C (en) Novel steroids
HRP920587A2 (en) Liposomes containing steroid esters a process for the preparation of stable camomile extract rich with active substances