YU48893B - Novi steroidni estri - Google Patents

Novi steroidni estri

Info

Publication number
YU48893B
YU48893B YU6492A YU6492A YU48893B YU 48893 B YU48893 B YU 48893B YU 6492 A YU6492 A YU 6492A YU 6492 A YU6492 A YU 6492A YU 48893 B YU48893 B YU 48893B
Authority
YU
Yugoslavia
Prior art keywords
straight
carbon atoms
hydrocarbon series
saturated
hydrogen
Prior art date
Application number
YU6492A
Other languages
English (en)
Other versions
YU6492A (sh
Inventor
Bengt Axelsson
Ralph Brattsand
Leif Kallstrom
Arne Thalen
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Priority to SI9210064A priority Critical patent/SI9210064B/sl
Publication of YU6492A publication Critical patent/YU6492A/sh
Publication of YU48893B publication Critical patent/YU48893B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Jedinjenja opšte formule ili njegova stereoizomerna komponenta, gde je u formuli 1,2 položaj zasićen ili je dvostruka veza. R1 je vodonik ili pravi ili račvasti ugljovodonični niz koji ima 1-4 atoma ugljenika, R2 je vodonik ili pravi ili račvasti ugljovodonični niz koji ima od 1-10 atoma ugljenika, R3 je acil koji ima pravi ili račvasti, zasićeni ili nezasićeni ugljovodonični niz koji ima od 11-20 atoma ugljenika i oba X1 i X2 su fluor pod uslovom da kada je 1,2-položaj dvoguba veza, R1 i R2 nisu istovremeno metil grupe. Prijava sadrži još 1 nezavisan i 10 zavisnih zahteva.
YU6492A 1991-02-04 1992-01-22 Novi steroidni estri YU48893B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SI9210064A SI9210064B (sl) 1991-02-04 1992-01-22 Nove antiinflamatorno in antialergijsko aktivne spojine, glukokortikosteroidi ter postopki za njihovo pripravo

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9100342A SE9100342D0 (sv) 1991-02-04 1991-02-04 Novel steroid esters

Publications (2)

Publication Number Publication Date
YU6492A YU6492A (sh) 1994-12-28
YU48893B true YU48893B (sh) 2002-10-18

Family

ID=20381807

Family Applications (1)

Application Number Title Priority Date Filing Date
YU6492A YU48893B (sh) 1991-02-04 1992-01-22 Novi steroidni estri

Country Status (38)

Country Link
US (1) US5614514A (sh)
EP (1) EP0572451B1 (sh)
JP (1) JP2947933B2 (sh)
KR (1) KR100205835B1 (sh)
CN (3) CN1039329C (sh)
AP (1) AP365A (sh)
AT (1) ATE164589T1 (sh)
BG (1) BG61816B1 (sh)
CA (1) CA2100453A1 (sh)
CZ (1) CZ282057B6 (sh)
DE (1) DE69224982T2 (sh)
DK (1) DK0572451T3 (sh)
DZ (1) DZ1554A1 (sh)
EE (1) EE03110B1 (sh)
ES (1) ES2114931T3 (sh)
FI (1) FI933451A0 (sh)
HK (1) HK1004335A1 (sh)
HU (1) HU221168B1 (sh)
IE (1) IE920167A1 (sh)
IL (1) IL100542A (sh)
IS (1) IS1653B (sh)
MA (1) MA22407A1 (sh)
MX (1) MX9200374A (sh)
MY (1) MY111502A (sh)
NO (1) NO304074B1 (sh)
NZ (1) NZ241211A (sh)
PL (1) PL170383B1 (sh)
PT (1) PT100087B (sh)
RO (1) RO111272B1 (sh)
RU (1) RU2112775C1 (sh)
SE (1) SE9100342D0 (sh)
SK (1) SK281802B6 (sh)
TN (1) TNSN92008A1 (sh)
TW (1) TW287166B (sh)
UA (1) UA43825C2 (sh)
WO (1) WO1992013873A1 (sh)
YU (1) YU48893B (sh)
ZA (1) ZA92234B (sh)

Families Citing this family (32)

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SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
KR960700266A (ko) * 1993-01-08 1996-01-19 클래스 빌헬름슨 신규 결장- 또는 회장-특이성 스테로이드 유도체(Novel Colon-or lleum-Specific Steroid Derivatives)
US5980949A (en) * 1994-10-03 1999-11-09 Astra Aktiebolag Formulation for inhalation
US5983956A (en) 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700133D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
US7300667B1 (en) 1999-05-27 2007-11-27 Euro-Celtique, S.A. Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract
MXPA01012169A (es) 1999-05-27 2002-06-21 Euro Celtique Sa Preparaciones para la aplicacion de agentes anti-infecciosos y/o anti-lamatorios para partes externas o internas del cuerpo humano o animal en la remodelacion funcional y cosmetica y tratamientos para reparacion de tejidos.
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
WO2003070745A2 (en) * 2002-02-20 2003-08-28 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids
US20050009798A1 (en) 2002-02-20 2005-01-13 Sepracor Inc. Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists
PL375162A1 (en) 2002-07-08 2005-11-28 Pliva-Istrazivacki Institut D.O.O. Novel compounds, compositions as carriers for steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
NZ537717A (en) 2002-07-08 2006-04-28 Pliva Istrazivacki Inst D New compounds, compositions and methods for treatment of inflammatory diseases and conditions
US20040157810A1 (en) * 2002-08-23 2004-08-12 Teicher Martin H. Corticosteroid conjugates and uses thereof
WO2004033478A2 (en) * 2002-10-08 2004-04-22 Sepracor Inc. Fatty acid modified forms of glucocorticoids and their use as anti-inflammatory
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
HRP20030604A2 (en) 2003-07-25 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromenes, preparation thereof andtheir antiinflammatory action
HRP20030603A2 (en) 2003-07-25 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Substituted furochromene compounds of antiinflammatory action
WO2005016352A1 (en) * 2003-08-05 2005-02-24 Sepracor Inc. AMINO ACID AND PEPTIDE-MODIFIED FORMS OF GLUCOCORTICOIDS IN COMBINATION WITH ß2 ADRENERGIC AGONISTS
ES2337915T3 (es) 2004-10-27 2010-04-30 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugados con adtividad antiinflamatoria.
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法
US8737506B1 (en) 2010-12-29 2014-05-27 Sprint Communications Company L.P. Determination of transmit diversity transmission delays
US8437713B1 (en) 2011-02-16 2013-05-07 Sprint Communications Company L.P. Wireless transmit diversity control by location of a wireless communication device
US8565686B2 (en) 2011-06-30 2013-10-22 Sprint Communications Company L.P. Power status multipath search window sizing for wireless communications
EP2797601B1 (en) 2012-02-10 2018-03-21 Taiwan Liposome Company Ltd Pharmaceutical compositions to reduce complications of ocular steroid
JP5965187B2 (ja) * 2012-03-30 2016-08-03 小林製薬株式会社 油性軟膏剤
CN109985048B (zh) * 2017-12-29 2021-06-29 广州市赛普特医药科技股份有限公司 2β,3α,5α-三羟基雄甾-6-酮用于炎症反应的治疗

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US3126375A (en) * 1964-03-24 Chioacyl
US3197469A (en) * 1958-08-06 1965-07-27 Pharmaceutical Res Products In 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3357974A (en) * 1965-12-28 1967-12-12 Merck & Co Inc Processes for preparing 16alpha, 17alpha-acetals and ketals of 16alpha, 17alpha, 21-trihydroxy-delta4-pregnene-3, 20-diones
US3758686A (en) * 1971-12-07 1973-09-11 American Cyanamid Co Method of using steroid acetonides
SE378109B (sh) * 1972-05-19 1975-08-18 Bofors Ab
US3796701A (en) * 1973-02-26 1974-03-12 Squibb & Sons Inc 5alpha,9-oxazino steroids and 9-carboxamido steroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4304727A (en) * 1980-12-05 1981-12-08 The Upjohn Company 9α-Debromination
JPS58176485A (ja) * 1982-04-08 1983-10-15 Nippon Denso Co Ltd 可変容量圧縮機
US4749649A (en) * 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen
JPS6067496A (ja) * 1983-09-26 1985-04-17 Ota Seiyaku Kk フルオシノロン１６，１７−アセトニド２１−ブチレ−トおよびその製造法
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters

Also Published As

Publication number Publication date
EP0572451B1 (en) 1998-04-01
CZ282057B6 (cs) 1997-05-14
PL170383B1 (pl) 1996-12-31
UA43825C2 (uk) 2002-01-15
IL100542A0 (en) 1992-09-06
CN1064078A (zh) 1992-09-02
NZ241211A (en) 1993-08-26
PT100087A (pt) 1993-05-31
MY111502A (en) 2000-07-31
KR100205835B1 (ko) 1999-07-01
HK1004335A1 (en) 1998-11-20
RU2112775C1 (ru) 1998-06-10
CN1158726A (zh) 1997-09-10
DK0572451T3 (da) 1998-10-19
ZA92234B (en) 1992-10-28
CN1076607C (zh) 2001-12-26
DE69224982D1 (de) 1998-05-07
SK79793A3 (en) 1994-03-09
AU1235892A (en) 1992-09-07
MX9200374A (es) 1992-08-01
JP2947933B2 (ja) 1999-09-13
IE920167A1 (en) 1992-08-12
EP0572451A1 (en) 1993-12-08
CA2100453A1 (en) 1992-08-05
NO932762L (no) 1993-08-02
CZ149593A3 (en) 1994-03-16
ATE164589T1 (de) 1998-04-15
ES2114931T3 (es) 1998-06-16
CN1155418A (zh) 1997-07-30
HU221168B1 (en) 2002-08-28
SE9100342D0 (sv) 1991-02-04
PT100087B (pt) 1999-09-30
RO111272B1 (ro) 1996-08-30
MA22407A1 (fr) 1992-10-01
IL100542A (en) 1997-02-18
HU9302243D0 (en) 1993-10-28
CN1039329C (zh) 1998-07-29
IS3809A (is) 1992-08-05
WO1992013873A1 (en) 1992-08-20
JPH06505233A (ja) 1994-06-16
DE69224982T2 (de) 1998-07-30
NO304074B1 (no) 1998-10-19
AU661472B2 (en) 1995-07-27
AP365A (en) 1994-10-21
IS1653B (is) 1997-06-20
BG98011A (bg) 1994-04-29
CN1076606C (zh) 2001-12-26
EE03110B1 (et) 1998-08-17
US5614514A (en) 1997-03-25
AP9200354A0 (en) 1992-01-31
SK281802B6 (sk) 2001-08-06
YU6492A (sh) 1994-12-28
BG61816B1 (bg) 1998-06-30
TNSN92008A1 (fr) 1993-06-08
DZ1554A1 (fr) 2002-02-17
FI933451A (fi) 1993-08-03
FI933451A0 (fi) 1993-08-03
HUT64972A (en) 1994-03-28
NO932762D0 (no) 1993-08-02
TW287166B (sh) 1996-10-01

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