BG60949B1 - Антихипертензивно средство - Google Patents

Антихипертензивно средство Download PDF

Info

Publication number
BG60949B1
BG60949B1 BG96664A BG9666492A BG60949B1 BG 60949 B1 BG60949 B1 BG 60949B1 BG 96664 A BG96664 A BG 96664A BG 9666492 A BG9666492 A BG 9666492A BG 60949 B1 BG60949 B1 BG 60949B1
Authority
BG
Bulgaria
Prior art keywords
pyridazodiazepine
alkyl
formula
benzimidazolyl
agent
Prior art date
Application number
BG96664A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG96664A (bg
Inventor
Jean-Paul Clozel
Rita Mueller
Wolfgang Osterrieder
Original Assignee
F. Hoffmann- La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann- La Roche Ag filed Critical F. Hoffmann- La Roche Ag
Publication of BG96664A publication Critical patent/BG96664A/bg
Publication of BG60949B1 publication Critical patent/BG60949B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • External Artificial Organs (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
BG96664A 1991-07-23 1992-07-21 Антихипертензивно средство BG60949B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH219191 1991-07-23

Publications (2)

Publication Number Publication Date
BG96664A BG96664A (bg) 1993-12-24
BG60949B1 true BG60949B1 (bg) 1996-07-31

Family

ID=4228024

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96664A BG60949B1 (bg) 1991-07-23 1992-07-21 Антихипертензивно средство

Country Status (31)

Country Link
US (1) US5620975A (pt)
EP (1) EP0524512B1 (pt)
JP (1) JPH0680009B2 (pt)
KR (1) KR100260479B1 (pt)
CN (1) CN1040505C (pt)
AT (1) ATE260661T1 (pt)
AU (1) AU656207B2 (pt)
BG (1) BG60949B1 (pt)
BR (1) BR9202830A (pt)
CA (1) CA2074039C (pt)
CZ (1) CZ281691B6 (pt)
DE (1) DE59209993D1 (pt)
DK (1) DK0524512T3 (pt)
ES (1) ES2215160T3 (pt)
HR (1) HRP930953B1 (pt)
HU (1) HU214029B (pt)
IE (1) IE922378A1 (pt)
IL (1) IL102541A (pt)
IS (1) IS3887A (pt)
MX (1) MX9204212A (pt)
MY (1) MY118064A (pt)
NO (1) NO301047B1 (pt)
NZ (1) NZ243577A (pt)
PT (1) PT524512E (pt)
RO (1) RO110905B (pt)
RU (1) RU2084225C1 (pt)
SK (1) SK278918B6 (pt)
TW (1) TW216770B (pt)
UY (1) UY23449A1 (pt)
YU (2) YU49198B (pt)
ZA (1) ZA925322B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0634175B1 (de) * 1993-07-15 2001-01-10 F. Hoffmann-La Roche Ag Pharmazeutische Kombination, die einen Hemmer des Renin-Angiotensin-Systems und einen Endothelin-Antagonisten enthält
IL131816A (en) 1997-04-04 2003-06-24 Exxon Res & Engineering Compan Composite structures having high containment strength
EP1438297A1 (en) 2001-10-10 2004-07-21 Aryx Therapeutics Mibefradil-based compounds as calcium channel blockers useful in the treatment of hypertension and angina
US7687086B1 (en) 2003-02-28 2010-03-30 University Of Portland Method for obtaining taxanes
EP2537534B1 (en) 2011-06-22 2014-12-17 Hexal AG Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
DE3542794A1 (de) * 1985-12-04 1987-06-11 Bayer Ag Antihypertensives kombinationspraeparat
CA1319144C (en) * 1986-11-14 1993-06-15 Quirico Branca Tetrahydronaphthalene derivatives
FR2607004B1 (fr) * 1986-11-20 1990-06-01 Synthelabo Compositions pharmaceutiques contenant du diltiazem et un inhibiteur de l'enzyme de conversion de l'angiotensine
US5110813A (en) * 1987-09-15 1992-05-05 Alcoholism And Drug Addiction Research Foundation Reduction of voluntary alcohol consumption by treatment with angiotensin converting enzyme inhibitors
US4871731A (en) * 1987-10-07 1989-10-03 Marion Laboratories, Inc. Captopril and diltiazem composition and the like
KR940005408B1 (ko) * 1990-12-03 1994-06-18 만도기계 주식회사 파워 윈도우 모우터 회전자의 선단부 흔들림 측정장치

Also Published As

Publication number Publication date
TW216770B (pt) 1993-12-01
SK278918B6 (sk) 1998-04-08
AU2041692A (en) 1993-01-28
US5620975A (en) 1997-04-15
CN1040505C (zh) 1998-11-04
BG96664A (bg) 1993-12-24
HRP930953A2 (en) 1995-10-31
IE922378A1 (en) 1993-01-27
IS3887A (is) 1993-01-24
RO110905B (ro) 1996-05-30
HUT62792A (en) 1993-06-28
YU49198B (sh) 2004-09-03
CA2074039C (en) 2004-11-02
DK0524512T3 (da) 2004-07-05
AU656207B2 (en) 1995-01-27
UY23449A1 (es) 1993-01-21
ES2215160T3 (es) 2004-10-01
EP0524512A2 (de) 1993-01-27
MX9204212A (es) 1993-08-01
HRP930953B1 (en) 2003-06-30
NO922903L (no) 1993-01-25
CA2074039A1 (en) 1993-01-24
YU72392A (sh) 1997-05-28
NO301047B1 (no) 1997-09-08
ZA925322B (en) 1993-03-31
CN1068737A (zh) 1993-02-10
MY118064A (en) 2004-08-30
NO922903D0 (no) 1992-07-22
KR930001910A (ko) 1993-02-22
JPH05194217A (ja) 1993-08-03
BR9202830A (pt) 1993-03-23
PT524512E (pt) 2004-07-30
EP0524512A3 (en) 1993-09-01
RU2084225C1 (ru) 1997-07-20
CZ281691B6 (cs) 1996-12-11
SK227092A3 (en) 1996-02-07
HU9202367D0 (en) 1992-10-28
EP0524512B1 (de) 2004-03-03
KR100260479B1 (ko) 2000-07-01
DE59209993D1 (de) 2004-04-08
ATE260661T1 (de) 2004-03-15
NZ243577A (en) 1994-09-27
CZ227092A3 (en) 1993-02-17
IL102541A (en) 1995-12-08
JPH0680009B2 (ja) 1994-10-12
HU214029B (en) 1997-12-29
IL102541A0 (en) 1993-01-14

Similar Documents

Publication Publication Date Title
US8980832B2 (en) Use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
US7834056B2 (en) Pharmaceutical composition for gout
EP0786991B1 (en) Polyamine compounds for treating vascular proliferative disorders
US5624945A (en) Use of riluzole for the treatment of neuro-aids
EA002525B1 (ru) Сочетание ингибитора тирозинкиназы и химической стерилизации для лечения рака предстательной железы
US5028628A (en) Methods of treating pulmonary hypertension
BG60949B1 (bg) Антихипертензивно средство
US6844361B2 (en) Pharmaceutical composition comprising a sodium hydrogen exchange inhibitor and an angiotensin converting enzyme inhibitor
RU2432948C2 (ru) Применение активаторов растворимой гуанилатциклазы для лечения нарушений кровоснабжения
WO1997048396A1 (en) A method of treating liver disease and like indications with vasodilating agents
JP4733348B2 (ja) 心不全、他の加齢関連臓器機能不全および加齢関連障害の予防のための、ならびに寿命を延長するための、ナトリウム−水素交換阻害剤であるカリポライドとａｃｅ阻害剤との組み合わせ製剤
US3622671A (en) Substituted 3-hydrazino pyridazines as hypotensives
JPWO2003047591A1 (ja) 肺高血圧症予防治療剤
JPS6396124A (ja) アニパミル含有医薬
JPH01283224A (ja) 抗高血圧の組み合わせ調合物
NZ273242A (en) Treatment of liver disease by administration of a vasodilator which increases the oxygen supply to the liver; pharmaceutical compositions
IE43955B1 (en) Pharmaceutical composition and dosage units thereof
JPWO2018034351A1 (ja) 生薬成分を含む肺高血圧症の予防又は治療剤
Salzmann et al. Effects of the vasodilator endralazine given with the antihypertensive agent guanfacine on heart rate and blood pressure of spontaneously hypertensive rats and normotensive dogs
HU197214B (en) Process for producing pharmaceutical compositions containing 3-etoxycarbonyl-1,6-dimetil-4-oxo-6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidinium-methosulfate as active component for preventing and treating gastrointestinal damages
JPH0761939B2 (ja) 脳への酸素供給を増進させる薬剤組成物および該薬剤組成物の製造方法