BG18852A3 - Метод за получаване на 1-фенокси -2- хидрокси-3- циклоаскиламино пропани - Google Patents

Метод за получаване на 1-фенокси -2- хидрокси-3- циклоаскиламино пропани

Info

Publication number
BG18852A3
BG18852A3 BG017137A BG1713770A BG18852A3 BG 18852 A3 BG18852 A3 BG 18852A3 BG 017137 A BG017137 A BG 017137A BG 1713770 A BG1713770 A BG 1713770A BG 18852 A3 BG18852 A3 BG 18852A3
Authority
BG
Bulgaria
Prior art keywords
cycloacylamino
propanes
phenoxy
hydroxy
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
BG017137A
Other languages
Bulgarian (bg)
English (en)
Inventor
Herbert Koeppe
Werner Kummer
Helmut Staehle
Karl Zeile
Albrecht Engelhardt
Werner Traunecker
Original Assignee
C.H.Boehringer Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H.Boehringer Sohn filed Critical C.H.Boehringer Sohn
Publication of BG18852A3 publication Critical patent/BG18852A3/xx
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • E—FIXED CONSTRUCTIONS
    • E04—BUILDING
    • E04H—BUILDINGS OR LIKE STRUCTURES FOR PARTICULAR PURPOSES; SWIMMING OR SPLASH BATHS OR POOLS; MASTS; FENCING; TENTS OR CANOPIES, IN GENERAL
    • E04H13/00—Monuments; Tombs; Burial vaults; Columbaria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Architecture (AREA)
  • Civil Engineering (AREA)
  • Structural Engineering (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
BG017137A 1969-07-23 1970-07-22 Метод за получаване на 1-фенокси -2- хидрокси-3- циклоаскиламино пропани Expired BG18852A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1937477A DE1937477C3 (de) 1969-07-23 1969-07-23 I -Phenoxy-2-hydroxy-3-(l -methylcycloalkylamino)-propane, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
BG18852A3 true BG18852A3 (bg) 1975-03-20

Family

ID=5740681

Family Applications (9)

Application Number Title Priority Date Filing Date
BG017138A BG17508A3 (bg) 1969-07-23 1970-03-22 Метод за получаване на 1- фенокси 2- хидрокси-3- циклоалкил- аминопропани
BG017134A BG17750A3 (bg) 1969-07-23 1970-03-23 Метод за получаване на нови 1-фенокси-2-хидрокси-3- циклоалкиламинопропани
BG018645A BG19132A3 (bg) 1969-07-23 1970-07-22 Метод за получаване на 1-(2аминофенокси)-2-хидрокси-3 (1-метилциклохексиламино) пропан
BG017136A BG17507A3 (bg) 1969-07-23 1970-07-22 Метод за получаване на 1- фенокси-2- хидрокси- 3- циклоалкил аминопропани
BG017137A Expired BG18852A3 (bg) 1969-07-23 1970-07-22 Метод за получаване на 1-фенокси -2- хидрокси-3- циклоаскиламино пропани
BG015254A BG17749A3 (bg) 1969-07-23 1970-07-22 Метод за получаване на фенокси-2-хидрокси -3- циклоалкиламинопропани
BG017135A BG17751A3 (bg) 1969-07-23 1970-07-22 Метод за получаване на нови 1-фенокси-2-хидрокси- -3-циклоалкиламинопропани
BG017132A BG17505A3 (bg) 1969-07-23 1970-07-24 Метод за получаване на нови 1- фенокси -2- хидрокси-3- циклоалкиламинопропани
BG017133A BG17506A3 (bg) 1969-07-23 1970-07-24 Метод за получаване на 1- фенокси-2- хидрокси- з- циклоалкиламино- пропани

Family Applications Before (4)

Application Number Title Priority Date Filing Date
BG017138A BG17508A3 (bg) 1969-07-23 1970-03-22 Метод за получаване на 1- фенокси 2- хидрокси-3- циклоалкил- аминопропани
BG017134A BG17750A3 (bg) 1969-07-23 1970-03-23 Метод за получаване на нови 1-фенокси-2-хидрокси-3- циклоалкиламинопропани
BG018645A BG19132A3 (bg) 1969-07-23 1970-07-22 Метод за получаване на 1-(2аминофенокси)-2-хидрокси-3 (1-метилциклохексиламино) пропан
BG017136A BG17507A3 (bg) 1969-07-23 1970-07-22 Метод за получаване на 1- фенокси-2- хидрокси- 3- циклоалкил аминопропани

Family Applications After (4)

Application Number Title Priority Date Filing Date
BG015254A BG17749A3 (bg) 1969-07-23 1970-07-22 Метод за получаване на фенокси-2-хидрокси -3- циклоалкиламинопропани
BG017135A BG17751A3 (bg) 1969-07-23 1970-07-22 Метод за получаване на нови 1-фенокси-2-хидрокси- -3-циклоалкиламинопропани
BG017132A BG17505A3 (bg) 1969-07-23 1970-07-24 Метод за получаване на нови 1- фенокси -2- хидрокси-3- циклоалкиламинопропани
BG017133A BG17506A3 (bg) 1969-07-23 1970-07-24 Метод за получаване на 1- фенокси-2- хидрокси- з- циклоалкиламино- пропани

Country Status (17)

Country Link
US (1) US3755413A (fi)
JP (5) JPS5133106B1 (fi)
AT (9) AT304474B (fi)
BE (1) BE753774A (fi)
BG (9) BG17508A3 (fi)
CH (10) CH536811A (fi)
CS (9) CS170524B2 (fi)
DE (1) DE1937477C3 (fi)
DK (1) DK140281B (fi)
ES (8) ES382014A1 (fi)
FR (1) FR2059551B1 (fi)
GB (1) GB1314896A (fi)
NL (1) NL169874C (fi)
PL (9) PL90028B1 (fi)
RO (9) RO56318A (fi)
SE (1) SE370391B (fi)
YU (5) YU34395B (fi)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021576A (en) * 1969-07-23 1977-05-03 Boehringer Ingelheim Gmbh Pharmaceutical compositions containing a 1-(2'-ethynyl-phenoxy)-2-hydroxy-3-(cycloalkyl-amino)-propane and method of use
US3937706A (en) * 1969-07-23 1976-02-10 Boehringer Ingelheim Gmbh 1-(2'ethynyl-phenoxy)-2-hydroxy-3-(cycloalkyl-amino)-propanes and salts thereof
US4038313A (en) * 1970-01-08 1977-07-26 Ciba-Geigy Corporation Cycloalkylureido phenoxy propanolamines
US4120978A (en) * 1970-01-08 1978-10-17 Ciba-Geigy Corporation Pharmaceutical composition for inhibiting and blocking cardioselective beta-receptors
SE354851B (fi) * 1970-02-18 1973-03-26 Haessle Ab
US4145442A (en) * 1972-04-04 1979-03-20 Aktiebolaget Hassle Phenoxy-hydroxypropylamines, their preparation, and method and pharmaceutical preparations for treating cardiovascular diseases
US4038414A (en) * 1972-06-08 1977-07-26 Ciba-Geigy Corporation Amines and processes for their manufacture
US4035420A (en) * 1972-07-06 1977-07-12 Aktiebolaget Hassle Substituted ureido alkylene phenoxy propanolamines
DE2309887C2 (de) * 1973-02-28 1983-11-10 C.H. Boehringer Sohn, 6507 Ingelheim 1-Aryloxy-2-hydroxy-3-alkinylaminopropan-Derivate und deren physiologisch verträgliche Säureadditionssalze, pharmazeutische Präparate und Herstellungsverfahren für die Verbindungen
US4220659A (en) * 1974-02-22 1980-09-02 Boehringer Ingelheim Gmbh 1-Phenoxy-2-hydroxy-3-alkynylamino-propanes and salts thereof
DK405775A (da) * 1974-09-12 1976-03-13 American Cyanamid Co Fremgangsmade til fremstilling af alkanolaminer
US4165384A (en) * 1974-11-01 1979-08-21 Aktiebolaget Hassle Amide substituted phenoxy propanol amines
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4471127A (en) * 1981-09-08 1984-09-11 Ciba-Geigy Corporation 1-5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols
US5039801A (en) * 1985-12-20 1991-08-13 The United States Of America As Represented By The Department Of Health & Human Services Thermal fragmentation of methylbenzylurea disastereomers or secondary amines and preparation of optically active secondary amines
JPS6364630U (fi) * 1986-10-17 1988-04-28

Also Published As

Publication number Publication date
YU186070A (en) 1978-12-31
CH536811A (de) 1973-06-29
NL7010928A (fi) 1971-01-26
RO59210A (fi) 1976-01-15
JPS5210862B1 (fi) 1977-03-26
ES394913A1 (es) 1974-12-16
PL90026B1 (fi) 1976-12-31
RO59159A (fi) 1976-02-15
CH575376A5 (fi) 1976-05-14
BE753774A (fr) 1971-01-22
BG17751A3 (bg) 1973-12-25
DE1937477A1 (de) 1971-02-04
DK140281C (fi) 1979-12-10
DK140281B (da) 1979-07-23
CH536813A (de) 1973-06-29
BG17506A3 (bg) 1973-11-10
CH570363A5 (fi) 1975-12-15
RO59209A (fi) 1976-01-15
YU254675A (en) 1979-04-30
ES394918A1 (es) 1974-12-01
RO59112A (fi) 1976-01-15
RO60111A (fi) 1976-06-15
PL90027B1 (fi) 1976-12-31
AT306703B (de) 1973-04-25
BG19132A3 (bg) 1975-04-30
BG17750A3 (bg) 1973-12-25
ES394916A1 (es) 1974-12-16
AT304478B (de) 1973-01-10
CS170527B2 (fi) 1976-08-27
AT306704B (de) 1973-04-25
NL169874C (nl) 1982-09-01
RO60112A (fi) 1976-08-15
JPS5210861B1 (fi) 1977-03-26
GB1314896A (en) 1973-04-26
ES394915A1 (es) 1974-12-16
ES394914A1 (es) 1974-12-01
YU34113B (en) 1978-12-31
BG17505A3 (bg) 1973-11-10
BG17507A3 (bg) 1973-11-10
AT306702B (de) 1973-04-25
CH537360A (de) 1973-05-31
CS170531B2 (fi) 1976-08-27
CS170530B2 (fi) 1976-08-27
YU254475A (en) 1978-12-31
SE370391B (fi) 1974-10-14
AT304474B (de) 1973-01-10
NL169874B (nl) 1982-04-01
PL90029B1 (fi) 1976-12-31
YU34395B (en) 1979-07-10
ES394917A1 (es) 1974-12-01
YU34663B (en) 1979-12-31
ES382014A1 (es) 1973-06-16
PL90030B1 (fi) 1976-12-31
CS170526B2 (fi) 1976-08-27
PL90025B1 (fi) 1976-12-31
CH536812A (de) 1973-06-29
CS170525B2 (fi) 1976-08-27
JPS5133106B1 (fi) 1976-09-17
FR2059551B1 (fi) 1974-09-20
CH536810A (de) 1973-06-29
RO59211A (fi) 1976-01-15
YU255175A (en) 1978-06-30
BG17508A3 (bg) 1973-11-10
JPS5210863B1 (fi) 1977-03-26
CH536809A (de) 1973-06-29
RO59089A (fi) 1975-11-15
AT304475B (de) 1973-01-10
AT304476B (de) 1973-01-10
YU34662B (en) 1979-12-31
CS170528B2 (fi) 1976-08-27
FR2059551A1 (fi) 1971-06-04
ES394919A1 (es) 1974-12-01
JPS5238556B1 (fi) 1977-09-29
CS170532B2 (fi) 1976-08-27
PL90038B1 (fi) 1976-12-31
YU34396B (en) 1979-07-10
PL79772B1 (fi) 1975-06-30
DE1937477B2 (de) 1979-08-02
AT304477B (de) 1973-01-10
PL90028B1 (fi) 1976-12-31
AT303706B (de) 1972-12-11
BG17749A3 (bg) 1973-12-25
RO56318A (fi) 1974-09-01
DE1937477C3 (de) 1980-04-10
YU254575A (en) 1979-04-30
PL90039B1 (fi) 1976-12-31
CS170524B2 (fi) 1976-08-27
CH550140A (de) 1974-06-14
US3755413A (en) 1973-08-28
CS170529B2 (fi) 1976-08-27
CH550139A (de) 1974-06-14

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