BG108019A - Parenteral formulation containing epothilone analogs - Google Patents
Parenteral formulation containing epothilone analogsInfo
- Publication number
- BG108019A BG108019A BG108019A BG10801903A BG108019A BG 108019 A BG108019 A BG 108019A BG 108019 A BG108019 A BG 108019A BG 10801903 A BG10801903 A BG 10801903A BG 108019 A BG108019 A BG 108019A
- Authority
- BG
- Bulgaria
- Prior art keywords
- vial
- diluent
- analog
- epothilone
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26422801P | 2001-01-25 | 2001-01-25 | |
PCT/US2002/001102 WO2002062338A1 (en) | 2001-01-25 | 2002-01-16 | Parenteral formulation containing epothilone analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
BG108019A true BG108019A (en) | 2004-09-30 |
Family
ID=23005123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG108019A BG108019A (en) | 2001-01-25 | 2003-07-22 | Parenteral formulation containing epothilone analogs |
Country Status (24)
Country | Link |
---|---|
US (5) | US7022330B2 (pl) |
EP (1) | EP1353667A1 (pl) |
JP (1) | JP2004521122A (pl) |
KR (1) | KR20030071853A (pl) |
CN (2) | CN1489466A (pl) |
AR (2) | AR032408A1 (pl) |
BG (1) | BG108019A (pl) |
BR (1) | BR0206511A (pl) |
CA (2) | CA2434566A1 (pl) |
CZ (1) | CZ20032022A3 (pl) |
EE (1) | EE200300323A (pl) |
HU (1) | HUP0302567A2 (pl) |
IL (1) | IL156580A0 (pl) |
IS (1) | IS6890A (pl) |
MX (1) | MXPA03006485A (pl) |
NO (1) | NO20033342L (pl) |
PE (1) | PE20020733A1 (pl) |
PL (1) | PL367260A1 (pl) |
RU (1) | RU2003126171A (pl) |
SI (1) | SI1353668T1 (pl) |
SK (1) | SK8552003A3 (pl) |
UY (1) | UY27134A1 (pl) |
WO (1) | WO2002062338A1 (pl) |
ZA (3) | ZA200305126B (pl) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
JP4579351B2 (ja) | 1996-12-03 | 2010-11-10 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロンの合成とその中間体及びその類似物並びにその使用 |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
UA75365C2 (en) * | 2000-08-16 | 2006-04-17 | Bristol Myers Squibb Co | Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon |
JP2004521122A (ja) * | 2001-01-25 | 2004-07-15 | ブリストル−マイヤーズ スクイブ カンパニー | エポチロン類似体の非経口製剤 |
EE200300396A (et) | 2001-02-20 | 2003-12-15 | Bristol-Myers Squibb Company | Epotilooni derivaatide kasutamine refraktaarsete kasvajate raviks |
CZ305799B6 (cs) * | 2001-03-14 | 2016-03-23 | Bristol-Myers Squibb Company | Kombinace analogů epothilonu a chemoterapeutických činidel pro léčení proliferačních nemocí |
TW200400191A (en) * | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
EP1506203B1 (en) | 2002-08-23 | 2007-01-03 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
US20050136105A1 (en) * | 2003-12-22 | 2005-06-23 | Allen Marni L. | Consumer customized dosage forms |
DK1718283T3 (da) * | 2004-01-22 | 2013-04-22 | Univ Miami | Topisk co-enzyme Q10 formuleringer og fremgangsmåder for anvendelse. |
DK1658848T3 (da) * | 2004-10-29 | 2007-11-26 | Pharma Mar Sa | Formuleringer omfattende ecteinascidin og et disaccharid |
ATE397442T1 (de) * | 2004-11-18 | 2008-06-15 | Bristol Myers Squibb Co | Magensaftresistent beschichtetes pellet mit ixabepilon |
US20060134214A1 (en) * | 2004-11-18 | 2006-06-22 | Ismat Ullah | Enteric coated bead comprising epothilone or epothilone analog, and preparation and administration thereof |
EP1674098A1 (en) * | 2004-12-23 | 2006-06-28 | Schering Aktiengesellschaft | Stable and tolerable parental formulations of highly reactive organic drug substances with low or no solubility in water |
AU2006336468B2 (en) | 2005-02-11 | 2012-04-12 | University Of Southern California | Method of expressing proteins with disulfide bridges |
GB0522082D0 (en) | 2005-10-31 | 2005-12-07 | Pharma Mar Sa | Formulations |
US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
EP2029156A4 (en) * | 2006-05-01 | 2010-07-21 | Univ Southern California | POLY THERAPY FOR TREATING CANCER |
WO2007140299A2 (en) * | 2006-05-25 | 2007-12-06 | Bristol-Myers Squibb Company | Use of ixabepilone in combination with cyp3a4 inhibitors for pharmaceuticals |
CN101732310B (zh) * | 2006-07-12 | 2011-07-20 | 湖南迪诺制药有限公司 | 埃博霉素b的用途 |
WO2010056901A2 (en) | 2008-11-13 | 2010-05-20 | University Of Southern California | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
WO2010056847A2 (en) * | 2008-11-13 | 2010-05-20 | Taigen Biotechnology Co., Ltd. | Lyophilization formulation |
JP2012526828A (ja) | 2009-05-11 | 2012-11-01 | バーグ バイオシステムズ,エルエルシー | エピメタボリックシフター、多次元細胞内分子、または環境影響因子を使用する代謝性障害の治療方法 |
EP2571525A4 (en) | 2010-05-18 | 2016-04-27 | Cerulean Pharma Inc | Compositions and methods for treating autoimmune and other diseases |
US8618146B2 (en) | 2011-01-03 | 2013-12-31 | Dr. Reddy's Laboratories Limited | Epothilone compound formulations |
ES2762451T3 (es) | 2011-04-04 | 2020-05-25 | Berg Llc | Tratamiento de tumores del sistema nervioso central con coenzima Q10 |
US8809562B2 (en) | 2011-06-06 | 2014-08-19 | Chevron Phillips Chemical Company Lp | Use of metallocene compounds for cancer treatment |
EA032775B1 (ru) | 2013-04-08 | 2019-07-31 | Берг Ллк | Способы лечения злокачественной опухоли с использованием комбинированной терапии с коферментом q10 |
JP6595478B2 (ja) | 2013-09-04 | 2019-10-23 | バーグ エルエルシー | コエンザイムq10の連続注入によるがんの治療方法 |
CN107041886A (zh) | 2016-02-06 | 2017-08-15 | 北京华昊中天生物技术有限公司 | 脱环氧埃坡霉素衍生物制剂、制备及其治疗肿瘤的应用 |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
EP4087545A1 (en) | 2020-01-10 | 2022-11-16 | R-Pharm US Operating LLC | Compositions of ixabepilone |
PL4062913T3 (pl) | 2020-09-02 | 2024-07-22 | Beijing Biostar Pharmaceuticals Co., Ltd. | Stały preparat doustny utidelonu |
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US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
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US6211412B1 (en) | 1999-03-29 | 2001-04-03 | The University Of Kansas | Synthesis of epothilones |
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UA75365C2 (en) * | 2000-08-16 | 2006-04-17 | Bristol Myers Squibb Co | Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon |
US20030017169A1 (en) * | 2000-12-29 | 2003-01-23 | Sidney Pestka | Controlled release systems for polymers |
JP2004521122A (ja) * | 2001-01-25 | 2004-07-15 | ブリストル−マイヤーズ スクイブ カンパニー | エポチロン類似体の非経口製剤 |
NZ526871A (en) * | 2001-01-25 | 2006-01-27 | Bristol Myers Squibb Co | Pharmaceutical dosage forms of epothilones for oral administration |
HU229349B1 (en) * | 2001-01-25 | 2013-11-28 | Bristol Myers Squibb Co | Methods for preparation of pharmaceutical composition containing epothilone analogs useful for treatment of cancer |
EE200300396A (et) | 2001-02-20 | 2003-12-15 | Bristol-Myers Squibb Company | Epotilooni derivaatide kasutamine refraktaarsete kasvajate raviks |
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2002
- 2002-01-16 JP JP2002562345A patent/JP2004521122A/ja active Pending
- 2002-01-16 CN CNA028041798A patent/CN1489466A/zh active Pending
- 2002-01-16 WO PCT/US2002/001102 patent/WO2002062338A1/en not_active Application Discontinuation
- 2002-01-16 PL PL02367260A patent/PL367260A1/pl not_active Application Discontinuation
- 2002-01-16 CZ CZ20032022A patent/CZ20032022A3/cs unknown
- 2002-01-16 HU HU0302567A patent/HUP0302567A2/hu unknown
- 2002-01-16 EE EEP200300323A patent/EE200300323A/xx unknown
- 2002-01-16 KR KR10-2003-7009824A patent/KR20030071853A/ko not_active Application Discontinuation
- 2002-01-16 IL IL15658002A patent/IL156580A0/xx unknown
- 2002-01-16 SK SK855-2003A patent/SK8552003A3/sk unknown
- 2002-01-16 MX MXPA03006485A patent/MXPA03006485A/es unknown
- 2002-01-16 CA CA002434566A patent/CA2434566A1/en not_active Abandoned
- 2002-01-16 BR BR0206511-8A patent/BR0206511A/pt not_active Application Discontinuation
- 2002-01-16 RU RU2003126171/15A patent/RU2003126171A/ru not_active Application Discontinuation
- 2002-01-16 EP EP02709040A patent/EP1353667A1/en not_active Withdrawn
- 2002-01-17 US US10/051,727 patent/US7022330B2/en not_active Expired - Lifetime
- 2002-01-22 SI SI200230687T patent/SI1353668T1/sl unknown
- 2002-01-22 CA CA2681962A patent/CA2681962C/en not_active Expired - Lifetime
- 2002-01-22 CN CN2007101422373A patent/CN101112373B/zh not_active Expired - Fee Related
- 2002-01-25 PE PE2002000060A patent/PE20020733A1/es not_active Application Discontinuation
- 2002-01-25 AR ARP020100286A patent/AR032408A1/es unknown
- 2002-01-25 UY UY27134A patent/UY27134A1/es not_active Application Discontinuation
-
2003
- 2003-07-01 ZA ZA200305126A patent/ZA200305126B/xx unknown
- 2003-07-01 ZA ZA200305123A patent/ZA200305123B/en unknown
- 2003-07-17 ZA ZA200305536A patent/ZA200305536B/en unknown
- 2003-07-22 BG BG108019A patent/BG108019A/xx unknown
- 2003-07-24 NO NO20033342A patent/NO20033342L/no not_active Application Discontinuation
- 2003-07-24 IS IS6890A patent/IS6890A/is unknown
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2005
- 2005-09-14 US US11/226,017 patent/US20060013836A1/en not_active Abandoned
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2008
- 2008-11-04 US US12/264,375 patent/US8632788B2/en not_active Expired - Fee Related
-
2013
- 2013-12-19 US US14/134,172 patent/US20140107169A1/en not_active Abandoned
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2014
- 2014-10-17 AR ARP140103915A patent/AR098109A2/es unknown
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2015
- 2015-04-14 US US14/686,005 patent/US20150218179A1/en not_active Abandoned
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