BG107061A - Method for the preparation of citalopram - Google Patents

Method for the preparation of citalopram

Info

Publication number
BG107061A
BG107061A BG107061A BG10706102A BG107061A BG 107061 A BG107061 A BG 107061A BG 107061 A BG107061 A BG 107061A BG 10706102 A BG10706102 A BG 10706102A BG 107061 A BG107061 A BG 107061A
Authority
BG
Bulgaria
Prior art keywords
group
compound
formula
citalopram
alkynyl
Prior art date
Application number
BG107061A
Other languages
Bulgarian (bg)
English (en)
Inventor
Hans Petersen
Michael Rock
Haleh Ahmadian
Original Assignee
H.Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbeck A/S filed Critical H.Lundbeck A/S
Publication of BG107061A publication Critical patent/BG107061A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
BG107061A 2000-02-24 2002-09-04 Method for the preparation of citalopram BG107061A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200000296 2000-02-24
DKPA200000401 2000-03-13
PCT/DK2001/000123 WO2001043525A2 (en) 2000-02-24 2001-02-22 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
BG107061A true BG107061A (en) 2003-05-30

Family

ID=26068779

Family Applications (1)

Application Number Title Priority Date Filing Date
BG107061A BG107061A (en) 2000-02-24 2002-09-04 Method for the preparation of citalopram

Country Status (26)

Country Link
US (1) US6420574B2 (hr)
EP (1) EP1259501A2 (hr)
JP (1) JP2003523955A (hr)
KR (1) KR20020081355A (hr)
CN (1) CN1608057A (hr)
AR (1) AR029658A1 (hr)
AU (1) AU2001235358A1 (hr)
BE (1) BE1011177A6 (hr)
BG (1) BG107061A (hr)
BR (1) BR0108937A (hr)
CA (1) CA2401236A1 (hr)
EA (1) EA005315B1 (hr)
FR (1) FR2805812A1 (hr)
GR (1) GR1004073B (hr)
HR (1) HRP20020660A2 (hr)
HU (1) HUP0300212A2 (hr)
IE (1) IES20010163A2 (hr)
IL (1) IL151059A0 (hr)
IS (1) IS6487A (hr)
IT (1) ITMI20010386A1 (hr)
MX (1) MXPA02008228A (hr)
NL (1) NL1017415C1 (hr)
NO (1) NO20023928L (hr)
PL (1) PL363119A1 (hr)
SK (1) SK13672002A3 (hr)
WO (1) WO2001043525A2 (hr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) * 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
HUP0200169A3 (en) 1999-10-25 2002-11-28 Lundbeck & Co As H Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
WO2001047909A1 (en) 1999-12-28 2001-07-05 H. Lundbeck A/S Method for the preparation of citalopram
PL198803B1 (pl) 1999-12-30 2008-07-31 Lundbeck & Co As H Sposób wytwarzania 5-cyjano-3H-izobenzofuran-1-onu
ES2206177T3 (es) * 2000-01-14 2004-05-16 H. Lundbeck A/S Metodo para la preparacion de 5-cianoftalida.
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010157A2 (en) * 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
BR0109176A (pt) 2000-03-13 2003-04-22 Lundbeck & Co As H Método para preparação de citalopram e composto da fórmula
CA2402553A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
IL151488A0 (en) 2000-03-14 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
EP1274699A1 (en) * 2000-03-16 2003-01-15 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure cithalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
MXPA04004368A (es) * 2001-11-08 2004-08-11 Sepracor Inc Metodos para tratar depresion y otros transtornos del sistema nervioso central utilizando desmetil-y didesmetil-metabolitos del citalopram enantiomericamente enriquecidos.
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
WO2005047274A1 (en) * 2003-11-12 2005-05-26 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
AU2008252631B2 (en) * 2007-05-18 2012-12-20 Cipla Limited Process for the preparation of escitalopram via desmethylcitalopram, optical resolution and methylation of the S-isomer
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (hr) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
US5296007A (en) 1986-11-17 1994-03-22 Ensci Inc. Process for removing sulfur from coal
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
JP3526581B2 (ja) 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CZ292911B6 (cs) 1997-11-11 2004-01-14 H. Lundbeck A/S Způsob výroby citalopramu
PL199423B1 (pl) 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate

Also Published As

Publication number Publication date
IL151059A0 (en) 2003-04-10
IES20010163A2 (en) 2002-03-06
GR1004073B (el) 2002-11-26
WO2001043525A3 (en) 2002-01-31
HRP20020660A2 (en) 2004-12-31
AU2001235358A1 (en) 2001-06-25
US20010027256A1 (en) 2001-10-04
FR2805812A1 (fr) 2001-09-07
IS6487A (is) 2002-07-29
NO20023928D0 (no) 2002-08-19
SK13672002A3 (sk) 2003-03-04
US6420574B2 (en) 2002-07-16
AR029658A1 (es) 2003-07-10
EA005315B1 (ru) 2004-12-30
HUP0300212A2 (hu) 2003-06-28
NO20023928L (no) 2002-08-19
WO2001043525A2 (en) 2001-06-21
CN1608057A (zh) 2005-04-20
BR0108937A (pt) 2003-06-17
ITMI20010386A1 (it) 2002-08-26
MXPA02008228A (es) 2004-04-05
EP1259501A2 (en) 2002-11-27
PL363119A1 (en) 2004-11-15
JP2003523955A (ja) 2003-08-12
BE1011177A6 (fr) 2001-07-03
NL1017415C1 (nl) 2001-05-18
EA200200898A1 (ru) 2003-02-27
GR20010100098A (el) 2001-10-31
KR20020081355A (ko) 2002-10-26
CA2401236A1 (en) 2001-06-21

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