BG107047A - Method for the preparation of citalopram - Google Patents

Method for the preparation of citalopram

Info

Publication number
BG107047A
BG107047A BG107047A BG10704702A BG107047A BG 107047 A BG107047 A BG 107047A BG 107047 A BG107047 A BG 107047A BG 10704702 A BG10704702 A BG 10704702A BG 107047 A BG107047 A BG 107047A
Authority
BG
Bulgaria
Prior art keywords
citalopram
preparation
alkylation
fluorophenyl
present
Prior art date
Application number
BG107047A
Other languages
Bulgarian (bg)
English (en)
Inventor
Hans Petersen
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of BG107047A publication Critical patent/BG107047A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG107047A 2000-03-13 2002-09-02 Method for the preparation of citalopram BG107047A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200000401 2000-03-13
DKPA200000415 2000-03-14
PCT/DK2001/000168 WO2001068631A1 (en) 2000-03-13 2001-03-13 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
BG107047A true BG107047A (en) 2003-04-30

Family

ID=26068790

Family Applications (1)

Application Number Title Priority Date Filing Date
BG107047A BG107047A (en) 2000-03-13 2002-09-02 Method for the preparation of citalopram

Country Status (22)

Country Link
US (2) US6762308B2 (sk)
EP (1) EP1265883A1 (sk)
JP (1) JP2003527387A (sk)
KR (1) KR20020080481A (sk)
CN (1) CN1429219A (sk)
AU (1) AU2001242298A1 (sk)
BG (1) BG107047A (sk)
BR (1) BR0109176A (sk)
CA (1) CA2402388A1 (sk)
CZ (1) CZ20023384A3 (sk)
EA (1) EA200200969A1 (sk)
HR (1) HRP20020744A2 (sk)
HU (1) HUP0300274A2 (sk)
IL (1) IL151490A0 (sk)
IS (1) IS6529A (sk)
MX (1) MXPA02008869A (sk)
NO (1) NO20024213L (sk)
NZ (1) NZ521201A (sk)
PL (1) PL360110A1 (sk)
SK (1) SK14602002A3 (sk)
TR (1) TR200202166T2 (sk)
WO (1) WO2001068631A1 (sk)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL198024B1 (pl) 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
JP2003527385A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
JP2003527387A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PT1265882E (pt) 2000-03-14 2004-06-30 Lundbeck & Co As H Metodo para preparacao de citalopram; composto e citalopram
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US7613106B2 (en) * 2005-01-04 2009-11-03 Avaya Inc. Dial plan transparency for fragmented networks
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (sk) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
EA001728B1 (ru) 1997-07-08 2001-08-27 Х.Лундбекк А/С Способ получения циталопрама
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
SK283907B6 (sk) 1997-11-11 2004-04-06 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
AU746665B2 (en) 1998-10-20 2002-05-02 H. Lundbeck A/S Method for the preparation of citalopram
BR9916955A (pt) 1998-12-23 2001-09-11 Lundbeck & Co As H Método para preparação de 5-cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PL198024B1 (pl) 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692421A5 (de) 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
PL355532A1 (en) 1999-12-28 2004-05-04 H.Lundbeck A/S Method for the preparation of citalopram
CZ20022627A3 (cs) 1999-12-30 2002-10-16 H. Lundbeck A/S Způsob výroby citalopramu
SK286879B6 (sk) 2000-01-14 2009-07-06 H. Lundbeck A/S Spôsob prípravy 5-kyanoftalidu
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
JP2003527387A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PT1265882E (pt) 2000-03-14 2004-06-30 Lundbeck & Co As H Metodo para preparacao de citalopram; composto e citalopram
TR200202168T2 (tr) 2000-03-16 2002-12-23 H. Lundbeck A/S 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu
AU2001272368A1 (en) 2000-07-06 2002-01-21 H. Lundbeck, A/S Method for the preparation of citalopram
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
DK1181713T3 (da) 2000-12-22 2005-01-31 Lundbeck & Co As H Fremgangsmåde til fremstilling af rent citalopram
KR100430746B1 (ko) 2000-12-28 2004-05-10 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법

Also Published As

Publication number Publication date
US20040215025A1 (en) 2004-10-28
EP1265883A1 (en) 2002-12-18
US6992198B2 (en) 2006-01-31
US6762308B2 (en) 2004-07-13
EA200200969A1 (ru) 2003-02-27
CA2402388A1 (en) 2001-09-20
NO20024213D0 (no) 2002-09-04
IL151490A0 (en) 2003-04-10
CN1429219A (zh) 2003-07-09
CZ20023384A3 (cs) 2003-01-15
NZ521201A (en) 2004-02-27
IS6529A (is) 2002-08-27
AU2001242298A1 (en) 2001-09-24
WO2001068631A1 (en) 2001-09-20
US20030092919A1 (en) 2003-05-15
BR0109176A (pt) 2003-04-22
HUP0300274A2 (hu) 2003-06-28
KR20020080481A (ko) 2002-10-23
NO20024213L (no) 2002-11-13
JP2003527387A (ja) 2003-09-16
PL360110A1 (en) 2004-09-06
TR200202166T2 (tr) 2002-12-23
MXPA02008869A (es) 2003-02-10
SK14602002A3 (sk) 2003-02-04
HRP20020744A2 (en) 2004-12-31

Similar Documents

Publication Publication Date Title
HK1046897A1 (en) Methods for preparing n-Ä(aliphatic or aromatic)carbonyl)Ü-2- aminoacetamide compounds and for cyclizing such compounds.
YU68802A (sh) Kristalna baza citaloprama
BG105009A (en) Method for producing 4-carboxyamino-2-substituted 1,2,3,4-tetrahydroquinoline
AR029598A1 (es) Metodo para la preparacion de citalopram
ZA200206699B (en) Method for the preparation of citalopram.
BG107047A (en) Method for the preparation of citalopram
BG107049A (en) Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
BG107046A (en) Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
HK1052512A1 (en) Method for the preparation of citalopram
MXPA02006167A (es) Promocion de la angiogenesis con survivina.
BG103649A (en) Method for the preparation of eprosartan
ES2195923T3 (es) Procedimiento para epoxidar cicloyexanonas sustituidas.
BG103650A (en) Method for the preparation of eprosartan
CA2322501A1 (en) Processes for the preparation of (r)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
BR0101437A (pt) Método para preparar um ciclopropeno
DE69906101D1 (de) 3-bicycloindole als liganden des 5-ht 1d rezeptors
DK1328275T3 (da) Substituerede 4,5-dihydro-1,2,4-triazin-3-oner, 1,2,4-triazin-3-oner og deres anvendelse som fungicider og insekticider
HUP0302821A2 (hu) Eljárás szubsztituált 5-amino-N-fenil-1,2,4-triazol-3-szulfonamid-származékok előállítására
MY123517A (en) Process for preparing 10, 11-methanobenzosuberane derivatives
GB2353794B (en) Deadplate assembly for I.S. machine
IL135002A0 (en) Method for preparing optionally substituted benzofuranones
AU2002229809A1 (en) Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
ECSP003511A (es) Procedimiento para preparar derivados de 10,11-metanobenzosuberano
ZA200106687B (en) Method for the preparation of citalopram.
ZA200104971B (en) Method for the preparation of citalopram.