BG106964A - Ваксина за профилактична или терапевтична имунизация против hiv - Google Patents
Ваксина за профилактична или терапевтична имунизация против hiv Download PDFInfo
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- BG106964A BG106964A BG106964A BG10696402A BG106964A BG 106964 A BG106964 A BG 106964A BG 106964 A BG106964 A BG 106964A BG 10696402 A BG10696402 A BG 10696402A BG 106964 A BG106964 A BG 106964A
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- hiv
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0002200A GB0002200D0 (en) | 2000-01-31 | 2000-01-31 | Novel use |
| GB0009336A GB0009336D0 (en) | 2000-04-14 | 2000-04-14 | Novel use |
| GB0013806A GB0013806D0 (en) | 2000-06-06 | 2000-06-06 | Novel use |
| PCT/EP2000/005998 WO2001000232A2 (en) | 1999-06-29 | 2000-06-28 | Use of cpg as an adjuvant for hiv vaccine |
| PCT/EP2001/000944 WO2001054719A2 (en) | 2000-01-31 | 2001-01-29 | Vaccine for the prophylactic or therapeutic immunization against hiv |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG106964A true BG106964A (bg) | 2004-01-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG106964A BG106964A (bg) | 2000-01-31 | 2002-07-30 | Ваксина за профилактична или терапевтична имунизация против hiv |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US20030158134A1 (pl) |
| EP (1) | EP1251870A2 (pl) |
| JP (1) | JP2003529559A (pl) |
| KR (2) | KR20070073987A (pl) |
| CN (1) | CN1326873C (pl) |
| AP (1) | AP2002002592A0 (pl) |
| AU (1) | AU783005B2 (pl) |
| BG (1) | BG106964A (pl) |
| BR (1) | BR0107972A (pl) |
| CA (1) | CA2398611A1 (pl) |
| CZ (1) | CZ20022643A3 (pl) |
| DZ (1) | DZ3286A1 (pl) |
| EA (1) | EA200200724A1 (pl) |
| HK (1) | HK1051317A1 (pl) |
| HU (1) | HUP0204250A3 (pl) |
| IL (1) | IL150756A0 (pl) |
| MX (1) | MXPA02007413A (pl) |
| NO (1) | NO20023616L (pl) |
| NZ (1) | NZ520327A (pl) |
| OA (1) | OA12168A (pl) |
| PL (1) | PL211762B1 (pl) |
| SK (1) | SK11122002A3 (pl) |
| WO (1) | WO2001054719A2 (pl) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| IT1297090B1 (it) * | 1997-12-01 | 1999-08-03 | Barbara Ensoli | Tat di hiv-1 o suoi derivati, da soli od in combinazione, a scopo vaccinale, profilattico e terapeutico, contro l'aids i tumori e le |
| IL139813A0 (en) | 1998-05-22 | 2002-02-10 | Loeb Health Res Inst At The Ot | Methods and products for inducing mucosal immunity |
| CA2358385C (en) | 1998-12-31 | 2013-08-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| JP2002533124A (ja) | 1998-12-31 | 2002-10-08 | カイロン コーポレイション | Ｈｉｖポリペプチドの改善された発現およびウイルス様粒子の生成 |
| US20050244434A1 (en) * | 1999-08-12 | 2005-11-03 | Cohen David I | Tat-based tolerogen compositions and methods of making and using same |
| US20050226890A1 (en) * | 1999-08-12 | 2005-10-13 | Cohen David I | Tat-based vaccine compositions and methods of making and using same |
| KR20020075789A (ko) | 2000-02-04 | 2002-10-05 | 듀크 유니버시티 | 인체 면역결핍 바이러스 백신 |
| WO2003004620A2 (en) | 2001-07-05 | 2003-01-16 | Chiron, Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| EP1279404A1 (en) | 2001-07-26 | 2003-01-29 | Istituto Superiore di Sanità | Use of HIV-1 tat, fragments or derivatives thereof, to target or to activate antigen-presenting cells, to deliver cargo molecules for vaccination or to treat other diseases |
| GB0118367D0 (en) * | 2001-07-27 | 2001-09-19 | Glaxosmithkline Biolog Sa | Novel use |
| FR2828404B1 (fr) * | 2001-08-10 | 2005-07-15 | Neovacs | Superimmunogene composite a usage vaccinal bifonctionnel pour le traitement des maladies associees a un desordre tissulaire stromal |
| US20030170614A1 (en) | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
| SG2013034475A (en) | 2001-11-21 | 2016-10-28 | Univ Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
| EP1944043A1 (en) | 2001-11-21 | 2008-07-16 | The Trustees of the University of Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
| GB0206359D0 (en) | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| GB0206360D0 (en) | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| JP2005533752A (ja) * | 2002-03-19 | 2005-11-10 | パウダーメド リミテッド | Ｈｉｖｄｎａワクチン接種におけるアジュバントとしてのイミダゾキノリンアミン |
| GB0210682D0 (en) * | 2002-05-09 | 2002-06-19 | Glaxosmithkline Biolog Sa | Novel use |
| KR101196178B1 (ko) | 2002-05-16 | 2012-11-01 | 버베리안 노딕 에이/에스 | Ｈｉｖ 조절/부속 단백질의 융합 단백질 |
| JP2005533855A (ja) | 2002-07-24 | 2005-11-10 | インターツェル・アクチェンゲゼルシャフト | 病原性ウイルスからの別のリーディングフレームによりコードされる抗原 |
| CA2484339A1 (en) | 2002-09-13 | 2004-03-25 | Intercell Ag | Method for isolating hepatitis c virus peptides |
| AU2003283647B2 (en) | 2002-10-29 | 2010-04-15 | Coley Pharmaceutical Gmbh | Use of CPG oligonucleotides in the treatment of hepatitis C virus infection |
| GB0225788D0 (en) * | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| GB0225786D0 (en) * | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| CA2502015A1 (en) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | 5' cpg nucleic acids and methods of use |
| JP2006521321A (ja) * | 2003-03-24 | 2006-09-21 | インターツェル・アクチェンゲゼルシャフト | 免疫応答を促進するためのミョウバンおよびＴｈ１免疫応答誘起アジュバントの使用 |
| US7704514B2 (en) | 2003-03-24 | 2010-04-27 | Intercell Ag | Vaccines |
| US7943139B2 (en) | 2004-01-09 | 2011-05-17 | Morehouse School Of Medicine | Methods of generating a humoral immune response against human immunodeficiency virus (HIV) comprising administering Nef apoptotic motif-containing polypeptide-conjugates |
| GB0405480D0 (en) * | 2004-03-11 | 2004-04-21 | Istituto Superiore Di Sanito | Novel tat complexes,and vaccines comprising them |
| US20050208482A1 (en) * | 2004-03-16 | 2005-09-22 | Cohen David I | Tat-based immunomodulatory compositions and methods for their discovery and use |
| FR2868318B1 (fr) * | 2004-04-01 | 2012-11-16 | Commissariat Energie Atomique | Antigene tat stabilise et ses applications pour la vaccination anti-vih |
| ES2585810T3 (es) | 2005-03-23 | 2016-10-10 | Glaxosmithkline Biologicals S.A. | Uso de un virus de la gripe y un adyuvante de emulsión de aceite en agua para inducir respuesta de células T CD4 y/o una respuesta de células B de memoria mejorada |
| PL2043682T3 (pl) | 2006-07-17 | 2014-09-30 | Glaxosmithkline Biologicals Sa | Szczepionka przeciw grypie |
| WO2008094188A2 (en) * | 2006-07-17 | 2008-08-07 | Anza Therapeutics, Inc. | Methods and compositions using listeria for enhancing immunogenicity by prime boost |
| WO2008063586A2 (en) * | 2006-11-17 | 2008-05-29 | Duke University | Multicomponent vaccine |
| JP5869206B2 (ja) * | 2007-03-02 | 2016-02-24 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 新規方法および組成物 |
| US9717788B2 (en) | 2007-03-02 | 2017-08-01 | Glaxosmithkline Biologicals Sa | Method of inducing an immune response against HIV employing HIV immunogens, adenoviral vectors encoding said immunogens, and adjuvant |
| TW200908994A (en) | 2007-04-20 | 2009-03-01 | Glaxosmithkline Biolog Sa | Vaccine |
| CN101883858B (zh) | 2007-11-28 | 2015-07-22 | 宾夕法尼亚大学托管会 | 猿猴亚家族E腺病毒SAdV-39、-25.2、-26、-30、-37和-38及其应用 |
| KR101614369B1 (ko) | 2007-11-28 | 2016-04-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 유인원 아과 ｃ 아데노바이러스 ｓａｄｖ-40, -31, 및 -34 및 그것의 사용 |
| EP2325298B1 (en) | 2008-03-04 | 2016-10-05 | The Trustees Of The University Of Pennsylvania | SIMIAN ADENOVIRUSES SAdV-36, -42.1, -42.2, AND -44 AND USES THEREOF |
| WO2010051367A1 (en) | 2008-10-31 | 2010-05-06 | The Trustees Of The University Of Pennsylvania | Simian adenoviruses sadv-43, -45,-48,-49, and -50 and uses thereof |
| DK2411043T3 (da) | 2009-03-23 | 2013-10-21 | Pin Pharma Inc | Behandling af cancer med immunostimulatorisk hiv tat derivat-polypeptider |
| CN102575232B (zh) | 2009-05-29 | 2015-07-22 | 宾夕法尼亚大学托管会 | 猿腺病毒41及其应用 |
| EP2643465B1 (en) | 2010-11-23 | 2016-05-11 | The Trustees Of The University Of Pennsylvania | Subfamily e simian adenovirus a1321 and uses thereof |
| KR20150014505A (ko) | 2012-05-18 | 2015-02-06 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 아과 e 원숭이 아데노바이러스 a1302, a1320, a1331 및 a1337 및 이것들의 사용 |
| JP2016533352A (ja) | 2013-10-04 | 2016-10-27 | ピーアイエヌ ファーマ インコーポレイテッド | 免疫刺激性ＨＩＶ Ｔａｔ誘導体ポリペプチドによる癌の治療 |
| MA44179B1 (fr) | 2014-05-13 | 2020-10-28 | Univ Pennsylvania | Compositions comprenant un virus adeno-associe exprimant des constructions a double anticorps et leurs utilisations |
| CN104001155B (zh) * | 2014-06-12 | 2016-04-13 | 中山大学 | 一种Tat蛋白及其制备方法和应用 |
| US10188749B2 (en) | 2016-04-14 | 2019-01-29 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| EP3565535A4 (en) | 2017-01-05 | 2020-12-30 | Fred Hutchinson Cancer Research Center | SYSTEMS AND METHODS FOR IMPROVING THE EFFECTIVENESS OF A VACCINE |
| JP2023515908A (ja) | 2020-03-01 | 2023-04-14 | ヴァルネヴァ・オーストリア・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ＣｐＧアジュバント化ＳＡＲＳ－ＣｏＶ－２ウイルスワクチン |
| EP4114463A4 (en) | 2020-03-01 | 2023-09-06 | Dynavax Technologies Corporation | Coronavirus vaccines comprising a tlr9 agonist |
| AU2022264509A1 (en) | 2021-04-27 | 2023-12-14 | Generation Bio Co. | Non-viral dna vectors expressing therapeutic antibodies and uses thereof |
| CA3245737A1 (en) | 2022-03-14 | 2023-09-21 | Generation Bio Co. | PRIME-BOOST HETEROLOGICAL VACCINE COMPOSITIONS AND METHODS OF USE |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5863542A (en) * | 1991-03-07 | 1999-01-26 | Virogenetics Corporation | Recombinant attenuated ALVAC canaryopox virus containing heterologous HIV or SIV inserts |
| CZ282235B6 (cs) * | 1992-06-25 | 1997-06-11 | Smithkline Beecham Biologicals (S.A.) | Očkovací prostředek, jeho použití k výrobě vakcíny, způsob léčby patogenních infekcí tímto prostředkem a způsob jeho výroby |
| JPH11501310A (ja) * | 1995-03-08 | 1999-02-02 | ネオバック | レトロウイルスの調節タンパク質から誘導された無毒の免疫原、抗体、製造方法およびそれらを含んでなる医薬組成物 |
| GB9720585D0 (en) * | 1997-09-26 | 1997-11-26 | Smithkline Beecham Biolog | Vaccine |
| US20050033022A1 (en) * | 1997-09-26 | 2005-02-10 | Smithkline Beecham Biologicals Sa | Fusion proteins comprising HIV-1 Tat and/or Nef proteins |
| FR2773156B1 (fr) * | 1997-12-26 | 2000-03-31 | Biovacs Inc | Nouveaux immunogenes anti-retroviraux (toxoides), nouveaux procedes de preparation et application a la prevention et au traitement du sida |
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2001
- 2001-01-29 JP JP2001554702A patent/JP2003529559A/ja active Pending
- 2001-01-29 US US10/203,013 patent/US20030158134A1/en not_active Abandoned
- 2001-01-29 SK SK1112-2002A patent/SK11122002A3/sk not_active Application Discontinuation
- 2001-01-29 WO PCT/EP2001/000944 patent/WO2001054719A2/en not_active Ceased
- 2001-01-29 BR BR0107972-7A patent/BR0107972A/pt not_active IP Right Cessation
- 2001-01-29 EP EP01946790A patent/EP1251870A2/en not_active Withdrawn
- 2001-01-29 AU AU57910/01A patent/AU783005B2/en not_active Ceased
- 2001-01-29 CA CA002398611A patent/CA2398611A1/en not_active Abandoned
- 2001-01-29 MX MXPA02007413A patent/MXPA02007413A/es active IP Right Grant
- 2001-01-29 KR KR1020077013960A patent/KR20070073987A/ko not_active Ceased
- 2001-01-29 DZ DZ013286A patent/DZ3286A1/fr active
- 2001-01-29 IL IL15075601A patent/IL150756A0/xx unknown
- 2001-01-29 NZ NZ520327A patent/NZ520327A/en not_active IP Right Cessation
- 2001-01-29 CZ CZ20022643A patent/CZ20022643A3/cs unknown
- 2001-01-29 CN CNB018071562A patent/CN1326873C/zh not_active Expired - Fee Related
- 2001-01-29 HU HU0204250A patent/HUP0204250A3/hu unknown
- 2001-01-29 OA OA1200200228A patent/OA12168A/en unknown
- 2001-01-29 PL PL357210A patent/PL211762B1/pl not_active IP Right Cessation
- 2001-01-29 HK HK03102061.7A patent/HK1051317A1/zh unknown
- 2001-01-29 EA EA200200724A patent/EA200200724A1/ru unknown
- 2001-01-29 KR KR1020027009825A patent/KR100808348B1/ko not_active Expired - Fee Related
- 2001-01-29 AP APAP/P/2002/002592A patent/AP2002002592A0/en unknown
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2002
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- 2002-07-30 NO NO20023616A patent/NO20023616L/no unknown
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2005
- 2005-04-29 US US11/119,212 patent/US20050266025A1/en not_active Abandoned
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2008
- 2008-05-08 US US12/117,205 patent/US20090104229A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02007413A (es) | 2004-07-30 |
| BR0107972A (pt) | 2002-11-05 |
| NZ520327A (en) | 2004-06-25 |
| US20050266025A1 (en) | 2005-12-01 |
| DZ3286A1 (fr) | 2001-08-02 |
| CN1419456A (zh) | 2003-05-21 |
| JP2003529559A (ja) | 2003-10-07 |
| PL211762B1 (pl) | 2012-06-29 |
| HUP0204250A3 (en) | 2005-06-28 |
| IL150756A0 (en) | 2003-02-12 |
| NO20023616D0 (no) | 2002-07-30 |
| KR20070073987A (ko) | 2007-07-10 |
| KR100808348B1 (ko) | 2008-02-27 |
| EA200200724A1 (ru) | 2003-02-27 |
| PL357210A1 (pl) | 2004-07-26 |
| CA2398611A1 (en) | 2001-08-02 |
| CZ20022643A3 (cs) | 2003-02-12 |
| WO2001054719A3 (en) | 2001-12-20 |
| HK1051317A1 (zh) | 2003-08-01 |
| WO2001054719A2 (en) | 2001-08-02 |
| CN1326873C (zh) | 2007-07-18 |
| SK11122002A3 (sk) | 2003-01-09 |
| NO20023616L (no) | 2002-09-17 |
| OA12168A (en) | 2006-05-08 |
| AU5791001A (en) | 2001-08-07 |
| US20030158134A1 (en) | 2003-08-21 |
| US20090104229A1 (en) | 2009-04-23 |
| EP1251870A2 (en) | 2002-10-30 |
| AU783005B2 (en) | 2005-09-15 |
| HUP0204250A1 (hu) | 2003-03-28 |
| AP2002002592A0 (en) | 2002-09-30 |
| KR20020073569A (ko) | 2002-09-27 |
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