BG106939A - Method for the preparation of citalopram - Google Patents

Method for the preparation of citalopram

Info

Publication number
BG106939A
BG106939A BG106939A BG10693902A BG106939A BG 106939 A BG106939 A BG 106939A BG 106939 A BG106939 A BG 106939A BG 10693902 A BG10693902 A BG 10693902A BG 106939 A BG106939 A BG 106939A
Authority
BG
Bulgaria
Prior art keywords
citalopram
preparation
formula
diene
relates
Prior art date
Application number
BG106939A
Other languages
Bulgarian (bg)
English (en)
Inventor
Hans Petersen
Jakob Felding
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of BG106939A publication Critical patent/BG106939A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/34—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton and at least one hydroxy group bound to another carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/28—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
BG106939A 1999-12-28 2002-07-22 Method for the preparation of citalopram BG106939A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK1999/000739 WO2001047909A1 (en) 1999-12-28 1999-12-28 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
BG106939A true BG106939A (en) 2003-03-31

Family

ID=8157173

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106939A BG106939A (en) 1999-12-28 2002-07-22 Method for the preparation of citalopram

Country Status (26)

Country Link
US (1) US6762307B2 (xx)
EP (1) EP1246812B1 (xx)
JP (1) JP2003519136A (xx)
KR (1) KR20020073489A (xx)
CN (1) CN1398263A (xx)
AT (1) ATE261953T1 (xx)
AU (1) AU778751B2 (xx)
BG (1) BG106939A (xx)
CA (1) CA2395404A1 (xx)
CZ (1) CZ20022213A3 (xx)
DE (1) DE69915713T2 (xx)
DK (1) DK1246812T3 (xx)
EA (1) EA004742B1 (xx)
ES (1) ES2219095T3 (xx)
HU (1) HUP0203635A3 (xx)
IL (1) IL150335A0 (xx)
IS (1) IS6435A (xx)
MX (1) MXPA02006503A (xx)
NO (1) NO20023126D0 (xx)
NZ (1) NZ519739A (xx)
PL (1) PL355532A1 (xx)
PT (1) PT1246812E (xx)
SI (1) SI1246812T1 (xx)
SK (1) SK9282002A3 (xx)
TR (1) TR200201678T2 (xx)
WO (1) WO2001047909A1 (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
HUP0203840A3 (en) 1999-12-30 2005-02-28 Lundbeck & Co As H Method for the preparation of citalopram
IL150561A0 (en) 2000-01-14 2003-02-12 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CA2402553A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
CN1429219A (zh) 2000-03-13 2003-07-09 H·隆德贝克有限公司 制备西酞普兰的方法
ATE257832T1 (de) 2000-03-14 2004-01-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
ITMI20040717A1 (it) * 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
EP1951726A2 (en) * 2005-11-14 2008-08-06 H.Lundbeck A/S Method for the preparation of escitalopram
WO2009147687A2 (en) * 2008-06-03 2009-12-10 Shodhana Laboratories Limited An improved process for the separation of enantiomerically pure compounds
WO2010004575A2 (en) * 2008-06-16 2010-01-14 Shodhana Laboratories Limited Preparation of escitalopram, its salts and intermediates

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (xx) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DK1015416T3 (da) 1997-07-08 2001-11-05 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EA002770B1 (ru) 1997-11-11 2002-08-29 Х.Лундбекк А/С Способ получения циталопрама
KR100411505B1 (ko) 1998-10-20 2003-12-18 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
CA2356188C (en) 1998-12-23 2006-05-23 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2229774T3 (es) 1999-10-25 2005-04-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
HUP0203840A3 (en) 1999-12-30 2005-02-28 Lundbeck & Co As H Method for the preparation of citalopram
IL150561A0 (en) 2000-01-14 2003-02-12 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
FI20011621A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
EA003581B1 (ru) 2000-12-22 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама
EA003459B1 (ru) 2000-12-28 2003-06-26 Х.Лундбекк А/С Способ получения чистого циталопрама

Also Published As

Publication number Publication date
EA004742B1 (ru) 2004-08-26
NZ519739A (en) 2004-03-26
HUP0203635A2 (hu) 2003-02-28
EP1246812B1 (en) 2004-03-17
IL150335A0 (en) 2002-12-01
IS6435A (is) 2002-06-19
CA2395404A1 (en) 2001-07-05
NO20023126L (no) 2002-06-27
AU1858300A (en) 2001-07-09
ES2219095T3 (es) 2004-11-16
US20030060641A1 (en) 2003-03-27
WO2001047909A1 (en) 2001-07-05
CN1398263A (zh) 2003-02-19
EP1246812A1 (en) 2002-10-09
JP2003519136A (ja) 2003-06-17
KR20020073489A (ko) 2002-09-26
ATE261953T1 (de) 2004-04-15
PT1246812E (pt) 2004-08-31
EA200200719A1 (ru) 2002-12-26
TR200201678T2 (tr) 2002-10-21
DE69915713D1 (de) 2004-04-22
SK9282002A3 (en) 2002-11-06
HUP0203635A3 (en) 2005-02-28
SI1246812T1 (en) 2004-08-31
DK1246812T3 (da) 2004-07-05
US6762307B2 (en) 2004-07-13
NO20023126D0 (no) 2002-06-27
CZ20022213A3 (cs) 2002-09-11
DE69915713T2 (de) 2005-03-03
PL355532A1 (en) 2004-05-04
MXPA02006503A (es) 2002-12-09
AU778751B2 (en) 2004-12-16

Similar Documents

Publication Publication Date Title
CA2291134A1 (en) Method for the preparation of citalopram
BG106939A (en) Method for the preparation of citalopram
HK1068877A1 (en) Process for the production of beraprost and its salts
CA2418770A1 (en) Acylacetonitrile compound, process for preparation thereof, and miticide containing the same
ES2195510T3 (es) Derivados de imidazopiridina y procedimiento para prepararlos.
BR0211652A (pt) Processo para produção de composto de piridina
PL360499A1 (en) Method of manufacture of donepezyl
BG107050A (en) Method for the preparation of citalopram
EP1378502A4 (en) OLIGOLACTIC ACID ESTER WITH CHAIN
IL156768A0 (en) Process for preparing (+/-) trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine
EP1114812A4 (en) PROCESS FOR THE PREPARATION OF FLUOROUS BENZOIC ACIDS
DE69800073D1 (de) Verfahren zur Herstellung von 2-Cyanobiphenyl-Verbindungen
IL150089A0 (en) Vitamin d precursors, method and intermediates
WO2001018231A3 (de) VERFAHREN ZUR HERSTELLUNG VON (R)- ODER (S)-HYDROXY-η-BUTYROLACTON
BR9917603A (pt) Método para a preparação do citalopram
DE69815906D1 (de) Verfahren zur Herstellung von Chloroacetylaminothiazoleaceticsäure Derivate
HU0201584D0 (xx)
WO2002100804A3 (en) Novel use of sulfamic acids as resolving agent.
EP1408025A4 (en) 3, 3-DIALCOXY-2-HYDROXYIMINOPROPIONITRILES, PROCESS FOR THE PREPARATION, AND PROCESS FOR THE PRODUCTION OF 5-AMINO-4-NITROSOPYRAZOLES, OR CORRESPONDING SALTS THEREOF THROUGH THESE NITRILES
ATE272618T1 (de) Verfahren zur herstellung von s-alkylcysteinen