BG106912A - Дифенилетерни съединения, приложими в терапията - Google Patents
Дифенилетерни съединения, приложими в терапиятаInfo
- Publication number
- BG106912A BG106912A BG106912A BG10691202A BG106912A BG 106912 A BG106912 A BG 106912A BG 106912 A BG106912 A BG 106912A BG 10691202 A BG10691202 A BG 10691202A BG 106912 A BG106912 A BG 106912A
- Authority
- BG
- Bulgaria
- Prior art keywords
- therapy
- diphenyl ether
- compounds useful
- ether compounds
- disorder
- Prior art date
Links
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- H—ELECTRICITY
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- H04L12/00—Data switching networks
- H04L12/02—Details
- H04L12/14—Charging, metering or billing arrangements for data wireline or wireless communications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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- C—CHEMISTRY; METALLURGY
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- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
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- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
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- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
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- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
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- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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- Pyrrole Compounds (AREA)
Abstract
ДИФЕНИЛЕТЕРНИ СЪЕДИНЕНИЯ, ПРИЛОЖИМИ В ТЕРАПИЯТА@(57) Изобретението се отнася до съединения с обща формула, в която R3 e независимо CF3, OCF3, C1-4 алкилтио- или C1-4 алкокси- и n има стойност 1, 2 или 3, а другите заместители имат значенията, посочени в описанието, или до техни фармацевтично приемливи соли, солвати или полиморфни форми. Дифенилетерните съединения инхибират обратното захващане на моноамини и по-специално проявяват активност като селективни инхибитори на обратното захващане на серотонин. Те са приложими за лечение на психични разстройства като депресия, дефицит на вниманието с хиперактивно поведение, обсесивно-компулсивно разстройство, разстройство от постравматичен стрес, разстройства вследствие привикване към вещества и сексуална дисфункция, включваща преждевременна еякулация.
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GBGB0007884.0A GB0007884D0 (en) | 2000-03-31 | 2000-03-31 | Diphenyl ether compounds useful in therapy |
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BG106912A true BG106912A (bg) | 2003-01-31 |
BG65369B1 BG65369B1 (bg) | 2008-04-30 |
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BG106912A BG65369B1 (bg) | 2000-03-31 | 2002-07-09 | Дифенилетерни съединения, приложими в терапията |
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US6410736B1 (en) | 1999-11-29 | 2002-06-25 | Pfizer Inc. | Biaryl ether derivatives useful as monoamine reuptake inhibitors |
BR0113610A (pt) * | 2000-08-31 | 2003-06-24 | Pfizer | Derivados da fenoxibenzilamina como inibidores seletivos de recuperação de serotonina |
US6610747B2 (en) | 2000-08-31 | 2003-08-26 | Pfizer Inc. | Phenoxybenzylamine derivatives as SSRIs |
US6436938B1 (en) * | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
US20020107244A1 (en) * | 2001-02-02 | 2002-08-08 | Howard Harry R. | Combination treatment for depression |
US20020183306A1 (en) * | 2001-05-30 | 2002-12-05 | Pfizer Inc. | Combination treatment for sleep disorders including sleep apnea |
GB0202282D0 (en) | 2002-01-31 | 2002-03-20 | Pfizer Ltd | Treatment of male sexual dysfunction |
US6800652B2 (en) | 2002-08-16 | 2004-10-05 | Pfizer Inc. | Diaryl compounds |
GB0219154D0 (en) * | 2002-08-16 | 2002-09-25 | Pfizer Ltd | Diaryl compounds |
CA2451267A1 (en) * | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
GB0318706D0 (en) * | 2003-08-08 | 2003-09-10 | Pfizer Ltd | Selective serotonin reuptake inhibitors in the treatment of disease |
BRPI0414637A (pt) * | 2003-09-22 | 2006-11-14 | Pfizer | processo para a preparação de um composto éter difenìlico |
JP2009544579A (ja) | 2006-06-29 | 2009-12-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 置換ベンジルアミン化合物 |
CN101511790A (zh) * | 2006-06-29 | 2009-08-19 | 詹森药业有限公司 | 取代的氨基甲基苯甲酰胺化合物 |
CN101511775A (zh) | 2006-06-29 | 2009-08-19 | 詹森药业有限公司 | 丁基和丁炔基苄基胺化合物 |
US10220100B2 (en) | 2011-07-14 | 2019-03-05 | Keith R. Latham | Halogenated phenols for diagnostics, antioxidant protection and drug delivery |
US20130017163A1 (en) | 2011-07-14 | 2013-01-17 | Latham Keith R | Halogenated phenols for diagnostics, antioxidant protection and drug delivery |
EP2919788A4 (en) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA |
CN107001259B (zh) * | 2014-08-27 | 2019-12-06 | 豪夫迈·罗氏有限公司 | 作为taar配体的取代的氮杂环丁烷衍生物 |
CA3109419A1 (en) * | 2018-08-24 | 2020-02-27 | Xeniopro GmbH | Novel compounds |
JP7413346B2 (ja) | 2019-03-06 | 2024-01-15 | 第一三共株式会社 | ピロロピラゾール誘導体 |
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DE3851598T2 (de) * | 1987-09-09 | 1995-05-24 | Zeneca Ltd | Schimmelbekämpfungsmittel. |
US4940731A (en) * | 1989-08-30 | 1990-07-10 | Pfizer Inc. | Method of treating premature ejaculation using sertraline |
ZA923283B (en) * | 1991-05-29 | 1993-01-27 | Akzo Nv | Phenoxyphenyl derivatives |
EP1154984A1 (en) * | 1999-02-23 | 2001-11-21 | Pfizer Products Inc. | Inhibitors for uptake of serotonine, dopamine or norepinephrine |
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