ZA200207738B - Diphenyl ether compounds useful in therapy. - Google Patents

Diphenyl ether compounds useful in therapy. Download PDF

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Publication number
ZA200207738B
ZA200207738B ZA200207738A ZA200207738A ZA200207738B ZA 200207738 B ZA200207738 B ZA 200207738B ZA 200207738 A ZA200207738 A ZA 200207738A ZA 200207738 A ZA200207738 A ZA 200207738A ZA 200207738 B ZA200207738 B ZA 200207738B
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South Africa
Prior art keywords
methyl
polymorphs
acceptable salts
solvates
hydrogen
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ZA200207738A
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English (en)
Inventor
Andrews Mark David
David Hepworth
Middleton Donald Stuart
Alan Stobie
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Pfizer
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Publication of ZA200207738B publication Critical patent/ZA200207738B/en

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US6410736B1 (en) 1999-11-29 2002-06-25 Pfizer Inc. Biaryl ether derivatives useful as monoamine reuptake inhibitors
EE200300084A (et) * 2000-08-31 2005-02-15 Pfizer Inc. Fenoksübensüülamiini derivaadid kui selektiivsed serotoniini tagasihaarde inhibiitorid
US6610747B2 (en) 2000-08-31 2003-08-26 Pfizer Inc. Phenoxybenzylamine derivatives as SSRIs
US6436938B1 (en) * 2001-01-22 2002-08-20 Pfizer Inc. Combination treatment for depression
US20020107244A1 (en) * 2001-02-02 2002-08-08 Howard Harry R. Combination treatment for depression
US20020183306A1 (en) * 2001-05-30 2002-12-05 Pfizer Inc. Combination treatment for sleep disorders including sleep apnea
GB0202282D0 (en) 2002-01-31 2002-03-20 Pfizer Ltd Treatment of male sexual dysfunction
GB0219154D0 (en) * 2002-08-16 2002-09-25 Pfizer Ltd Diaryl compounds
US6800652B2 (en) 2002-08-16 2004-10-05 Pfizer Inc. Diaryl compounds
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
GB0318706D0 (en) * 2003-08-08 2003-09-10 Pfizer Ltd Selective serotonin reuptake inhibitors in the treatment of disease
KR20060070566A (ko) * 2003-09-22 2006-06-23 화이자 인코포레이티드 디페닐 에테르 화합물의 신규 제조방법
CA2656083A1 (en) * 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Substituted aminomethyl benzamide compounds
WO2008002817A1 (en) * 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Butyl and butynyl benzyl amine compounds
CA2656089A1 (en) 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Substituted benzyl amine compounds
US20130017163A1 (en) * 2011-07-14 2013-01-17 Latham Keith R Halogenated phenols for diagnostics, antioxidant protection and drug delivery
US10220100B2 (en) 2011-07-14 2019-03-05 Keith R. Latham Halogenated phenols for diagnostics, antioxidant protection and drug delivery
EP2919788A4 (en) 2012-11-14 2016-05-25 Univ Johns Hopkins METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA
MX2016016488A (es) * 2014-08-27 2017-03-30 Hoffmann La Roche Derivados de azetidina sustituidos como ligandos de receptores asociados a aminas en trazas (taar).
CN118290322A (zh) * 2018-08-24 2024-07-05 赛尼欧普罗有限责任公司 用于治疗病态状况的芳香型分子
JP7413346B2 (ja) 2019-03-06 2024-01-15 第一三共株式会社 ピロロピラゾール誘導体

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US4940731A (en) * 1989-08-30 1990-07-10 Pfizer Inc. Method of treating premature ejaculation using sertraline
ZA923283B (en) * 1991-05-29 1993-01-27 Akzo Nv Phenoxyphenyl derivatives
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AP2002002633A0 (en) 2002-09-30
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PA8514501A1 (es) 2002-10-24
CZ20023191A3 (cs) 2003-11-12
NZ519972A (en) 2003-07-25
HUP0301075A3 (en) 2005-04-28
TWI281909B (en) 2007-06-01
AP1308A (en) 2004-09-10
JP3936866B2 (ja) 2007-06-27
BG106912A (bg) 2003-01-31
MXPA02009697A (es) 2003-03-27
NO20024663L (no) 2002-09-27
TNSN01046A1 (fr) 2005-11-10
KR100570238B1 (ko) 2006-04-12
AU4442901A (en) 2001-10-08
HRP20020764A2 (en) 2005-10-31
SK13752002A3 (sk) 2004-01-08
EE200200568A (et) 2004-06-15
DE60112059D1 (de) 2005-08-25
IL150631A0 (en) 2003-02-12
CN1419534A (zh) 2003-05-21
AU784934B2 (en) 2006-08-03
PE20011138A1 (es) 2001-11-12
DZ3405A1 (bg) 2001-10-04
MA26885A1 (fr) 2004-12-20
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CR6741A (es) 2003-11-25
DE60112059T2 (de) 2006-04-13
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HUP0301075A2 (hu) 2003-08-28
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CA2404439A1 (en) 2001-10-04
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HK1051997A1 (en) 2003-08-29
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JP2003528845A (ja) 2003-09-30
GEP20053505B (en) 2005-05-10
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