BG105986A - Пролекарства на тромбинови инхибитори - Google Patents
Пролекарства на тромбинови инхибитори Download PDFInfo
- Publication number
- BG105986A BG105986A BG105986A BG10598601A BG105986A BG 105986 A BG105986 A BG 105986A BG 105986 A BG105986 A BG 105986A BG 10598601 A BG10598601 A BG 10598601A BG 105986 A BG105986 A BG 105986A
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- cycloalkyl
- ooc
- radicals
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19915930 | 1999-04-09 | ||
DE19934123 | 1999-07-23 | ||
DE19947920 | 1999-10-06 | ||
PCT/EP2000/003009 WO2000061609A2 (fr) | 1999-04-09 | 2000-04-05 | Promedicaments d'inhibiteurs de la thrombine |
Publications (1)
Publication Number | Publication Date |
---|---|
BG105986A true BG105986A (bg) | 2002-06-28 |
Family
ID=27219075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG105986A BG105986A (bg) | 1999-04-09 | 2001-10-05 | Пролекарства на тромбинови инхибитори |
Country Status (18)
Country | Link |
---|---|
US (1) | US7144902B1 (fr) |
EP (1) | EP1165601A2 (fr) |
JP (1) | JP2002542165A (fr) |
KR (1) | KR20010108481A (fr) |
CN (1) | CN1355810A (fr) |
AU (1) | AU765244B2 (fr) |
BG (1) | BG105986A (fr) |
BR (1) | BR0009674A (fr) |
CA (1) | CA2370267A1 (fr) |
HK (1) | HK1046289A1 (fr) |
HU (1) | HUP0202401A3 (fr) |
IL (1) | IL145772A0 (fr) |
NO (1) | NO20014875L (fr) |
NZ (1) | NZ515026A (fr) |
PL (1) | PL352824A1 (fr) |
SK (1) | SK14222001A3 (fr) |
TR (1) | TR200102912T2 (fr) |
WO (1) | WO2000061609A2 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10064797A1 (de) * | 2000-12-22 | 2002-06-27 | Knoll Ag | Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon |
AU2003245060A1 (en) * | 2002-06-27 | 2004-01-19 | Lg Life Sciences Ltd. | Peptidic thrombin inhibitor compound |
AU2004239468B2 (en) * | 2003-05-16 | 2009-09-10 | National Institute For Biological Standards And Control (Nibsc) | Activation mixture |
PT1737889E (pt) | 2004-10-19 | 2010-12-13 | Lonza Ag | Método para síntese de péptidos em fase sólida |
EP3530290A1 (fr) * | 2005-05-05 | 2019-08-28 | GlaxoSmithKline Intellectual Property Development Limited | Conjugués d'un ester d'aminoacide alpha et d'un médicament hydrolysables par la carboxylestérase |
EP2559690B1 (fr) | 2005-05-10 | 2016-03-30 | Incyte Holdings Corporation | Modulateurs de l'indolamine 2,3-dioxygenase et leurs procedes d'utilisation |
JP5294874B2 (ja) | 2005-12-20 | 2013-09-18 | インサイト・コーポレイション | インドールアミン2,3−ジオキシゲナーゼのモジュレーターとしてのn−ヒドロキシアミジノヘテロ環 |
CL2007002650A1 (es) * | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
WO2008036642A2 (fr) * | 2006-09-19 | 2008-03-27 | Incyte Corporation | N-hydroxyamidinohétérocycles en tant que modulateurs d'indoléamine 2,3-dioxygénase |
RS53688B9 (sr) | 2008-07-08 | 2020-01-31 | Incyte Holdings Corp | 1,2,5-oksadiazoli kao inhibitori indoleamin 2,3-dioksigenaze |
MX2012006913A (es) * | 2009-12-18 | 2012-08-23 | Activesite Pharmaceuticals Inc | Profarmacos de inhibidores de calicreina plasmatica. |
US9206123B2 (en) | 2009-12-18 | 2015-12-08 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
EP2697196A1 (fr) | 2011-04-13 | 2014-02-19 | Activesite Pharmaceuticals, Inc. | Promédicaments d'inhibiteurs de la kallicréine plasmatique |
ME03792B (fr) | 2013-11-08 | 2021-04-20 | Incyte Holdings Corp | Procédé pour la synthèse d'un inhibiteur de l'indoleamine 2,3-dioxygénase |
EP3187497A4 (fr) * | 2014-08-26 | 2018-02-07 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique |
CN106674190B (zh) * | 2016-12-13 | 2019-05-10 | 台州市创源工业技术有限公司 | 一种2-噻吩甲胺的合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL112795A (en) | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them |
TW541316B (en) | 1995-12-21 | 2003-07-11 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
IL120311A (en) | 1996-03-01 | 2001-10-31 | Akzo Nobel Nv | Serine protease inhibitors and pharmaceuticals containing them |
DE19632773A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
WO1999037611A1 (fr) | 1998-01-26 | 1999-07-29 | Basf Aktiengesellschaft | Amidines heterocycliques utilisees comme inhibiteurs de la kallicreine |
WO1999037668A1 (fr) | 1998-01-26 | 1999-07-29 | Basf Aktiengesellschaft | Inhibiteurs de la thrombine |
KR20000047461A (ko) * | 1998-12-29 | 2000-07-25 | 성재갑 | 트롬빈 억제제 |
WO2000061608A2 (fr) * | 1999-04-09 | 2000-10-19 | Basf Aktiengesellschaft | Inhibiteurs de faible poids moleculaire des proteases du complement |
-
2000
- 2000-04-05 US US09/958,349 patent/US7144902B1/en not_active Expired - Fee Related
- 2000-04-05 SK SK1422-2001A patent/SK14222001A3/sk not_active Application Discontinuation
- 2000-04-05 JP JP2000611551A patent/JP2002542165A/ja active Pending
- 2000-04-05 CN CN00807958A patent/CN1355810A/zh active Pending
- 2000-04-05 BR BR0009674-1A patent/BR0009674A/pt not_active IP Right Cessation
- 2000-04-05 HU HU0202401A patent/HUP0202401A3/hu unknown
- 2000-04-05 WO PCT/EP2000/003009 patent/WO2000061609A2/fr not_active Application Discontinuation
- 2000-04-05 CA CA002370267A patent/CA2370267A1/fr not_active Abandoned
- 2000-04-05 AU AU41156/00A patent/AU765244B2/en not_active Ceased
- 2000-04-05 KR KR1020017012870A patent/KR20010108481A/ko not_active Application Discontinuation
- 2000-04-05 EP EP00920661A patent/EP1165601A2/fr not_active Withdrawn
- 2000-04-05 IL IL14577200A patent/IL145772A0/xx unknown
- 2000-04-05 PL PL00352824A patent/PL352824A1/xx unknown
- 2000-04-05 TR TR2001/02912T patent/TR200102912T2/xx unknown
- 2000-04-05 NZ NZ515026A patent/NZ515026A/en unknown
-
2001
- 2001-10-05 BG BG105986A patent/BG105986A/bg unknown
- 2001-10-08 NO NO20014875A patent/NO20014875L/no not_active Application Discontinuation
-
2002
- 2002-10-30 HK HK02107849.6A patent/HK1046289A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
NZ515026A (en) | 2003-10-31 |
IL145772A0 (en) | 2002-07-25 |
KR20010108481A (ko) | 2001-12-07 |
HUP0202401A2 (en) | 2002-10-28 |
SK14222001A3 (sk) | 2002-07-02 |
JP2002542165A (ja) | 2002-12-10 |
EP1165601A2 (fr) | 2002-01-02 |
AU765244B2 (en) | 2003-09-11 |
WO2000061609A3 (fr) | 2001-03-15 |
TR200102912T2 (tr) | 2002-03-21 |
PL352824A1 (en) | 2003-09-08 |
WO2000061609A2 (fr) | 2000-10-19 |
NO20014875L (no) | 2001-11-13 |
HK1046289A1 (zh) | 2003-01-03 |
NO20014875D0 (no) | 2001-10-08 |
CA2370267A1 (fr) | 2000-10-19 |
WO2000061609B1 (fr) | 2001-04-26 |
HUP0202401A3 (en) | 2003-11-28 |
CN1355810A (zh) | 2002-06-26 |
BR0009674A (pt) | 2002-01-15 |
US7144902B1 (en) | 2006-12-05 |
AU4115600A (en) | 2000-11-14 |
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