BG104553A - 11 бета-халоген-7алфа-заместени-естратриени, метод за получаване на съдържащи ги фармацевтични препарати, и използването им за получаване на лекарствени средства - Google Patents

11 бета-халоген-7алфа-заместени-естратриени, метод за получаване на съдържащи ги фармацевтични препарати, и използването им за получаване на лекарствени средства Download PDF

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Publication number
BG104553A
BG104553A BG104553A BG10455300A BG104553A BG 104553 A BG104553 A BG 104553A BG 104553 A BG104553 A BG 104553A BG 10455300 A BG10455300 A BG 10455300A BG 104553 A BG104553 A BG 104553A
Authority
BG
Bulgaria
Prior art keywords
fluoro
trien
estra
pentyl
dihydroxy
Prior art date
Application number
BG104553A
Other languages
Bulgarian (bg)
English (en)
Inventor
Rolf Bohlmann
Nikolaus Heinrich
Helmut Hofmeister
Jorg Kroll
Hermann Kuenzer
Gerhard Sauer
Ludwig Zorn
Karl-Heinrich Fritzemeier
Monika Lessl
Rosemarie Lichtner
Yukishige Nishino
Karsten Parczyk
Martin Schneider
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1997158390 external-priority patent/DE19758390A1/de
Priority claimed from DE1998106357 external-priority patent/DE19806357A1/de
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of BG104553A publication Critical patent/BG104553A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG104553A 1997-12-23 2000-06-23 11 бета-халоген-7алфа-заместени-естратриени, метод за получаване на съдържащи ги фармацевтични препарати, и използването им за получаване на лекарствени средства BG104553A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1997158390 DE19758390A1 (de) 1997-12-23 1997-12-23 11ß-Halogen-7alpha-substituierte-Estratriene, Verfahren zur Herstellung pharmazeutischer Präparate, die diese 11ß-Halogen-7alpha-substituierte Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
DE1998106357 DE19806357A1 (de) 1998-02-10 1998-02-10 11beta-Halogen-7alpha-substituierte-Estratriene, Verfahren zur Herstellung pharmazeutischer Präparate, die diese 11beta-Halogen-7alpha-substituierte Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
PCT/EP1998/008470 WO1999033855A1 (de) 1997-12-23 1998-12-23 11β-HALOGEN-7α-SUBSTITUIERTE-ESTRATRIENE, VERFAHREN ZUR HERSTELLUNG PHARMAZEUTISCHER PRÄPARATE, DIE DIESE 11β-HALOGEN-7α-SUBSTITUIERTE-ESTRATRIENE ENTHALTEN, SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN

Publications (1)

Publication Number Publication Date
BG104553A true BG104553A (bg) 2001-02-28

Family

ID=26042916

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104553A BG104553A (bg) 1997-12-23 2000-06-23 11 бета-халоген-7алфа-заместени-естратриени, метод за получаване на съдържащи ги фармацевтични препарати, и използването им за получаване на лекарствени средства

Country Status (27)

Country Link
US (1) US6780855B2 (xx)
EP (1) EP1042355B1 (xx)
JP (1) JP2001527088A (xx)
KR (1) KR20010024806A (xx)
CN (1) CN1131235C (xx)
AR (1) AR015500A1 (xx)
AT (1) ATE232543T1 (xx)
AU (1) AU750801B2 (xx)
BG (1) BG104553A (xx)
BR (1) BR9814416A (xx)
CA (1) CA2316444A1 (xx)
DE (1) DE59807213D1 (xx)
DK (1) DK1042355T3 (xx)
EA (1) EA002623B1 (xx)
EE (1) EE200000380A (xx)
ES (1) ES2191371T3 (xx)
HU (1) HUP0100568A3 (xx)
ID (1) ID26207A (xx)
IL (1) IL136938A0 (xx)
IS (1) IS5526A (xx)
NO (1) NO20003286L (xx)
NZ (1) NZ505348A (xx)
PE (1) PE20000129A1 (xx)
PL (1) PL341299A1 (xx)
SK (1) SK9442000A3 (xx)
TR (1) TR200001973T2 (xx)
WO (1) WO1999033855A1 (xx)

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DE102007049630A1 (de) 2007-10-11 2009-10-29 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
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JP5298631B2 (ja) 2007-05-18 2013-09-25 住友化学株式会社 有機硫黄化合物及びその有害節足動物防除用途
JP2009001551A (ja) 2007-05-18 2009-01-08 Sumitomo Chemical Co Ltd 有機硫黄化合物及びその有害節足動物防除用途
DE102007032800A1 (de) 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
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NZ591955A (en) 2007-10-16 2011-10-28 Repros Therapeutics Inc Trans-clomiphene for diabetes mellitus type 2
EP2053055A1 (de) * 2007-10-24 2009-04-29 Bayer Schering Pharma Aktiengesellschaft 11.beta.-Fluoro-3-acetoxyestra-3,5-dien-17-on und Verfahren zu seiner Herstellung
DE102007058747A1 (de) 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
EP2070942A1 (de) 2007-12-13 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Aromatisierung von 19-Nor-androst-4-en-3-onen zu Estra-1,3,5(10)-trienen
EP2070909A1 (de) 2007-12-15 2009-06-17 Bayer Schering Pharma AG Nichtsteroidale Progesteronrezeptor-Modulatoren
EP2070941A1 (en) 2007-12-14 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Stereoselective synthesis of selective estrogen receptor down-regulators
EP2258375A1 (de) 2009-06-04 2010-12-08 Bayer Schering Pharma Aktiengesellschaft 17B-alkyl-17alpha-oxy-estratriene
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010030538A1 (de) 2010-06-25 2011-12-29 Bayer Schering Pharma Aktiengesellschaft 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
DE102011004899A1 (de) 2011-03-01 2012-09-06 Bayer Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102011087987A1 (de) 2011-12-08 2013-06-13 Bayer Intellectual Property Gmbh 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
ES2681023T3 (es) 2012-02-29 2018-09-11 Repros Therapeutics Inc. Terapia de combinación para tratar el déficit de andrógenos
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CN104387435B (zh) * 2014-12-10 2017-05-10 天津孚音生物科技发展有限公司 一种化合物及其制备方法与应用
CN106146599A (zh) * 2015-04-07 2016-11-23 江苏希迪制药有限公司 一种回收因亚砜构型比例不合格的氟维司群或其衍生物的方法
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Also Published As

Publication number Publication date
NO20003286D0 (no) 2000-06-22
AU2276399A (en) 1999-07-19
SK9442000A3 (en) 2001-04-09
CN1131235C (zh) 2003-12-17
WO1999033855A1 (de) 1999-07-08
CN1286693A (zh) 2001-03-07
US6780855B2 (en) 2004-08-24
DE59807213D1 (de) 2003-03-20
NZ505348A (en) 2002-10-25
EA200000711A1 (ru) 2001-02-26
KR20010024806A (ko) 2001-03-26
EP1042355B1 (de) 2003-02-12
JP2001527088A (ja) 2001-12-25
ID26207A (id) 2000-12-07
PE20000129A1 (es) 2000-03-11
AR015500A1 (es) 2001-05-02
EE200000380A (et) 2001-12-17
IL136938A0 (en) 2001-06-14
EP1042355A1 (de) 2000-10-11
NO20003286L (no) 2000-08-23
EA002623B1 (ru) 2002-06-27
DK1042355T3 (da) 2003-04-22
HUP0100568A2 (hu) 2001-08-28
CA2316444A1 (en) 1999-07-08
US20030069434A1 (en) 2003-04-10
HUP0100568A3 (en) 2002-01-28
AU750801B2 (en) 2002-07-25
BR9814416A (pt) 2000-10-10
ATE232543T1 (de) 2003-02-15
TR200001973T2 (tr) 2001-01-22
ES2191371T3 (es) 2003-09-01
PL341299A1 (en) 2001-04-09
IS5526A (is) 2000-06-09

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