BG104161A - Recombinant expression of insulin c-peptide - Google Patents

Recombinant expression of insulin c-peptide

Info

Publication number
BG104161A
BG104161A BG104161A BG10416100A BG104161A BG 104161 A BG104161 A BG 104161A BG 104161 A BG104161 A BG 104161A BG 10416100 A BG10416100 A BG 10416100A BG 104161 A BG104161 A BG 104161A
Authority
BG
Bulgaria
Prior art keywords
insulin
peptide
recombinant expression
polypeptide
multimer
Prior art date
Application number
BG104161A
Other languages
Bulgarian (bg)
English (en)
Inventor
Stefan Stahl
Mathias Uhlen
Per-Ake Nygren
Per Jonasson
Original Assignee
Creative Peptides Sweden Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Creative Peptides Sweden Ab filed Critical Creative Peptides Sweden Ab
Publication of BG104161A publication Critical patent/BG104161A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BG104161A 1997-08-07 2000-02-17 Recombinant expression of insulin c-peptide BG104161A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9716790.2A GB9716790D0 (en) 1997-08-07 1997-08-07 Recombinant DNA molecules comprising multimeric copies of a gene sequence and expression thereof
PCT/GB1998/002382 WO1999007735A2 (en) 1997-08-07 1998-08-07 Recombinant expression of insulin c-peptide

Publications (1)

Publication Number Publication Date
BG104161A true BG104161A (en) 2000-12-29

Family

ID=10817184

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104161A BG104161A (en) 1997-08-07 2000-02-17 Recombinant expression of insulin c-peptide

Country Status (21)

Country Link
US (1) US6558924B1 (ru)
EP (1) EP1001980A1 (ru)
JP (1) JP2001512745A (ru)
KR (1) KR20010022590A (ru)
CN (1) CN1268141A (ru)
AU (1) AU750685B2 (ru)
BG (1) BG104161A (ru)
BR (1) BR9811850A (ru)
CA (1) CA2297382A1 (ru)
EA (1) EA200000202A1 (ru)
EE (1) EE200000072A (ru)
GB (1) GB9716790D0 (ru)
HU (1) HUP0004626A1 (ru)
IL (1) IL134372A0 (ru)
IS (1) IS5368A (ru)
NO (1) NO20000575L (ru)
NZ (1) NZ502450A (ru)
PL (1) PL339085A1 (ru)
SK (1) SK1532000A3 (ru)
TR (1) TR200000288T2 (ru)
WO (1) WO1999007735A2 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040005669A1 (en) * 1997-08-07 2004-01-08 Stefan Stahl Recombinant expression of insulin C-peptide
FR2810675B1 (fr) * 2000-06-22 2002-09-27 Pf Medicament Construction modifiee en aval du codon d'initiation pour la surexpression de proteines recombinantes
FR2810674A1 (fr) * 2000-06-22 2001-12-28 Pf Medicament Construction modifiee en amont du codon d'initiation pour la surexpression de proteines recombinantes
AU2002233230B2 (en) * 2000-12-20 2007-02-01 F. Hoffmann-La Roche Ag Erythropoietin conjugates
CN101044154A (zh) * 2002-02-14 2007-09-26 威廉·J·鲁特 治疗宿主中切割的嵌合分子
SG159387A1 (en) 2002-11-26 2010-03-30 Biocon Ltd In Modified natriuretic compounds, conjugates, and uses thereof
US20050026826A1 (en) * 2003-01-17 2005-02-03 Margarethe Hoenig Feline proinsulin, insulin and constituent peptides
US7795384B2 (en) * 2003-06-03 2010-09-14 Shanghai Centre Of Research & Development Of New Drugs Fusion protein suitable for high efficiency expression and the production method thereof
KR20070033965A (ko) * 2004-03-10 2007-03-27 크레이톤 유니버시티 에스트로젠 수용체 및 사용 방법
CN103119055A (zh) 2010-05-17 2013-05-22 塞比克斯公司 聚乙二醇化c肽
CA2855770A1 (en) 2011-11-17 2013-05-23 Cebix Ab Pegylated c-peptide
EP2839010B1 (en) * 2012-03-19 2018-04-25 Madeleine Pharmaceuticals Pty Ltd Method of producing a recombinant peptide
US10627415B2 (en) 2015-03-12 2020-04-21 Board Of Trustees Of Michigan State University Compositions and methods for diagnosing, monitoring, and treating an autoimmune disease
CN109705221B (zh) * 2018-12-27 2021-03-09 美康生物科技股份有限公司 C肽免疫原及其单克隆抗体对及该抗体对在c肽磁微粒化学发光免疫试剂中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5210872B2 (ru) 1973-07-14 1977-03-26
GB2068971B (en) 1980-01-30 1983-06-08 Searle & Co Recombinant dna techniques
CA1213537A (en) 1984-05-01 1986-11-04 Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee Polypeptide expression method
DE3852074D1 (de) 1987-03-20 1994-12-15 Creative Biomolecules Inc Verfahren zur reinigung von rekombinanten polypeptiden.
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
SE501169C2 (sv) 1988-02-05 1994-11-28 Aake Nygren Framställning av serumalbuminbindande fusionsproteiner vilka innehåller protein G-domäner
US5130236A (en) 1989-12-07 1992-07-14 Eli Lilly And Company Process for producing des(64,65)-proinsulin
US5595887A (en) 1990-07-16 1997-01-21 Bionebraska, Inc. Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment
GB9015825D0 (en) 1990-07-18 1990-09-05 Ciba Geigy Ag In vitro processing of fusion proteins
JPH07108232B2 (ja) 1990-10-09 1995-11-22 エム・ディ・リサーチ株式会社 ペプチド又は蛋白質の製造方法
US5953418A (en) 1995-06-14 1999-09-14 David Hall Providing selective data broadcast receiver addressability
CA2213512A1 (en) 1995-12-22 1997-07-03 Toray Industries, Inc. Method for producing bioactive fusion protein

Also Published As

Publication number Publication date
AU8640798A (en) 1999-03-01
WO1999007735A3 (en) 1999-04-29
CA2297382A1 (en) 1999-02-18
US6558924B1 (en) 2003-05-06
WO1999007735A2 (en) 1999-02-18
NO20000575L (no) 2000-04-04
EA200000202A1 (ru) 2001-04-23
GB9716790D0 (en) 1997-10-15
PL339085A1 (en) 2000-12-04
KR20010022590A (ko) 2001-03-26
EE200000072A (et) 2000-10-16
HUP0004626A1 (hu) 2001-04-28
IL134372A0 (en) 2001-04-30
NZ502450A (en) 2002-10-25
JP2001512745A (ja) 2001-08-28
EP1001980A1 (en) 2000-05-24
TR200000288T2 (tr) 2000-06-21
BR9811850A (pt) 2000-08-08
IS5368A (is) 2000-02-01
AU750685B2 (en) 2002-07-25
CN1268141A (zh) 2000-09-27
SK1532000A3 (en) 2000-09-12
NO20000575D0 (no) 2000-02-04

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