BG103687A - Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative processes and conditions related to the central nervous system - Google Patents

Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative processes and conditions related to the central nervous system

Info

Publication number
BG103687A
BG103687A BG103687A BG10368799A BG103687A BG 103687 A BG103687 A BG 103687A BG 103687 A BG103687 A BG 103687A BG 10368799 A BG10368799 A BG 10368799A BG 103687 A BG103687 A BG 103687A
Authority
BG
Bulgaria
Prior art keywords
quinazolinones
atropisomers
heteroaryl
treatment
nervous system
Prior art date
Application number
BG103687A
Other languages
Bulgarian (bg)
English (en)
Inventor
Bertrand Chenard
Keith DEVRIES
Jr. Willard WELCH
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG103687A publication Critical patent/BG103687A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG103687A 1997-02-28 1999-08-24 Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative processes and conditions related to the central nervous system BG103687A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3854097P 1997-02-28 1997-02-28
PCT/IB1998/000151 WO1998038187A1 (fr) 1997-02-28 1998-02-06 Atropisomeres de 3-heteroaryl-4(3h)-quinazolinones pour le traitement des troubles neurodegeneratifs et des troubles lies a un traumatisme du systeme nerveux central

Publications (1)

Publication Number Publication Date
BG103687A true BG103687A (en) 2000-06-30

Family

ID=21900535

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103687A BG103687A (en) 1997-02-28 1999-08-24 Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative processes and conditions related to the central nervous system

Country Status (40)

Country Link
US (1) US6380204B1 (fr)
EP (1) EP0964860B1 (fr)
JP (1) JP3299990B2 (fr)
KR (1) KR20000075812A (fr)
CN (1) CN1248254A (fr)
AP (1) AP9801202A0 (fr)
AR (1) AR011886A1 (fr)
AT (1) ATE264854T1 (fr)
AU (1) AU732448B2 (fr)
BG (1) BG103687A (fr)
BR (1) BR9807807A (fr)
CA (1) CA2282279C (fr)
CO (1) CO4950615A1 (fr)
DE (1) DE69823339T2 (fr)
DK (1) DK0964860T3 (fr)
DZ (1) DZ2438A1 (fr)
EA (1) EA001961B1 (fr)
ES (1) ES2218801T3 (fr)
GT (1) GT199800039A (fr)
HN (1) HN1998000028A (fr)
HR (1) HRP980108B1 (fr)
HU (1) HUP0000935A3 (fr)
ID (1) ID23435A (fr)
IL (1) IL130897A0 (fr)
IS (1) IS5141A (fr)
MA (1) MA24485A1 (fr)
NO (1) NO994178L (fr)
NZ (1) NZ336627A (fr)
OA (1) OA11088A (fr)
PA (1) PA8446901A1 (fr)
PE (1) PE57999A1 (fr)
PL (1) PL335307A1 (fr)
PT (1) PT964860E (fr)
SK (1) SK113199A3 (fr)
TN (1) TNSN98034A1 (fr)
TR (1) TR199902094T2 (fr)
TW (1) TW530055B (fr)
UA (1) UA58536C2 (fr)
WO (1) WO1998038187A1 (fr)
ZA (1) ZA981665B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323208B1 (en) * 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
JPH11279158A (ja) * 1998-02-09 1999-10-12 Pfizer Prod Inc キナゾリン―4―オン誘導体の製造方法
US6890930B1 (en) * 1999-09-28 2005-05-10 3-Dimensional Pharmaceuticals, Inc. Quinazolinones
US20080146562A1 (en) * 2003-08-08 2008-06-19 Ulysses Pharmaceutical Products Inc., Halogenated quinazolinyl nitrofurans as antibacterial agents
AU2004262533A1 (en) * 2003-08-08 2005-02-17 Ulysses Pharmaceutical Products Inc. Halogenated quinazolinyl nitrofurans as antibacterial agents
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
WO2007056124A2 (fr) * 2005-11-04 2007-05-18 Hydra Biosciences, Inc. Composés destinés à moduler la fonction de trpv3
MX2009003673A (es) * 2006-10-04 2009-04-22 Pfizer Prod Inc Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio.
WO2008140750A1 (fr) * 2007-05-10 2008-11-20 Hydra Biosciences Inc. Composés modulant la fonction du trp v3
MX2011009955A (es) * 2009-03-24 2011-11-18 Gilead Calistoga Llc Atropisomeros de derivados de 2-purinil-3-tolil-quinazolinona y metodos de uso.
EP2435048B1 (fr) * 2009-05-29 2019-07-03 Merck Sharp & Dohme Corp. Inhibiteurs de pde10 radio-marqués
US9216177B2 (en) 2011-02-28 2015-12-22 Drexel University Small molecular inhibitors of RAD51 recombinase and methods thereof
AU2021212754A1 (en) 2020-01-29 2022-08-04 Kamari Pharma Ltd. Compounds and compositions for use in treating skin disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3748325A (en) 1970-04-06 1973-07-24 Karamchand Premchand Private Process for the preparation of quinazolinone derivatives
US4183931A (en) * 1977-09-08 1980-01-15 Research Corporation 2-Ketoalkyl-4(3H)-quinazolinones
WO1992013535A1 (fr) 1991-02-06 1992-08-20 Research Corporation Technologies, Inc. Quinazolones substituees a activite anticonvulsivante
PT901487E (pt) * 1996-05-15 2003-08-29 Pfizer 4(3h)-quinazolinonas 2,3,6-trissubstituidas
EP0807633B1 (fr) * 1996-05-15 2002-11-06 Pfizer Inc. (5,6)-Pyrimidin-4-ones condensées à hétéroaryle, substituées en 2,3

Also Published As

Publication number Publication date
DZ2438A1 (fr) 2003-01-11
IL130897A0 (en) 2001-01-28
EA199900689A1 (ru) 2000-02-28
HUP0000935A2 (hu) 2001-04-28
PE57999A1 (es) 1999-06-21
HUP0000935A3 (en) 2002-04-29
GT199800039A (es) 1999-08-13
HN1998000028A (es) 1999-02-09
SK113199A3 (en) 2001-10-08
TW530055B (en) 2003-05-01
US6380204B1 (en) 2002-04-30
BR9807807A (pt) 2000-02-22
JP3299990B2 (ja) 2002-07-08
DE69823339D1 (de) 2004-05-27
AU5775998A (en) 1998-09-18
DE69823339T2 (de) 2005-05-12
PA8446901A1 (es) 2000-05-24
KR20000075812A (ko) 2000-12-26
DK0964860T3 (da) 2004-07-26
ES2218801T3 (es) 2004-11-16
JP2000509732A (ja) 2000-08-02
CO4950615A1 (es) 2000-09-01
TR199902094T2 (xx) 1999-12-21
CN1248254A (zh) 2000-03-22
MA24485A1 (fr) 1998-10-01
NZ336627A (en) 2000-12-22
HRP980108A2 (en) 1998-12-31
ZA981665B (en) 1999-08-17
EA001961B1 (ru) 2001-10-22
ID23435A (id) 2000-04-20
PT964860E (pt) 2004-07-30
AP9801202A0 (en) 1999-08-26
TNSN98034A1 (fr) 2005-03-15
WO1998038187A1 (fr) 1998-09-03
UA58536C2 (uk) 2003-08-15
ATE264854T1 (de) 2004-05-15
AU732448B2 (en) 2001-04-26
OA11088A (en) 2002-03-15
IS5141A (is) 1999-07-30
EP0964860A1 (fr) 1999-12-22
EP0964860B1 (fr) 2004-04-21
CA2282279C (fr) 2004-11-02
CA2282279A1 (fr) 1998-09-03
NO994178D0 (no) 1999-08-27
AR011886A1 (es) 2000-09-13
NO994178L (no) 1999-08-27
PL335307A1 (en) 2000-04-10
HRP980108B1 (en) 2004-10-31

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