BG102583A - Фенилтиазолови производни с антихерпесвирусни свойства - Google Patents
Фенилтиазолови производни с антихерпесвирусни свойстваInfo
- Publication number
- BG102583A BG102583A BG102583A BG10258398A BG102583A BG 102583 A BG102583 A BG 102583A BG 102583 A BG102583 A BG 102583A BG 10258398 A BG10258398 A BG 10258398A BG 102583 A BG102583 A BG 102583A
- Authority
- BG
- Bulgaria
- Prior art keywords
- antiherpesviral
- properties
- herpes
- helicaso
- primase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретението се отнася до методи за инхибиране на херпесната репликация и за лечение на херпесна инфекция в бозайници чрез инхибиране на херпесния хеликазо-примазен ензимен комплекс. Изобретението се отнася също така до тиазолилфенилови производни,инхибиращи херпесната хеликазо-примаза, с формула в която R и Z имат значенията, посочени в описанието, а Z ехарактеризиращ признак, както и до фармацевтични състави, които ги съдържат, и до методи за тяхното приложение и получаване.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US943395P | 1995-12-29 | 1995-12-29 | |
US2320996P | 1996-08-02 | 1996-08-02 | |
PCT/US1996/019131 WO1997024343A1 (en) | 1995-12-29 | 1996-12-04 | Phenyl thiazole derivatives with anti herpes virus properties |
Publications (1)
Publication Number | Publication Date |
---|---|
BG102583A true BG102583A (bg) | 1999-06-30 |
Family
ID=26679472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG102583A Pending BG102583A (bg) | 1995-12-29 | 1998-06-26 | Фенилтиазолови производни с антихерпесвирусни свойства |
Country Status (26)
Country | Link |
---|---|
US (3) | US6057451A (bg) |
EP (1) | EP0871619B1 (bg) |
JP (1) | JP4327249B2 (bg) |
KR (1) | KR19990076964A (bg) |
AR (1) | AR037060A1 (bg) |
AT (1) | ATE227279T1 (bg) |
AU (1) | AU1682897A (bg) |
BG (1) | BG102583A (bg) |
BR (1) | BR9612435A (bg) |
CA (1) | CA2192433C (bg) |
CZ (1) | CZ207298A3 (bg) |
DE (1) | DE69624728T2 (bg) |
DK (1) | DK0871619T3 (bg) |
EA (1) | EA199800611A1 (bg) |
EE (1) | EE9800154A (bg) |
ES (1) | ES2186811T3 (bg) |
HU (1) | HUP9902341A2 (bg) |
IL (1) | IL124436A0 (bg) |
MX (1) | MX9805291A (bg) |
NO (1) | NO982950L (bg) |
NZ (1) | NZ331104A (bg) |
PL (1) | PL327582A1 (bg) |
PT (1) | PT871619E (bg) |
SK (1) | SK89398A3 (bg) |
TR (1) | TR199801244T2 (bg) |
WO (1) | WO1997024343A1 (bg) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6100282A (en) | 1998-01-02 | 2000-08-08 | Hoffman-La Roche Inc. | Thiazole derivatives |
SI0928790T1 (en) * | 1998-01-02 | 2003-06-30 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
WO2000026197A1 (en) | 1998-10-29 | 2000-05-11 | Bristol-Myers Squibb Company | Novel inhibitors of impdh enzyme |
WO2000029399A1 (en) * | 1998-11-12 | 2000-05-25 | Boehringer Ingelheim (Canada) Ltd. | Antiherpes compounds |
US6166028A (en) | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
WO2000051998A1 (en) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
JP2002539119A (ja) | 1999-03-08 | 2002-11-19 | バイエル アクチェンゲゼルシャフト | チアゾリルウレア誘導体および抗ウイルス剤としてのそれらの使用 |
DE19927415A1 (de) * | 1999-06-16 | 2000-12-21 | Bayer Ag | Indolinylharnstoffderivate |
KR20020064147A (ko) * | 1999-07-01 | 2002-08-07 | 아지노모토 가부시키가이샤 | 헤테로사이클릭 화합물 및 이의 의약 용도 |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
DOP2000000109A (es) | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
US6867299B2 (en) * | 2000-02-24 | 2005-03-15 | Hoffmann-La Roche Inc. | Oxamide IMPDH inhibitors |
CA2412720A1 (en) * | 2000-06-15 | 2001-12-20 | Bayer Aktiengesellschaft | Method for identifying compounds with anti-herpes activity |
DE10038022A1 (de) * | 2000-08-04 | 2002-02-14 | Bayer Ag | Inverse Thiazolylamid-Derivate |
ATE328868T1 (de) * | 2000-08-21 | 2006-06-15 | Pacific Corp | Neue (thio)harnstoffverbindungen und arzneimittelkompositionen, die diese enthalten |
CN100439332C (zh) * | 2000-08-21 | 2008-12-03 | 株式会社太平洋 | 硫脲衍生物以及包含该衍生物的药物组合物 |
EP1311477A4 (en) * | 2000-08-21 | 2005-01-12 | Pacific Corp | NEW THIOCARBAMIDIC ACID DERIVATIVES AND MEDICAMENTS CONTAINING THEM |
EP1340750B8 (en) * | 2000-11-10 | 2005-10-19 | Astellas Pharma Inc. | Amide derivatives |
DE10129714A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Topische Anwendung von Thiazolylamiden |
US6858637B2 (en) | 2002-03-28 | 2005-02-22 | Neurogen Corporation | Substituted biaryl amides as C5a receptor modulators |
EP1487796A4 (en) * | 2002-03-28 | 2005-11-16 | Neurogen Corp | SUBSTITUTED BIARYLAMIDES AS MODULATORS OF THE C5A RECEPTOR |
WO2003095435A1 (fr) * | 2002-05-09 | 2003-11-20 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'amides |
US20050250814A1 (en) * | 2002-10-30 | 2005-11-10 | Cangyou Zhou | Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity |
DE10254336A1 (de) * | 2002-11-21 | 2004-06-03 | Merck Patent Gmbh | Carbonsäureamide |
CA2514573A1 (en) * | 2003-01-27 | 2004-08-12 | Astellas Pharma Inc. | Thiazole derivatives and their use as vap-1 inhibitors |
WO2004087138A1 (en) * | 2003-03-31 | 2004-10-14 | Sucampo Ag | Method for treating vascular hyperpermeable disease |
TW200505894A (en) * | 2003-08-08 | 2005-02-16 | Yamanouchi Pharma Co Ltd | Tetrahydro-2H-thiopyran-4-carboxamide derivative |
FR2860514A1 (fr) | 2003-10-03 | 2005-04-08 | Sanofi Synthelabo | Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique |
KR20050039573A (ko) * | 2003-10-23 | 2005-04-29 | 주식회사 태평양 | 티오우레아계 유도체의 용해성과 생체이용률이 개선된약제학적 조성물 |
US20070269420A1 (en) * | 2003-11-24 | 2007-11-22 | Chunduru Srinivas K | Compounds, Compositions and Methods for Treatment and Prophylaxis of Hepatitis C Viral Infections and Associated Diseases |
EP1730196B1 (en) | 2004-03-12 | 2010-12-22 | Vasgene Therapeutics, Inc. | Antibodies binding to ephb4 for inhibiting angiogenesis and tumor growth |
JP5011739B2 (ja) * | 2005-02-03 | 2012-08-29 | アステラス製薬株式会社 | テトラヒドロ−2h−チオピラン−4−カルボキサミド誘導体を含有する医薬組成物 |
DE102005014248A1 (de) | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid |
AP2358A (en) * | 2005-05-09 | 2012-01-30 | Achillion Pharmaceuticals Inc | Thiazole compounds and methods of use. |
CA2613354A1 (en) * | 2005-06-24 | 2007-01-04 | Migenix Inc. | Non-nucleoside anti-hepacivirus agents and uses thereof |
CA2637530A1 (en) * | 2006-01-18 | 2007-09-07 | Siena Biotech S.P.A. | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof |
EP2069286B1 (en) * | 2006-08-30 | 2012-09-19 | F. Hoffmann-La Roche AG | Inhibitors for glyt-1 |
TW200906826A (en) * | 2007-06-12 | 2009-02-16 | Genelabs Tech Inc | Anti-viral inhibitors and methods of use |
US20110201659A1 (en) | 2008-10-20 | 2011-08-18 | Astellas Pharma Inc. | Agent for preventing or treating zoster-associated pain |
US8629157B2 (en) | 2009-01-05 | 2014-01-14 | Boehringer Ingelheim International Gmbh | Pyrrolidine compounds which modulate the CB2 receptor |
WO2011047390A2 (en) | 2009-10-16 | 2011-04-21 | University Of Maryland, Baltimore County | Heterocyclic benzoxazole compositions as inhibitors of hepatitis c virus |
WO2012113920A1 (en) | 2011-02-24 | 2012-08-30 | Katholieke Universiteit Leuven | Arylsulfone derivatives with activity against human betaherpesviruses |
KR101399484B1 (ko) * | 2011-07-14 | 2014-05-29 | 한국화학연구원 | 허피스바이러스 엑소뉴클리에이즈 활성 억제 물질을 유효성분으로 함유하는 항허피스바이러스용 약학적 조성물 |
UY35772A (es) | 2013-10-14 | 2015-05-29 | Bayer Cropscience Ag | Nuevos compuestos plaguicidas |
AU2015346657B9 (en) * | 2014-11-10 | 2020-01-16 | Evrys Bio, Llc | Anti-HCMV compositions and methods |
US20180016243A1 (en) * | 2015-02-13 | 2018-01-18 | Azienda Ospedaliera Universitaria Senese | Human helicase ddx3 inhibitors as therapeutic agents |
UA123734C2 (uk) | 2016-04-06 | 2021-05-26 | Інновейтів Молекьюлз Ґмбх | Похідні амінотіазолу, отримані як противірусні засоби |
WO2018132372A1 (en) | 2017-01-10 | 2018-07-19 | Sanford Burnham Prebys Medical Discovery Institute | Small molecule activators of nicotinamide phosphoribosyltransferase (nampt) and uses thereof |
UA126163C2 (uk) | 2017-10-05 | 2022-08-25 | Інновейтів Молекьюлз Ґмбх | Енантіомери серії противірусних сполук |
EP3818053B1 (en) | 2018-07-05 | 2023-03-29 | Sanford Burnham Prebys Medical Discovery Institute | Fused ring compound having urea structure |
WO2020053654A1 (en) | 2018-09-12 | 2020-03-19 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
MX2021006421A (es) * | 2018-12-19 | 2021-08-16 | Leo Pharma As | Anilidas de aminoácidos como moduladores de moléculas pequeñas de interleucinas-17 (il-17). |
KR20220070005A (ko) | 2019-09-26 | 2022-05-27 | 노파르티스 아게 | 항바이러스성 피라졸로피리디논 화합물 |
WO2024047508A1 (en) | 2022-08-29 | 2024-03-07 | Assembly Biosciences, Inc. | Pharmaceutical compositions for herpes virus |
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GB2276164A (en) * | 1993-03-17 | 1994-09-21 | Glaxo Group Ltd | Aniline and benzanilide derivatives |
IT1266582B1 (it) * | 1993-07-30 | 1997-01-09 | Recordati Chem Pharm | Derivati (di)azacicloesanici e diazacicloeptanici |
WO1995032710A1 (en) * | 1994-05-27 | 1995-12-07 | Merck & Co., Inc. | Compounds for inhibiting osteoclast-mediated bone resorption |
WO1999042455A1 (en) * | 1998-02-19 | 1999-08-26 | Tularik Inc. | Antiviral agents |
-
1996
- 1996-12-04 NZ NZ331104A patent/NZ331104A/xx unknown
- 1996-12-04 WO PCT/US1996/019131 patent/WO1997024343A1/en active IP Right Grant
- 1996-12-04 PT PT96945567T patent/PT871619E/pt unknown
- 1996-12-04 JP JP52432597A patent/JP4327249B2/ja not_active Expired - Fee Related
- 1996-12-04 EA EA199800611A patent/EA199800611A1/ru unknown
- 1996-12-04 AT AT96945567T patent/ATE227279T1/de active
- 1996-12-04 DK DK96945567T patent/DK0871619T3/da active
- 1996-12-04 AU AU16828/97A patent/AU1682897A/en not_active Abandoned
- 1996-12-04 EP EP96945567A patent/EP0871619B1/en not_active Expired - Lifetime
- 1996-12-04 ES ES96945567T patent/ES2186811T3/es not_active Expired - Lifetime
- 1996-12-04 PL PL96327582A patent/PL327582A1/xx unknown
- 1996-12-04 EE EE9800154A patent/EE9800154A/xx unknown
- 1996-12-04 DE DE69624728T patent/DE69624728T2/de not_active Expired - Lifetime
- 1996-12-04 IL IL12443696A patent/IL124436A0/xx unknown
- 1996-12-04 HU HU9902341A patent/HUP9902341A2/hu unknown
- 1996-12-04 TR TR1998/01244T patent/TR199801244T2/xx unknown
- 1996-12-04 BR BR9612435A patent/BR9612435A/pt unknown
- 1996-12-04 KR KR1019980705092A patent/KR19990076964A/ko not_active Application Discontinuation
- 1996-12-04 SK SK893-98A patent/SK89398A3/sk unknown
- 1996-12-04 CZ CZ982072A patent/CZ207298A3/cs unknown
- 1996-12-04 US US08/759,201 patent/US6057451A/en not_active Expired - Lifetime
- 1996-12-09 CA CA002192433A patent/CA2192433C/en not_active Expired - Fee Related
- 1996-12-30 AR ARP960105968A patent/AR037060A1/es not_active Withdrawn
-
1998
- 1998-06-25 NO NO982950A patent/NO982950L/no not_active Application Discontinuation
- 1998-06-26 BG BG102583A patent/BG102583A/bg active Pending
- 1998-06-29 MX MX9805291A patent/MX9805291A/es not_active IP Right Cessation
-
1999
- 1999-12-08 US US09/456,857 patent/US6348477B1/en not_active Expired - Lifetime
-
2000
- 2000-10-10 US US09/685,686 patent/US6458959B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69624728D1 (de) | 2002-12-12 |
CZ207298A3 (cs) | 1998-11-11 |
BR9612435A (pt) | 1999-07-13 |
SK89398A3 (en) | 1998-11-04 |
EE9800154A (et) | 1998-12-15 |
US6348477B1 (en) | 2002-02-19 |
TR199801244T2 (xx) | 1998-12-21 |
ES2186811T3 (es) | 2003-05-16 |
AU1682897A (en) | 1997-07-28 |
US6458959B1 (en) | 2002-10-01 |
EA199800611A1 (ru) | 1999-04-29 |
NZ331104A (en) | 2000-03-27 |
DE69624728T2 (de) | 2003-07-10 |
JP2000502702A (ja) | 2000-03-07 |
DK0871619T3 (da) | 2003-03-03 |
CA2192433C (en) | 2008-01-08 |
WO1997024343A1 (en) | 1997-07-10 |
NO982950D0 (no) | 1998-06-25 |
MX9805291A (es) | 1998-10-31 |
PT871619E (pt) | 2003-03-31 |
NO982950L (no) | 1998-06-25 |
AR037060A1 (es) | 2004-10-20 |
IL124436A0 (en) | 1998-12-06 |
JP4327249B2 (ja) | 2009-09-09 |
CA2192433A1 (en) | 1997-06-30 |
PL327582A1 (en) | 1998-12-21 |
US6057451A (en) | 2000-05-02 |
ATE227279T1 (de) | 2002-11-15 |
EP0871619B1 (en) | 2002-11-06 |
KR19990076964A (ko) | 1999-10-25 |
HUP9902341A2 (hu) | 1999-10-28 |
EP0871619A1 (en) | 1998-10-21 |
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