AR037060A1 - Compuesto anti-virus de herpes que no son nucleosidos, procedimiento para prepararlos, composicion farmaceutica que los contiene, metodo para inhibir replicacion de un virus de herpes, metodo para tratar una infeccion por herpes en un mamifero, inhibidor de helicasa-primasa de herpes, metodo para id - Google Patents
Compuesto anti-virus de herpes que no son nucleosidos, procedimiento para prepararlos, composicion farmaceutica que los contiene, metodo para inhibir replicacion de un virus de herpes, metodo para tratar una infeccion por herpes en un mamifero, inhibidor de helicasa-primasa de herpes, metodo para idInfo
- Publication number
- AR037060A1 AR037060A1 ARP960105968A ARP960105968A AR037060A1 AR 037060 A1 AR037060 A1 AR 037060A1 AR P960105968 A ARP960105968 A AR P960105968A AR P960105968 A ARP960105968 A AR P960105968A AR 037060 A1 AR037060 A1 AR 037060A1
- Authority
- AR
- Argentina
- Prior art keywords
- herpes
- amino
- virus
- pharmaceutical composition
- nucleosides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos anti-virus de herpes que no son nucleósidos de la fórmula (1) en la que: R se selecciona del grupo que consta de hidrógeno, alquilo inferior, amino, alquil inferior-amino, di(alquil inferior)-amino, alcanoil inferior-amino, (alcoxi inferior-carbonil)-amino, di(alcoxi inferior-carbonil)-amino, {(alquil inferior-amino)carbonil}-amino y piridinilamino; y Z se selecciona del grupo que consta de amidas inversas amino-sustituidas, amidas sustituidas, alcoxi amino-sustituido y (aminocarbonil)-alquilo. Los compuestos inhiben a la helicasa-primasa de herpes. Procedimiento para prepararlos, composición farmacéutica que los contiene, método para inhibir la replicación de un virus de herpes, método para tratar una infección por herpes en un mamífero, inhibidor de helicasa-primasa de herpes, método para identificarlo y composición farmacéutica que lo contiene.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US943395P | 1995-12-29 | 1995-12-29 | |
US2320996P | 1996-08-02 | 1996-08-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR037060A1 true AR037060A1 (es) | 2004-10-20 |
Family
ID=26679472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960105968A Withdrawn AR037060A1 (es) | 1995-12-29 | 1996-12-30 | Compuesto anti-virus de herpes que no son nucleosidos, procedimiento para prepararlos, composicion farmaceutica que los contiene, metodo para inhibir replicacion de un virus de herpes, metodo para tratar una infeccion por herpes en un mamifero, inhibidor de helicasa-primasa de herpes, metodo para id |
Country Status (26)
Country | Link |
---|---|
US (3) | US6057451A (es) |
EP (1) | EP0871619B1 (es) |
JP (1) | JP4327249B2 (es) |
KR (1) | KR19990076964A (es) |
AR (1) | AR037060A1 (es) |
AT (1) | ATE227279T1 (es) |
AU (1) | AU1682897A (es) |
BG (1) | BG102583A (es) |
BR (1) | BR9612435A (es) |
CA (1) | CA2192433C (es) |
CZ (1) | CZ207298A3 (es) |
DE (1) | DE69624728T2 (es) |
DK (1) | DK0871619T3 (es) |
EA (1) | EA199800611A1 (es) |
EE (1) | EE9800154A (es) |
ES (1) | ES2186811T3 (es) |
HU (1) | HUP9902341A2 (es) |
IL (1) | IL124436A0 (es) |
MX (1) | MX9805291A (es) |
NO (1) | NO982950D0 (es) |
NZ (1) | NZ331104A (es) |
PL (1) | PL327582A1 (es) |
PT (1) | PT871619E (es) |
SK (1) | SK89398A3 (es) |
TR (1) | TR199801244T2 (es) |
WO (1) | WO1997024343A1 (es) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0928790B1 (en) * | 1998-01-02 | 2003-03-05 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
US6100282A (en) | 1998-01-02 | 2000-08-08 | Hoffman-La Roche Inc. | Thiazole derivatives |
EP1127054A4 (en) * | 1998-10-29 | 2006-11-02 | Bristol Myers Squibb Co | INHIBITORS OF IMPDH ENZYME |
WO2000029399A1 (en) * | 1998-11-12 | 2000-05-25 | Boehringer Ingelheim (Canada) Ltd. | Antiherpes compounds |
US6166028A (en) | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
US6395897B1 (en) | 1999-03-02 | 2002-05-28 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5 |
US6500817B1 (en) | 1999-03-08 | 2002-12-31 | Bayer Aktiengesellschaft | Thiazolyl urea derivatives and their utilization as antiviral agents |
DE19927415A1 (de) * | 1999-06-16 | 2000-12-21 | Bayer Ag | Indolinylharnstoffderivate |
WO2001002359A1 (fr) * | 1999-07-01 | 2001-01-11 | Ajinomoto Co., Inc. | Composes heterocycliques et leurs applications en medecine |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
DOP2000000109A (es) | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
US6867299B2 (en) | 2000-02-24 | 2005-03-15 | Hoffmann-La Roche Inc. | Oxamide IMPDH inhibitors |
CA2412720A1 (en) * | 2000-06-15 | 2001-12-20 | Bayer Aktiengesellschaft | Method for identifying compounds with anti-herpes activity |
DE10038022A1 (de) * | 2000-08-04 | 2002-02-14 | Bayer Ag | Inverse Thiazolylamid-Derivate |
ATE328868T1 (de) * | 2000-08-21 | 2006-06-15 | Pacific Corp | Neue (thio)harnstoffverbindungen und arzneimittelkompositionen, die diese enthalten |
ATE393141T1 (de) | 2000-08-21 | 2008-05-15 | Pacific Corp | Neue thiourea-derivate und pharmazeutische zusammensetzungen die diese enthalten |
EP1311477A4 (en) * | 2000-08-21 | 2005-01-12 | Pacific Corp | NEW THIOCARBAMIDIC ACID DERIVATIVES AND MEDICAMENTS CONTAINING THEM |
ATE302197T1 (de) * | 2000-11-10 | 2005-09-15 | Yamanouchi Pharma Co Ltd | Amidderivate |
DE10129714A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Topische Anwendung von Thiazolylamiden |
US6858637B2 (en) | 2002-03-28 | 2005-02-22 | Neurogen Corporation | Substituted biaryl amides as C5a receptor modulators |
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WO2003095435A1 (fr) * | 2002-05-09 | 2003-11-20 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'amides |
JP2006514618A (ja) * | 2002-10-30 | 2006-05-11 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性のピペリジニル−アルファ−アミノアミドモジュレーター |
DE10254336A1 (de) * | 2002-11-21 | 2004-06-03 | Merck Patent Gmbh | Carbonsäureamide |
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EP1608365B1 (en) * | 2003-03-31 | 2013-10-02 | R-Tech Ueno, Ltd. | Method for treating vascular hyperpermeable disease |
TW200505894A (en) | 2003-08-08 | 2005-02-16 | Yamanouchi Pharma Co Ltd | Tetrahydro-2H-thiopyran-4-carboxamide derivative |
FR2860514A1 (fr) * | 2003-10-03 | 2005-04-08 | Sanofi Synthelabo | Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique |
KR20050039573A (ko) * | 2003-10-23 | 2005-04-29 | 주식회사 태평양 | 티오우레아계 유도체의 용해성과 생체이용률이 개선된약제학적 조성물 |
US20070269420A1 (en) * | 2003-11-24 | 2007-11-22 | Chunduru Srinivas K | Compounds, Compositions and Methods for Treatment and Prophylaxis of Hepatitis C Viral Infections and Associated Diseases |
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JP5011739B2 (ja) * | 2005-02-03 | 2012-08-29 | アステラス製薬株式会社 | テトラヒドロ−2h−チオピラン−4−カルボキサミド誘導体を含有する医薬組成物 |
DE102005014248A1 (de) | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid |
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CA2613354A1 (en) * | 2005-06-24 | 2007-01-04 | Migenix Inc. | Non-nucleoside anti-hepacivirus agents and uses thereof |
EP1991528A2 (en) * | 2006-01-18 | 2008-11-19 | Siena Biotech S.p.A. | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof |
CA2661863A1 (en) * | 2006-08-30 | 2008-03-06 | F. Hoffmann-La Roche Ag | Inhibitors for glyt-1 |
TW200906826A (en) * | 2007-06-12 | 2009-02-16 | Genelabs Tech Inc | Anti-viral inhibitors and methods of use |
EP2351565A1 (en) | 2008-10-20 | 2011-08-03 | Astellas Pharma Inc. | Medicine for preventing or treating pain related to herpes zoster |
US8629157B2 (en) | 2009-01-05 | 2014-01-14 | Boehringer Ingelheim International Gmbh | Pyrrolidine compounds which modulate the CB2 receptor |
US8822515B2 (en) | 2009-10-16 | 2014-09-02 | University Of Maryland, Baltimore County | Heterocyclic benzoxazole compositions as inhibitors of hepatitis C virus |
WO2012113920A1 (en) | 2011-02-24 | 2012-08-30 | Katholieke Universiteit Leuven | Arylsulfone derivatives with activity against human betaherpesviruses |
KR101399484B1 (ko) * | 2011-07-14 | 2014-05-29 | 한국화학연구원 | 허피스바이러스 엑소뉴클리에이즈 활성 억제 물질을 유효성분으로 함유하는 항허피스바이러스용 약학적 조성물 |
UY35772A (es) | 2013-10-14 | 2015-05-29 | Bayer Cropscience Ag | Nuevos compuestos plaguicidas |
MX2017006043A (es) * | 2014-11-10 | 2018-02-13 | Forge Life Science Llc | Metodo y composiciones de anti-hcmv. |
JP6749344B2 (ja) * | 2015-02-13 | 2020-09-02 | アジエンダ・オスペダリエラ・ウニベルシタリア・セネーゼ | 治療剤としてのヒトヘリカーゼddx3阻害剤 |
MX2018012116A (es) | 2016-04-06 | 2019-05-23 | Innovative Molecules Gmbh | Derivados de aminotiazol utiles como agentes antiviricos. |
EP3568390B1 (en) * | 2017-01-10 | 2024-03-06 | Sanford Burnham Prebys Medical Discovery Institute | Small molecule activators of nicotinamide phosphoribosyltransferase (nampt) and uses thereof |
CN111433203B (zh) | 2017-10-05 | 2024-02-13 | 创新分子股份有限公司 | 作为抗病毒化合物的取代噻唑的对映异构体 |
EP3818053B1 (en) | 2018-07-05 | 2023-03-29 | Sanford Burnham Prebys Medical Discovery Institute | Fused ring compound having urea structure |
JP7273951B2 (ja) | 2018-09-12 | 2023-05-15 | ノバルティス アーゲー | 抗ウイルス性ピリドピラジンジオン化合物 |
MX2021006421A (es) * | 2018-12-19 | 2021-08-16 | Leo Pharma As | Anilidas de aminoácidos como moduladores de moléculas pequeñas de interleucinas-17 (il-17). |
CN114667285A (zh) | 2019-09-26 | 2022-06-24 | 诺华股份有限公司 | 抗病毒吡唑并吡啶酮化合物 |
WO2024047508A1 (en) | 2022-08-29 | 2024-03-07 | Assembly Biosciences, Inc. | Pharmaceutical compositions for herpes virus |
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IT1266582B1 (it) * | 1993-07-30 | 1997-01-09 | Recordati Chem Pharm | Derivati (di)azacicloesanici e diazacicloeptanici |
DE69528829T2 (de) * | 1994-05-27 | 2003-08-07 | Merck & Co Inc | Präparate zur hemmung der durch osteoklasten vermittelten knochenresorption |
AU3289299A (en) * | 1998-02-19 | 1999-09-06 | Tularik Inc. | Antiviral agents |
-
1996
- 1996-12-04 HU HU9902341A patent/HUP9902341A2/hu unknown
- 1996-12-04 AU AU16828/97A patent/AU1682897A/en not_active Abandoned
- 1996-12-04 EP EP96945567A patent/EP0871619B1/en not_active Expired - Lifetime
- 1996-12-04 BR BR9612435A patent/BR9612435A/pt unknown
- 1996-12-04 AT AT96945567T patent/ATE227279T1/de active
- 1996-12-04 NZ NZ331104A patent/NZ331104A/xx unknown
- 1996-12-04 IL IL12443696A patent/IL124436A0/xx unknown
- 1996-12-04 DE DE69624728T patent/DE69624728T2/de not_active Expired - Lifetime
- 1996-12-04 ES ES96945567T patent/ES2186811T3/es not_active Expired - Lifetime
- 1996-12-04 EE EE9800154A patent/EE9800154A/xx unknown
- 1996-12-04 DK DK96945567T patent/DK0871619T3/da active
- 1996-12-04 SK SK893-98A patent/SK89398A3/sk unknown
- 1996-12-04 TR TR1998/01244T patent/TR199801244T2/xx unknown
- 1996-12-04 PT PT96945567T patent/PT871619E/pt unknown
- 1996-12-04 EA EA199800611A patent/EA199800611A1/ru unknown
- 1996-12-04 KR KR1019980705092A patent/KR19990076964A/ko not_active Application Discontinuation
- 1996-12-04 CZ CZ982072A patent/CZ207298A3/cs unknown
- 1996-12-04 US US08/759,201 patent/US6057451A/en not_active Expired - Lifetime
- 1996-12-04 WO PCT/US1996/019131 patent/WO1997024343A1/en active IP Right Grant
- 1996-12-04 PL PL96327582A patent/PL327582A1/xx unknown
- 1996-12-04 JP JP52432597A patent/JP4327249B2/ja not_active Expired - Fee Related
- 1996-12-09 CA CA002192433A patent/CA2192433C/en not_active Expired - Fee Related
- 1996-12-30 AR ARP960105968A patent/AR037060A1/es not_active Withdrawn
-
1998
- 1998-06-25 NO NO982950A patent/NO982950D0/no not_active Application Discontinuation
- 1998-06-26 BG BG102583A patent/BG102583A/xx active Pending
- 1998-06-29 MX MX9805291A patent/MX9805291A/es not_active IP Right Cessation
-
1999
- 1999-12-08 US US09/456,857 patent/US6348477B1/en not_active Expired - Lifetime
-
2000
- 2000-10-10 US US09/685,686 patent/US6458959B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6348477B1 (en) | 2002-02-19 |
KR19990076964A (ko) | 1999-10-25 |
EA199800611A1 (ru) | 1999-04-29 |
BR9612435A (pt) | 1999-07-13 |
SK89398A3 (en) | 1998-11-04 |
CA2192433C (en) | 2008-01-08 |
CA2192433A1 (en) | 1997-06-30 |
BG102583A (en) | 1999-06-30 |
EP0871619A1 (en) | 1998-10-21 |
JP4327249B2 (ja) | 2009-09-09 |
ES2186811T3 (es) | 2003-05-16 |
MX9805291A (es) | 1998-10-31 |
DE69624728T2 (de) | 2003-07-10 |
PL327582A1 (en) | 1998-12-21 |
NO982950L (no) | 1998-06-25 |
WO1997024343A1 (en) | 1997-07-10 |
ATE227279T1 (de) | 2002-11-15 |
EP0871619B1 (en) | 2002-11-06 |
DE69624728D1 (de) | 2002-12-12 |
TR199801244T2 (xx) | 1998-12-21 |
JP2000502702A (ja) | 2000-03-07 |
NO982950D0 (no) | 1998-06-25 |
CZ207298A3 (cs) | 1998-11-11 |
DK0871619T3 (da) | 2003-03-03 |
US6458959B1 (en) | 2002-10-01 |
AU1682897A (en) | 1997-07-28 |
EE9800154A (et) | 1998-12-15 |
PT871619E (pt) | 2003-03-31 |
IL124436A0 (en) | 1998-12-06 |
US6057451A (en) | 2000-05-02 |
HUP9902341A2 (hu) | 1999-10-28 |
NZ331104A (en) | 2000-03-27 |
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