ATE302197T1 - Amidderivate - Google Patents

Amidderivate

Info

Publication number
ATE302197T1
ATE302197T1 AT01981033T AT01981033T ATE302197T1 AT E302197 T1 ATE302197 T1 AT E302197T1 AT 01981033 T AT01981033 T AT 01981033T AT 01981033 T AT01981033 T AT 01981033T AT E302197 T1 ATE302197 T1 AT E302197T1
Authority
AT
Austria
Prior art keywords
accompanied
amide derivative
infection
herpes
hsv
Prior art date
Application number
AT01981033T
Other languages
English (en)
Inventor
Toru Kontani
Junji Miyata
Wataru Hamaguchi
Yoji Miyazaki
Hiroshi Suzuki
Eiichi Nakai
Shunji Kageyama
Original Assignee
Yamanouchi Pharma Co Ltd
Rational Drug Design Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd, Rational Drug Design Lab filed Critical Yamanouchi Pharma Co Ltd
Application granted granted Critical
Publication of ATE302197T1 publication Critical patent/ATE302197T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70Sulfur atoms
    • C07D277/74Sulfur atoms substituted by carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/40Unsubstituted amino or imino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/64Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
AT01981033T 2000-11-10 2001-11-08 Amidderivate ATE302197T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000344354 2000-11-10
PCT/JP2001/009790 WO2002038554A1 (fr) 2000-11-10 2001-11-08 Derives amides

Publications (1)

Publication Number Publication Date
ATE302197T1 true ATE302197T1 (de) 2005-09-15

Family

ID=18818562

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01981033T ATE302197T1 (de) 2000-11-10 2001-11-08 Amidderivate

Country Status (11)

Country Link
US (1) US6949543B2 (de)
EP (1) EP1340750B8 (de)
JP (1) JP3913172B2 (de)
KR (1) KR20030045180A (de)
CN (1) CN1473157A (de)
AT (1) ATE302197T1 (de)
AU (1) AU2002212734A1 (de)
CA (1) CA2428184C (de)
DE (1) DE60112790T2 (de)
ES (1) ES2247177T3 (de)
WO (1) WO2002038554A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003095435A1 (fr) * 2002-05-09 2003-11-20 Yamanouchi Pharmaceutical Co., Ltd. Derives d'amides
TW200505894A (en) 2003-08-08 2005-02-16 Yamanouchi Pharma Co Ltd Tetrahydro-2H-thiopyran-4-carboxamide derivative
JP5010917B2 (ja) * 2003-08-29 2012-08-29 エグゼリクシス, インコーポレイテッド c−Kit調節因子および使用方法
CA2553442A1 (en) * 2004-02-11 2005-08-25 Irm Llc Compounds and compositions as lxr modulators
CA2562714A1 (en) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Substituted thiophene-2-carboxylic acid amides, the production thereof and the use thereof as drugs
JPWO2006082821A1 (ja) * 2005-02-02 2008-06-26 アステラス製薬株式会社 ヘルペスウイルスが関与する疾患の予防若しくは治療剤
CA2596850A1 (en) * 2005-02-02 2006-08-10 Astellas Pharma Inc. Medicament for genital herpes
WO2006082822A1 (ja) * 2005-02-02 2006-08-10 Astellas Pharma Inc. アシクロビル耐性ヘルペスウイルスによる疾患の予防・治療剤
JP4832093B2 (ja) * 2005-02-02 2011-12-07 アステラス製薬株式会社 テトラヒドロ−2h−チオピラン−4−カルボキサミド誘導体の製造方法
JP5011739B2 (ja) * 2005-02-03 2012-08-29 アステラス製薬株式会社 テトラヒドロ−2h−チオピラン−4−カルボキサミド誘導体を含有する医薬組成物
CA2661863A1 (en) * 2006-08-30 2008-03-06 F. Hoffmann-La Roche Ag Inhibitors for glyt-1
US9403789B2 (en) 2008-02-21 2016-08-02 Sequoia Pharmaceuticals, Inc. Benzofuran-containing amino acid inhibitors of cytochrome P450
EP2351565A1 (de) 2008-10-20 2011-08-03 Astellas Pharma Inc. Medizin zur verhinderung oder behandlung von schmerzen aufgrund von gürtelrose
US9212134B2 (en) 2010-09-13 2015-12-15 Microbiotix, Inc. Inhibitors of viral entry into mammalian cells
JP5641054B2 (ja) * 2010-12-03 2014-12-17 富士通株式会社 新規化合物、並びに、キネシンスピンドルタンパク質阻害剤及びその応用
CN103275034B (zh) * 2013-04-16 2015-07-08 南京工业大学 一类小分子cathepsin D抑制剂的制备方法
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997024343A1 (en) * 1995-12-29 1997-07-10 Boehringer Ingelheim Pharmaceuticals, Inc. Phenyl thiazole derivatives with anti herpes virus properties
AU3289299A (en) * 1998-02-19 1999-09-06 Tularik Inc. Antiviral agents
WO2000029399A1 (en) * 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Antiherpes compounds

Also Published As

Publication number Publication date
KR20030045180A (ko) 2003-06-09
US6949543B2 (en) 2005-09-27
EP1340750A1 (de) 2003-09-03
CA2428184C (en) 2010-03-30
EP1340750A4 (de) 2004-01-21
AU2002212734A1 (en) 2002-05-21
ES2247177T3 (es) 2006-03-01
CA2428184A1 (en) 2002-05-16
US20040034232A1 (en) 2004-02-19
WO2002038554A1 (fr) 2002-05-16
DE60112790T2 (de) 2006-05-18
EP1340750B8 (de) 2005-10-19
DE60112790D1 (de) 2005-09-22
JPWO2002038554A1 (ja) 2004-03-18
JP3913172B2 (ja) 2007-05-09
CN1473157A (zh) 2004-02-04
EP1340750B1 (de) 2005-08-17

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