BG101876A - Нсv геномни последователности за диагностика и лечение - Google Patents

Нсv геномни последователности за диагностика и лечение

Info

Publication number
BG101876A
BG101876A BG101876A BG10187697A BG101876A BG 101876 A BG101876 A BG 101876A BG 101876 A BG101876 A BG 101876A BG 10187697 A BG10187697 A BG 10187697A BG 101876 A BG101876 A BG 101876A
Authority
BG
Bulgaria
Prior art keywords
treatment
hcv
diagnostics
genome sequences
hcv genome
Prior art date
Application number
BG101876A
Other languages
English (en)
Inventor
Tai-An Cha
Eileen Beall
Bruce Irvine
Janice Kolberg
Michael Urdea
Original Assignee
Chiron Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24800701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG101876(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corporation filed Critical Chiron Corporation
Publication of BG101876A publication Critical patent/BG101876A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Изобретението се отнася до състав и метод за диагностика и лечение на хепатит С вирусна инфекция (НСV). Съставът включва несрещана в природата аминокиселинна последователност най-малко с осем последователни нуклеотида от централната част на НСV последователността и може да служи като основен компонент при изготвянето на антитела и ваксини. По метода се получава хибридизационен продукт с НСV аминокиселинна последователност и се определят НСV генотиповете.
BG101876A 1991-05-08 1997-09-04 Нсv геномни последователности за диагностика и лечение BG101876A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69732691A 1991-05-08 1991-05-08
PCT/US1992/004036 WO1992019743A2 (en) 1991-05-08 1992-05-08 Hcv genomic sequences for diagnostics and therapeutics

Publications (1)

Publication Number Publication Date
BG101876A true BG101876A (bg) 1998-11-30

Family

ID=24800701

Family Applications (3)

Application Number Title Priority Date Filing Date
BG101876A BG64627B1 (bg) 1991-05-08 1993-11-05 Нсv геномни последователности за диагностика и лечение
BG98200A BG62142B1 (bg) 1991-05-08 1993-11-05 Нсv геномни последователности за диагностика и лечение
BG101876A BG101876A (bg) 1991-05-08 1997-09-04 Нсv геномни последователности за диагностика и лечение

Family Applications Before (2)

Application Number Title Priority Date Filing Date
BG101876A BG64627B1 (bg) 1991-05-08 1993-11-05 Нсv геномни последователности за диагностика и лечение
BG98200A BG62142B1 (bg) 1991-05-08 1993-11-05 Нсv геномни последователности за диагностика и лечение

Country Status (20)

Country Link
EP (2) EP0585398B1 (bg)
JP (7) JPH06508026A (bg)
KR (1) KR100193801B1 (bg)
AT (1) ATE252154T1 (bg)
BG (3) BG64627B1 (bg)
CA (1) CA2108466C (bg)
CZ (2) CZ288722B6 (bg)
DE (1) DE69233234T2 (bg)
DK (1) DK0585398T3 (bg)
ES (1) ES2207633T3 (bg)
FI (1) FI115725B (bg)
HU (1) HU227548B1 (bg)
IE (1) IE921482A1 (bg)
NO (1) NO309532B1 (bg)
PL (2) PL170151B1 (bg)
PT (1) PT100472B (bg)
RO (1) RO117267B1 (bg)
RU (1) RU2155228C2 (bg)
SK (1) SK284205B6 (bg)
WO (1) WO1992019743A2 (bg)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428145A (en) * 1991-08-09 1995-06-27 Immuno Japan, Inc. Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems
EP0532167A3 (en) * 1991-08-09 1993-03-31 Immuno Japan Inc. Non-a, non-b hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems
EP0532258A2 (en) * 1991-09-09 1993-03-17 Immuno Japan Inc. Oligonucleotides and determination system of HCV genotypes
ES2065863T3 (es) 1991-11-21 2003-09-01 Common Services Agency Analisis para la deteccion de virus de la hepatitis c.
US6667387B1 (en) 1996-09-30 2003-12-23 N.V. Innogenetics S.A. HCV core peptides
US6709828B1 (en) 1992-03-06 2004-03-23 N.V. Innogenetics S.A. Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them
EP0642592A4 (en) * 1992-05-29 1997-01-02 Abbott Lab LIGASE CHAIN REACTION STARTING WITH RNA SEQUENCES.
DK0662157T3 (da) * 1992-09-10 2001-08-27 Isis Pharmaceuticals Inc Præparater og fremgangsmåde til behandling af Hepatitis C-virus-associerede sygdomme
US6423489B1 (en) * 1992-09-10 2002-07-23 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of Hepatitis C virus-associated diseases
JPH06153961A (ja) * 1992-11-27 1994-06-03 Imuno Japan:Kk Ｃ型肝炎ウイルス部分遺伝子、ならびにｃ型肝炎ウイルス遺 伝子の高感度検出法
US5846704A (en) 1992-11-27 1998-12-08 N.V. Innogenetics S.A. Process for typing of HCV isolates
US7258977B1 (en) 1992-11-27 2007-08-21 Innogenetics N.V. Process for typing of HCV isolates
US7255997B1 (en) 1993-04-27 2007-08-14 N.V. Innogenetics S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
ATE551423T1 (de) 1993-04-27 2012-04-15 Innogenetics Nv Sequenzen von hepatitis c virus-genotypen sowie ihre verwendungen als therapeutika und diagnostika
JPH0775585A (ja) * 1993-06-14 1995-03-20 Immuno Japan:Kk Ｃ型肝炎ウイルス関連オリゴヌクレオチドならびにｃ型肝炎 ウイルス遺伝子型判定方法
US5882852A (en) * 1993-06-29 1999-03-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates
US5514539A (en) 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
US7070790B1 (en) 1993-06-29 2006-07-04 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
AU8003894A (en) * 1993-10-29 1995-05-22 Srl Inc. Antigen peptide compound and immunoassay method
EP0759979A4 (en) * 1994-05-10 1999-10-20 Gen Hospital Corp ANTISENSE OLIGONUCLEOTIDES INHIBITION OF HEPATITIS C VIRUS
PT804584E (pt) 1994-10-21 2002-11-29 Innogenetics Nv Sequencias de virus da hepatite c genotipo 7 e sua utilizacao como agentes profilacticos terapeuticos e de diagnostico
US5851759A (en) * 1996-04-19 1998-12-22 Chiron Corporation Heteroduplex tracking assay (HTA) for genotyping HCV
IT1284847B1 (it) * 1996-06-07 1998-05-22 Sorin Biomedica Diagnostics Sp Procedimento per la rivelazione di acidi nucleici specifici di hcv
JP2001521765A (ja) * 1997-11-04 2001-11-13 ロシュ ダイアグノスティックス ゲーエムベーハー 特異的かつ高感度な核酸検出方法
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6858590B2 (en) 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
WO2002013855A2 (en) 2000-08-17 2002-02-21 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6586584B2 (en) 2001-01-29 2003-07-01 Becton, Dickinson And Company Sequences and methods for detection of Hepatitis C virus
US7196183B2 (en) 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US8124747B2 (en) 2003-08-29 2012-02-28 Innogenetics HCV clade and prototype sequences thereof
CN1977050B (zh) 2004-01-07 2012-09-05 第三次浪潮技术公司 丙型肝炎病毒基因型的确定
KR100733186B1 (ko) * 2005-05-31 2007-06-27 재단법인 목암생명공학연구소 Ｈｃｖ 유전자에 특이적인 작은 간섭 ｒｎａ 및 그를유효성분으로 포함하는 ｃ형 간염 치료제
EP2185195A2 (en) 2007-08-16 2010-05-19 Tripep Ab Immunogen platform

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU220204B (hu) * 1987-11-18 2001-11-28 Chiron Corp. HCV polipeptidek és HCV polinukleotidok, ilyen polinukleotidokat tartalmazó vektorok és ezekkel transzformált gazdasejtek, valamint HCV fertőzés kimutatására szolgáló diagnosztikumok és immunvizsgálati készlet
WO1990011089A1 (en) * 1989-03-17 1990-10-04 Chiron Corporation Nanbv diagnostics and vaccines
DE4040339C2 (de) * 1989-12-18 1999-07-08 Wellcome Found Virales Agens
WO1991014779A1 (en) * 1990-03-28 1991-10-03 Mitsui Toatsu Chemicals, Incorporated Diagnostic for hepatitis virus
ATE194844T1 (de) * 1990-04-06 2000-08-15 Genelabs Tech Inc Hepatitis c-virus-epitope
EP0464287A1 (en) * 1990-06-25 1992-01-08 The Research Foundation for Microbial Diseases of Osaka University Non-A, non-B hepatitis virus genomic cDNA and antigen polypeptide
NZ238681A (en) * 1990-06-25 1992-03-26 Univ Osaka Res Found Non-a, non-b hepatitis virus particles and their production
EP0510952A1 (en) * 1991-04-26 1992-10-28 Immuno Japan Inc. Oligonucleotide primers and their application for high-fidelity detection of non-a, non-b hepatitis virus

Also Published As

Publication number Publication date
RO117267B1 (ro) 2001-12-28
CZ288722B6 (cs) 2001-08-15
JP2003009893A (ja) 2003-01-14
JP2003009892A (ja) 2003-01-14
HU227548B1 (en) 2011-08-29
DK0585398T3 (da) 2004-02-02
AU2155892A (en) 1992-12-21
JP2008178416A (ja) 2008-08-07
PL169880B1 (pl) 1996-09-30
JPH06508026A (ja) 1994-09-14
EP0585398B1 (en) 2003-10-15
JP2004290204A (ja) 2004-10-21
BG62142B1 (bg) 1999-03-31
JP2003009891A (ja) 2003-01-14
BG64627B1 (bg) 2005-09-30
PL170151B1 (pl) 1996-10-31
NO309532B1 (no) 2001-02-12
FI934937A0 (fi) 1993-11-08
EP1394256A2 (en) 2004-03-03
SK123293A3 (en) 1994-06-08
RU2155228C2 (ru) 2000-08-27
EP1394256A3 (en) 2008-03-12
WO1992019743A2 (en) 1992-11-12
HU9303166D0 (en) 1994-03-28
CZ121096A3 (en) 1996-08-14
IE921482A1 (en) 1992-11-18
EP0585398A1 (en) 1994-03-09
PT100472B (pt) 1999-08-31
NO934019D0 (no) 1993-11-05
BG98200A (bg) 1995-01-31
ES2207633T3 (es) 2004-06-01
FI934937A (fi) 1994-01-05
CA2108466C (en) 2007-07-10
DE69233234T2 (de) 2004-08-05
PT100472A (pt) 1993-08-31
ATE252154T1 (de) 2003-11-15
NO934019L (no) 1993-11-05
KR100193801B1 (ko) 1999-06-15
HUT69609A (en) 1995-09-28
CA2108466A1 (en) 1992-11-09
SK284205B6 (sk) 2004-10-05
DE69233234D1 (de) 2003-12-04
FI115725B (fi) 2005-06-30
CZ288720B6 (cs) 2001-08-15
AU668355B2 (en) 1996-05-02
WO1992019743A3 (en) 1993-11-25
CZ237793A3 (en) 1994-04-13
JP2003024090A (ja) 2003-01-28

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