BG101822A - Метод за получаване на орални дозирани форми, съдържащи бета-лактамов антибиотик - Google Patents

Метод за получаване на орални дозирани форми, съдържащи бета-лактамов антибиотик

Info

Publication number
BG101822A
BG101822A BG101822A BG10182297A BG101822A BG 101822 A BG101822 A BG 101822A BG 101822 A BG101822 A BG 101822A BG 10182297 A BG10182297 A BG 10182297A BG 101822 A BG101822 A BG 101822A
Authority
BG
Bulgaria
Prior art keywords
dosage forms
oral dosage
lactam antibiotic
forms containing
containing beta
Prior art date
Application number
BG101822A
Other languages
English (en)
Other versions
BG63528B1 (bg
Inventor
Jan SUBRANDS
Koutrik Cornelis Van
Original Assignee
Astellas Pharma Europe B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Europe B.V. filed Critical Astellas Pharma Europe B.V.
Publication of BG101822A publication Critical patent/BG101822A/bg
Publication of BG63528B1 publication Critical patent/BG63528B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Методът е приложим за получаване на гранулат, съдържащ орално действащ бета-лактамов антибиотик с разтворимост във вода 1 : 10. Той се състои в навлажняване на компонентите и приготвяне на гранулата с воден разтвор, който не съдържа съществени количества от свързващо средство за мокро гранулиране. Изобретението се отнася също до орални дозирани форми, съдържащи посочения антибиотик в гранулна форма, целулозен продукт и разпадащо средство, които се диспергират бързо, когато се поставят във воднасреда. Изобретението се отнася и до метод за приготвяне на дозираните форми.
BG101822A 1995-02-08 1997-08-08 Метод за получаване на орални дозирани форми, съдържащи бета-лактамов антибиотик BG63528B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95200313 1995-02-08
PCT/EP1996/000547 WO1996024337A1 (en) 1995-02-08 1996-02-08 ORAL DOSAGE-FORMS CONTAINING A β-LACTAM ANTIBIOTIC

Publications (2)

Publication Number Publication Date
BG101822A true BG101822A (bg) 1998-04-30
BG63528B1 BG63528B1 (bg) 2002-04-30

Family

ID=8220003

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101822A BG63528B1 (bg) 1995-02-08 1997-08-08 Метод за получаване на орални дозирани форми, съдържащи бета-лактамов антибиотик

Country Status (19)

Country Link
US (1) US5948422A (bg)
EP (1) EP0801559B1 (bg)
CN (1) CN1125636C (bg)
AT (1) ATE216576T1 (bg)
AU (1) AU4789696A (bg)
BG (1) BG63528B1 (bg)
BR (1) BR9607189A (bg)
CZ (1) CZ293718B6 (bg)
DE (1) DE69620866T2 (bg)
DK (1) DK0801559T3 (bg)
EA (2) EA003736B1 (bg)
ES (1) ES2175073T3 (bg)
HU (1) HU227938B1 (bg)
MX (1) MX9706062A (bg)
NO (1) NO319993B1 (bg)
PL (1) PL186386B1 (bg)
PT (1) PT801559E (bg)
WO (1) WO1996024337A1 (bg)
ZA (1) ZA961018B (bg)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI225402B (en) * 1996-03-13 2004-12-21 Biochemie Gmbh Auxiliary-free agglomerates
SK3999A3 (en) 1996-07-16 1999-07-12 Gist Brocades Nv 'beta'-lactam granules free of organic solvents
US6080427A (en) * 1997-04-17 2000-06-27 Bristol-Myers Squibb Company Cefadroxil monohydrate tablet formulation
NZ507271A (en) * 1998-03-06 2003-03-28 Eurand Internat S Fast disintegrating tablets
US7399751B2 (en) * 1999-11-04 2008-07-15 Sertoli Technologies, Inc. Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
DE19922537A1 (de) * 1999-05-10 2000-11-16 Roland Bodmeier Darreichungsform zur Applikation in Körperöffnungen
US20040034039A1 (en) * 2000-09-22 2004-02-19 Yoshinori Nakano Solid preparations
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
JP2004522752A (ja) * 2001-02-05 2004-07-29 アール．ピー． シェーラー テクノロジーズ インコーポレイテッド 薬学的活性剤の味を軽減するための方法および組成物
WO2003077842A2 (en) * 2002-03-12 2003-09-25 Bristol-Myers Squibb Company Palatable oral suspension and method
CA2500712C (en) * 2002-10-02 2011-08-09 Meiji Seika Kaisha, Ltd. Antibiotic pharmaceutical composition with improved oral absorbability
NO346973B1 (en) * 2002-12-20 2023-03-20 Niconovum Ab A physically and chemically stable nicotine-containing particulate material
CA2531022C (en) * 2003-07-03 2014-09-09 Jannette Dufour Compositions containing sertoli cells and myoid cells and use thereof in cellular transplants
WO2005021056A1 (en) * 2003-08-21 2005-03-10 Cns, Inc. Effervescent delivery system
EP1951207A2 (en) * 2005-11-17 2008-08-06 Novartis AG Pharmaceutical composition
US9402809B2 (en) 2006-03-16 2016-08-02 Niconovum Usa, Inc. Snuff composition
US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
EP2046351A2 (en) * 2006-07-28 2009-04-15 Sertocell Biotechnology (US) Corp. Adult sertoli cells and uses thereof
US8833378B2 (en) * 2008-09-17 2014-09-16 Niconovum Ab Process for preparing snuff composition
WO2010077911A1 (en) * 2008-12-17 2010-07-08 Altheus Therapeutics, Inc. Enema formulations
WO2023204773A1 (en) * 2022-04-20 2023-10-26 Bilim Ilac Sanayii Ve Ticaret A.S. Tablet formulations for the treatment of urinary system infections and method for the preparation of such formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3344030A (en) * 1964-06-15 1967-09-26 American Home Prod Reinforced directly compressed nongranulated pharmaceutical crystalline lactose tables
DE2251250C3 (de) * 1972-10-19 1981-06-25 Hoechst Ag, 6230 Frankfurt Verfahren zur Herstellung hochdosierter Antibiotica-Tabletten
DE2251249A1 (de) * 1972-10-19 1974-05-02 Hoechst Ag Verfahren zur herstellung von penicillin-verbindungen enthaltenden tabletten
DE3887179T2 (de) * 1987-03-02 1994-06-16 Brocades Pharma Bv Pharmazeutische Zusammensetzung, pharmazeutisches Granulat und Verfahren zu ihrer Herstellung.
US5049394A (en) * 1987-09-11 1991-09-17 E. R. Squibb & Sons, Inc. Pharmaceutical composition containing high drug load and method for preparing same
ATE108996T1 (de) * 1988-02-25 1994-08-15 Brocades Pharma Bv Verfahren zur herstellung eines pharmazeutischen granulats.
US5643591A (en) * 1991-01-16 1997-07-01 Fmc Corporation Solid dosage forms
JPH09512015A (ja) * 1994-04-13 1997-12-02 リサーチ・コーポレイション・テクノロジーズ・インコーポレイテッド セルトーリ細胞および同種移植片または異種移植片を用いる疾患処置方法
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin

Also Published As

Publication number Publication date
WO1996024337A1 (en) 1996-08-15
PL321567A1 (en) 1997-12-08
DE69620866D1 (de) 2002-05-29
CZ230297A3 (en) 1997-11-12
HUP9801677A3 (en) 1999-05-28
BR9607189A (pt) 1997-11-11
DK0801559T3 (da) 2002-06-17
CN1125636C (zh) 2003-10-29
PT801559E (pt) 2002-09-30
DE69620866T2 (de) 2003-02-27
ES2175073T3 (es) 2002-11-16
MX9706062A (es) 1997-10-31
HUP9801677A2 (hu) 1998-11-30
NO319993B1 (no) 2005-10-10
ZA961018B (en) 1997-08-08
CZ293718B6 (cs) 2004-07-14
EA199700093A1 (ru) 1998-02-26
EA000361B1 (ru) 1999-06-24
BG63528B1 (bg) 2002-04-30
HU227938B1 (en) 2012-06-28
EA003736B1 (ru) 2003-08-28
EA199900205A1 (ru) 2000-06-26
NO973646L (no) 1997-09-11
PL186386B1 (pl) 2004-01-30
NO973646D0 (no) 1997-08-07
EP0801559A1 (en) 1997-10-22
CN1173816A (zh) 1998-02-18
AU4789696A (en) 1996-08-27
EP0801559B1 (en) 2002-04-24
US5948422A (en) 1999-09-07
ATE216576T1 (de) 2002-05-15

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