BG101768A - Метод за екстрахиране на клавуланова киселина - Google Patents

Метод за екстрахиране на клавуланова киселина

Info

Publication number
BG101768A
BG101768A BG101768A BG10176897A BG101768A BG 101768 A BG101768 A BG 101768A BG 101768 A BG101768 A BG 101768A BG 10176897 A BG10176897 A BG 10176897A BG 101768 A BG101768 A BG 101768A
Authority
BG
Bulgaria
Prior art keywords
clavulanic acid
acid extraction
phase
mixingregion
highturbulancy
Prior art date
Application number
BG101768A
Other languages
English (en)
Other versions
BG63308B1 (bg
Inventor
Simon Ruddick
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of BG101768A publication Critical patent/BG101768A/bg
Publication of BG63308B1 publication Critical patent/BG63308B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретението се отнася до метод за обратно екстрахиране, при който -лактамови антибиотици или клавуланова киселина се екстрахират от фаза на органичен разтворител във фаза на водна среда. Използва се смесителен регион, в който фазите бързо се смесват при висока турбулентност и напречно преплъзване.
BG101768A 1995-01-19 1997-07-07 Метод за екстрахиране на клавуланова киселина BG63308B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9500977.5A GB9500977D0 (en) 1995-01-19 1995-01-19 Novel process
PCT/EP1996/000270 WO1996022296A1 (en) 1995-01-19 1996-01-17 Clavulanic acid extraction process

Publications (2)

Publication Number Publication Date
BG101768A true BG101768A (bg) 1998-10-30
BG63308B1 BG63308B1 (bg) 2001-09-28

Family

ID=10768206

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101768A BG63308B1 (bg) 1995-01-19 1997-07-07 Метод за екстрахиране на клавуланова киселина

Country Status (31)

Country Link
US (1) US6172221B1 (bg)
EP (1) EP0804441B1 (bg)
JP (1) JP4111998B2 (bg)
KR (1) KR100446199B1 (bg)
CN (1) CN1105724C (bg)
AP (1) AP672A (bg)
AT (1) ATE261976T1 (bg)
BG (1) BG63308B1 (bg)
BR (1) BR9606919A (bg)
CA (1) CA2210748C (bg)
CZ (1) CZ294581B6 (bg)
DE (1) DE69631878T2 (bg)
DK (1) DK0804441T3 (bg)
EA (1) EA000277B1 (bg)
ES (1) ES2217302T3 (bg)
FI (1) FI113776B (bg)
GB (1) GB9500977D0 (bg)
HK (1) HK1004134A1 (bg)
HU (1) HU228768B1 (bg)
MX (1) MX9705498A (bg)
NO (1) NO317281B1 (bg)
NZ (1) NZ300604A (bg)
OA (1) OA10501A (bg)
PL (1) PL184468B1 (bg)
PT (1) PT804441E (bg)
RO (1) RO115956B1 (bg)
SK (1) SK284484B6 (bg)
TR (1) TR199700665T1 (bg)
UA (1) UA45380C2 (bg)
WO (1) WO1996022296A1 (bg)
ZA (1) ZA96392B (bg)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
KR20190039137A (ko) 2016-07-14 2019-04-10 아카오젠, 인코포레이티드 박테리아 감염 치료에서 사용하기 위한 세프티부텐과 클라불란산의 조합
WO2020176806A1 (en) * 2019-02-27 2020-09-03 3-Delta, Inc. Compositions that contain lipophilic plant material and surfactant, and related methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB8404749D0 (en) * 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process

Also Published As

Publication number Publication date
DE69631878T2 (de) 2005-02-03
EP0804441B1 (en) 2004-03-17
BG63308B1 (bg) 2001-09-28
CN1179161A (zh) 1998-04-15
KR100446199B1 (ko) 2005-08-04
CZ294581B6 (cs) 2005-02-16
ATE261976T1 (de) 2004-04-15
CA2210748C (en) 2008-04-01
JP4111998B2 (ja) 2008-07-02
DE69631878D1 (de) 2004-04-22
ES2217302T3 (es) 2004-11-01
AU706196B2 (en) 1999-06-10
PT804441E (pt) 2004-07-30
WO1996022296A1 (en) 1996-07-25
CA2210748A1 (en) 1996-07-25
JPH10512557A (ja) 1998-12-02
KR19980701485A (ko) 1998-05-15
PL321381A1 (en) 1997-12-08
EA199700121A1 (ru) 1997-12-30
SK284484B6 (sk) 2005-04-01
HU228768B1 (en) 2013-05-28
NO973328L (no) 1997-09-18
AP672A (en) 1998-09-09
HUP9801699A2 (hu) 1998-11-30
NZ300604A (en) 2000-06-23
HUP9801699A3 (en) 1999-03-01
UA45380C2 (uk) 2002-04-15
FI973057A0 (fi) 1997-07-18
TR199700665T1 (xx) 1998-01-21
OA10501A (en) 2002-04-24
BR9606919A (pt) 1997-11-11
US6172221B1 (en) 2001-01-09
AU4539096A (en) 1996-08-07
CN1105724C (zh) 2003-04-16
EP0804441A1 (en) 1997-11-05
HK1004134A1 (en) 1998-11-20
EA000277B1 (ru) 1999-02-25
GB9500977D0 (en) 1995-03-08
AP9701022A0 (en) 1997-07-31
PL184468B1 (pl) 2002-11-29
SK96397A3 (en) 1998-02-04
NO317281B1 (no) 2004-10-04
DK0804441T3 (da) 2004-07-12
FI113776B (fi) 2004-06-15
NO973328D0 (no) 1997-07-18
ZA96392B (en) 1996-08-29
CZ225297A3 (en) 1997-12-17
FI973057A (fi) 1997-07-18
MX9705498A (es) 1997-10-31
RO115956B1 (ro) 2000-08-30

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