BG101501A - Нитробензамиди, полезни като противоаритмични средства - Google Patents

Нитробензамиди, полезни като противоаритмични средства

Info

Publication number
BG101501A
BG101501A BG101501A BG10150197A BG101501A BG 101501 A BG101501 A BG 101501A BG 101501 A BG101501 A BG 101501A BG 10150197 A BG10150197 A BG 10150197A BG 101501 A BG101501 A BG 101501A
Authority
BG
Bulgaria
Prior art keywords
atoms
group
carbon
nitro
alkyl
Prior art date
Application number
BG101501A
Other languages
English (en)
Other versions
BG63367B1 (bg
Inventor
Guy Nadler
Michel Martin
Original Assignee
Smithkline Beecham Laboratoires Pharmaceutiques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Laboratoires Pharmaceutiques filed Critical Smithkline Beecham Laboratoires Pharmaceutiques
Publication of BG101501A publication Critical patent/BG101501A/bg
Publication of BG63367B1 publication Critical patent/BG63367B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретението се отнася до съединения с формула@@или техни сол или солват, в която формула Ar означава заместен или незаместен арил, при което евентуалните заместители са избрани между С1-6 алкил, хидрокси или С1-6 алкокси; А означава С1-4 n-алкиленова група, в която всеки въглероден атом е заместен евентуално с една или две С1-6 алкилови групи; R1 означава водород или С1-6 алкил; R2 е 4-нитрогрупа; всеки R3 и R4, означава водород; Х е -СО-NH-група и Z означава СН2СН2СН2. Изобретението се отнася и до метод за получаване на посочените съединения, до фармацевтичен състав, който ги съдържа, и доизползването им в медицината.
BG101501A 1994-10-26 1997-05-20 Нитробензамиди, полезни като противоаритмични средства BG63367B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9412806A FR2726267B1 (fr) 1994-10-26 1994-10-26 Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer
PCT/EP1995/004203 WO1996013479A1 (en) 1994-10-26 1995-10-24 Nitro-benzamides useful as anti-arrhythmic agents

Publications (2)

Publication Number Publication Date
BG101501A true BG101501A (bg) 1998-01-30
BG63367B1 BG63367B1 (bg) 2001-11-30

Family

ID=9468229

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101501A BG63367B1 (bg) 1994-10-26 1997-05-20 Нитробензамиди, полезни като противоаритмични средства

Country Status (36)

Country Link
US (3) US5977179A (bg)
EP (1) EP0788474B1 (bg)
JP (1) JPH10508013A (bg)
KR (1) KR100369958B1 (bg)
CN (1) CN1071740C (bg)
AP (1) AP694A (bg)
AT (1) ATE192428T1 (bg)
AU (1) AU697357B2 (bg)
BG (1) BG63367B1 (bg)
BR (1) BR9509432A (bg)
CA (1) CA2203814A1 (bg)
CZ (1) CZ290326B6 (bg)
DE (1) DE69516708T2 (bg)
DK (1) DK0788474T3 (bg)
DZ (1) DZ1937A1 (bg)
ES (1) ES2145306T3 (bg)
FI (1) FI971755A (bg)
FR (1) FR2726267B1 (bg)
GR (1) GR3033748T3 (bg)
HK (1) HK1002764A1 (bg)
HU (1) HU222889B1 (bg)
ID (1) ID18094A (bg)
IL (1) IL115732A (bg)
MA (1) MA23706A1 (bg)
NO (1) NO971955L (bg)
NZ (1) NZ295368A (bg)
OA (1) OA10478A (bg)
PL (1) PL181936B1 (bg)
PT (1) PT788474E (bg)
RO (1) RO117174B1 (bg)
RU (1) RU2159227C2 (bg)
SK (1) SK281743B6 (bg)
TR (1) TR199501320A2 (bg)
UA (1) UA50722C2 (bg)
WO (1) WO1996013479A1 (bg)
ZA (1) ZA958984B (bg)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2726267B1 (fr) 1994-10-26 1998-01-02 Smithkline Beecham Lab Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer
GB9706376D0 (en) * 1997-03-27 1997-05-14 Smithkline Beecham Plc Novel pharmaceutical
GB9923933D0 (en) * 1999-10-08 1999-12-08 Smithkline Beecham Lab Novel pharmaceutical
GB9923934D0 (en) * 1999-10-08 1999-12-08 Smithkline Beecham Plc Novel pharmaceutical
MXPA02007036A (es) 2000-01-20 2002-12-13 Eisai Co Ltd Compuesto de piperidina novedoso y composicion farmaceutica del mismo.
DK1558226T3 (da) * 2002-10-11 2012-05-07 Baxter Int Fremgangsmåde til cardiobeskyttelse og neurobeskyttelse ved intravenøs indgivelse af halogenerede, flygtige anæstetika
KR20050114641A (ko) 2003-03-07 2005-12-06 아스텔라스세이야쿠 가부시키가이샤 2,6-이치환된 스티릴을 갖는 질소 함유 헤테로환 유도체
RU2700263C1 (ru) * 2019-05-16 2019-09-16 федеральное государственное автономное образовательное учреждение высшего образования «Национальный исследовательский Томский политехнический университет» Средство, обладающее антиаритмическим действием

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE242344C (bg)
US3139456A (en) * 1960-07-27 1964-06-30 Searle & Co Nu-(substituted phenoxyalkyl)-aralkylamines
DE3242344A1 (de) * 1982-11-16 1984-05-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue alkylendiaminoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
EG18188A (en) * 1986-05-01 1992-09-30 Pfizer Ltd Process for preparation anti-arhythmia agents
GB8706662D0 (en) * 1987-03-20 1987-04-23 Pfizer Ltd Anti-arrhythmia agents
CA2100258C (en) * 1991-01-11 1999-12-14 Bernard Andre Dumaitre Acridine derivatives
US5208252A (en) * 1992-07-24 1993-05-04 Ortho Pharmaceutical Corporation Aminoethylthiophene derivatives
DE4422517A1 (de) * 1994-06-28 1996-01-04 Dresden Arzneimittel Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO1996004231A1 (fr) * 1994-08-04 1996-02-15 C & C Research Labs. Nouveau derive amine, procede d'obtention de ce derive et son utilisation comme antiarythmique
FR2726267B1 (fr) 1994-10-26 1998-01-02 Smithkline Beecham Lab Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer

Also Published As

Publication number Publication date
UA50722C2 (uk) 2002-11-15
HUT77004A (hu) 1998-03-02
BG63367B1 (bg) 2001-11-30
MX9703112A (es) 1997-07-31
WO1996013479A1 (en) 1996-05-09
AU3869995A (en) 1996-05-23
GR3033748T3 (en) 2000-10-31
EP0788474A1 (en) 1997-08-13
NO971955L (no) 1997-06-25
SK281743B6 (sk) 2001-07-10
RO117174B1 (ro) 2001-11-30
IL115732A (en) 2000-08-31
US6570037B2 (en) 2003-05-27
DK0788474T3 (da) 2000-09-11
OA10478A (en) 2002-04-09
HU222889B1 (hu) 2003-12-29
HK1002764A1 (en) 1998-09-18
DE69516708D1 (de) 2000-06-08
FR2726267B1 (fr) 1998-01-02
MA23706A1 (fr) 1996-07-01
BR9509432A (pt) 1998-01-06
IL115732A0 (en) 1996-05-14
RU2159227C2 (ru) 2000-11-20
KR100369958B1 (ko) 2003-04-08
SK50597A3 (en) 1997-11-05
DZ1937A1 (fr) 2002-02-17
AP9700965A0 (en) 1997-04-30
AP694A (en) 1998-11-18
PT788474E (pt) 2000-08-31
US20020107243A1 (en) 2002-08-08
JPH10508013A (ja) 1998-08-04
CN1071740C (zh) 2001-09-26
ATE192428T1 (de) 2000-05-15
AU697357B2 (en) 1998-10-01
PL319904A1 (en) 1997-09-01
US5977179A (en) 1999-11-02
CA2203814A1 (en) 1996-05-09
ID18094A (id) 1998-02-26
PL181936B1 (pl) 2001-10-31
NZ295368A (en) 1998-12-23
FI971755A (fi) 1997-06-23
CZ125297A3 (en) 1997-10-15
CZ290326B6 (cs) 2002-07-17
FR2726267A1 (fr) 1996-05-03
ES2145306T3 (es) 2000-07-01
CN1170402A (zh) 1998-01-14
EP0788474B1 (en) 2000-05-03
FI971755A0 (fi) 1997-04-24
NO971955D0 (no) 1997-04-25
US20010025054A1 (en) 2001-09-27
ZA958984B (en) 1997-04-24
DE69516708T2 (de) 2000-09-28
TR199501320A2 (tr) 1996-06-21

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