BG100192A - 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents - Google Patents
2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agentsInfo
- Publication number
- BG100192A BG100192A BG100192A BG10019295A BG100192A BG 100192 A BG100192 A BG 100192A BG 100192 A BG100192 A BG 100192A BG 10019295 A BG10019295 A BG 10019295A BG 100192 A BG100192 A BG 100192A
- Authority
- BG
- Bulgaria
- Prior art keywords
- complexes
- pyridylmethylenepolyazamacrocyclophosphonic
- derivatives
- contrast agents
- acids
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000002872 contrast media Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/281—Means for the use of in vitro contrast agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/057,588 US5462725A (en) | 1993-05-06 | 1993-05-06 | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| PCT/US1994/005009 WO1994026275A1 (en) | 1993-05-06 | 1994-05-05 | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG100192A true BG100192A (en) | 1996-12-31 |
Family
ID=22011534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG100192A BG100192A (en) | 1993-05-06 | 1995-12-05 | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5462725A (xx) |
| EP (1) | EP0711300B1 (xx) |
| JP (1) | JPH08510245A (xx) |
| CN (1) | CN1125905A (xx) |
| AT (1) | ATE227297T1 (xx) |
| AU (1) | AU678583B2 (xx) |
| BG (1) | BG100192A (xx) |
| CA (1) | CA2162174A1 (xx) |
| CZ (1) | CZ289595A3 (xx) |
| DE (1) | DE69431660T2 (xx) |
| FI (1) | FI955319A (xx) |
| HU (1) | HUT74565A (xx) |
| LV (1) | LV11430B (xx) |
| NO (1) | NO301829B1 (xx) |
| PL (1) | PL311643A1 (xx) |
| SG (1) | SG46458A1 (xx) |
| WO (1) | WO1994026275A1 (xx) |
Families Citing this family (68)
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| US5409689A (en) * | 1993-08-13 | 1995-04-25 | Concat, Ltd. | MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms |
| DE19523891C1 (de) * | 1995-06-30 | 1996-11-21 | Hoechst Ag | Chirale Mangan-triazanonankomplexe und Verfahren zu ihrer Herstellung |
| EP0898574B1 (en) * | 1996-04-19 | 2003-11-12 | Dow Global Technologies Inc. | Fluorescent chelates as visual tissue specific imaging agents |
| US6685914B1 (en) | 1999-09-13 | 2004-02-03 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
| DE60024891T2 (de) * | 1999-09-13 | 2006-08-24 | Bristol-Myers Squibb Pharma Co. | Makrocyclische Chelatbildner für Metallopharmazeutika |
| EP1362861B1 (en) * | 1999-09-13 | 2005-12-14 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
| US7338651B2 (en) * | 2001-09-04 | 2008-03-04 | Texas Tech University System | Multi-use multimodal imaging chelates |
| JP2005507005A (ja) * | 2001-10-22 | 2005-03-10 | テキサス テック ユニバーシティー | 組織特異的螢光キレート |
| WO2003098232A2 (en) * | 2002-05-17 | 2003-11-27 | Case Western Reserve University | Chemical shift markers for improved wireless fiducial marker tracking |
| EP1778699A4 (en) * | 2004-08-10 | 2009-02-25 | Dow Global Technologies Inc | TARGETING OF CHELANTS AND CHELATES |
| EP1637524A1 (en) * | 2004-09-20 | 2006-03-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | 10-substituted 1-, 4, 7,-tris (carboxymethyl)-1,4,7,10-tetraazacyclo-dodecane derivative for use as contrast agents |
| ES2579805T3 (es) | 2004-09-23 | 2016-08-16 | Genentech, Inc. | Anticuerpos y conjugados modificados por ingeniería genética con cisteína |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
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| HUE034263T2 (en) | 2006-10-27 | 2018-02-28 | Genentech Inc | Antibodies and immunoconjugates and their applications |
| EP2468776A3 (en) | 2007-02-09 | 2012-11-14 | Genentech, Inc. | Anti-Robo4 antibodies and uses therefor |
| RU2557319C2 (ru) | 2007-07-16 | 2015-07-20 | Дженентек, Инк. | ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА ПРОТИВ CD79b И ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ПРИМЕНЕНИЯ |
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| US8499251B2 (en) | 2009-01-07 | 2013-07-30 | Microsoft Corporation | Virtual page turn |
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| KR101763808B1 (ko) | 2009-06-04 | 2017-08-16 | 노파르티스 아게 | ＩｇＧ 콘쥬게이션을 위한 자리의 확인 방법 |
| KR20120123299A (ko) | 2009-12-04 | 2012-11-08 | 제넨테크, 인크. | 다중특이적 항체, 항체 유사체, 조성물 및 방법 |
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| JP7403444B2 (ja) | 2017-10-20 | 2023-12-22 | エフ． ホフマン－ラ ロシュ アーゲー | 抗体の複写保護措置 |
| MX2020005562A (es) | 2017-11-30 | 2020-08-20 | Genentech Inc | Anticuerpos anti-pd-l1 y métodos para utilizarlos para la detección de pd-l1. |
| EP3492460A1 (en) * | 2017-12-01 | 2019-06-05 | Ustav Organicke Chemie A Biochemie Av Cr, V.v.i. | Compounds for separation of rare earth elements, method of separation, and use thereof |
| KR20200131838A (ko) | 2018-03-14 | 2020-11-24 | 에프. 호프만-라 로슈 아게 | 항체의 친화성 성숙화를 위한 방법 |
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| JP2021522192A (ja) | 2018-04-18 | 2021-08-30 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規抗チミジンキナーゼ抗体 |
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| BR112022009371A2 (pt) | 2019-11-15 | 2022-08-09 | Hoffmann La Roche | Métodos para determinar a quantidade ou concentração de um ou mais analitos antibióticos, tubos de amostragem, usos de um reagente de derivatização nucleofílica e analito antibiótico |
| CN116457660A (zh) | 2020-10-30 | 2023-07-18 | 豪夫迈·罗氏有限公司 | Timp1作为胆管癌的标志物 |
| US20230406909A1 (en) | 2020-11-02 | 2023-12-21 | Roche Diagnostics Operations, Inc. | Sars-cov-2 nucleocapsid antibodies |
| WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
| CN117099001A (zh) | 2021-04-01 | 2023-11-21 | 豪夫迈·罗氏有限公司 | Psp94作为血液生物标志物用于子宫内膜异位症的非侵入性诊断 |
| WO2022243210A1 (en) | 2021-05-17 | 2022-11-24 | F. Hoffmann-La Roche Ag | sFRP4 AS BLOOD BIOMARKER FOR THE NON-INVASIVE DIAGNOSIS OF ADENOMYOSIS |
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| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| WO2023247752A1 (en) | 2022-06-23 | 2023-12-28 | F. Hoffmann-La Roche Ag | Method for diagnosing endometriosis and for classifying the stage of endometriosis |
| WO2024017982A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2024017983A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2024017985A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
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|---|---|---|---|---|
| US2609390A (en) * | 1950-06-01 | 1952-09-02 | Frederick C Bersworth | Phosphonic alkylene polyamino acids and method of producing same |
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| US3331773A (en) * | 1966-07-22 | 1967-07-18 | Grace W R & Co | Process for inhibiting precipitation in water |
| US3434969A (en) * | 1967-08-11 | 1969-03-25 | Calgon Corp | Scale inhibiting |
| US4980148A (en) * | 1985-02-06 | 1990-12-25 | Mallinckrodt, Inc. | Methods for enhancing magnetic resonance imaging |
| US4899755A (en) * | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
| US4880008A (en) * | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
| EP0353450B1 (en) * | 1988-06-24 | 1995-03-29 | The Dow Chemical Company | Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates |
| GB8914543D0 (en) * | 1989-06-23 | 1989-08-09 | Parker David | Chemical compounds |
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| FR2672051B1 (fr) * | 1991-01-24 | 1993-05-21 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes polymetalliques, composition de diagnostic et therapeutique. |
| IL106159A0 (en) * | 1992-06-30 | 1993-10-20 | Dow Chemical Co | Targeted delivery of growth factors for bone regeneration |
| EP0588229A3 (en) * | 1992-09-12 | 1994-06-15 | Hoechst Ag | Macrocyclic chelating agents for the preparation of technetium or rhenium complexes |
-
1993
- 1993-05-06 US US08/057,588 patent/US5462725A/en not_active Expired - Fee Related
-
1994
- 1994-05-05 JP JP6525558A patent/JPH08510245A/ja not_active Ceased
- 1994-05-05 AU AU69447/94A patent/AU678583B2/en not_active Ceased
- 1994-05-05 SG SG1996004873A patent/SG46458A1/en unknown
- 1994-05-05 CZ CZ952895A patent/CZ289595A3/cs unknown
- 1994-05-05 CA CA002162174A patent/CA2162174A1/en not_active Abandoned
- 1994-05-05 HU HU9503174A patent/HUT74565A/hu unknown
- 1994-05-05 WO PCT/US1994/005009 patent/WO1994026275A1/en active IP Right Grant
- 1994-05-05 AT AT94917922T patent/ATE227297T1/de not_active IP Right Cessation
- 1994-05-05 DE DE69431660T patent/DE69431660T2/de not_active Expired - Fee Related
- 1994-05-05 PL PL94311643A patent/PL311643A1/xx unknown
- 1994-05-05 CN CN94192527.7A patent/CN1125905A/zh active Pending
- 1994-05-05 EP EP94917922A patent/EP0711300B1/en not_active Expired - Lifetime
-
1995
- 1995-11-06 FI FI955319A patent/FI955319A/fi unknown
- 1995-11-06 NO NO954440A patent/NO301829B1/no unknown
- 1995-12-05 BG BG100192A patent/BG100192A/xx unknown
- 1995-12-06 LV LVP-95-362A patent/LV11430B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE227297T1 (de) | 2002-11-15 |
| LV11430B (en) | 1997-04-20 |
| CZ289595A3 (en) | 1997-01-15 |
| FI955319A (fi) | 1995-12-22 |
| NO301829B1 (no) | 1997-12-15 |
| PL311643A1 (en) | 1996-03-04 |
| HUT74565A (en) | 1997-01-28 |
| EP0711300A4 (en) | 1996-03-12 |
| EP0711300B1 (en) | 2002-11-06 |
| SG46458A1 (en) | 1998-02-20 |
| JPH08510245A (ja) | 1996-10-29 |
| AU678583B2 (en) | 1997-06-05 |
| CA2162174A1 (en) | 1994-11-24 |
| DE69431660D1 (de) | 2002-12-12 |
| AU6944794A (en) | 1994-12-12 |
| DE69431660T2 (de) | 2003-08-21 |
| CN1125905A (zh) | 1996-07-03 |
| WO1994026275A1 (en) | 1994-11-24 |
| NO954440L (no) | 1996-01-05 |
| LV11430A (lv) | 1996-08-20 |
| NO954440D0 (no) | 1995-11-06 |
| HU9503174D0 (en) | 1996-01-29 |
| FI955319A0 (fi) | 1995-11-06 |
| US5462725A (en) | 1995-10-31 |
| EP0711300A1 (en) | 1996-05-15 |
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