NO954440L - 2 pyridylmetylenpolyazamakrocyklo-fosfonsyrer, komplekser og derivater derav, for anvendelse som kontrastmidler - Google Patents
2 pyridylmetylenpolyazamakrocyklo-fosfonsyrer, komplekser og derivater derav, for anvendelse som kontrastmidlerInfo
- Publication number
- NO954440L NO954440L NO954440A NO954440A NO954440L NO 954440 L NO954440 L NO 954440L NO 954440 A NO954440 A NO 954440A NO 954440 A NO954440 A NO 954440A NO 954440 L NO954440 L NO 954440L
- Authority
- NO
- Norway
- Prior art keywords
- complexes
- derivatives
- contrast agents
- polyazamacrocyclophosphonic
- pyridylmethylene
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000002872 contrast media Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/281—Means for the use of in vitro contrast agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/057,588 US5462725A (en) | 1993-05-06 | 1993-05-06 | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| PCT/US1994/005009 WO1994026275A1 (en) | 1993-05-06 | 1994-05-05 | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO954440D0 NO954440D0 (no) | 1995-11-06 |
| NO954440L true NO954440L (no) | 1996-01-05 |
| NO301829B1 NO301829B1 (no) | 1997-12-15 |
Family
ID=22011534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO954440A NO301829B1 (no) | 1993-05-06 | 1995-11-06 | 2-pyridylmetylenpolyazamakrocyklo-fosfonsyrer, komplekser og farmasöytiske preparater basert på disse |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5462725A (no) |
| EP (1) | EP0711300B1 (no) |
| JP (1) | JPH08510245A (no) |
| CN (1) | CN1125905A (no) |
| AT (1) | ATE227297T1 (no) |
| AU (1) | AU678583B2 (no) |
| BG (1) | BG100192A (no) |
| CA (1) | CA2162174A1 (no) |
| CZ (1) | CZ289595A3 (no) |
| DE (1) | DE69431660T2 (no) |
| FI (1) | FI955319A (no) |
| HU (1) | HUT74565A (no) |
| LV (1) | LV11430B (no) |
| NO (1) | NO301829B1 (no) |
| PL (1) | PL311643A1 (no) |
| SG (1) | SG46458A1 (no) |
| WO (1) | WO1994026275A1 (no) |
Families Citing this family (68)
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| US5409689A (en) * | 1993-08-13 | 1995-04-25 | Concat, Ltd. | MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms |
| DE19523891C1 (de) * | 1995-06-30 | 1996-11-21 | Hoechst Ag | Chirale Mangan-triazanonankomplexe und Verfahren zu ihrer Herstellung |
| CA2251924C (en) * | 1996-04-19 | 2006-05-30 | The Dow Chemical Company | Fluorescent chelates as visual tissue specific imaging agents |
| DE60006587T2 (de) * | 1999-09-13 | 2004-09-16 | Bristol-Myers Squibb Pharma Co. | Makrozyclische liganden für metallpharmazeutika |
| EP1362861B1 (en) * | 1999-09-13 | 2005-12-14 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
| US6685914B1 (en) | 1999-09-13 | 2004-02-03 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
| EP1429783A4 (en) * | 2001-09-04 | 2006-08-09 | Univ Texas Tech | MULTIMODAL IMAGING CHELATES FOR MULTIPLE USES |
| JP2005507005A (ja) * | 2001-10-22 | 2005-03-10 | テキサス テック ユニバーシティー | 組織特異的螢光キレート |
| AU2003234576A1 (en) * | 2002-05-17 | 2003-12-02 | Case Western Reserve University | Chemical shift markers for improved wireless fiducial marker tracking |
| EP1778699A4 (en) * | 2004-08-10 | 2009-02-25 | Dow Global Technologies Inc | TARGETING OF CHELANTS AND CHELATES |
| EP1637524A1 (en) * | 2004-09-20 | 2006-03-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | 10-substituted 1-, 4, 7,-tris (carboxymethyl)-1,4,7,10-tetraazacyclo-dodecane derivative for use as contrast agents |
| NZ553500A (en) | 2004-09-23 | 2009-11-27 | Genentech Inc Genentech Inc | Cysteine engineered antibodies and conjugates withCysteine engineered antibodies and conjugates with a free cysteine amino acid in the heavy chain a free cysteine amino acid in the heavy chain |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| CA2581639C (en) * | 2004-09-30 | 2016-07-26 | Molecular Devices Corporation | Luminescent lanthanide complexes |
| EP2447282B1 (en) | 2006-05-30 | 2016-01-27 | Genentech, Inc. | Anti-CD22 Antibodies, their Immunoconjugates and uses thereof |
| PL2845866T3 (pl) | 2006-10-27 | 2017-10-31 | Genentech Inc | Przeciwciała i immunokoniugaty oraz ich zastosowanie |
| NZ578701A (en) | 2007-02-09 | 2012-02-24 | Genentech Inc | Anti-robo4 antibodies and uses therefor |
| PE20090481A1 (es) | 2007-07-16 | 2009-05-18 | Genentech Inc | Anticuerpos anti-cd79b e inmunoconjugados humanizados y metodos de uso |
| CR20190516A (es) | 2007-07-16 | 2020-02-18 | Genentech Inc | ANTICUERPOS ANTI-CD79B E INMUNOCONJUGADOS (Divisional 2015-0040) |
| CN101981055B (zh) | 2008-01-31 | 2016-03-09 | 健泰科生物技术公司 | 抗cd79b抗体和免疫偶联物及使用方法 |
| US8499251B2 (en) | 2009-01-07 | 2013-07-30 | Microsoft Corporation | Virtual page turn |
| CA2757382A1 (en) | 2009-04-01 | 2010-10-21 | Kristi Elkins | Anti-fcrh5 antibodies and immunoconjugates |
| KR20180056805A (ko) | 2009-06-04 | 2018-05-29 | 노파르티스 아게 | ＩｇＧ 콘쥬게이션을 위한 자리의 확인 방법 |
| CN107337734A (zh) | 2009-12-04 | 2017-11-10 | 弗·哈夫曼-拉罗切有限公司 | 多特异性抗体、抗体类似物、组合物和方法 |
| EP2577310B1 (en) | 2010-06-03 | 2018-11-14 | F.Hoffmann-La Roche Ag | Immuno-pet imaging of antibodies and immunoconjugates and uses therefor |
| EP2579897A1 (en) | 2010-06-08 | 2013-04-17 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| RU2017128512A (ru) | 2012-07-04 | 2019-02-15 | Ф. Хоффманн-Ля Рош Аг | Антитела к теофиллину и способы их применения |
| CN104411725B (zh) | 2012-07-04 | 2018-09-28 | 弗·哈夫曼-拉罗切有限公司 | 抗生物素抗体及使用方法 |
| CN107973856B (zh) | 2012-07-04 | 2021-11-23 | 弗·哈夫曼-拉罗切有限公司 | 共价连接的抗原-抗体缀合物 |
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| PL3089996T3 (pl) | 2014-01-03 | 2021-12-13 | F. Hoffmann-La Roche Ag | Dwuswoiste przeciwciała przeciw haptenowi/przeciw receptorowi występującemu w barierze krew-mózg, ich kompleksy i ich zastosowanie jako przenośniki wahadłowe występujące w barierze krew-mózg |
| RU2694981C2 (ru) | 2014-01-03 | 2019-07-18 | Ф. Хоффманн-Ля Рош Аг | Ковалентно связанные конъюгаты хеликар-антитело против хеликара и их применения |
| AR101844A1 (es) | 2014-09-12 | 2017-01-18 | Genentech Inc | Anticuerpos y conjugados modificados genéticamente con cisteína |
| CN107001447B (zh) | 2014-12-17 | 2021-07-23 | 豪夫迈·罗氏有限公司 | 采用分选酶的酶介导多肽缀合新方法 |
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| CN108138158B (zh) | 2015-09-25 | 2021-11-09 | 豪夫迈·罗氏有限公司 | 可溶性分选酶a |
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| EP3492460A1 (en) * | 2017-12-01 | 2019-06-05 | Ustav Organicke Chemie A Biochemie Av Cr, V.v.i. | Compounds for separation of rare earth elements, method of separation, and use thereof |
| JP7333332B2 (ja) | 2018-03-14 | 2023-08-24 | エフ． ホフマン－ラ ロシュ アーゲー | 抗体のアフィニティ成熟のための方法 |
| WO2019175127A1 (en) | 2018-03-14 | 2019-09-19 | F. Hoffmann-La Roche Ag | Novel anti-troponint antibodies |
| WO2019201901A1 (en) | 2018-04-18 | 2019-10-24 | F. Hoffmann-La Roche Ag | Novel anti-thymidine kinase antibodies |
| WO2020043868A1 (en) | 2018-08-31 | 2020-03-05 | F. Hoffmann-La Roche Ag | Thymidine kinase (tk-1) in prognostic indices for dlbcl |
| US20220001043A1 (en) | 2018-09-28 | 2022-01-06 | Imaginab, Inc. | Cd8 imaging constructs and methods of use thereof |
| BR112022000945A2 (pt) | 2019-07-22 | 2022-03-08 | Hoffmann La Roche | Métodos para avaliar se uma paciente tem endometriose ou está em risco de desenvolver endometriose, para selecionar uma paciente para terapia e para monitorar uma paciente que sofre de endometriose ou que está sendo tratada para endometriose |
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| CN116457660A (zh) | 2020-10-30 | 2023-07-18 | 豪夫迈·罗氏有限公司 | Timp1作为胆管癌的标志物 |
| US20230406909A1 (en) | 2020-11-02 | 2023-12-21 | Roche Diagnostics Operations, Inc. | Sars-cov-2 nucleocapsid antibodies |
| WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
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| CN117337394A (zh) | 2021-05-17 | 2024-01-02 | 豪夫迈·罗氏有限公司 | sFRP4作为血液生物标志物用于子宫腺肌病的非侵入性诊断 |
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| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| WO2023247752A1 (en) | 2022-06-23 | 2023-12-28 | F. Hoffmann-La Roche Ag | Method for diagnosing endometriosis and for classifying the stage of endometriosis |
| WO2024017983A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2024017982A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2024017985A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2024030772A1 (en) * | 2022-08-01 | 2024-02-08 | Portland State University | High relaxivity contrast agents and stereoselective preparation |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2609390A (en) * | 1950-06-01 | 1952-09-02 | Frederick C Bersworth | Phosphonic alkylene polyamino acids and method of producing same |
| US3336221A (en) * | 1964-11-05 | 1967-08-15 | Calgon Corp | Method of inhibiting precipitation and scale formation |
| US3331773A (en) * | 1966-07-22 | 1967-07-18 | Grace W R & Co | Process for inhibiting precipitation in water |
| US3434969A (en) * | 1967-08-11 | 1969-03-25 | Calgon Corp | Scale inhibiting |
| US4980148A (en) * | 1985-02-06 | 1990-12-25 | Mallinckrodt, Inc. | Methods for enhancing magnetic resonance imaging |
| US4880008A (en) * | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
| US4899755A (en) * | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
| NZ229700A (en) * | 1988-06-24 | 1993-01-27 | Dow Chemical Co | Tetraazacyclododecane derivatives containing a linker/spacer moiety capable of forming antibody conjugates; complexes with radionuclides and conjugates of such compounds and complexes with antibodies or antibody fragments |
| GB8914543D0 (en) * | 1989-06-23 | 1989-08-09 | Parker David | Chemical compounds |
| US5247077A (en) * | 1989-06-23 | 1993-09-21 | Celltech Limited | Tri-aza macrocycles and processes for their preparation |
| FR2672051B1 (fr) * | 1991-01-24 | 1993-05-21 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes polymetalliques, composition de diagnostic et therapeutique. |
| IL106159A0 (en) * | 1992-06-30 | 1993-10-20 | Dow Chemical Co | Targeted delivery of growth factors for bone regeneration |
| EP0588229A3 (en) * | 1992-09-12 | 1994-06-15 | Hoechst Ag | Macrocyclic chelating agents for the preparation of technetium or rhenium complexes |
-
1993
- 1993-05-06 US US08/057,588 patent/US5462725A/en not_active Expired - Fee Related
-
1994
- 1994-05-05 JP JP6525558A patent/JPH08510245A/ja not_active Ceased
- 1994-05-05 WO PCT/US1994/005009 patent/WO1994026275A1/en active IP Right Grant
- 1994-05-05 HU HU9503174A patent/HUT74565A/hu unknown
- 1994-05-05 EP EP94917922A patent/EP0711300B1/en not_active Expired - Lifetime
- 1994-05-05 DE DE69431660T patent/DE69431660T2/de not_active Expired - Fee Related
- 1994-05-05 AT AT94917922T patent/ATE227297T1/de not_active IP Right Cessation
- 1994-05-05 CN CN94192527.7A patent/CN1125905A/zh active Pending
- 1994-05-05 AU AU69447/94A patent/AU678583B2/en not_active Ceased
- 1994-05-05 SG SG1996004873A patent/SG46458A1/en unknown
- 1994-05-05 PL PL94311643A patent/PL311643A1/xx unknown
- 1994-05-05 CA CA002162174A patent/CA2162174A1/en not_active Abandoned
- 1994-05-05 CZ CZ952895A patent/CZ289595A3/cs unknown
-
1995
- 1995-11-06 FI FI955319A patent/FI955319A/fi unknown
- 1995-11-06 NO NO954440A patent/NO301829B1/no unknown
- 1995-12-05 BG BG100192A patent/BG100192A/xx unknown
- 1995-12-06 LV LVP-95-362A patent/LV11430B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LV11430B (en) | 1997-04-20 |
| LV11430A (lv) | 1996-08-20 |
| EP0711300B1 (en) | 2002-11-06 |
| PL311643A1 (en) | 1996-03-04 |
| AU6944794A (en) | 1994-12-12 |
| AU678583B2 (en) | 1997-06-05 |
| EP0711300A1 (en) | 1996-05-15 |
| WO1994026275A1 (en) | 1994-11-24 |
| JPH08510245A (ja) | 1996-10-29 |
| SG46458A1 (en) | 1998-02-20 |
| BG100192A (en) | 1996-12-31 |
| HU9503174D0 (en) | 1996-01-29 |
| NO301829B1 (no) | 1997-12-15 |
| ATE227297T1 (de) | 2002-11-15 |
| CA2162174A1 (en) | 1994-11-24 |
| NO954440D0 (no) | 1995-11-06 |
| HUT74565A (en) | 1997-01-28 |
| DE69431660T2 (de) | 2003-08-21 |
| DE69431660D1 (de) | 2002-12-12 |
| CN1125905A (zh) | 1996-07-03 |
| FI955319A (fi) | 1995-12-22 |
| CZ289595A3 (en) | 1997-01-15 |
| EP0711300A4 (en) | 1996-03-12 |
| FI955319A0 (fi) | 1995-11-06 |
| US5462725A (en) | 1995-10-31 |
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