BE888214A - Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol - Google Patents

Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol

Info

Publication number
BE888214A
BE888214A BE0/204328A BE204328A BE888214A BE 888214 A BE888214 A BE 888214A BE 0/204328 A BE0/204328 A BE 0/204328A BE 204328 A BE204328 A BE 204328A BE 888214 A BE888214 A BE 888214A
Authority
BE
Belgium
Prior art keywords
monacolin
biosynthesis
cholesterol
derivatives
inhibitory activity
Prior art date
Application number
BE0/204328A
Other languages
English (en)
French (fr)
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12604367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE888214(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of BE888214A publication Critical patent/BE888214A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BE0/204328A 1980-03-31 1981-03-31 Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol BE888214A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55041292A JPH0692381B2 (ja) 1980-03-31 1980-03-31 Ｍｂ−５３０ａ誘導体

Publications (1)

Publication Number Publication Date
BE888214A true BE888214A (fr) 1981-09-30

Family

ID=12604367

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/204328A BE888214A (fr) 1980-03-31 1981-03-31 Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol

Country Status (15)

Country Link
JP (1) JPH0692381B2 (cs)
AT (1) ATA150781A (cs)
AU (1) AU6893281A (cs)
BE (1) BE888214A (cs)
CH (1) CH646966A5 (cs)
DE (2) DE3153666C2 (cs)
DK (3) DK151273C (cs)
FI (1) FI810991A7 (cs)
FR (1) FR2479222A1 (cs)
GB (1) GB2073193A (cs)
IE (1) IE52367B1 (cs)
IT (1) IT1144325B (cs)
MX (1) MX9203567A (cs)
NL (1) NL8101592A (cs)
SE (1) SE461590B (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472426A (en) * 1982-12-22 1984-09-18 Merck & Co., Inc. Antihypercholesterolemic compounds
ATE69602T1 (de) * 1985-09-13 1991-12-15 Sankyo Co Hydroxy-ml-236b-derivate, deren herstellung und anwendung.
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5075327A (en) * 1988-08-10 1991-12-24 Hoffmann-La Roche Inc. Antipsoriatic agents
US5073568A (en) * 1988-11-14 1991-12-17 Hoffmann-La Roche Inc. Antipsoriatic agents
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
US5200549A (en) * 1988-11-14 1993-04-06 Hoffman-La Roche Inc. Antipsoriatic agents
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
FR2937537A1 (fr) * 2008-10-29 2010-04-30 Centre Nat Rech Scient Nanoparticules de statine
KR101820099B1 (ko) 2013-01-18 2018-01-18 에스프린팅솔루션 주식회사 저항 발열체, 이를 채용한 가열 부재, 및 정착 장치
JP2021509907A (ja) * 2018-01-09 2021-04-08 リガンド・ファーマシューティカルズ・インコーポレイテッド アセタール化合物およびその治療的使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (cs) * 1974-06-07 1981-03-18
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
AU535944B2 (en) * 1979-06-15 1984-04-12 Merck & Co., Inc. Hypocholestermic fermentation products from aspergillus
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
ZA81703B (en) * 1980-02-04 1982-09-29 Merck & Co Inc New antihypercholesterolemic compounds,intermediates and processes

Also Published As

Publication number Publication date
IE810698L (en) 1981-09-30
FI810991L (fi) 1981-10-01
DK145481A (da) 1981-10-01
MX9203567A (es) 1992-09-01
JPH0692381B2 (ja) 1994-11-16
DK151273C (da) 1988-07-04
IT8167438A0 (it) 1981-03-30
DK32290A (da) 1990-02-07
DE3112566A1 (de) 1982-03-11
DK151273B (da) 1987-11-16
DK32190D0 (da) 1990-02-07
DK32190A (da) 1990-02-07
DE3112566C2 (cs) 1990-04-05
GB2073193A (en) 1981-10-14
SE8102047L (sv) 1981-10-01
JPS56138181A (en) 1981-10-28
FR2479222B1 (cs) 1983-08-26
IE52367B1 (en) 1987-09-30
DE3153666C2 (de) 1993-11-11
ATA150781A (de) 1983-03-15
AU6893281A (en) 1981-10-08
IT1144325B (it) 1986-10-29
DK167805B1 (da) 1993-12-20
SE461590B (sv) 1990-03-05
FI810991A7 (fi) 1981-10-01
NL8101592A (nl) 1981-10-16
FR2479222A1 (fr) 1981-10-02
DK32290D0 (da) 1990-02-07
CH646966A5 (de) 1984-12-28

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: SANKYO CY LTD

Effective date: 20010331