ES2016263B3 - Inhibicion de la via de 5-lipoxigenasa. - Google Patents

Inhibicion de la via de 5-lipoxigenasa.

Info

Publication number
ES2016263B3
ES2016263B3 ES86309674T ES86309674T ES2016263B3 ES 2016263 B3 ES2016263 B3 ES 2016263B3 ES 86309674 T ES86309674 T ES 86309674T ES 86309674 T ES86309674 T ES 86309674T ES 2016263 B3 ES2016263 B3 ES 2016263B3
Authority
ES
Spain
Prior art keywords
lipoxigenase
inhibition
lipoxigenase via
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86309674T
Other languages
English (en)
Inventor
Paul Elliot Bender
David Taylor Hill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of ES2016263B3 publication Critical patent/ES2016263B3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES86309674T 1985-12-12 1986-12-11 Inhibicion de la via de 5-lipoxigenasa. Expired - Lifetime ES2016263B3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80839685A 1985-12-12 1985-12-12
US06/856,735 US4728656A (en) 1985-12-12 1986-04-28 2,2-alkyldiylbis(thio)bis(imidazoles) useful for inhibition of the 5-lipoxygenase pathway

Publications (1)

Publication Number Publication Date
ES2016263B3 true ES2016263B3 (es) 1990-11-01

Family

ID=27123120

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86309674T Expired - Lifetime ES2016263B3 (es) 1985-12-12 1986-12-11 Inhibicion de la via de 5-lipoxigenasa.

Country Status (9)

Country Link
US (1) US4728656A (es)
EP (1) EP0229496B1 (es)
JP (1) JPH072737B2 (es)
AU (1) AU586056B2 (es)
DE (1) DE3672254D1 (es)
DK (1) DK593986A (es)
ES (1) ES2016263B3 (es)
GR (1) GR3000784T3 (es)
PT (1) PT83903B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847270A (en) * 1985-12-12 1989-07-11 Smithkline Beckman Corporation Inhibition of the 5-lipoxygenase pathway utilizing certain 2,2'-alkyldiyl bis(thio)bis-imidazoles and derivatives
US5021440A (en) * 1989-07-31 1991-06-04 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5030644A (en) * 1989-07-31 1991-07-09 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
IE904450A1 (en) * 1989-12-11 1991-06-19 Rhone Poulenc Sante Imidazoles
CA2293436C (en) 1997-06-12 2010-10-26 Rhone-Poulenc Rorer Limited Imidazolyl-cyclic acetals as tnf inhibitors
EP4008327A1 (en) 2009-04-29 2022-06-08 Amarin Pharmaceuticals Ireland Limited Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1178242A (en) * 1966-02-05 1970-01-21 Wellcome Found Novel Biologically Active Bis-Isothioureas
DE2823197A1 (de) * 1978-05-24 1979-11-29 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4188397A (en) * 1978-09-22 1980-02-12 Smithkline Corporation 2,2-Alkyldiylbis(thio)bis(imidazoles)
GR71915B (es) * 1979-11-27 1983-08-16 Pfizer

Also Published As

Publication number Publication date
AU586056B2 (en) 1989-06-29
DK593986A (da) 1987-06-13
JPS62153285A (ja) 1987-07-08
PT83903A (en) 1987-01-01
DK593986D0 (da) 1986-12-10
DE3672254D1 (de) 1990-08-02
JPH072737B2 (ja) 1995-01-18
US4728656A (en) 1988-03-01
PT83903B (en) 1988-10-19
EP0229496B1 (en) 1990-06-27
GR3000784T3 (en) 1991-10-10
AU6645386A (en) 1987-06-18
EP0229496A1 (en) 1987-07-22

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