BE862785A - Derives de pyrimido(6,1-a)isoquinoleine-2-one, leur procede de preparation et leur application en therapeutique - Google Patents

Derives de pyrimido(6,1-a)isoquinoleine-2-one, leur procede de preparation et leur application en therapeutique

Info

Publication number
BE862785A
BE862785A BE184225A BE184225A BE862785A BE 862785 A BE862785 A BE 862785A BE 184225 A BE184225 A BE 184225A BE 184225 A BE184225 A BE 184225A BE 862785 A BE862785 A BE 862785A
Authority
BE
Belgium
Prior art keywords
isoquinoleine
pyrimido
derivatives
preparation process
therapeutic application
Prior art date
Application number
BE184225A
Other languages
English (en)
French (fr)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19772720085 external-priority patent/DE2720085A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of BE862785A publication Critical patent/BE862785A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE184225A 1977-05-05 1978-01-10 Derives de pyrimido(6,1-a)isoquinoleine-2-one, leur procede de preparation et leur application en therapeutique BE862785A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772720085 DE2720085A1 (de) 1977-05-05 1977-05-05 Pyrimido(6,1-a)isochinolin-2-on- derivate

Publications (1)

Publication Number Publication Date
BE862785A true BE862785A (fr) 1978-07-10

Family

ID=6008073

Family Applications (1)

Application Number Title Priority Date Filing Date
BE184225A BE862785A (fr) 1977-05-05 1978-01-10 Derives de pyrimido(6,1-a)isoquinoleine-2-one, leur procede de preparation et leur application en therapeutique

Country Status (18)

Country Link
US (2) US4482556A (pt)
JP (2) JPS53137997A (pt)
AT (1) AT372383B (pt)
BE (1) BE862785A (pt)
CH (2) CH640854A5 (pt)
DK (2) DK158789C (pt)
EG (1) EG12982A (pt)
ES (3) ES464776A1 (pt)
FI (1) FI64370C (pt)
FR (1) FR2389623B1 (pt)
GR (1) GR72114B (pt)
IL (1) IL53336A (pt)
IT (1) IT1192252B (pt)
NL (1) NL185078C (pt)
NO (2) NO148032C (pt)
PT (1) PT67265B (pt)
SE (2) SE436357B (pt)
ZA (1) ZA776706B (pt)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010759A3 (en) * 1978-11-03 1981-08-19 Hoechst Aktiengesellschaft Pyrimido (6,1-a) isoquinolin-4-ones, process for their preparation and their application in medicaments; intermediates and their preparation
US4581172A (en) * 1983-05-05 1986-04-08 Hoffmann-La Roche Inc. Substituted pyrimido[6,1-a]isoquinolin-4-ones,pyrimido[6,1-a]benzozepin-4-ones and pyrimido[6,1-a]benzodiazepin-4-ones useful for prevention of thromboses and treating hypertension

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2470130A2 (fr) * 1979-11-21 1981-05-29 Hoechst Ag Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique
DE3135831A1 (de) * 1981-09-10 1983-04-28 Hoechst Ag, 6230 Frankfurt 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3816995A1 (de) * 1988-05-19 1989-11-23 Hoechst Ag Verwendung von pyrimido-(6,1-a)-isochinolin-4-on-derivaten und medizinische zubereitungen auf basis dieser verbindungen
DE68902811D1 (de) * 1988-11-19 1992-10-15 Hoechst Ag Pharmazeutische zusammensetzungen mit einem gehalt an labdan-di-terpenoid-derivaten und pyrimido(6,1-a)isochinolin-4-on-derivaten und ihre anwendung.
CN100415743C (zh) * 1999-03-31 2008-09-03 韦尔纳利斯有限公司 嘧啶并[6,1-a] 异喹啉-4-酮衍生物
WO2005007092A2 (en) * 2003-07-08 2005-01-27 Smithkline Beecham Corporation Novel chemical compounds
CN101671336B (zh) 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
GB201613054D0 (en) 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process
IL280075B2 (en) * 2018-07-13 2024-06-01 Chia Tai Tianqing Pharmaceutical Group Co Ltd A conjugated tricyclic compound as a dual PDE3/PDE4 inhibitor
JP2023512471A (ja) * 2020-01-15 2023-03-27 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド Ｐｄｅ３／ｐｄｅ４二重阻害剤の結晶及びその使用
AU2021208129A1 (en) * 2020-01-15 2022-08-18 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Pharmaceutical composition of tricyclic PDE3/PDE4 dual inhibitor compound
JP2024517583A (ja) * 2021-04-29 2024-04-23 ▲蘇▼州盛迪▲亞▼生物医▲薬▼有限公司 イソキノリノン系化合物及びその用途
WO2024088402A1 (zh) * 2022-10-28 2024-05-02 江苏恒瑞医药股份有限公司 一种异喹啉酮类化合物的晶型及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3021331A (en) * 1959-07-20 1962-02-13 Pfizer & Co C Azabenzopyridocolines
US3081306A (en) * 1959-11-04 1963-03-12 Pfizer & Co C 2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines
US3297696A (en) * 1965-05-28 1967-01-10 Sandoz Ag 6-amino-8, 9-dihydro-13bh-isoquinolo-[2, 1-c] quinazolines and intermediates therefor
DE2126148A1 (en) * 1971-05-26 1972-12-07 Farbenfabriken Bayer Ag, 5090 Leverkusen Prepn of uracil derivs - useful as plant - protection agents and their inters
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
US5740368A (en) * 1995-06-30 1998-04-14 Canon Kabushiki Kaisha Method and apparatus for providing information on a managed peripheral device to plural agents

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010759A3 (en) * 1978-11-03 1981-08-19 Hoechst Aktiengesellschaft Pyrimido (6,1-a) isoquinolin-4-ones, process for their preparation and their application in medicaments; intermediates and their preparation
US4400506A (en) * 1978-11-03 1983-08-23 Hoechst Aktiengesellschaft Processes for the manufacture of pyrimido[6,1-a]isoquinolinones
US4581172A (en) * 1983-05-05 1986-04-08 Hoffmann-La Roche Inc. Substituted pyrimido[6,1-a]isoquinolin-4-ones,pyrimido[6,1-a]benzozepin-4-ones and pyrimido[6,1-a]benzodiazepin-4-ones useful for prevention of thromboses and treating hypertension

Also Published As

Publication number Publication date
NL7800149A (nl) 1978-11-07
IL53336A0 (en) 1978-01-31
CH642949A5 (de) 1984-05-15
ATA784477A (de) 1983-02-15
IL53336A (en) 1984-02-29
NO148032C (no) 1983-07-27
ES464776A1 (es) 1979-01-01
NL185078B (nl) 1989-08-16
ES472606A1 (es) 1979-02-16
PT67265B (de) 1981-01-05
ES475027A1 (es) 1979-05-16
DK267089A (da) 1989-06-01
SE436357B (sv) 1984-12-03
ZA776706B (en) 1978-08-30
SE7712513L (sv) 1978-11-06
GR72114B (pt) 1983-09-15
PT67265A (de) 1977-12-01
NO148032B (no) 1983-04-18
DK158789C (da) 1990-11-26
FI773286A (fi) 1978-11-06
DK158789B (da) 1990-07-16
AT372383B (de) 1983-09-26
NL185078C (nl) 1990-01-16
NO774131L (no) 1978-11-07
SE8206619L (sv) 1982-11-19
DK489477A (da) 1978-11-06
FR2389623B1 (pt) 1980-10-31
FI64370B (fi) 1983-07-29
FI64370C (fi) 1983-11-10
NO821266L (no) 1978-11-07
US4482556A (en) 1984-11-13
CH640854A5 (de) 1984-01-31
JPS6041677A (ja) 1985-03-05
DK267089D0 (da) 1989-06-01
IT1192252B (it) 1988-03-31
SE8206619D0 (sv) 1982-11-19
FR2389623A1 (pt) 1978-12-01
JPS6225150B2 (pt) 1987-06-01
JPS53137997A (en) 1978-12-01
US4598148A (en) 1986-07-01
EG12982A (en) 1982-03-31
JPS6312871B2 (pt) 1988-03-23
IT7822619A0 (it) 1978-04-21
SE439307B (sv) 1985-06-10

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: HOECHST A.G.

Effective date: 19920131