ES472606A1 - Procedimiento para la preparacion de derivados de pirimido (6,1-a) isoquinolein-2-ona - Google Patents
Procedimiento para la preparacion de derivados de pirimido (6,1-a) isoquinolein-2-onaInfo
- Publication number
- ES472606A1 ES472606A1 ES472606A ES472606A ES472606A1 ES 472606 A1 ES472606 A1 ES 472606A1 ES 472606 A ES472606 A ES 472606A ES 472606 A ES472606 A ES 472606A ES 472606 A1 ES472606 A1 ES 472606A1
- Authority
- ES
- Spain
- Prior art keywords
- pyrimido
- isoquinolin
- derivatives
- intermediates
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CIVQDIGHVMGTPD-UHFFFAOYSA-N pyrimido[6,1-a]isoquinolin-4-one Chemical class C1=CC=C2C=CN3C(=O)N=CC=C3C2=C1 CIVQDIGHVMGTPD-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- -1 and anti-allergenics Substances 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 239000000168 bronchodilator agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
Procedimiento para la preparación de derivados de pirimido(6,1-a)isoquinolein-2-ona de la fórmula I **(Fórmula)** en que R1, R4 y R5, que pueden ser iguales o diferentes, significan hidrógeno, hidroxi, alcoxi inferior, dialcohilfosfinilalcoxi, aciloxi o halógeno, pudiendo dos grupos contiguos significar conjuntamente un grupo metilendioxi o etilendioxi, y R2 y R3, que pueden ser iguales o diferentes, significan hidrógeno, hidroxi, alcoxi inferior, amino o alcohilo sustituido con una anillo carbonado de 5 ó 6 miembros.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19772720085 DE2720085A1 (de) | 1977-05-05 | 1977-05-05 | Pyrimido(6,1-a)isochinolin-2-on- derivate |
Publications (1)
Publication Number | Publication Date |
---|---|
ES472606A1 true ES472606A1 (es) | 1979-02-16 |
Family
ID=6008073
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES464776A Expired ES464776A1 (es) | 1977-05-05 | 1977-12-06 | Procedimiento para la preparacion de derivados de pirimido (6,1-a)isoquinolein-2-ona |
ES472606A Expired ES472606A1 (es) | 1977-05-05 | 1978-08-16 | Procedimiento para la preparacion de derivados de pirimido (6,1-a) isoquinolein-2-ona |
ES475027A Expired ES475027A1 (es) | 1977-05-05 | 1978-11-13 | Procedimiento para la preparacion de derivados de pirimido (6,1-a)isoquinolein-2-ona. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES464776A Expired ES464776A1 (es) | 1977-05-05 | 1977-12-06 | Procedimiento para la preparacion de derivados de pirimido (6,1-a)isoquinolein-2-ona |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES475027A Expired ES475027A1 (es) | 1977-05-05 | 1978-11-13 | Procedimiento para la preparacion de derivados de pirimido (6,1-a)isoquinolein-2-ona. |
Country Status (18)
Country | Link |
---|---|
US (2) | US4482556A (es) |
JP (2) | JPS53137997A (es) |
AT (1) | AT372383B (es) |
BE (1) | BE862785A (es) |
CH (2) | CH640854A5 (es) |
DK (2) | DK158789C (es) |
EG (1) | EG12982A (es) |
ES (3) | ES464776A1 (es) |
FI (1) | FI64370C (es) |
FR (1) | FR2389623B1 (es) |
GR (1) | GR72114B (es) |
IL (1) | IL53336A (es) |
IT (1) | IT1192252B (es) |
NL (1) | NL185078C (es) |
NO (2) | NO148032C (es) |
PT (1) | PT67265B (es) |
SE (2) | SE436357B (es) |
ZA (1) | ZA776706B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2847693A1 (de) * | 1978-11-03 | 1980-05-22 | Hoechst Ag | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
FR2470130A2 (fr) * | 1979-11-21 | 1981-05-29 | Hoechst Ag | Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique |
DE3135831A1 (de) * | 1981-09-10 | 1983-04-28 | Hoechst Ag, 6230 Frankfurt | 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
ZW6284A1 (en) * | 1983-05-05 | 1985-10-30 | Hoffmann La Roche | Novel pyrimidone derivatives |
DE3816995A1 (de) * | 1988-05-19 | 1989-11-23 | Hoechst Ag | Verwendung von pyrimido-(6,1-a)-isochinolin-4-on-derivaten und medizinische zubereitungen auf basis dieser verbindungen |
DE68902811D1 (de) * | 1988-11-19 | 1992-10-15 | Hoechst Ag | Pharmazeutische zusammensetzungen mit einem gehalt an labdan-di-terpenoid-derivaten und pyrimido(6,1-a)isochinolin-4-on-derivaten und ihre anwendung. |
JP4685243B2 (ja) * | 1999-03-31 | 2011-05-18 | ベローナ・ファーマ・ピーエルシー | ピリミド[6,1−a]イソキノリン−4−オン誘導体 |
WO2005007092A2 (en) * | 2003-07-08 | 2005-01-27 | Smithkline Beecham Corporation | Novel chemical compounds |
CN101671336B (zh) | 2009-09-23 | 2013-11-13 | 辽宁利锋科技开发有限公司 | 芳杂环并嘧啶衍生物和类似物及其制备方法和用途 |
GB201613054D0 (en) | 2016-07-28 | 2016-09-14 | Verona Pharma Plc | New compound and process |
EP3822272A4 (en) * | 2018-07-13 | 2022-04-06 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | CONDENSED TRICYCLIC COMPOUND AS PDE3/PDE4 DOUBLE INHIBITOR |
CN114929701A (zh) * | 2020-01-15 | 2022-08-19 | 正大天晴药业集团股份有限公司 | 一种pde3/pde4双重抑制剂的结晶及其应用 |
AU2021208129A1 (en) * | 2020-01-15 | 2022-08-18 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Pharmaceutical composition of tricyclic PDE3/PDE4 dual inhibitor compound |
KR20240004495A (ko) * | 2021-04-29 | 2024-01-11 | 쑤저우 선카디아 바이오파마수티컬즈 컴퍼니 리미티드 | 이소퀴놀론 화합물과 이의 용도 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3021331A (en) * | 1959-07-20 | 1962-02-13 | Pfizer & Co C | Azabenzopyridocolines |
US3081306A (en) * | 1959-11-04 | 1963-03-12 | Pfizer & Co C | 2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines |
US3297696A (en) * | 1965-05-28 | 1967-01-10 | Sandoz Ag | 6-amino-8, 9-dihydro-13bh-isoquinolo-[2, 1-c] quinazolines and intermediates therefor |
DE2126148A1 (en) * | 1971-05-26 | 1972-12-07 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Prepn of uracil derivs - useful as plant - protection agents and their inters |
DE2847693A1 (de) * | 1978-11-03 | 1980-05-22 | Hoechst Ag | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
US5740368A (en) * | 1995-06-30 | 1998-04-14 | Canon Kabushiki Kaisha | Method and apparatus for providing information on a managed peripheral device to plural agents |
-
1977
- 1977-11-02 FI FI773286A patent/FI64370C/fi not_active IP Right Cessation
- 1977-11-03 DK DK489477A patent/DK158789C/da active
- 1977-11-03 AT AT0784477A patent/AT372383B/de active
- 1977-11-04 SE SE7712513A patent/SE436357B/sv not_active IP Right Cessation
- 1977-11-08 IL IL53336A patent/IL53336A/xx unknown
- 1977-11-09 ZA ZA00776706A patent/ZA776706B/xx unknown
- 1977-11-11 PT PT67265A patent/PT67265B/pt unknown
- 1977-11-19 JP JP13845577A patent/JPS53137997A/ja active Granted
- 1977-12-02 NO NO774131A patent/NO148032C/no unknown
- 1977-12-06 ES ES464776A patent/ES464776A1/es not_active Expired
- 1977-12-10 EG EG680/77A patent/EG12982A/xx active
-
1978
- 1978-01-01 CH CH1331977A patent/CH640854A5/de not_active IP Right Cessation
- 1978-01-05 NL NLAANVRAGE7800149,A patent/NL185078C/xx not_active IP Right Cessation
- 1978-01-10 BE BE184225A patent/BE862785A/xx not_active IP Right Cessation
- 1978-02-02 FR FR7802935A patent/FR2389623B1/fr not_active Expired
- 1978-03-14 GR GR55702A patent/GR72114B/el unknown
- 1978-04-21 IT IT22619/78A patent/IT1192252B/it active
- 1978-08-16 ES ES472606A patent/ES472606A1/es not_active Expired
- 1978-10-19 CH CH1084178A patent/CH642949A5/de not_active IP Right Cessation
- 1978-11-13 ES ES475027A patent/ES475027A1/es not_active Expired
-
1980
- 1980-03-26 US US06/134,080 patent/US4482556A/en not_active Expired - Lifetime
-
1982
- 1982-04-19 NO NO821266A patent/NO821266L/no unknown
- 1982-11-19 SE SE8206619A patent/SE439307B/sv not_active IP Right Cessation
-
1984
- 1984-06-18 JP JP59123892A patent/JPS6041677A/ja active Granted
- 1984-09-19 US US06/652,005 patent/US4598148A/en not_active Expired - Lifetime
-
1989
- 1989-06-01 DK DK267089A patent/DK267089A/da not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19980302 |