ES475027A1 - Procedimiento para la preparacion de derivados de pirimido (6,1-a)isoquinolein-2-ona. - Google Patents

Procedimiento para la preparacion de derivados de pirimido (6,1-a)isoquinolein-2-ona.

Info

Publication number
ES475027A1
ES475027A1 ES475027A ES475027A ES475027A1 ES 475027 A1 ES475027 A1 ES 475027A1 ES 475027 A ES475027 A ES 475027A ES 475027 A ES475027 A ES 475027A ES 475027 A1 ES475027 A1 ES 475027A1
Authority
ES
Spain
Prior art keywords
pyrimido
isoquinolin
derivatives
intermediates
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES475027A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19772720085 external-priority patent/DE2720085A1/de
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES475027A1 publication Critical patent/ES475027A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

Procedimiento para la preparación de derivados de dirimido (6,1-a)isoquinolein-2-ona de la fórmula I *** en la que R1, R4 y R5 que pueden ser iguales o diferentes, significan hidrógeno, hidroxi, alcoxi inferior, dialcohilfosfinilalcoxi, aciloxi o halógeno, pudiendo dos grupos continuos significar conjuntamente un grupo metilendioxi o etilendioxi, y R2 y R4, que pueden ser iguales o diferentes, significan hidrógeno, hidroxi, alcoxi inferior, amino, alcohilamino, dialcohilamino, arilamino, alcohilo, amino o alcohilo sustituido por un anillo carbonado de 5 ó 6 miembros, que contiene hasta 3 heteroátomos del grupo de N, O ó S.
ES475027A 1977-05-05 1978-11-13 Procedimiento para la preparacion de derivados de pirimido (6,1-a)isoquinolein-2-ona. Expired ES475027A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772720085 DE2720085A1 (de) 1977-05-05 1977-05-05 Pyrimido(6,1-a)isochinolin-2-on- derivate

Publications (1)

Publication Number Publication Date
ES475027A1 true ES475027A1 (es) 1979-05-16

Family

ID=6008073

Family Applications (3)

Application Number Title Priority Date Filing Date
ES464776A Expired ES464776A1 (es) 1977-05-05 1977-12-06 Procedimiento para la preparacion de derivados de pirimido (6,1-a)isoquinolein-2-ona
ES472606A Expired ES472606A1 (es) 1977-05-05 1978-08-16 Procedimiento para la preparacion de derivados de pirimido (6,1-a) isoquinolein-2-ona
ES475027A Expired ES475027A1 (es) 1977-05-05 1978-11-13 Procedimiento para la preparacion de derivados de pirimido (6,1-a)isoquinolein-2-ona.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES464776A Expired ES464776A1 (es) 1977-05-05 1977-12-06 Procedimiento para la preparacion de derivados de pirimido (6,1-a)isoquinolein-2-ona
ES472606A Expired ES472606A1 (es) 1977-05-05 1978-08-16 Procedimiento para la preparacion de derivados de pirimido (6,1-a) isoquinolein-2-ona

Country Status (18)

Country Link
US (2) US4482556A (es)
JP (2) JPS53137997A (es)
AT (1) AT372383B (es)
BE (1) BE862785A (es)
CH (2) CH640854A5 (es)
DK (2) DK158789C (es)
EG (1) EG12982A (es)
ES (3) ES464776A1 (es)
FI (1) FI64370C (es)
FR (1) FR2389623B1 (es)
GR (1) GR72114B (es)
IL (1) IL53336A (es)
IT (1) IT1192252B (es)
NL (1) NL185078C (es)
NO (2) NO148032C (es)
PT (1) PT67265B (es)
SE (2) SE436357B (es)
ZA (1) ZA776706B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
FR2470130A2 (fr) * 1979-11-21 1981-05-29 Hoechst Ag Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique
DE3135831A1 (de) * 1981-09-10 1983-04-28 Hoechst Ag, 6230 Frankfurt 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ZW6284A1 (en) * 1983-05-05 1985-10-30 Hoffmann La Roche Novel pyrimidone derivatives
DE3816995A1 (de) * 1988-05-19 1989-11-23 Hoechst Ag Verwendung von pyrimido-(6,1-a)-isochinolin-4-on-derivaten und medizinische zubereitungen auf basis dieser verbindungen
EP0370379B1 (en) * 1988-11-19 1992-09-09 Hoechst Aktiengesellschaft Pharmaceutical compositions comprising labdane diterpenoid derivatives and pyrimido(6,1-a) isoquinolin-4-one derivatives and their use
CA2368413C (en) * 1999-03-31 2008-07-29 Vernalis Limited Derivatives of pyrimido[6,1-a]isoquinolin-4-one
EP1641766A2 (en) * 2003-07-08 2006-04-05 Smithkline Beecham Corporation Novel chemical compounds
CN101671336B (zh) 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
GB201613054D0 (en) 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process
US20210323960A1 (en) * 2018-07-13 2021-10-21 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Fused tri-cyclic compound as pde3/pde4 dual inhibitor
WO2021143841A1 (zh) * 2020-01-15 2021-07-22 正大天晴药业集团股份有限公司 三并环类pde3/pde4双重抑制剂化合物的药物组合物
EP4092022A4 (en) * 2020-01-15 2024-01-24 Chia Tai Tianqing Pharmaceutical Group Co Ltd DUAL PDE3/PDE4 INHIBITOR CRYSTAL AND USE THEREOF
EP4332102A1 (en) * 2021-04-29 2024-03-06 Suzhou Suncadia Biopharmaceuticals Co., Ltd. Isoquinolone compound and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3021331A (en) * 1959-07-20 1962-02-13 Pfizer & Co C Azabenzopyridocolines
US3081306A (en) * 1959-11-04 1963-03-12 Pfizer & Co C 2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines
US3297696A (en) * 1965-05-28 1967-01-10 Sandoz Ag 6-amino-8, 9-dihydro-13bh-isoquinolo-[2, 1-c] quinazolines and intermediates therefor
DE2126148A1 (en) * 1971-05-26 1972-12-07 Farbenfabriken Bayer Ag, 5090 Leverkusen Prepn of uracil derivs - useful as plant - protection agents and their inters
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
US5740368A (en) * 1995-06-30 1998-04-14 Canon Kabushiki Kaisha Method and apparatus for providing information on a managed peripheral device to plural agents

Also Published As

Publication number Publication date
CH642949A5 (de) 1984-05-15
AT372383B (de) 1983-09-26
NO774131L (no) 1978-11-07
PT67265B (de) 1981-01-05
US4598148A (en) 1986-07-01
FI64370C (fi) 1983-11-10
GR72114B (es) 1983-09-15
IT7822619A0 (it) 1978-04-21
BE862785A (fr) 1978-07-10
FR2389623A1 (es) 1978-12-01
DK267089D0 (da) 1989-06-01
IL53336A (en) 1984-02-29
PT67265A (de) 1977-12-01
DK489477A (da) 1978-11-06
SE439307B (sv) 1985-06-10
ZA776706B (en) 1978-08-30
ES464776A1 (es) 1979-01-01
IT1192252B (it) 1988-03-31
FI64370B (fi) 1983-07-29
SE8206619L (sv) 1982-11-19
NL7800149A (nl) 1978-11-07
JPS6312871B2 (es) 1988-03-23
SE436357B (sv) 1984-12-03
JPS6041677A (ja) 1985-03-05
NL185078C (nl) 1990-01-16
SE7712513L (sv) 1978-11-06
NO148032C (no) 1983-07-27
NO148032B (no) 1983-04-18
EG12982A (en) 1982-03-31
JPS6225150B2 (es) 1987-06-01
NL185078B (nl) 1989-08-16
DK158789C (da) 1990-11-26
JPS53137997A (en) 1978-12-01
FR2389623B1 (es) 1980-10-31
SE8206619D0 (sv) 1982-11-19
CH640854A5 (de) 1984-01-31
US4482556A (en) 1984-11-13
IL53336A0 (en) 1978-01-31
ES472606A1 (es) 1979-02-16
ATA784477A (de) 1983-02-15
FI773286A (fi) 1978-11-06
DK158789B (da) 1990-07-16
NO821266L (no) 1978-11-07
DK267089A (da) 1989-06-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971201