CN114929701A - 一种pde3/pde4双重抑制剂的结晶及其应用 - Google Patents

一种pde3/pde4双重抑制剂的结晶及其应用 Download PDF

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Publication number
CN114929701A
CN114929701A CN202180008505.0A CN202180008505A CN114929701A CN 114929701 A CN114929701 A CN 114929701A CN 202180008505 A CN202180008505 A CN 202180008505A CN 114929701 A CN114929701 A CN 114929701A
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formula
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姚文俊
罗云富
张鹏
姚婷
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

一种式(I)的三并环类化合物或其药学上可接受的盐的结晶及其制备方法，以及其在制备治疗与PDE3和/或PDE4相关疾病的药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
CN202180008505.0A 2020-01-15 2021-01-15 一种pde3/pde4双重抑制剂的结晶及其应用 Pending CN114929701A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020100438825 2020-01-15
CN202010043882 2020-01-15
PCT/CN2021/072151 WO2021143843A1 (zh) 2020-01-15 2021-01-15 一种pde3/pde4双重抑制剂的结晶及其应用

Publications (1)

Publication Number Publication Date
CN114929701A true CN114929701A (zh) 2022-08-19

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CN202180008505.0A Pending CN114929701A (zh) 2020-01-15 2021-01-15 一种pde3/pde4双重抑制剂的结晶及其应用

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Country Link
US (1) US20230115817A1 (zh)
EP (1) EP4092022A4 (zh)
JP (1) JP2023512471A (zh)
CN (1) CN114929701A (zh)
AU (1) AU2021207159A1 (zh)
CA (1) CA3167381A1 (zh)
WO (1) WO2021143843A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023109802A1 (zh) * 2021-12-14 2023-06-22 海思科医药集团股份有限公司 三环稠杂环类pde3/4双重抑制及其用途
WO2023138676A1 (zh) * 2022-01-21 2023-07-27 四川海思科制药有限公司 三环稠杂环类pde3/4双重抑制及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482556A (en) * 1977-05-05 1984-11-13 Hoechst Aktiengesellschaft Pyrimido (6,1-a)isoquinolin-4-one derivatives
EP0124893A2 (de) * 1983-05-05 1984-11-14 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Neue Pyrimidonderivate
CN1348453A (zh) * 1999-03-31 2002-05-08 韦尔纳利斯有限公司 嘧啶并[6,1－a] 异喹啉－4－酮衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1271482A (zh) 1998-07-22 2000-10-25 三菱电机株式会社 移动通信系统及移动通信方法
EP3822272A4 (en) * 2018-07-13 2022-04-06 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. CONDENSED TRICYCLIC COMPOUND AS PDE3/PDE4 DOUBLE INHIBITOR

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482556A (en) * 1977-05-05 1984-11-13 Hoechst Aktiengesellschaft Pyrimido (6,1-a)isoquinolin-4-one derivatives
EP0124893A2 (de) * 1983-05-05 1984-11-14 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Neue Pyrimidonderivate
CN1348453A (zh) * 1999-03-31 2002-05-08 韦尔纳利斯有限公司 嘧啶并[6,1－a] 异喹啉－4－酮衍生物

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EP4092022A1 (en) 2022-11-23
JP2023512471A (ja) 2023-03-27
US20230115817A1 (en) 2023-04-13
AU2021207159A1 (en) 2022-08-18
EP4092022A4 (en) 2024-01-24
WO2021143843A1 (zh) 2021-07-22
CA3167381A1 (en) 2021-07-22

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