BE862785A - PYRIMIDO (6,1-A) ISOQUINOLEINE-2-ONE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION - Google Patents

PYRIMIDO (6,1-A) ISOQUINOLEINE-2-ONE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Info

Publication number
BE862785A
BE862785A BE184225A BE184225A BE862785A BE 862785 A BE862785 A BE 862785A BE 184225 A BE184225 A BE 184225A BE 184225 A BE184225 A BE 184225A BE 862785 A BE862785 A BE 862785A
Authority
BE
Belgium
Prior art keywords
isoquinoleine
pyrimido
derivatives
preparation process
therapeutic application
Prior art date
Application number
BE184225A
Other languages
French (fr)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19772720085 external-priority patent/DE2720085A1/en
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of BE862785A publication Critical patent/BE862785A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE184225A 1977-05-05 1978-01-10 PYRIMIDO (6,1-A) ISOQUINOLEINE-2-ONE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION BE862785A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772720085 DE2720085A1 (en) 1977-05-05 1977-05-05 PYRIMIDO (6.1-A) ISOCHINOLIN-2-ON DERIVATIVES

Publications (1)

Publication Number Publication Date
BE862785A true BE862785A (en) 1978-07-10

Family

ID=6008073

Family Applications (1)

Application Number Title Priority Date Filing Date
BE184225A BE862785A (en) 1977-05-05 1978-01-10 PYRIMIDO (6,1-A) ISOQUINOLEINE-2-ONE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Country Status (18)

Country Link
US (2) US4482556A (en)
JP (2) JPS53137997A (en)
AT (1) AT372383B (en)
BE (1) BE862785A (en)
CH (2) CH640854A5 (en)
DK (2) DK158789C (en)
EG (1) EG12982A (en)
ES (3) ES464776A1 (en)
FI (1) FI64370C (en)
FR (1) FR2389623B1 (en)
GR (1) GR72114B (en)
IL (1) IL53336A (en)
IT (1) IT1192252B (en)
NL (1) NL185078C (en)
NO (2) NO148032C (en)
PT (1) PT67265B (en)
SE (2) SE436357B (en)
ZA (1) ZA776706B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010759A3 (en) * 1978-11-03 1981-08-19 Hoechst Aktiengesellschaft Pyrimido (6,1-a) isoquinolin-4-ones, process for their preparation and their application in medicaments; intermediates and their preparation
US4581172A (en) * 1983-05-05 1986-04-08 Hoffmann-La Roche Inc. Substituted pyrimido[6,1-a]isoquinolin-4-ones,pyrimido[6,1-a]benzozepin-4-ones and pyrimido[6,1-a]benzodiazepin-4-ones useful for prevention of thromboses and treating hypertension

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2470130A2 (en) * 1979-11-21 1981-05-29 Hoechst Ag Amino-pyrimido-isoquinolinone derivs. - useful as hypotensives, bronchodilators and antiallergic agents
DE3135831A1 (en) * 1981-09-10 1983-04-28 Hoechst Ag, 6230 Frankfurt 9,10-SUBSTITUTED 2-MESITYLIMINO-3-ALKYL-3,4,6,7-TETRAHYDRO-2H-PYRIMIDO (6.1-A) ISOCHINOLIN-4-ONE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
DE3816995A1 (en) * 1988-05-19 1989-11-23 Hoechst Ag USE OF PYRIMIDO- (6,1-A) -ISOCHINOLIN-4-ON-DERIVATIVES AND MEDICAL PREPARATIONS BASED ON THESE COMPOUNDS
DE68902811D1 (en) * 1988-11-19 1992-10-15 Hoechst Ag PHARMACEUTICAL COMPOSITIONS CONTAINING LABDAN-DI-TERPENOID DERIVATIVES AND PYRIMIDO (6,1-A) ISOCHINOLIN-4-ON DERIVATIVES AND THEIR USE.
ES2208310T3 (en) * 1999-03-31 2004-06-16 Vernalis Limited PYRIMIDATE DERIVATIVES (6,1-A) ISOQUINOLIN-4-ONA.
EP1641766A2 (en) * 2003-07-08 2006-04-05 Smithkline Beecham Corporation Novel chemical compounds
CN101671336B (en) 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 Aromatic heterocyclic pyridine derivatives and analogs and preparation method and application thereof
GB201613054D0 (en) 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process
IL280075B2 (en) * 2018-07-13 2024-06-01 Chia Tai Tianqing Pharmaceutical Group Co Ltd Fused tri-cyclic compound as pde3/pde4 dual inhibitor
AU2021207159A1 (en) * 2020-01-15 2022-08-18 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Crystal of PDE3/PDE4 dual inhibitor and use thereof
CA3167378A1 (en) * 2020-01-15 2021-07-22 Chia Tai Tianqing Pharmaceutical Group Co., Ltd Pharmaceutical composition of tricyclic pde3/pde4 dual inhibitor compound
EP4332102A1 (en) * 2021-04-29 2024-03-06 Suzhou Suncadia Biopharmaceuticals Co., Ltd. Isoquinolone compound and use thereof
WO2024088402A1 (en) * 2022-10-28 2024-05-02 江苏恒瑞医药股份有限公司 Crystal form of isoquinolinone compound and preparation method therefor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3021331A (en) * 1959-07-20 1962-02-13 Pfizer & Co C Azabenzopyridocolines
US3081306A (en) * 1959-11-04 1963-03-12 Pfizer & Co C 2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines
US3297696A (en) * 1965-05-28 1967-01-10 Sandoz Ag 6-amino-8, 9-dihydro-13bh-isoquinolo-[2, 1-c] quinazolines and intermediates therefor
DE2126148A1 (en) * 1971-05-26 1972-12-07 Farbenfabriken Bayer Ag, 5090 Leverkusen Prepn of uracil derivs - useful as plant - protection agents and their inters
DE2847693A1 (en) * 1978-11-03 1980-05-22 Hoechst Ag METHOD FOR PRODUCING PYRIMIDO- (6,1-A) -ISOCHINOLIN-2-ONES
US5740368A (en) * 1995-06-30 1998-04-14 Canon Kabushiki Kaisha Method and apparatus for providing information on a managed peripheral device to plural agents

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010759A3 (en) * 1978-11-03 1981-08-19 Hoechst Aktiengesellschaft Pyrimido (6,1-a) isoquinolin-4-ones, process for their preparation and their application in medicaments; intermediates and their preparation
US4400506A (en) * 1978-11-03 1983-08-23 Hoechst Aktiengesellschaft Processes for the manufacture of pyrimido[6,1-a]isoquinolinones
US4581172A (en) * 1983-05-05 1986-04-08 Hoffmann-La Roche Inc. Substituted pyrimido[6,1-a]isoquinolin-4-ones,pyrimido[6,1-a]benzozepin-4-ones and pyrimido[6,1-a]benzodiazepin-4-ones useful for prevention of thromboses and treating hypertension

Also Published As

Publication number Publication date
IL53336A (en) 1984-02-29
FI773286A (en) 1978-11-06
IT7822619A0 (en) 1978-04-21
CH640854A5 (en) 1984-01-31
FI64370B (en) 1983-07-29
FR2389623A1 (en) 1978-12-01
IT1192252B (en) 1988-03-31
EG12982A (en) 1982-03-31
SE8206619L (en) 1982-11-19
IL53336A0 (en) 1978-01-31
NO774131L (en) 1978-11-07
NO148032C (en) 1983-07-27
JPS6225150B2 (en) 1987-06-01
GR72114B (en) 1983-09-15
DK489477A (en) 1978-11-06
NL185078C (en) 1990-01-16
JPS53137997A (en) 1978-12-01
NL7800149A (en) 1978-11-07
FI64370C (en) 1983-11-10
JPS6312871B2 (en) 1988-03-23
ATA784477A (en) 1983-02-15
SE7712513L (en) 1978-11-06
ES475027A1 (en) 1979-05-16
DK267089A (en) 1989-06-01
ZA776706B (en) 1978-08-30
DK158789B (en) 1990-07-16
SE439307B (en) 1985-06-10
CH642949A5 (en) 1984-05-15
PT67265A (en) 1977-12-01
AT372383B (en) 1983-09-26
ES464776A1 (en) 1979-01-01
US4598148A (en) 1986-07-01
DK267089D0 (en) 1989-06-01
SE8206619D0 (en) 1982-11-19
JPS6041677A (en) 1985-03-05
PT67265B (en) 1981-01-05
SE436357B (en) 1984-12-03
ES472606A1 (en) 1979-02-16
NO148032B (en) 1983-04-18
NO821266L (en) 1978-11-07
US4482556A (en) 1984-11-13
FR2389623B1 (en) 1980-10-31
NL185078B (en) 1989-08-16
DK158789C (en) 1990-11-26

Similar Documents

Publication Publication Date Title
BE867421A (en) MEVALONOLACTONE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR2383157B1 (en) CHALCON DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
BE878723A (en) 4-ANILINOQUINAZOLINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
BE892758A (en) PHENYLCYCLOBUTYL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR2504920B1 (en) PHENYLCYCLOBUTYL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR2393795B1 (en) CARBOSTYRYL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS
LU80081A1 (en) NEW HYDROXYMETHYL-5 OXAZOLIDINONES-2, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
BE849794A (en) CARBOSTYRILE DERIVATIVES AND THEIR PREPARATION PROCESS
FR2532648B1 (en) CARBOSTYRILE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
BE881134A (en) NEW NOR-TROPANE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
BE858520A (en) THIAZOLIDINE DERIVATIVES THEIR PREPARATION PROCESS THEIR THERAPEUTIC APPLICATION
FR2349579A1 (en) 1,2-DIHYDRONAPHTALENE DERIVATIVES AND THEIR PREPARATION PROCESS
BE854268A (en) PYRROLIDONS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR2343748A1 (en) 2,3-DIHYDRO IMIDAZO (2,1-B) THIAZOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
BE869721A (en) DERIVATIVES OF CYCLOALCOYLINDENEMETHYLPHENYLACETIC ACIDS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
BE862785A (en) PYRIMIDO (6,1-A) ISOQUINOLEINE-2-ONE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
BE864312A (en) NEW PYRROLIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
BE854133A (en) 1,3-DIHYDRO-HETEROARYLSPITO (ISOBENZOFURANNES) AND THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
BE866676A (en) BISAMIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
BE854812A (en) BENZENESULFONYLUREES, THEIR PROCESS FOR PREPARATION AND THEIR THERAPEUTIC APPLICATION
BE883713A (en) NEW CARBOSTYRILE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR2398753B1 (en) PYRANOCHROMONE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
PT68267A (en) PROCESS FOR PREPARING OXADIAZOLE-1,2,4 DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
BE863402A (en) AZACYCLOALCANES, AZACYCLOALCENES AND DERIVATIVES THEREOF, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS
BE882270A (en) BENZOTHIAZOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: HOECHST A.G.

Effective date: 19920131