BE2011C041I2 - - Google Patents

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Publication number
BE2011C041I2
BE2011C041I2 BE2011C041C BE2011C041C BE2011C041I2 BE 2011C041 I2 BE2011C041 I2 BE 2011C041I2 BE 2011C041 C BE2011C041 C BE 2011C041C BE 2011C041 C BE2011C041 C BE 2011C041C BE 2011C041 I2 BE2011C041 I2 BE 2011C041I2
Authority
BE
Belgium
Application number
BE2011C041C
Other languages
French (fr)
Original Assignee
Bristol-Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Co filed Critical Bristol-Myers Squibb Co
Publication of BE2011C041I2 publication Critical patent/BE2011C041I2/fr

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70521CD28, CD152
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047Cells of the immune system
    • G01N33/505Cells of the immune system involving T-cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BE2011C041C 2000-05-26 2011-11-10 BE2011C041I2 (enrdf_load_html_response)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
PCT/US2001/017139 WO2001092337A2 (en) 2000-05-26 2001-05-23 Soluble ctla4 mutant molecules and uses thereof

Publications (1)

Publication Number Publication Date
BE2011C041I2 true BE2011C041I2 (enrdf_load_html_response) 2020-08-20

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2011C041C BE2011C041I2 (enrdf_load_html_response) 2000-05-26 2011-11-10

Country Status (41)

Country Link
EP (3) EP1248802B9 (enrdf_load_html_response)
JP (1) JP4328525B2 (enrdf_load_html_response)
KR (2) KR100889887B1 (enrdf_load_html_response)
CN (2) CN101255192A (enrdf_load_html_response)
AR (1) AR031699A1 (enrdf_load_html_response)
AT (1) ATE271066T1 (enrdf_load_html_response)
AU (2) AU6346601A (enrdf_load_html_response)
BE (1) BE2011C041I2 (enrdf_load_html_response)
BR (1) BRPI0111191B8 (enrdf_load_html_response)
CA (1) CA2409748C (enrdf_load_html_response)
CY (2) CY2011019I2 (enrdf_load_html_response)
CZ (1) CZ304451B6 (enrdf_load_html_response)
DE (2) DE60104282T2 (enrdf_load_html_response)
DK (1) DK1248802T3 (enrdf_load_html_response)
EC (1) ECSP024365A (enrdf_load_html_response)
EE (2) EE05458B1 (enrdf_load_html_response)
EG (1) EG24459A (enrdf_load_html_response)
ES (2) ES2571852T3 (enrdf_load_html_response)
FR (1) FR11C0053I2 (enrdf_load_html_response)
GE (1) GEP20053658B (enrdf_load_html_response)
HK (1) HK1048126B (enrdf_load_html_response)
HU (2) HU228137B1 (enrdf_load_html_response)
IL (1) IL152315A (enrdf_load_html_response)
LT (1) LT5133B (enrdf_load_html_response)
LU (1) LU91902I2 (enrdf_load_html_response)
LV (1) LV12994B (enrdf_load_html_response)
MX (1) MXPA02011534A (enrdf_load_html_response)
MY (1) MY136113A (enrdf_load_html_response)
NO (2) NO330797B1 (enrdf_load_html_response)
PE (1) PE20011338A1 (enrdf_load_html_response)
PL (1) PL206267B1 (enrdf_load_html_response)
PT (1) PT1248802E (enrdf_load_html_response)
RU (1) RU2283847C2 (enrdf_load_html_response)
SI (1) SI1248802T1 (enrdf_load_html_response)
SK (1) SK288131B6 (enrdf_load_html_response)
TR (1) TR200402703T4 (enrdf_load_html_response)
TW (2) TWI319405B (enrdf_load_html_response)
UA (1) UA87432C2 (enrdf_load_html_response)
UY (1) UY26723A1 (enrdf_load_html_response)
WO (1) WO2001092337A2 (enrdf_load_html_response)
ZA (1) ZA200208944B (enrdf_load_html_response)

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US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
JP2004517806A (ja) * 2000-07-03 2004-06-17 ブリストル−マイヤーズ スクイブ カンパニー 可溶性ctla4分子を使用するリウマチ疾患の処置方法
ATE390931T1 (de) 2001-05-23 2008-04-15 Bristol Myers Squibb Co Verfahren zum schützen eines allogenen inseltransplantats mit löslichen ctla4- mutationsmolekülen
WO2003088991A1 (en) * 2002-04-19 2003-10-30 Bristol-Myers Squibb Company Methods for treating an autoimmune disease using a soluble ctla4 molecule and a dmard or nsaid
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
EP1576182B2 (en) * 2002-12-23 2020-01-15 Bristol-Myers Squibb Company Product quality enhancement in mammalian cell culture processes for protein production
EP1575998A4 (en) 2002-12-23 2007-07-25 Bristol Myers Squibb Co PROCESS FOR CULTIVATING MAMMALIAN CELLS FOR PROTEIN PRODUCTION
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AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
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US9758566B2 (en) 2012-03-29 2017-09-12 The General Hospital Corporation Recombinant cytotoxic T-lymphocyte-associated protein 4 (CTLA4)
CN107540742B (zh) 2012-05-11 2021-06-29 米迪缪尼有限公司 Ctla-4变体
US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
MX377570B (es) * 2012-06-27 2025-03-10 Orban Biotech Llc Proteínas de fusión ctla4 para el tratamiento de la diabetes.
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
US10513723B2 (en) 2014-01-13 2019-12-24 Amgen Inc. Decreasing ornithine production to decrease high mannose glycoform content of recombinant proteins
GB2523399B (en) 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
BR122018011329A2 (pt) 2014-06-04 2019-09-10 Amgen Inc método para colheita de uma proteína recombinante
KR102623965B1 (ko) 2014-12-01 2024-01-11 암젠 인크 당단백질의 글리칸 함량 수준을 조작하는 방법
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CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
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CN109453383A (zh) * 2018-11-12 2019-03-12 陈慧慧 免疫检查点的抑制剂在制备治疗青光眼及其他眼部免疫损伤机制相关疾病药物中的应用
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CN119072496A (zh) 2022-03-02 2024-12-03 瑞泽恩制药公司 高滴度抗体的制造工艺

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PL366231A1 (en) 2005-01-24
ATE271066T1 (de) 2004-07-15
LT2002114A (en) 2003-12-29
CN1441810A (zh) 2003-09-10
HUP0302201A2 (hu) 2003-10-28
ES2571852T3 (es) 2016-05-27
CY2011019I1 (el) 2016-12-14
IL152315A (en) 2010-04-15
PT1248802E (pt) 2004-11-30
IL152315A0 (en) 2003-05-29
WO2001092337A2 (en) 2001-12-06
FR11C0053I1 (enrdf_load_html_response) 2012-01-13
EE200200659A (et) 2004-06-15
HU228137B1 (en) 2012-12-28
CN101255192A (zh) 2008-09-03
EP1536234A2 (en) 2005-06-01
HUP0302201A3 (en) 2010-01-28
HK1048126B (en) 2005-03-04
PL206267B1 (pl) 2010-07-30
CZ20023892A3 (cs) 2003-09-17
TWI319405B (en) 2010-01-11
CA2409748A1 (en) 2001-12-06
ZA200208944B (en) 2004-02-13
EP1248802B9 (en) 2005-05-11
NO2011027I1 (no) 2012-01-09
EP1248802B1 (en) 2004-07-14
CA2409748C (en) 2008-09-16
LV12994B (en) 2003-08-20
SK15702002A3 (sk) 2004-01-08
BR0111191A (pt) 2004-07-06
MXPA02011534A (es) 2004-08-12
RU2283847C2 (ru) 2006-09-20
EG24459A (en) 2009-07-16
BRPI0111191B1 (pt) 2019-12-31
DE122011100063I1 (de) 2012-06-14
HK1048126A1 (en) 2003-03-21
TWI314933B (en) 2009-09-21
KR100895134B1 (ko) 2009-05-04
HK1071931A1 (en) 2005-08-05
UY26723A1 (es) 2001-12-28
KR100889887B1 (ko) 2009-03-24
SK288131B6 (sk) 2013-10-02
WO2001092337A3 (en) 2002-05-10
SI1248802T1 (en) 2005-02-28
NO2011027I2 (enrdf_load_html_response) 2011-12-15
MY136113A (en) 2008-08-29
TR200402703T4 (tr) 2004-11-22
BRPI0111191B8 (pt) 2021-05-25
TW200906857A (en) 2009-02-16
EE05458B1 (et) 2011-08-15
DK1248802T3 (da) 2004-11-15
EP1536234A3 (en) 2009-06-03
GEP20053658B (en) 2005-11-10
PE20011338A1 (es) 2002-01-13
DE60104282D1 (de) 2004-08-19
NO20025656L (no) 2002-11-25
JP4328525B2 (ja) 2009-09-09
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
NO330797B1 (no) 2011-07-18
AU2001263466B2 (en) 2006-04-27
FR11C0053I2 (fr) 2013-01-11
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
EE05557B1 (et) 2012-08-15
EP1536234B1 (en) 2016-03-16
UA87432C2 (uk) 2009-07-27
NO20025656D0 (no) 2002-11-25
JP2004511213A (ja) 2004-04-15
ES2225549T3 (es) 2005-03-16
DE60104282T2 (de) 2005-10-13
CZ304451B6 (cs) 2014-05-14
AU6346601A (en) 2001-12-11
AU2001263466C1 (en) 2006-10-26
LT5133B (lt) 2004-05-25
EE201100050A (et) 2011-10-17
CY1117625T1 (el) 2017-04-26
CN1309735C (zh) 2007-04-11
EP3029062A1 (en) 2016-06-08
AR031699A1 (es) 2003-10-01
ECSP024365A (es) 2003-03-31
HUS1300012I1 (hu) 2016-08-29
KR20030009502A (ko) 2003-01-29

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