BE2011C041I2 - - Google Patents

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Publication number
BE2011C041I2
BE2011C041I2 BE2011C041C BE2011C041C BE2011C041I2 BE 2011C041 I2 BE2011C041 I2 BE 2011C041I2 BE 2011C041 C BE2011C041 C BE 2011C041C BE 2011C041 C BE2011C041 C BE 2011C041C BE 2011C041 I2 BE2011C041 I2 BE 2011C041I2
Authority
BE
Belgium
Application number
BE2011C041C
Other languages
French (fr)
Original Assignee
Bristol-Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Co filed Critical Bristol-Myers Squibb Co
Publication of BE2011C041I2 publication Critical patent/BE2011C041I2/fr

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70521CD28, CD152
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047Cells of the immune system
    • G01N33/505Cells of the immune system involving T-cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BE2011C041C 2000-05-26 2011-11-10 BE2011C041I2 (enrdf_load_html_response)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
PCT/US2001/017139 WO2001092337A2 (en) 2000-05-26 2001-05-23 Soluble ctla4 mutant molecules and uses thereof

Publications (1)

Publication Number Publication Date
BE2011C041I2 true BE2011C041I2 (enrdf_load_html_response) 2020-08-20

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2011C041C BE2011C041I2 (enrdf_load_html_response) 2000-05-26 2011-11-10

Country Status (41)

Country Link
EP (3) EP1248802B9 (enrdf_load_html_response)
JP (1) JP4328525B2 (enrdf_load_html_response)
KR (2) KR100895134B1 (enrdf_load_html_response)
CN (2) CN101255192A (enrdf_load_html_response)
AR (1) AR031699A1 (enrdf_load_html_response)
AT (1) ATE271066T1 (enrdf_load_html_response)
AU (2) AU2001263466C1 (enrdf_load_html_response)
BE (1) BE2011C041I2 (enrdf_load_html_response)
BR (1) BRPI0111191B8 (enrdf_load_html_response)
CA (1) CA2409748C (enrdf_load_html_response)
CY (2) CY2011019I2 (enrdf_load_html_response)
CZ (1) CZ304451B6 (enrdf_load_html_response)
DE (2) DE60104282T2 (enrdf_load_html_response)
DK (1) DK1248802T3 (enrdf_load_html_response)
EC (1) ECSP024365A (enrdf_load_html_response)
EE (2) EE05458B1 (enrdf_load_html_response)
EG (1) EG24459A (enrdf_load_html_response)
ES (2) ES2225549T3 (enrdf_load_html_response)
FR (1) FR11C0053I2 (enrdf_load_html_response)
GE (1) GEP20053658B (enrdf_load_html_response)
HK (1) HK1048126B (enrdf_load_html_response)
HU (2) HU228137B1 (enrdf_load_html_response)
IL (1) IL152315A (enrdf_load_html_response)
LT (1) LT5133B (enrdf_load_html_response)
LU (1) LU91902I2 (enrdf_load_html_response)
LV (1) LV12994B (enrdf_load_html_response)
MX (1) MXPA02011534A (enrdf_load_html_response)
MY (1) MY136113A (enrdf_load_html_response)
NO (2) NO330797B1 (enrdf_load_html_response)
PE (1) PE20011338A1 (enrdf_load_html_response)
PL (1) PL206267B1 (enrdf_load_html_response)
PT (1) PT1248802E (enrdf_load_html_response)
RU (1) RU2283847C2 (enrdf_load_html_response)
SI (1) SI1248802T1 (enrdf_load_html_response)
SK (1) SK288131B6 (enrdf_load_html_response)
TR (1) TR200402703T4 (enrdf_load_html_response)
TW (2) TWI314933B (enrdf_load_html_response)
UA (1) UA87432C2 (enrdf_load_html_response)
UY (1) UY26723A1 (enrdf_load_html_response)
WO (1) WO2001092337A2 (enrdf_load_html_response)
ZA (1) ZA200208944B (enrdf_load_html_response)

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US6887471B1 (en) 1991-06-27 2005-05-03 Bristol-Myers Squibb Company Method to inhibit T cell interactions with soluble B7
US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
PL212205B1 (pl) * 2000-07-03 2012-08-31 Bristol Myers Squibb Co Zastosowanie rozpuszczalnej zmutowanej cząsteczki CTLA4
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
MXPA03010568A (es) 2001-05-23 2005-03-07 Squibb Bristol Myers Co Metodos para proteger trasplantes alogenicos de celulas de isletas usando moleculas mutantes ctla4 solubles.
EP1496931A4 (en) * 2002-04-19 2009-07-01 Bristol Myers Squibb Co METHODS OF TREATING AUTOIMMUNE DISEASE USING SOLUBLE CTLA4 MOLECULE AND ARMM OR NSAID
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
US7541164B2 (en) * 2002-12-23 2009-06-02 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
EP1576182B2 (en) * 2002-12-23 2020-01-15 Bristol-Myers Squibb Company Product quality enhancement in mammalian cell culture processes for protein production
AU2003299971A1 (en) 2002-12-30 2004-07-29 Amgen Inc. Combination therapy with co-stimulatory factors
CA2543484C (en) 2003-10-27 2014-02-04 Amgen Inc. Modulation of immune response to an immunogen with ctla-4 and tnfbp
WO2007076032A2 (en) * 2005-12-20 2007-07-05 Bristol-Myers Squibb Company Compositions and methods for producing a composition
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
US7510844B2 (en) 2006-01-24 2009-03-31 Bristol-Myers Squibb Company CD86 and CD80 receptor competition assays
WO2008005290A2 (en) 2006-06-29 2008-01-10 The Trustees Of Columbia University In The City Of New York Methods for testing anti-thrombotic agents
GB0620934D0 (en) * 2006-10-20 2006-11-29 Cambridge Antibody Tech Protein variants
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DK2222697T3 (da) 2007-11-01 2013-03-11 Perseid Therapeutics Llc Immunsuppressive polypeptider og nukleinsyrer
LT2344540T (lt) 2008-10-02 2018-03-26 Aptevo Research And Development Llc Prie daugybinių taikinių prisirišantys cd86 antagonistiniai baltymai
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US9758566B2 (en) 2012-03-29 2017-09-12 The General Hospital Corporation Recombinant cytotoxic T-lymphocyte-associated protein 4 (CTLA4)
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US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
EP3811966A1 (en) * 2012-06-27 2021-04-28 Phaim Pharma Ltd Ctla4 fusion proteins for the treatment of diabetes
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
CN106029896B (zh) 2014-01-13 2020-10-27 美国安进公司 调控鸟氨酸代谢以操控重组蛋白的高甘露糖糖型含量
GB2523399B (en) 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
LT3926051T (lt) 2014-06-04 2024-06-10 Amgen Inc. Žinduolių ląstelių kultūros surinkimo metodai
CA2969225C (en) 2014-12-01 2023-08-22 Amgen Inc. Process for manipulating the level of glycan content of a glycoprotein
US10590457B2 (en) 2015-02-11 2020-03-17 Bristol Myers-Squibb Company Compositions for cell culture and methods of using the same
JP2018512856A (ja) 2015-04-17 2018-05-24 アルパイン イミューン サイエンシズ インコーポレイテッド 調整可能な親和性を有する免疫調節タンパク質
CA2997947A1 (en) 2015-09-09 2017-03-16 The Trustees Of Columbia University In The City Of New York Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease
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CN109715210B (zh) * 2016-09-19 2023-05-30 昂科医药 Cd80和cd86结合蛋白组合物及其用途
CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
CN111031790A (zh) 2017-04-20 2020-04-17 E开创生物技术股份有限公司 产生基因修改的动物的方法
WO2019074983A1 (en) 2017-10-10 2019-04-18 Alpine Immune Sciences, Inc. CTLA-4 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
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CN109453383A (zh) * 2018-11-12 2019-03-12 陈慧慧 免疫检查点的抑制剂在制备治疗青光眼及其他眼部免疫损伤机制相关疾病药物中的应用
CN115551530A (zh) 2019-08-27 2022-12-30 通尼克斯制药有限公司 经修饰的tff2多肽
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Also Published As

Publication number Publication date
FR11C0053I2 (fr) 2013-01-11
KR100895134B1 (ko) 2009-05-04
EP3029062A1 (en) 2016-06-08
PL366231A1 (en) 2005-01-24
ATE271066T1 (de) 2004-07-15
MY136113A (en) 2008-08-29
SI1248802T1 (en) 2005-02-28
DE122011100063I1 (de) 2012-06-14
WO2001092337A2 (en) 2001-12-06
ECSP024365A (es) 2003-03-31
HUP0302201A3 (en) 2010-01-28
UA87432C2 (uk) 2009-07-27
KR20030009502A (ko) 2003-01-29
TWI314933B (en) 2009-09-21
CY1117625T1 (el) 2017-04-26
AU2001263466C1 (en) 2006-10-26
TWI319405B (en) 2010-01-11
JP4328525B2 (ja) 2009-09-09
KR100889887B1 (ko) 2009-03-24
NO20025656D0 (no) 2002-11-25
PL206267B1 (pl) 2010-07-30
EE201100050A (et) 2011-10-17
PT1248802E (pt) 2004-11-30
BRPI0111191B1 (pt) 2019-12-31
IL152315A (en) 2010-04-15
NO20025656L (no) 2002-11-25
RU2283847C2 (ru) 2006-09-20
EP1536234A3 (en) 2009-06-03
ES2225549T3 (es) 2005-03-16
GEP20053658B (en) 2005-11-10
ZA200208944B (en) 2004-02-13
LU91902I2 (fr) 2012-01-16
CA2409748C (en) 2008-09-16
EE05458B1 (et) 2011-08-15
IL152315A0 (en) 2003-05-29
EE200200659A (et) 2004-06-15
DE60104282T2 (de) 2005-10-13
LT2002114A (en) 2003-12-29
ES2571852T3 (es) 2016-05-27
CY2011019I1 (el) 2016-12-14
EP1536234A2 (en) 2005-06-01
HUS1300012I1 (hu) 2016-08-29
EG24459A (en) 2009-07-16
UY26723A1 (es) 2001-12-28
NO2011027I1 (no) 2012-01-09
SK15702002A3 (sk) 2004-01-08
CN101255192A (zh) 2008-09-03
EP1536234B1 (en) 2016-03-16
KR20070094019A (ko) 2007-09-19
HU228137B1 (en) 2012-12-28
BRPI0111191B8 (pt) 2021-05-25
BR0111191A (pt) 2004-07-06
PE20011338A1 (es) 2002-01-13
NO2011027I2 (enrdf_load_html_response) 2011-12-15
EP1248802B9 (en) 2005-05-11
HK1048126B (en) 2005-03-04
CN1309735C (zh) 2007-04-11
FR11C0053I1 (enrdf_load_html_response) 2012-01-13
CN1441810A (zh) 2003-09-10
LT5133B (lt) 2004-05-25
NO330797B1 (no) 2011-07-18
HK1071931A1 (en) 2005-08-05
JP2004511213A (ja) 2004-04-15
DK1248802T3 (da) 2004-11-15
EE05557B1 (et) 2012-08-15
MXPA02011534A (es) 2004-08-12
DE60104282D1 (de) 2004-08-19
AR031699A1 (es) 2003-10-01
AU2001263466B2 (en) 2006-04-27
AU6346601A (en) 2001-12-11
CZ304451B6 (cs) 2014-05-14
WO2001092337A3 (en) 2002-05-10
LV12994B (en) 2003-08-20
HK1048126A1 (en) 2003-03-21
CA2409748A1 (en) 2001-12-06
SK288131B6 (sk) 2013-10-02
CZ20023892A3 (cs) 2003-09-17
EP1248802B1 (en) 2004-07-14
CY2011019I2 (el) 2016-12-14
EP1248802A2 (en) 2002-10-16
HUP0302201A2 (hu) 2003-10-28
TW200906857A (en) 2009-02-16
TR200402703T4 (tr) 2004-11-22

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