AU735695B2 - Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration - Google Patents
Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration Download PDFInfo
- Publication number
- AU735695B2 AU735695B2 AU50816/98A AU5081698A AU735695B2 AU 735695 B2 AU735695 B2 AU 735695B2 AU 50816/98 A AU50816/98 A AU 50816/98A AU 5081698 A AU5081698 A AU 5081698A AU 735695 B2 AU735695 B2 AU 735695B2
- Authority
- AU
- Australia
- Prior art keywords
- membrane
- nanofiltration
- contaminant
- sialyl
- permeate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 150000001720 carbohydrates Chemical class 0.000 title claims abstract description 66
- 238000001728 nano-filtration Methods 0.000 title claims abstract description 66
- 238000001223 reverse osmosis Methods 0.000 title claims abstract description 48
- 238000000108 ultra-filtration Methods 0.000 title abstract description 22
- 238000000746 purification Methods 0.000 title description 45
- 238000000034 method Methods 0.000 claims abstract description 93
- -1 nucleotide sugars Chemical class 0.000 claims abstract description 77
- 239000000356 contaminant Substances 0.000 claims abstract description 52
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 44
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 44
- 239000011541 reaction mixture Substances 0.000 claims abstract description 15
- 239000012528 membrane Substances 0.000 claims description 234
- 239000012466 permeate Substances 0.000 claims description 62
- 239000012465 retentate Substances 0.000 claims description 34
- OIZGSVFYNBZVIK-FHHHURIISA-N 3'-sialyllactose Chemical group O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)O[C@@H]1[C@@H](O)[C@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[C@H](CO)[C@@H]1O OIZGSVFYNBZVIK-FHHHURIISA-N 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 23
- 239000008101 lactose Substances 0.000 claims description 22
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 22
- 108700023372 Glycosyltransferases Proteins 0.000 claims description 12
- 150000008195 galaktosides Chemical class 0.000 claims description 8
- 238000005516 engineering process Methods 0.000 claims description 6
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- 230000002194 synthesizing effect Effects 0.000 claims description 4
- 239000000937 glycosyl acceptor Substances 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 abstract description 62
- 235000014633 carbohydrates Nutrition 0.000 abstract description 41
- 235000000346 sugar Nutrition 0.000 abstract description 41
- 230000015572 biosynthetic process Effects 0.000 abstract description 21
- 238000003786 synthesis reaction Methods 0.000 abstract description 21
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- 230000015556 catabolic process Effects 0.000 abstract description 4
- 238000006731 degradation reaction Methods 0.000 abstract description 3
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- 239000000463 material Substances 0.000 description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 28
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 27
- 125000000217 alkyl group Chemical group 0.000 description 27
- 150000003839 salts Chemical class 0.000 description 27
- 229910019142 PO4 Inorganic materials 0.000 description 26
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- 235000008504 concentrate Nutrition 0.000 description 23
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- 238000000926 separation method Methods 0.000 description 21
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- 238000006243 chemical reaction Methods 0.000 description 17
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- 229910052739 hydrogen Inorganic materials 0.000 description 15
- 102000004169 proteins and genes Human genes 0.000 description 15
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- 238000002474 experimental method Methods 0.000 description 11
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- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 10
- CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 description 10
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Classifications
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13B—PRODUCTION OF SUCROSE; APPARATUS SPECIALLY ADAPTED THEREFOR
- C13B20/00—Purification of sugar juices
- C13B20/16—Purification of sugar juices by physical means, e.g. osmosis or filtration
- C13B20/165—Purification of sugar juices by physical means, e.g. osmosis or filtration using membranes, e.g. osmosis, ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/025—Reverse osmosis; Hyperfiltration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/027—Nanofiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/029—Multistep processes comprising different kinds of membrane processes selected from reverse osmosis, hyperfiltration or nanofiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
- B01D61/04—Feed pretreatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K13/00—Sugars not otherwise provided for in this class
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Nanotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Sustainable Development (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
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| US2822696P | 1996-10-10 | 1996-10-10 | |
| US60/028226 | 1996-10-10 | ||
| PCT/US1997/018801 WO1998015581A1 (en) | 1996-10-10 | 1997-10-09 | Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration |
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| AU5081698A AU5081698A (en) | 1998-05-05 |
| AU735695B2 true AU735695B2 (en) | 2001-07-12 |
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| AU50816/98A Ceased AU735695B2 (en) | 1996-10-10 | 1997-10-09 | Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration |
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| EP (1) | EP0931097B1 (cg-RX-API-DMAC7.html) |
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| IL (2) | IL129363A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ335203A (cg-RX-API-DMAC7.html) |
| WO (1) | WO1998015581A1 (cg-RX-API-DMAC7.html) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006108273A1 (en) | 2005-04-11 | 2006-10-19 | National Research Council Of Canada | Identification of a beta-1,3-n-acetylgalactosaminyltransferase (cgte) from campylobacter jejuni lio87 |
| WO2007016792A1 (en) | 2005-08-11 | 2007-02-15 | National Research Council Of Canada | Orf11 from campylobacter jejuni is a sialate-o-acetyltransferase |
| EP2484759A2 (en) | 2004-02-04 | 2012-08-08 | BioGeneriX AG | Methods of refolding mammalian glycosyltransferases |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| NZ335203A (en) * | 1996-10-10 | 2000-10-27 | Neose Technologies Inc | Carbohydrate, purification using ultrafiltration, reverse osmosis and nanofiltration |
| EP1903114A3 (en) | 1997-12-01 | 2008-07-23 | Neose Technologies, Inc. | Enzymatic synthesis of gangliosides |
| CN1086391C (zh) * | 1998-12-12 | 2002-06-19 | 中国科学院新疆化学研究所 | 低聚糖纯化方法 |
| US6942754B2 (en) | 1999-03-23 | 2005-09-13 | Oji Paper Co., Ltd. | Process for producing xylooligosaccharide from lignocellulose pulp |
| US6824646B2 (en) | 1999-03-23 | 2004-11-30 | Oji Paper Co., Ltd. | Process for oxygen bleaching and enzyme treating lignocellulosic pulp with liquid treatment and recovery |
| CA2301371C (en) * | 1999-03-23 | 2009-09-01 | Oji Paper Co., Ltd. | Process for bleaching lignocellulose pulp |
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| EP2484759A2 (en) | 2004-02-04 | 2012-08-08 | BioGeneriX AG | Methods of refolding mammalian glycosyltransferases |
| WO2006108273A1 (en) | 2005-04-11 | 2006-10-19 | National Research Council Of Canada | Identification of a beta-1,3-n-acetylgalactosaminyltransferase (cgte) from campylobacter jejuni lio87 |
| WO2007016792A1 (en) | 2005-08-11 | 2007-02-15 | National Research Council Of Canada | Orf11 from campylobacter jejuni is a sialate-o-acetyltransferase |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001502005A (ja) | 2001-02-13 |
| KR20000049057A (ko) | 2000-07-25 |
| CA2268168A1 (en) | 1998-04-16 |
| DE69734205D1 (de) | 2005-10-20 |
| AU5081698A (en) | 1998-05-05 |
| IL129363A0 (en) | 2000-02-17 |
| IL129363A (en) | 2003-02-12 |
| HUP0001634A2 (hu) | 2000-09-28 |
| EP0931097B1 (en) | 2005-09-14 |
| DK0931097T3 (da) | 2006-01-16 |
| US20020148791A1 (en) | 2002-10-17 |
| NZ335203A (en) | 2000-10-27 |
| US6936173B2 (en) | 2005-08-30 |
| KR100490507B1 (ko) | 2005-05-19 |
| US6454946B1 (en) | 2002-09-24 |
| ATE304546T1 (de) | 2005-09-15 |
| EP0931097A1 (en) | 1999-07-28 |
| US20030029799A1 (en) | 2003-02-13 |
| CA2268168C (en) | 2008-04-29 |
| DE69734205T2 (de) | 2006-07-06 |
| EP0931097A4 (en) | 2000-01-12 |
| WO1998015581A1 (en) | 1998-04-16 |
| US20050269265A1 (en) | 2005-12-08 |
| IL149275A (en) | 2007-07-04 |
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