AU726914B2 - Bioactivated diagnostic imaging contrast agents - Google Patents

Bioactivated diagnostic imaging contrast agents Download PDF

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Publication number
AU726914B2
AU726914B2 AU25448/97A AU2544897A AU726914B2 AU 726914 B2 AU726914 B2 AU 726914B2 AU 25448/97 A AU25448/97 A AU 25448/97A AU 2544897 A AU2544897 A AU 2544897A AU 726914 B2 AU726914 B2 AU 726914B2
Authority
AU
Australia
Prior art keywords
prodrug
contrast agent
bioactivated
protein
iem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU25448/97A
Other languages
English (en)
Other versions
AU2544897A (en
Inventor
Stephane Dumas
Stephen O. Dunham
Randall B. Lauffer
Thomas J Mcmurry
David J. Parmelee
Daniel M Scott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epix Pharmaceuticals Inc
Original Assignee
Epix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epix Pharmaceuticals Inc filed Critical Epix Pharmaceuticals Inc
Publication of AU2544897A publication Critical patent/AU2544897A/en
Application granted granted Critical
Publication of AU726914B2 publication Critical patent/AU726914B2/en
Assigned to EPIX PHARMACEUTICALS, INC. reassignment EPIX PHARMACEUTICALS, INC. Request to Amend Deed and Register Assignors: EPIX MEDICAL, INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/14Peptides, e.g. proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0002General or multifunctional contrast agents, e.g. chelated agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/101Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/101Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU25448/97A 1996-04-01 1997-03-25 Bioactivated diagnostic imaging contrast agents Ceased AU726914B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1444896P 1996-04-01 1996-04-01
US60/014448 1996-04-01
PCT/US1997/004804 WO1997036619A2 (en) 1996-04-01 1997-03-25 Bioactivated diagnostic imaging contrast agents

Publications (2)

Publication Number Publication Date
AU2544897A AU2544897A (en) 1997-10-22
AU726914B2 true AU726914B2 (en) 2000-11-23

Family

ID=21765541

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25448/97A Ceased AU726914B2 (en) 1996-04-01 1997-03-25 Bioactivated diagnostic imaging contrast agents

Country Status (18)

Country Link
US (3) US6709646B2 (enExample)
EP (1) EP0907379B1 (enExample)
JP (2) JP2000507577A (enExample)
KR (1) KR20060025233A (enExample)
CN (1) CN1108824C (enExample)
AT (1) ATE268187T1 (enExample)
AU (1) AU726914B2 (enExample)
BR (1) BR9708470A (enExample)
CA (1) CA2247620A1 (enExample)
DE (1) DE69729380T2 (enExample)
DK (1) DK0907379T3 (enExample)
ES (1) ES2217408T3 (enExample)
IL (1) IL125895A (enExample)
IS (1) IS2059B (enExample)
NO (1) NO319674B1 (enExample)
NZ (1) NZ331629A (enExample)
PT (1) PT907379E (enExample)
WO (1) WO1997036619A2 (enExample)

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Also Published As

Publication number Publication date
DE69729380D1 (de) 2004-07-08
NZ331629A (en) 2000-04-28
JP2004210796A (ja) 2004-07-29
EP0907379B1 (en) 2004-06-02
AU2544897A (en) 1997-10-22
US20020034476A1 (en) 2002-03-21
IL125895A (en) 2001-09-13
US20060275216A1 (en) 2006-12-07
KR20060025233A (ko) 2006-03-20
CA2247620A1 (en) 1997-10-09
NO984543D0 (no) 1998-09-29
US20040156785A1 (en) 2004-08-12
PT907379E (pt) 2004-09-30
WO1997036619A2 (en) 1997-10-09
EP0907379A2 (en) 1999-04-14
ES2217408T3 (es) 2004-11-01
US6709646B2 (en) 2004-03-23
NO984543L (no) 1998-11-26
IS4833A (is) 1998-08-26
CN1108824C (zh) 2003-05-21
JP2000507577A (ja) 2000-06-20
CN1215341A (zh) 1999-04-28
IL125895A0 (en) 1999-04-11
US7147837B2 (en) 2006-12-12
DK0907379T3 (da) 2004-08-16
IS2059B (is) 2005-10-14
HK1016877A1 (en) 1999-11-12
WO1997036619A3 (en) 1998-01-29
NO319674B1 (no) 2005-09-05
ATE268187T1 (de) 2004-06-15
BR9708470A (pt) 1999-04-13
DE69729380T2 (de) 2005-07-14

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