AU632288B2 - Novel cc-1065 analogs having two cpi subunits - Google Patents

Novel cc-1065 analogs having two cpi subunits Download PDF

Info

Publication number
AU632288B2
AU632288B2 AU41922/89A AU4192289A AU632288B2 AU 632288 B2 AU632288 B2 AU 632288B2 AU 41922/89 A AU41922/89 A AU 41922/89A AU 4192289 A AU4192289 A AU 4192289A AU 632288 B2 AU632288 B2 AU 632288B2
Authority
AU
Australia
Prior art keywords
compound
alkyl
methyl
carbonyl
dipyrrol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU41922/89A
Other languages
English (en)
Other versions
AU4192289A (en
Inventor
Paul A. Aristoff
Robert C. Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU4192289A publication Critical patent/AU4192289A/en
Application granted granted Critical
Publication of AU632288B2 publication Critical patent/AU632288B2/en
Assigned to PHARMACIA & UPJOHN COMPANY reassignment PHARMACIA & UPJOHN COMPANY Request to Amend Deed and Register Assignors: UPJOHN COMPANY, THE
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Artificial Filaments (AREA)
  • Amplifiers (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Television Systems (AREA)
  • Television Receiver Circuits (AREA)
  • Stereophonic System (AREA)
AU41922/89A 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits Ceased AU632288B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12
US243350 1988-09-12

Publications (2)

Publication Number Publication Date
AU4192289A AU4192289A (en) 1990-04-02
AU632288B2 true AU632288B2 (en) 1992-12-24

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
AU41922/89A Ceased AU632288B2 (en) 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits

Country Status (14)

Country Link
US (1) US5541339A (enExample)
JP (1) JP3380237B2 (enExample)
KR (1) KR0137959B1 (enExample)
AT (1) ATE198335T1 (enExample)
AU (1) AU632288B2 (enExample)
CA (1) CA1340215C (enExample)
DE (1) DE68929275T2 (enExample)
DK (1) DK175458B1 (enExample)
FI (1) FI103668B (enExample)
GR (1) GR3035589T3 (enExample)
LV (1) LV12806B (enExample)
NO (1) NO303498B1 (enExample)
TW (1) TW217383B (enExample)
WO (1) WO1990002746A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0563475B1 (en) * 1992-03-25 2000-05-31 Immunogen Inc Cell binding agent conjugates of derivatives of CC-1065
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
DK1392359T4 (da) 2001-05-11 2013-06-10 Ludwig Inst For Cancer Res Ltd Specifikke bindingsproteiner og deres anvendelser.
EA200400595A1 (ru) 2001-11-09 2004-10-28 Бёрингер Ингельхайм Фармасьютиклз, Инк. Бензимидазолы, применяемые в качестве ингибиторов протеинкиназы
JP2005536533A (ja) * 2002-08-08 2005-12-02 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 置換ベンゾイミダゾール化合物
JP2006505571A (ja) * 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びｈｃｖ阻害剤としてのその使用
WO2005005389A2 (en) * 2003-07-07 2005-01-20 Merck Patent Gmbh Malonamide derivatives
WO2005079791A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
EP1928865A1 (en) * 2005-08-17 2008-06-11 Schering Corporation Novel high affinity thiophene-based and furan-based kinase ligands
US9090693B2 (en) 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
JP5618549B2 (ja) 2007-03-15 2014-11-05 ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド Ｅｇｆｒ抗体及びｓｒｃ阻害剤を用いる治療方法及び関連製剤
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
JP5532486B2 (ja) 2007-08-14 2014-06-25 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ Ｅｇｆ受容体を標的とするモノクローナル抗体１７５ならびにその誘導体および用途
HUE035798T2 (en) 2008-11-03 2018-05-28 Syntarga Bv CC-1065 analogues and conjugates
NO3056203T3 (enExample) 2010-04-21 2018-05-12
US20150265641A1 (en) 2012-10-22 2015-09-24 Arnold Glazier Methods for the Effective Treatment of Metastatic Cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
TR201810856T4 (tr) 2014-01-10 2018-08-27 Synthon Biopharmaceuticals Bv CYS'le bağlı antikor-ilaç konjugatlarını saflaştırmak için usul.
SG11201605437YA (en) * 2014-01-27 2016-08-30 Pfizer Bifunctional cytotoxic agents
US10973920B2 (en) 2014-06-30 2021-04-13 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
KR102046862B1 (ko) * 2015-03-20 2019-11-20 화이자 인코포레이티드 Cti 약물작용발생단을 함유하는 이관능성 세포독성제

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1229088A (en) * 1986-12-19 1988-07-15 Pharmacia & Upjohn Company Novel cc-1065 analogs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1229088A (en) * 1986-12-19 1988-07-15 Pharmacia & Upjohn Company Novel cc-1065 analogs

Also Published As

Publication number Publication date
FI103668B1 (fi) 1999-08-13
KR900701801A (ko) 1990-12-04
GR3035589T3 (en) 2001-06-29
DE68929275D1 (de) 2001-02-01
DE68929275T2 (de) 2001-05-23
KR0137959B1 (ko) 1998-05-15
FI911193A0 (fi) 1991-03-11
CA1340215C (en) 1998-12-15
JP3380237B2 (ja) 2003-02-24
ATE198335T1 (de) 2001-01-15
AU4192289A (en) 1990-04-02
FI103668B (fi) 1999-08-13
NO910958L (no) 1991-05-10
WO1990002746A1 (en) 1990-03-22
DK41791D0 (da) 1991-03-08
DK175458B1 (da) 2004-11-01
JPH04500664A (ja) 1992-02-06
NO910958D0 (no) 1991-03-11
DK41791A (da) 1991-03-08
US5541339A (en) 1996-07-30
LV12806A (en) 2002-03-20
TW217383B (enExample) 1993-12-11
NO303498B1 (no) 1998-07-20
LV12806B (lv) 2002-05-20

Similar Documents

Publication Publication Date Title
US5541339A (en) CC-1065 analogs having two CPI subunits
JP5276582B2 (ja) 抗ウイルス剤としての五環インドール誘導体
US5332837A (en) CC-1065 analogs
RU2014332C1 (ru) Способ получения замещенных пирролов или их фармацевтически приемлемых солей
CA2420592C (en) Fused pyrrolocarbazoles against inflammation
SA521421089B1 (ar) Shp2 مركبات ثنائية الحلقة غير متجانسة لتثبيط نشاط الـ
EP0359454B1 (en) CC-1065 analogs having two CPI subunits
JP2598819B2 (ja) 新規なｃｃ‐１０６５同族体
JP2008517987A (ja) 抗ウイルス薬としての四環式インドール誘導体
HK1000510B (en) Cc-1065 analogs
PT2807159T (pt) Novos derivados de indolizina, processos para a sua preparação e composições farmacêuticas que os contêm, para o tratamento de cancro
AU2008226639A1 (en) Compounds for the treatment of hepatitis C
TW200904411A (en) Therapeutic compounds
IL95622A (en) N-(n-alkyl diazaspiroalkylcarbonyl) substituted tricyclic 1, 4-diazepinones, their preparation andpharmaceutical compositions containing them
AU613392B2 (en) Imidazo (1,2-b) pyridazin-2-yl carbamate derivatives
GB2121796A (en) Amidines
SI9300390A (en) Pyrolo :3,2-b: carbazones, 1h benzofuro :3,2-f: indoles and 1h-:1: benzothieno :2,3-f: indoles and their use as anti-tumour agents
PT752992E (pt) Derivados de imidazo¬1,2-a|indeno¬1,2-e|pirazin-4-ona e composicoes farmaceuticas que os contem
Molina et al. Iminophosphorane-mediated bispyrido annulation onto five-membered rings. X-ray crystal structure of 6, 7-dibenzylamino-13-methoxymethyl-13H-diquino 4, 3-b: 3′, 4′-dpyrrole. acetonitrile complex
US12269821B2 (en) Discovery of novel first in class nature-inspired compounds targeting the mitochondrial function and pharmaceutical composition thereof
EP0575442B1 (en) Tetracyclic imidazoquinazoline derivatives, process for their preparation and pharmaceutical compositions containing them
IL319215A (en) Preparations for administering JAK kinase inhibitors
ES2370121T3 (es) Compuestos para el tratamiento de la hepatitis c.
AU2001285205A1 (en) Fused pyrrolocarbazoles against inflammation
MXPA06007325A (en) Novel fused pyrrolocarbazoles