ATE198335T1 - Cc-1065-analoge mit zwei cpi-subeinheiten - Google Patents

Cc-1065-analoge mit zwei cpi-subeinheiten

Info

Publication number
ATE198335T1
ATE198335T1 AT89308920T AT89308920T ATE198335T1 AT E198335 T1 ATE198335 T1 AT E198335T1 AT 89308920 T AT89308920 T AT 89308920T AT 89308920 T AT89308920 T AT 89308920T AT E198335 T1 ATE198335 T1 AT E198335T1
Authority
AT
Austria
Prior art keywords
pct
formula
date mar
compounds
cpi
Prior art date
Application number
AT89308920T
Other languages
German (de)
English (en)
Inventor
Robert C Kelly
Paul A Aristoff
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE198335T1 publication Critical patent/ATE198335T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Artificial Filaments (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Amplifiers (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Television Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Stereophonic System (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Television Receiver Circuits (AREA)
AT89308920T 1988-09-12 1989-09-04 Cc-1065-analoge mit zwei cpi-subeinheiten ATE198335T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12
PCT/US1989/003329 WO1990002746A1 (en) 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits

Publications (1)

Publication Number Publication Date
ATE198335T1 true ATE198335T1 (de) 2001-01-15

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89308920T ATE198335T1 (de) 1988-09-12 1989-09-04 Cc-1065-analoge mit zwei cpi-subeinheiten

Country Status (14)

Country Link
US (1) US5541339A (enExample)
JP (1) JP3380237B2 (enExample)
KR (1) KR0137959B1 (enExample)
AT (1) ATE198335T1 (enExample)
AU (1) AU632288B2 (enExample)
CA (1) CA1340215C (enExample)
DE (1) DE68929275T2 (enExample)
DK (1) DK175458B1 (enExample)
FI (1) FI103668B1 (enExample)
GR (1) GR3035589T3 (enExample)
LV (1) LV12806B (enExample)
NO (1) NO303498B1 (enExample)
TW (1) TW217383B (enExample)
WO (1) WO1990002746A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2076465C (en) * 1992-03-25 2002-11-26 Ravi V. J. Chari Cell binding agent conjugates of analogues and derivatives of cc-1065
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
US7589180B2 (en) 2001-05-11 2009-09-15 Abbott Laboratories Inc. Specific binding proteins and uses thereof
BR0214019A (pt) 2001-11-09 2004-10-13 Boehringer Ingelheim Phamaceut Benzimidazóis úteis como inibidores de proteìna quinase
EP1529046A1 (en) * 2002-08-08 2005-05-11 Boehringer Ingelheim Pharmaceuticals Inc. Substituted benzimidazole compounds
JP2006505571A (ja) * 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びｈｃｖ阻害剤としてのその使用
US20070213374A1 (en) * 2003-07-07 2007-09-13 Merck Patent Gmbh Malonamide Derivatives
WO2005079791A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
US7446195B2 (en) * 2005-08-17 2008-11-04 Schering Corporation High affinity thiophene-based and furan-based kinase ligands
EP2126127B1 (en) 2007-01-25 2016-09-28 Dana-Farber Cancer Institute, Inc. Use of anti-egfr antibodies in treatment of egfr mutant mediated disease
CA2680854C (en) 2007-03-15 2017-02-14 Ludwig Institute For Cancer Research Treatment method using egfr antibodies and src inhibitors and related formulations
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
US9283276B2 (en) 2007-08-14 2016-03-15 Ludwig Institute For Cancer Research Ltd. Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof
MX2011004625A (es) 2008-11-03 2011-07-20 Syntarga Bv Analogos cc-1065 novedosos y sus conjugados.
CA2956934C (en) 2010-04-21 2019-07-09 Syntarga B.V. Novel conjugates of cc-1065 analogs and bifunctional linkers
WO2014066400A2 (en) 2012-10-22 2014-05-01 Arnold Glazier Methods for the effective treatment of metastatic cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
AU2015205574B2 (en) 2014-01-10 2019-08-15 Byondis B.V. Method for purifying Cys-linked antibody-drug conjugates
CA2937731C (en) * 2014-01-27 2019-09-24 Pfizer Inc. Bifunctional cytotoxic agents
EP3160513B1 (en) 2014-06-30 2020-02-12 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
WO2016151432A1 (en) * 2015-03-20 2016-09-29 Pfizer Inc. Bifunctional cytotoxic agents containing the cti pharmacophore

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
MX9203200A (es) * 1986-12-19 1992-09-01 Upjohn Co Analogos de cc. 1065 novedosos.

Also Published As

Publication number Publication date
JP3380237B2 (ja) 2003-02-24
LV12806B (lv) 2002-05-20
CA1340215C (en) 1998-12-15
DK41791A (da) 1991-03-08
WO1990002746A1 (en) 1990-03-22
DE68929275D1 (de) 2001-02-01
DK41791D0 (da) 1991-03-08
KR900701801A (ko) 1990-12-04
TW217383B (enExample) 1993-12-11
NO910958L (no) 1991-05-10
KR0137959B1 (ko) 1998-05-15
DK175458B1 (da) 2004-11-01
DE68929275T2 (de) 2001-05-23
FI103668B (fi) 1999-08-13
AU4192289A (en) 1990-04-02
JPH04500664A (ja) 1992-02-06
GR3035589T3 (en) 2001-06-29
LV12806A (en) 2002-03-20
US5541339A (en) 1996-07-30
NO910958D0 (no) 1991-03-11
NO303498B1 (no) 1998-07-20
AU632288B2 (en) 1992-12-24
FI103668B1 (fi) 1999-08-13
FI911193A0 (fi) 1991-03-11

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee