ATE133181T1 - Dehydrodidemnin b - Google Patents

Dehydrodidemnin b

Info

Publication number
ATE133181T1
ATE133181T1 AT90914541T AT90914541T ATE133181T1 AT E133181 T1 ATE133181 T1 AT E133181T1 AT 90914541 T AT90914541 T AT 90914541T AT 90914541 T AT90914541 T AT 90914541T AT E133181 T1 ATE133181 T1 AT E133181T1
Authority
AT
Austria
Prior art keywords
dehydrodidemnine
dehydrodidemnin
synthesized
isolated
formula
Prior art date
Application number
AT90914541T
Other languages
English (en)
Inventor
Kenneth L Rinehart
A Lithgow-Bertelloni
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of ATE133181T1 publication Critical patent/ATE133181T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/857—Fish; fish eggs; shell fish; crustacea
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein
AT90914541T 1989-09-29 1990-10-01 Dehydrodidemnin b ATE133181T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898922026A GB8922026D0 (en) 1989-09-29 1989-09-29 Novel anti-viral and cytotoxic agent

Publications (1)

Publication Number Publication Date
ATE133181T1 true ATE133181T1 (de) 1996-02-15

Family

ID=10663828

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90914541T ATE133181T1 (de) 1989-09-29 1990-10-01 Dehydrodidemnin b

Country Status (10)

Country Link
US (4) US5834586A (de)
EP (1) EP0493480B1 (de)
JP (1) JP2919965B2 (de)
AT (1) ATE133181T1 (de)
AU (1) AU642169B2 (de)
DE (1) DE69024965T2 (de)
DK (1) DK0493480T3 (de)
ES (1) ES2082003T3 (de)
GB (1) GB8922026D0 (de)
WO (1) WO1991004985A1 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8922026D0 (en) 1989-09-29 1989-11-15 Pharma Mar Sa Novel anti-viral and cytotoxic agent
US20030148933A1 (en) * 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
ES2102322B1 (es) * 1995-07-13 1998-03-01 Pharma Mar Sa Procedimiento de preparacion de didemnina a.
US5801197A (en) * 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US6218424B1 (en) 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
US5801187A (en) * 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US6034058A (en) * 1997-04-15 2000-03-07 Rinehart; Kenneth L. Semi-synthetic alanyl dilemnin analogs
DE69840497D1 (de) * 1997-05-07 2009-03-12 William J Crumb Verwendung von Aplidine zur Behandlung von kardiovaskulären Erkrankungen
US6187796B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Sulfone hair growth compositions and uses
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6274602B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
AT405400B (de) * 1997-11-12 1999-07-26 Chemie Linz Gmbh Verfahren zur herstellung von 1-pyruvyl-l-prolin
AT405399B (de) * 1997-08-06 1999-07-26 Chemie Linz Gmbh Verfahren zur herstellung von 1-pyruvoyl-l-prolin
CZ291417B6 (cs) * 1997-08-06 2003-03-12 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Způsob výroby 1-pyruvyl-L-prolinu
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
CA2334204A1 (en) 1998-06-03 1999-12-09 Gpi Nil Holdings, Inc. Heterocyclic ester and amide hair growth compositions and uses
US6429215B1 (en) 1998-06-03 2002-08-06 Gpi Nil Holdings, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6335348B1 (en) 1998-08-14 2002-01-01 Gpi Nil Holdings, Inc. Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6506788B1 (en) 1998-08-14 2003-01-14 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
CA2391502A1 (en) * 1999-11-15 2001-05-25 Pharma Mar S.A Aplidine treatment of cancers
UA76718C2 (uk) * 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
NZ525196A (en) 2000-10-12 2004-09-24 Pharma Mar S Treatment of cancers by aplidine in conjunction with a myoprotector
CA2424823A1 (en) * 2000-10-12 2002-04-18 Pharma Mar, S.A. Treatment of cancers by aplidine in conjunction with a myoprotector
CA2462642A1 (en) * 2001-10-19 2003-04-24 Pharma Mar, S.A. Use of aplidine for the treatment of pancreatic cancer
NZ541634A (en) 2003-03-12 2008-08-29 Pharma Mar Sa Improved antitumoral treatments
ES2312979T3 (es) 2003-03-12 2009-03-01 Dana-Farber Cancer Institute, Inc. Aplidina para el tratamiento de mieloma multiple.
US20090226465A1 (en) * 2005-10-31 2009-09-10 Jackson David Y Macrocyclic depsipeptide antibody-drug conjugates and methods
PL2029155T3 (pl) 2006-02-28 2016-09-30 Ulepszony sposób leczenia szpiczaka mnogiego
WO2008080956A1 (en) * 2006-12-29 2008-07-10 Pharma Mar, S.A. Prognostic molecular markers for the cancer therapy with aplidine
CA2703024A1 (en) * 2007-10-19 2009-04-23 Giuseppe Longo Sorbello Improved antitumoral treatments
RU2010140888A (ru) * 2008-03-07 2012-04-20 Фарма Мар, С.А. (Es) Улучшенные противораковые терапии
EP2758519B1 (de) 2011-09-21 2017-03-29 King Abdullah University Of Science And Technology Biosynthetisches didemnin-gencluster in tistrella mobilis
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
IL296067A (en) * 2020-03-02 2022-11-01 Pharma Mar Sa Flitidepsin for use in combination to treat the corona virus
MX2022010922A (es) * 2020-03-02 2022-09-29 Pharma Mar Sa Compuestos para su uso en el tratamiento de la infeccion por coronavirus.
AU2021231197A1 (en) * 2020-03-02 2022-10-06 Pharma Mar, S.A. Compounds for use in inflammatory conditions
US20230158104A1 (en) * 2020-03-02 2023-05-25 Pharma Mar, S.A. Compounds for use in autoimmune conditions
CN115594739A (zh) * 2021-06-28 2023-01-13 浙江珲达生物科技有限公司（Cn） 一种dehydrodidemnin B类化合物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493796A (en) * 1980-09-12 1985-01-15 Board Of Trustees, Univ. Of Ill. Didemnins A, B, C, and derivatives thereof, as antiviral agents
US4950649A (en) 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
GB8922026D0 (en) 1989-09-29 1989-11-15 Pharma Mar Sa Novel anti-viral and cytotoxic agent
TW222637B (de) * 1991-12-12 1994-04-21 Hoechst Ag
US6034058A (en) 1997-04-15 2000-03-07 Rinehart; Kenneth L. Semi-synthetic alanyl dilemnin analogs
DE69840497D1 (de) 1997-05-07 2009-03-12 William J Crumb Verwendung von Aplidine zur Behandlung von kardiovaskulären Erkrankungen

Also Published As

Publication number Publication date
JP2919965B2 (ja) 1999-07-19
DK0493480T3 (da) 1996-05-20
GB8922026D0 (en) 1989-11-15
EP0493480B1 (de) 1996-01-17
WO1991004985A1 (en) 1991-04-18
US5834586A (en) 1998-11-10
AU642169B2 (en) 1993-10-14
AU6441290A (en) 1991-04-28
US6153731A (en) 2000-11-28
USRE39887E1 (en) 2007-10-16
EP0493480A1 (de) 1992-07-08
JPH05502441A (ja) 1993-04-28
US6710029B1 (en) 2004-03-23
DE69024965D1 (de) 1996-02-29
ES2082003T3 (es) 1996-03-16
DE69024965T2 (de) 1996-08-22

Similar Documents

Publication Publication Date Title
ATE133181T1 (de) Dehydrodidemnin b
MY104685A (en) Substituted thiazoles and their use as fungicides.
DK0611522T3 (da) Synergistiske mikrobicide sammensætninger
DE3884791D1 (de) Begasungs-Brutschrank.
NO930615L (no) Hypoglykemiske hydroksyurinstoffderivater
ATE265997T1 (de) Substituierte tetrahydronaphthalin- und dihydronaphthalin-derivate mit einer retinoiden und/oder retinoid antagonist-ähnlichen biologischen aktivität
DE3867659D1 (de) 1,5-diphenyl-1h-1,2,4-triazol-3-carboxamid-derivate und diese enthaltende herbizide zusammensetzungen.
ES2099274T3 (es) Derivados de estreptolisina o.
ES2066096T3 (es) 4-bencil-5-fenil-2,4-dihidro-3h-1,2,4-triazol-3-onas y su uso como anticonvulsivos.
FI944563A0 (fi) Mikro-organismeja, valmistusmenetelmä ja käyttö
ES2013025A6 (es) Un metodo para preparar 24r-escimnol.
FI964448A0 (fi) Uusi biologisesti aktiivinen peptidi ja sen valmistus
DE58903200D1 (de) Pflanzenwuchshemmendes mittel.
DE3878988T2 (de) 1,2-Di(4-isobutylphenyl)äthylen, dessen Herstellung und Verwendung als Zwischenprodukt.
ATE174911T1 (de) 1-dimethylcarbamoyl-1h-1,2,4-triazole- substituiert in stellungen 3 und 5
ATE204286T1 (de) Modifizierte alpha-d-glcp-(1,2)-alpha-d-glcp-(1, 3)-alpha-d-glcp-analoge
ES2181722T3 (es) Marcfortinas sustituidas en la posicion 14 y derivados utiles como agentes antiparasitarios.
ES2052499T3 (es) Complejos de (gem-heterociclodimenatamina-n,n') platino.
ES2116399T3 (es) Derivados tiazolicos de alcoxiacrilatos con una actividad fungicida.
ES2086449T3 (es) 2-terbutil-4-cloro-5-(4-ibutilmetilciclohexil)-metiltio-3(h)-piridazinona con actividad acaricida e insecticida.
UA16651A1 (uk) 1-1-феhил-2-метиламіhопропаhолу-1, 5, 6, 7-тріоксифлавоh-7-0-b-d-глюкуроhідат, що має аhтистресову активhість
MX9800306A (es) Mezclas fungicidas.
DE406117T1 (de) Mikrobieller futtermittelzusatz und dieser enthaltende futtermittel.
ITFE930013U1 (it) Bacchette orientali meccanizzate.
MY128749A (en) Fungicidal mixtures

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties