AU601498B2 - 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo-{1,5-a}pyrimidines - Google Patents

4,5-dihydro and 4,5,6,7-tetrahydropyrazolo-{1,5-a}pyrimidines Download PDF

Info

Publication number
AU601498B2
AU601498B2 AU79800/87A AU7980087A AU601498B2 AU 601498 B2 AU601498 B2 AU 601498B2 AU 79800/87 A AU79800/87 A AU 79800/87A AU 7980087 A AU7980087 A AU 7980087A AU 601498 B2 AU601498 B2 AU 601498B2
Authority
AU
Australia
Prior art keywords
alkyl
trifluoromethyl
carbonitrile
dihydro
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU79800/87A
Other languages
English (en)
Other versions
AU7980087A (en
Inventor
Herbert Joseph Brabander
John Paul Dusza
Joseph William Epstein
Shin Shyong Tseng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/919,730 external-priority patent/US4847256A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of AU7980087A publication Critical patent/AU7980087A/en
Application granted granted Critical
Publication of AU601498B2 publication Critical patent/AU601498B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU79800/87A 1986-10-16 1987-10-15 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo-{1,5-a}pyrimidines Ceased AU601498B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US91973186A 1986-10-16 1986-10-16
US919730 1986-10-16
US06/919,730 US4847256A (en) 1986-10-16 1986-10-16 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo(1,5-A)-pyrimidines
US919731 1986-10-16

Publications (2)

Publication Number Publication Date
AU7980087A AU7980087A (en) 1988-04-21
AU601498B2 true AU601498B2 (en) 1990-09-13

Family

ID=27129779

Family Applications (1)

Application Number Title Priority Date Filing Date
AU79800/87A Ceased AU601498B2 (en) 1986-10-16 1987-10-15 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo-{1,5-a}pyrimidines

Country Status (10)

Country Link
EP (1) EP0264773A1 (pt)
KR (1) KR880005132A (pt)
AU (1) AU601498B2 (pt)
DK (1) DK539087A (pt)
FI (1) FI87459C (pt)
HU (1) HU203103B (pt)
IL (1) IL84214A (pt)
NO (1) NO171067C (pt)
NZ (1) NZ222179A (pt)
PT (1) PT85936B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963553A (en) * 1986-10-16 1990-10-16 American Cyanamid Co. 4-[(substituted) alkylcarbonyl]-4,5-dihydro- and -4,5,6,7-tetrahydro-7-[(substituted)phenyl]pyrazolo[1,5-a]pyrimidines
US5126340A (en) * 1986-10-16 1992-06-30 American Cyanamid Company 4-[(substituted)alkylcarbonyl]-4,5-dihydro and -4,5,6,7-tetrahydro-7-[(substituted)-phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitriles
US5219857A (en) * 1986-10-16 1993-06-15 American Cyanamid Company Method of treating cognitive and related neural behavioral problems
DE68911951T2 (de) * 1988-02-22 1994-06-01 American Cyanamid Co 5-(Substituierte Amino)-8-(phenyl oder substituierte phenyl)-3H,6H-1,4,5a,8a-tetraazaacenaphthylen-3-one.
US4963552A (en) * 1989-08-28 1990-10-16 American Cyanamid Company 1-substitute-1,2-dihydro-4-((substituted)phenyl)imidazo-[1,5-a]pyrimidine-8-carbonitriles
DE4133957A1 (de) * 1991-10-14 1993-04-15 Wella Ag Haarfaerbemittel mit einem gehalt an aminopyrazolderivaten sowie neue pyrazolderivate
SG47588A1 (en) * 1992-03-26 1998-04-17 American Cyanamid Co An improved process for the synthesis of 5-[(substituted) amino] -8- [phenyl or substituted-phenyl]-3H, 6H-1, 4, 5A, 8A-tetraazaacenaphtylen-3- ones
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
DE10153344A1 (de) * 2001-10-29 2003-05-15 Gruenenthal Gmbh Verwendung von substituierten Pyrazolopyrimidinen als Liganden von Nucleosid-Transport-Proteinen und/oder von Purinorezeptoren
BR0208244A (pt) 2001-03-14 2004-03-02 Gr Nenthal Gmbh Pirazolo-e tiazolopirinidinas substituìdas
ES2222813B1 (es) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
TWI252851B (en) * 2003-07-24 2006-04-11 Ferrer Int 7-substituted 3-nitro-pyrazolo[1,5-a]pyrimidines and compositions and methods related thereto
WO2006033795A2 (en) * 2004-09-17 2006-03-30 Wyeth Substituted pyrazolo [1, 5-a] pyrimidines for inhibiting abnormal cell growth
WO2006033796A1 (en) * 2004-09-17 2006-03-30 Wyeth SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AND PROCESS FOR MAKING SAME

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4236005A (en) * 1979-07-02 1980-11-25 American Cyanamid Company Imidazo[1,5-a]pyrimidines
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
DK539087D0 (da) 1987-10-15
IL84214A (en) 1993-05-13
NO171067C (no) 1993-01-20
HUT47276A (en) 1989-02-28
EP0264773A1 (en) 1988-04-27
IL84214A0 (en) 1988-03-31
NO171067B (no) 1992-10-12
FI87459C (fi) 1993-01-11
PT85936B (pt) 1990-07-31
KR880005132A (ko) 1988-06-28
FI874547A0 (fi) 1987-10-15
DK539087A (da) 1988-04-17
NO874302L (no) 1988-04-18
HU203103B (en) 1991-05-28
PT85936A (en) 1987-11-01
NZ222179A (en) 1991-01-29
NO874302D0 (no) 1987-10-15
FI874547A (fi) 1988-04-17
FI87459B (fi) 1992-09-30
AU7980087A (en) 1988-04-21

Similar Documents

Publication Publication Date Title
AU601498B2 (en) 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo-{1,5-a}pyrimidines
US6670366B1 (en) Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction
US4847256A (en) 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo(1,5-A)-pyrimidines
KR900004833B1 (ko) N-치환-N-[3-(1,2,4-트리아졸로[4,3-b]피리다진-6-일)페닐]알칸아미드, 카바메이트 및 우레아 화합물과 그 제조 방법 및 조성물
US3840537A (en) Imidazo(5,1-f)triazinones
US5661147A (en) Imidazoquinazoline derivatives
JP4146514B2 (ja) ピロロピリミジン類およびその製造方法
NL1026029C2 (nl) Cannabinoïdreceptorliganden en toepassingen daarvan.
US4774245A (en) Imidazoquinoxaline compounds
US5169850A (en) N-(dialkylamino)methylene)-substituted pyrazolo(1,5-a)-pyrimidine-3-carboxamides and N-(dialkylamino)methylene-substituted-4,5-dihydropyrazolo-(1,5-a)-pyrimidine-3-carboxamides
MXPA03009331A (es) Diazepinas triciclicas como antagonistas de los receptores de oxitocina tocoliticos.
CZ281316B6 (cs) Pyrazolopyrimidinonové sloučeniny, způsob jejich přípravy a použití
US4902686A (en) Tricyclic heterocyclic compounds and their use in treating benzodiazepin receptor-related ailments
US4576943A (en) Pyrazolo[1,5-a]pyrimidines
US4654347A (en) Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
EA009742B1 (ru) Соединения бициклических пиразолила и имидазолила и их применение
CA2443556A1 (en) Novel 3-c(o)r substituted 10-cyclohexylbenzoyl pyrrolobenzodiazepines; tocolytic oxytocin receptor antagonists
JP2002501071A (ja) Ｇａｂａ受容体のリガンドとしてのトリアゾロ−ピリダジン誘導体
NZ208554A (en) (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
US5538977A (en) 3-Substituted-7-[3-(imidazol-1-yl)phenyl]-pyrazolo[1,5-a]pyrimidines
US5219857A (en) Method of treating cognitive and related neural behavioral problems
US5126340A (en) 4-[(substituted)alkylcarbonyl]-4,5-dihydro and -4,5,6,7-tetrahydro-7-[(substituted)-phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitriles
US4963553A (en) 4-[(substituted) alkylcarbonyl]-4,5-dihydro- and -4,5,6,7-tetrahydro-7-[(substituted)phenyl]pyrazolo[1,5-a]pyrimidines
US5059691A (en) N-((dialkylamino)methylene)-substituted pyrazolo (1,5-A)-pyrimidine-3-carboxamides and N-((dialkylamino)methylene)-substituted-4,5-dihydropyrazolo-(1,5-A)-pyrimidine-3-carboxamides
US4551530A (en) Pyridyl imidazo[1,2-a]pyrimidines