AU601464B2 - Pyrimidine derivatives - Google Patents

Pyrimidine derivatives Download PDF

Info

Publication number
AU601464B2
AU601464B2 AU76685/87A AU7668587A AU601464B2 AU 601464 B2 AU601464 B2 AU 601464B2 AU 76685/87 A AU76685/87 A AU 76685/87A AU 7668587 A AU7668587 A AU 7668587A AU 601464 B2 AU601464 B2 AU 601464B2
Authority
AU
Australia
Prior art keywords
dideoxy
ethyl
compound
uridine
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU76685/87A
Other languages
English (en)
Other versions
AU7668587A (en
Inventor
Robert Wilson Lambert
Joseph Armstrong Martin
Gareth John Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868619630A external-priority patent/GB8619630D0/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU7668587A publication Critical patent/AU7668587A/en
Application granted granted Critical
Publication of AU601464B2 publication Critical patent/AU601464B2/en
Assigned to F. HOFFMANN-LA ROCHE AG reassignment F. HOFFMANN-LA ROCHE AG Alteration of Name(s) in Register under S187 Assignors: F. HOFFMANN-LA ROCHE AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU76685/87A 1986-08-12 1987-08-07 Pyrimidine derivatives Ceased AU601464B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB868619630A GB8619630D0 (en) 1986-08-12 1986-08-12 Pyrimidine derivatives
GB8619630 1986-08-12
GB8710775 1987-05-07
GB878710775A GB8710775D0 (en) 1986-08-12 1987-05-07 Pyrimidine derivatives

Publications (2)

Publication Number Publication Date
AU7668587A AU7668587A (en) 1988-02-18
AU601464B2 true AU601464B2 (en) 1990-09-13

Family

ID=26291165

Family Applications (1)

Application Number Title Priority Date Filing Date
AU76685/87A Ceased AU601464B2 (en) 1986-08-12 1987-08-07 Pyrimidine derivatives

Country Status (22)

Country Link
US (2) US4886785A (enExample)
EP (1) EP0256400B1 (enExample)
JP (1) JPH0643421B2 (enExample)
CN (1) CN87105612A (enExample)
AR (1) AR243534A1 (enExample)
AU (1) AU601464B2 (enExample)
CA (1) CA1291125C (enExample)
CS (1) CS271473B2 (enExample)
DE (1) DE3781847D1 (enExample)
DK (1) DK163128C (enExample)
ES (1) ES2052526T3 (enExample)
FI (1) FI85273C (enExample)
GR (1) GR3006632T3 (enExample)
HU (1) HU196427B (enExample)
IE (1) IE60600B1 (enExample)
IL (1) IL83452A0 (enExample)
MC (1) MC1845A1 (enExample)
NO (1) NO169962C (enExample)
NZ (1) NZ221350A (enExample)
PH (1) PH23784A (enExample)
PT (1) PT85522B (enExample)
ZW (1) ZW14787A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO170884C (no) * 1986-08-18 1992-12-23 Hoffmann La Roche Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyrimidinderivater
US5495010A (en) * 1987-04-17 1996-02-27 The United States Of America As Represented By The Department Of Health And Human Services Acid stable purine dideoxynucleosides
US5459256A (en) * 1987-04-17 1995-10-17 The Government Of The United States Of America As Represented By The Department Of Health And Human Services Lipophilic, aminohydrolase-activated prodrugs
US5137724A (en) * 1990-05-23 1992-08-11 Stichting Rega Vzw Combinations of TS-inhibitors and viral TK-inhibitors in antiherpetic medicines
US5306722A (en) * 1992-09-02 1994-04-26 Bristol-Myers Squibb Company Thymidine derivatives and therapeutic method of use
US5550132A (en) * 1994-06-22 1996-08-27 University Of North Carolina Hydroxyalkylammonium-pyrimidines or purines and nucleoside derivatives, useful as inhibitors of inflammatory cytokines
GB9514268D0 (en) * 1995-07-13 1995-09-13 Hoffmann La Roche Pyrimidine nucleoside
GB9608199D0 (en) * 1995-08-04 1996-06-26 Hoffmann La Roche Pyrimide nucleoside derivatives
US5783689A (en) * 1996-11-12 1998-07-21 University Of Notre Dame Antibacterial and antifungal nucleosides
WO2010037122A1 (en) * 2008-09-29 2010-04-01 Gilead Palo Alto, Inc. Combinations of a rate control agent and an a-2-alpha receptor antagonist for use in multidetector computed tomography methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000260A (en) * 1974-08-29 1976-12-28 Research Corporation Anti herpes simplex viral compounds and their synthesis
AU7684187A (en) * 1986-08-18 1988-02-25 F. Hoffmann-La Roche Ag Pyrimidine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093715A (en) * 1977-04-28 1978-06-06 Research Corporation 5-Iodo-5'-amino-2',5'-dideoxycytidine and the pharmaceutically acceptable salts thereof
US4093716A (en) * 1977-04-28 1978-06-06 Research Corporation Compositions containing 5-amino-5-deoxythymidine and pharmaceutically acceptable salts thereof
FR2548190B1 (fr) * 1983-07-01 1986-04-25 Centre Nat Rech Scient Procede de preparation de la sinefungine et de composes analogues

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000260A (en) * 1974-08-29 1976-12-28 Research Corporation Anti herpes simplex viral compounds and their synthesis
AU7684187A (en) * 1986-08-18 1988-02-25 F. Hoffmann-La Roche Ag Pyrimidine derivatives

Also Published As

Publication number Publication date
PT85522B (pt) 1990-06-29
ZW14787A1 (en) 1988-03-30
AR243534A1 (es) 1993-08-31
HU196427B (en) 1988-11-28
HUT45078A (en) 1988-05-30
DK346787D0 (da) 1987-07-06
FI85273B (fi) 1991-12-13
DK346787A (da) 1988-02-13
NO873362D0 (no) 1987-08-11
US4956346A (en) 1990-09-11
EP0256400A3 (en) 1988-05-18
JPH0643421B2 (ja) 1994-06-08
NO873362L (no) 1988-02-15
IL83452A0 (en) 1988-01-31
GR3006632T3 (enExample) 1993-06-30
IE60600B1 (en) 1994-07-27
DK163128B (da) 1992-01-20
DK163128C (da) 1992-06-15
NO169962C (no) 1992-08-26
DE3781847D1 (de) 1992-10-29
IE872143L (en) 1988-02-12
ES2052526T3 (es) 1994-07-16
CS523687A2 (en) 1990-02-12
FI873342L (fi) 1988-02-13
FI873342A0 (fi) 1987-07-31
CA1291125C (en) 1991-10-22
NO169962B (no) 1992-05-18
US4886785A (en) 1989-12-12
EP0256400A2 (de) 1988-02-24
PH23784A (en) 1989-11-03
FI85273C (fi) 1992-03-25
MC1845A1 (fr) 1988-09-30
NZ221350A (en) 1990-02-26
EP0256400B1 (de) 1992-09-23
PT85522A (en) 1987-09-01
AU7668587A (en) 1988-02-18
JPS6344577A (ja) 1988-02-25
CS271473B2 (en) 1990-10-12
CN87105612A (zh) 1988-03-16

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