AU541627B2 - Stabilisation of lyophilised beta-lactams - Google Patents

Stabilisation of lyophilised beta-lactams

Info

Publication number
AU541627B2
AU541627B2 AU72097/81A AU7209781A AU541627B2 AU 541627 B2 AU541627 B2 AU 541627B2 AU 72097/81 A AU72097/81 A AU 72097/81A AU 7209781 A AU7209781 A AU 7209781A AU 541627 B2 AU541627 B2 AU 541627B2
Authority
AU
Australia
Prior art keywords
preparation
weight
stabilizing agent
antibacterial component
sugar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU72097/81A
Other languages
English (en)
Other versions
AU7209781A (en
Inventor
Eizo Hirai
Kazuhiro Shima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of AU7209781A publication Critical patent/AU7209781A/en
Application granted granted Critical
Publication of AU541627B2 publication Critical patent/AU541627B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
AU72097/81A 1980-06-23 1981-06-23 Stabilisation of lyophilised beta-lactams Expired AU541627B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8578980A JPS5711909A (en) 1980-06-23 1980-06-23 Stable freeze-dried preparation of beta-lactam
JP8578980 1980-06-23

Publications (2)

Publication Number Publication Date
AU7209781A AU7209781A (en) 1983-01-06
AU541627B2 true AU541627B2 (en) 1985-01-17

Family

ID=13868648

Family Applications (1)

Application Number Title Priority Date Filing Date
AU72097/81A Expired AU541627B2 (en) 1980-06-23 1981-06-23 Stabilisation of lyophilised beta-lactams

Country Status (31)

Country Link
US (1) US4418058A (enExample)
JP (1) JPS5711909A (enExample)
KR (1) KR840000693B1 (enExample)
AR (1) AR230007A1 (enExample)
AT (1) AT380790B (enExample)
AU (1) AU541627B2 (enExample)
BE (1) BE889351A (enExample)
BG (1) BG37991A3 (enExample)
CA (1) CA1164801A (enExample)
CH (1) CH648210A5 (enExample)
CS (1) CS221835B2 (enExample)
DD (1) DD159879A5 (enExample)
DE (1) DE3124592A1 (enExample)
DK (1) DK158443C (enExample)
ES (1) ES503283A0 (enExample)
FI (1) FI75490C (enExample)
FR (1) FR2484835A1 (enExample)
GB (1) GB2078737B (enExample)
GR (1) GR75646B (enExample)
HU (1) HU183494B (enExample)
IE (1) IE51331B1 (enExample)
IL (1) IL63136A (enExample)
IT (1) IT1144812B (enExample)
NL (1) NL191777C (enExample)
NO (1) NO156036C (enExample)
NZ (1) NZ197414A (enExample)
PT (1) PT73239B (enExample)
RO (1) RO82720B (enExample)
SE (1) SE460702B (enExample)
YU (1) YU44416B (enExample)
ZA (1) ZA814203B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS597193A (ja) * 1982-07-02 1984-01-14 Shionogi & Co Ltd マロニルメチル基の異性化方法
JPS6045514A (ja) * 1983-08-22 1985-03-12 Shionogi & Co Ltd 安定な抗菌性凍結乾燥製剤
US4797388A (en) * 1984-05-21 1989-01-10 Cetus Corporation Pharmaceutical compositions with galactitol as carrier
US4891391A (en) * 1985-01-03 1990-01-02 Morton Thiokol, Inc. Compositions containing antimicrobial agents in combination with stabilizers
US4816568A (en) * 1986-05-16 1989-03-28 International Minerals & Chemical Corp. Stabilization of growth hormones
DE3801179A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierung von cephalosporinderivaten durch trocknung mit einem stabilisator sowie stabile zubereitungsformen mit cephalosporinderivaten
AU2001271037A1 (en) * 2000-07-13 2002-01-30 Daiichi Pharmaceutical Co., Ltd. Pharmaceutical compositions containing dds compounds
US7378408B2 (en) * 2001-11-30 2008-05-27 Pfizer Inc. Methods of treatment and formulations of cephalosporin
KR102329764B1 (ko) 2013-03-15 2021-11-23 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140275000A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS532931B2 (enExample) * 1973-12-05 1978-02-01
US3928592A (en) * 1974-02-22 1975-12-23 Lilly Co Eli Antibiotic pharmaceutical compositions
US3993753A (en) * 1974-08-26 1976-11-23 American Home Products Corporation Anhydrous ampicillin stabilization and resultant compositions
GB1463563A (en) * 1974-10-10 1977-02-02 Beecham Group Ltd Pharmaceutical compositions
JPS5151511A (en) * 1974-10-25 1976-05-07 Tooru Tatsuhara Aminosanseizai no anteikaho
US4180571A (en) * 1976-03-25 1979-12-25 Shionogi & Co., Ltd. Arylmalonamido-1-oxadethiacephalosporins
JPS532931A (en) * 1976-06-30 1978-01-12 Saraya Kk Toilet bowl cleaning method
GR70338B (enExample) * 1976-12-17 1982-09-20 Scherico Ltd
JPS53104722A (en) * 1977-02-19 1978-09-12 Tsumura Juntendo Kk Production of powder for making herb medicine liquid agent
CA1127450A (en) * 1978-08-26 1982-07-13 Gordon L. Mcglennon Load multiplying mechanisms
US4259485A (en) * 1979-04-24 1981-03-31 Eli Lilly And Company Crystallization process

Also Published As

Publication number Publication date
IT8167863A0 (it) 1981-06-22
SE460702B (sv) 1989-11-13
SE8103904L (sv) 1981-12-24
AR230007A1 (es) 1984-02-29
GR75646B (enExample) 1984-08-02
AU7209781A (en) 1983-01-06
ES8203887A1 (es) 1982-04-01
GB2078737B (en) 1984-03-14
IE811347L (en) 1981-12-23
NO156036C (no) 1987-07-15
FI75490C (fi) 1988-07-11
DK158443B (da) 1990-05-21
IT1144812B (it) 1986-10-29
BE889351A (fr) 1981-10-16
IL63136A0 (en) 1981-09-13
PT73239B (en) 1982-07-22
JPS6364405B2 (enExample) 1988-12-12
NL191777C (nl) 1996-08-02
FI75490B (fi) 1988-03-31
GB2078737A (en) 1982-01-13
YU44416B (en) 1990-08-31
RO82720A (ro) 1984-05-23
ATA278881A (de) 1985-12-15
DK274981A (da) 1981-12-24
KR830005848A (ko) 1983-09-14
NL8102943A (nl) 1982-01-18
PT73239A (en) 1981-07-01
US4418058A (en) 1983-11-29
NZ197414A (en) 1984-10-19
DE3124592A1 (de) 1982-02-11
JPS5711909A (en) 1982-01-21
IE51331B1 (en) 1986-12-10
YU157381A (en) 1984-10-31
ES503283A0 (es) 1982-04-01
AT380790B (de) 1986-07-10
CH648210A5 (de) 1985-03-15
DD159879A5 (de) 1983-04-13
FR2484835B1 (enExample) 1983-07-01
RO82720B (ro) 1984-07-30
NL191777B (nl) 1996-04-01
ZA814203B (en) 1982-09-29
NO156036B (no) 1987-04-06
DK158443C (da) 1990-10-08
HU183494B (en) 1984-05-28
FI811948L (fi) 1981-12-24
FR2484835A1 (fr) 1981-12-24
DE3124592C2 (enExample) 1990-12-20
CA1164801A (en) 1984-04-03
CS221835B2 (en) 1983-04-29
BG37991A3 (en) 1985-09-16
IL63136A (en) 1984-07-31
NO812090L (no) 1981-12-28
KR840000693B1 (ko) 1984-05-21

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired