AU496854B2 - 6-chloro-2(1-piperazinyl)-pyrazine and its n-oxide - Google Patents

6-chloro-2(1-piperazinyl)-pyrazine and its n-oxide

Info

Publication number
AU496854B2
AU496854B2 AU12966/76A AU1296676A AU496854B2 AU 496854 B2 AU496854 B2 AU 496854B2 AU 12966/76 A AU12966/76 A AU 12966/76A AU 1296676 A AU1296676 A AU 1296676A AU 496854 B2 AU496854 B2 AU 496854B2
Authority
AU
Australia
Prior art keywords
pyrazine
piperazinyl
chloro
oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU12966/76A
Other languages
English (en)
Other versions
AU1296676A (en
Inventor
Walfred Spencer Saari And William Carl Lomma, Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU1296676A publication Critical patent/AU1296676A/en
Application granted granted Critical
Publication of AU496854B2 publication Critical patent/AU496854B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU12966/76A 1975-04-21 1976-04-13 6-chloro-2(1-piperazinyl)-pyrazine and its n-oxide Expired AU496854B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57005275A 1975-04-21 1975-04-21
USUS570,052 1975-04-21

Publications (2)

Publication Number Publication Date
AU1296676A AU1296676A (en) 1977-10-20
AU496854B2 true AU496854B2 (en) 1978-11-02

Family

ID=24277994

Family Applications (1)

Application Number Title Priority Date Filing Date
AU12966/76A Expired AU496854B2 (en) 1975-04-21 1976-04-13 6-chloro-2(1-piperazinyl)-pyrazine and its n-oxide

Country Status (36)

Country Link
JP (1) JPS51136688A (enrdf_load_html_response)
AR (1) AR210349A1 (enrdf_load_html_response)
AT (1) AT353795B (enrdf_load_html_response)
AU (1) AU496854B2 (enrdf_load_html_response)
BE (1) BE840904A (enrdf_load_html_response)
BG (1) BG34185A3 (enrdf_load_html_response)
CA (1) CA1059128A (enrdf_load_html_response)
CH (1) CH619462A5 (enrdf_load_html_response)
CS (1) CS195726B2 (enrdf_load_html_response)
CY (1) CY1090A (enrdf_load_html_response)
DD (1) DD124599A5 (enrdf_load_html_response)
DE (1) DE2617205C3 (enrdf_load_html_response)
DK (1) DK143899C (enrdf_load_html_response)
EG (1) EG12387A (enrdf_load_html_response)
ES (4) ES447150A1 (enrdf_load_html_response)
FI (1) FI62666C (enrdf_load_html_response)
FR (1) FR2308367A1 (enrdf_load_html_response)
GB (1) GB1492528A (enrdf_load_html_response)
GR (1) GR59900B (enrdf_load_html_response)
HK (1) HK60380A (enrdf_load_html_response)
HU (1) HU172684B (enrdf_load_html_response)
IE (1) IE42979B1 (enrdf_load_html_response)
IL (1) IL49391A (enrdf_load_html_response)
KE (1) KE3088A (enrdf_load_html_response)
LU (1) LU74795A1 (enrdf_load_html_response)
MY (1) MY8100225A (enrdf_load_html_response)
NL (1) NL167692C (enrdf_load_html_response)
NO (1) NO146599C (enrdf_load_html_response)
PH (1) PH12274A (enrdf_load_html_response)
PL (1) PL99664B1 (enrdf_load_html_response)
PT (1) PT65027B (enrdf_load_html_response)
RO (1) RO73278A (enrdf_load_html_response)
SE (1) SE421695B (enrdf_load_html_response)
SU (1) SU638260A3 (enrdf_load_html_response)
YU (1) YU100676A (enrdf_load_html_response)
ZA (1) ZA762320B (enrdf_load_html_response)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en) 1978-03-17 1979-08-07 Merck & Co., Inc. Piperazinylpyrazines
US4252816A (en) * 1979-12-03 1981-02-24 Merck & Co., Inc. Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en) 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) * 1982-05-06 1985-04-03 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) * 1983-03-25 1985-10-15 Degussa Aktiengesellschaft N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
EP0580465A1 (fr) * 1992-06-25 1994-01-26 Sanofi Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
IL135108A0 (en) * 1997-10-27 2001-05-20 Neurosearch As Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors
DE60003911T2 (de) * 1999-04-26 2004-05-27 Neurosearch A/S Heteroaryl-diazacycloalkane, ihre herstellung und verwendung
MXPA02007868A (es) * 2000-02-16 2003-02-10 Neurogen Corp Arilpirazinas sustituidas.
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
SE0202287D0 (sv) * 2002-07-19 2002-07-19 Biovitrum Ab New compounds
DE60311822T2 (de) * 2002-07-19 2007-12-06 Biovitrum Ab Neue piperazinyl-pyrazinon-derivate zur behandlung von 5-ht2a rezeptor-bedingten erkrankungen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2606906A (en) * 1948-10-14 1952-08-12 American Cyanamid Co 1-(2-pyridyl) piperazine and process of preparing same

Also Published As

Publication number Publication date
LU74795A1 (enrdf_load_html_response) 1977-02-07
ES459406A1 (es) 1978-08-16
IE42979L (en) 1976-10-21
DE2617205B2 (de) 1980-05-08
NO146599C (no) 1982-11-03
CH619462A5 (en) 1980-09-30
ES447150A1 (es) 1977-09-16
PT65027A (en) 1976-05-01
AT353795B (de) 1979-12-10
NL167692B (nl) 1981-08-17
SE421695B (sv) 1982-01-25
ZA762320B (en) 1977-11-30
PT65027B (en) 1978-04-03
AU1296676A (en) 1977-10-20
FR2308367A1 (fr) 1976-11-19
BE840904A (fr) 1976-08-16
FI760978A7 (enrdf_load_html_response) 1976-10-22
NL7603800A (nl) 1976-10-25
DK143899B (da) 1981-10-26
CS195726B2 (en) 1980-02-29
SU638260A3 (ru) 1978-12-15
AR210349A1 (es) 1977-07-29
IL49391A (en) 1979-09-30
BG34185A3 (bg) 1983-07-15
GR59900B (en) 1978-03-16
HU172684B (hu) 1978-11-28
FI62666B (fi) 1982-10-29
DK143899C (da) 1982-04-13
FR2308367B1 (enrdf_load_html_response) 1979-09-21
ES459405A1 (es) 1978-08-16
FI62666C (fi) 1983-02-10
DK164476A (da) 1976-10-22
NO761207L (enrdf_load_html_response) 1976-10-22
ATA288376A (de) 1979-05-15
SE7604093L (sv) 1976-10-22
DE2617205C3 (de) 1981-01-29
YU100676A (en) 1982-08-31
CA1059128A (en) 1979-07-24
PH12274A (en) 1978-12-12
IE42979B1 (en) 1980-11-19
JPS5522475B2 (enrdf_load_html_response) 1980-06-17
NL167692C (nl) 1982-01-18
KE3088A (en) 1980-11-07
NO146599B (no) 1982-07-26
HK60380A (en) 1980-11-07
GB1492528A (en) 1977-11-23
JPS51136688A (en) 1976-11-26
CY1090A (en) 1980-12-27
DD124599A5 (enrdf_load_html_response) 1977-03-02
DE2617205A1 (de) 1976-10-28
PL99664B1 (pl) 1978-07-31
EG12387A (en) 1978-12-31
MY8100225A (en) 1981-12-31
RO73278A (ro) 1982-09-09
IL49391A0 (en) 1976-06-30
ES459407A1 (es) 1978-08-16

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