AU3584200A - P53 inhibitors and therapeutic use of the same - Google Patents
P53 inhibitors and therapeutic use of the same Download PDFInfo
- Publication number
- AU3584200A AU3584200A AU35842/00A AU3584200A AU3584200A AU 3584200 A AU3584200 A AU 3584200A AU 35842/00 A AU35842/00 A AU 35842/00A AU 3584200 A AU3584200 A AU 3584200A AU 3584200 A AU3584200 A AU 3584200A
- Authority
- AU
- Australia
- Prior art keywords
- inhibitor
- alkyl
- aryl
- temporary
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11788199P | 1999-01-29 | 1999-01-29 | |
| US60117881 | 1999-01-29 | ||
| PCT/US2000/002104 WO2000044364A2 (en) | 1999-01-29 | 2000-01-28 | P53 inhibitors and their use for the treatment of cancer, hyperthermia, hypoxia, a burn, trauma to the central nervous system, a seizure, acute inflammation, tissue ageing, preservation of organs for transplant and preparation of a host for bone marrow transplant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU3584200A true AU3584200A (en) | 2000-08-18 |
Family
ID=22375329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU35842/00A Abandoned AU3584200A (en) | 1999-01-29 | 2000-01-28 | P53 inhibitors and therapeutic use of the same |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US6593353B1 (https=) |
| EP (1) | EP1143943B1 (https=) |
| JP (2) | JP2002535357A (https=) |
| AT (1) | ATE380548T1 (https=) |
| AU (1) | AU3584200A (https=) |
| CA (1) | CA2360671A1 (https=) |
| DE (1) | DE60037394T2 (https=) |
| IL (3) | IL144294A0 (https=) |
| NZ (1) | NZ513487A (https=) |
| WO (1) | WO2000044364A2 (https=) |
| ZA (1) | ZA200105823B (https=) |
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| IL144294A0 (en) * | 1999-01-29 | 2002-05-23 | Univ Illinois | P53 inhibitors and therapeutic use of the same |
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| WO2002014321A1 (en) * | 2000-08-11 | 2002-02-21 | The Regents Of The University Of California | Use of stat-6 inhibitors as therapeutic agents |
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| US6861431B2 (en) | 2001-03-23 | 2005-03-01 | The Board Of Trustees Of The University Of Illinois | Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same |
| US7601846B2 (en) | 2001-06-26 | 2009-10-13 | The Regents Of The University Of California | Compounds having activity as inhibitors of apoptosis |
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| DK2118123T3 (en) * | 2007-01-31 | 2016-01-25 | Dana Farber Cancer Inst Inc | Stabilized p53 peptides and uses thereof |
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| CA2695590C (en) | 2008-06-27 | 2018-01-09 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| CN102231983A (zh) * | 2008-10-01 | 2011-11-02 | 北卡罗来纳大学查珀尔希尔分校 | 使用选择性细胞周期蛋白依赖性激酶4/6抑制剂对抗电离辐射的造血防护 |
| JP2012504646A (ja) * | 2008-10-01 | 2012-02-23 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 選択的サイクリン依存性キナーゼ４／６阻害剤を用いた化学療法化合物に対する造血系の防護 |
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| CA2770412C (en) | 2009-08-07 | 2018-09-11 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| ES2711526T3 (es) | 2010-08-13 | 2019-05-06 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
| US20130230580A1 (en) * | 2010-09-14 | 2013-09-05 | Paul S. Frenette | Administration of SNS Neuroprotective Agents to Promote Hematopoietic Regeneration |
| WO2012068381A2 (en) | 2010-11-17 | 2012-05-24 | The University Of North Carolina At Chapel Hill | Protection of renal tissues from schema through inhibition of the proliferative kisses cdk4 and cdk6 |
| CA2836503C (en) | 2011-05-23 | 2020-09-22 | Yeda Research And Development Co. Ltd. | Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same |
| CA2844660A1 (en) | 2011-08-09 | 2013-02-14 | Leo E. Otterbein | Methods of treating dna damage |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES |
| BR112014020103A2 (pt) | 2012-02-15 | 2018-10-09 | Aileron Therapeutics, Inc. | macrociclos peptidomiméticos |
| ES2704855T3 (es) | 2012-09-12 | 2019-03-20 | Quark Pharmaceuticals Inc | Moléculas de oligonucleótido de doble cadena para p53 y métodos de uso de las mismas |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
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| US10314826B2 (en) | 2014-02-07 | 2019-06-11 | University Of Maryland, Baltimore | Methods of treatment of ischemia-induced angiogenesis and arteriogenesis |
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| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
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| AU2015320545C1 (en) | 2014-09-24 | 2020-05-14 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| EP3197478A4 (en) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2017044633A1 (en) | 2015-09-10 | 2017-03-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of mcl-1 |
| US20190015393A1 (en) * | 2016-01-18 | 2019-01-17 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | The use of a temporary inhibitor of p53 for preventing or reducing cancer relapse |
| EP3535396A1 (en) | 2016-11-01 | 2019-09-11 | Novartis AG | Methods and compositions for enhancing gene editing |
| US11091522B2 (en) | 2018-07-23 | 2021-08-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2020206046A1 (en) | 2019-04-01 | 2020-10-08 | The Broad Institute, Inc. | Methods and compositions for cell therapy |
| WO2020247336A1 (en) * | 2019-06-03 | 2020-12-10 | The Regents Of The University Of California | Pifithrin analogues and methods of treating rett syndrome |
| JP7429035B2 (ja) * | 2019-08-01 | 2024-02-07 | 東京都公立大学法人 | 機能不全ミトコンドリアを消去するための複合体、および細胞老化を抑制するための複合体 |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
| AU2023337518A1 (en) | 2022-09-06 | 2025-03-20 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Engineering sox/oct heterodimerization to induce high-grade developmental reset |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2463774A1 (fr) * | 1979-08-21 | 1981-02-27 | Yamanouchi Pharma Co Ltd | Derives du 2-phenylimidazo(2,1-b)benzothiazole |
| US5324731A (en) * | 1989-02-14 | 1994-06-28 | Amira, Inc. | Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated |
| CA2028756A1 (en) | 1989-11-24 | 1991-05-25 | Alfons H. M. Raeymaekers | Immunostimulating 6-aryl-5,6-dihydro-imidazo[2,1-b]thiazole derivatives |
| US6372249B1 (en) * | 1991-12-16 | 2002-04-16 | Baylor College Of Medicine | Senscent cell-derived inhibitors of DNA synthesis |
| JPH07291976A (ja) | 1994-04-27 | 1995-11-07 | Otsuka Pharmaceut Factory Inc | イミダゾ〔２，１−ｂ〕チアゾール誘導体 |
| JP3178843B2 (ja) | 1995-03-13 | 2001-06-25 | 日研化学株式会社 | イミダゾチアゾール化合物 |
| JP3847366B2 (ja) * | 1996-02-22 | 2006-11-22 | アンジェスＭｇ株式会社 | アンチセンスオリゴヌクレオチドを用いた固定性分裂終了細胞増殖剤 |
| WO1998017267A1 (en) | 1996-10-23 | 1998-04-30 | Zymogenetics, Inc. | Compositions and methods for treating bone deficit conditions |
| US5919808A (en) | 1996-10-23 | 1999-07-06 | Zymogenetics, Inc. | Compositions and methods for treating bone deficit conditions |
| JPH1129475A (ja) | 1997-07-07 | 1999-02-02 | Sumitomo Pharmaceut Co Ltd | Ｓｔａｔ６活性化阻害剤 |
| JPH11103640A (ja) | 1997-09-29 | 1999-04-20 | Mitsubishi Agricult Mach Co Ltd | ノッタの結節装置 |
| JPH11106340A (ja) | 1997-10-02 | 1999-04-20 | Sumitomo Pharmaceut Co Ltd | Ｓｔａｔ６活性化阻害剤 |
| IL144294A0 (en) * | 1999-01-29 | 2002-05-23 | Univ Illinois | P53 inhibitors and therapeutic use of the same |
-
2000
- 2000-01-28 IL IL14429400A patent/IL144294A0/xx unknown
- 2000-01-28 NZ NZ513487A patent/NZ513487A/xx unknown
- 2000-01-28 WO PCT/US2000/002104 patent/WO2000044364A2/en not_active Ceased
- 2000-01-28 US US09/493,527 patent/US6593353B1/en not_active Expired - Lifetime
- 2000-01-28 DE DE60037394T patent/DE60037394T2/de not_active Expired - Lifetime
- 2000-01-28 EP EP00914455A patent/EP1143943B1/en not_active Revoked
- 2000-01-28 AU AU35842/00A patent/AU3584200A/en not_active Abandoned
- 2000-01-28 AT AT00914455T patent/ATE380548T1/de not_active IP Right Cessation
- 2000-01-28 CA CA002360671A patent/CA2360671A1/en not_active Abandoned
- 2000-01-28 JP JP2000595668A patent/JP2002535357A/ja active Pending
-
2001
- 2001-06-13 US US09/880,417 patent/US7012087B2/en not_active Expired - Lifetime
- 2001-07-12 IL IL144294A patent/IL144294A/en not_active IP Right Cessation
- 2001-07-16 ZA ZA200105823A patent/ZA200105823B/en unknown
- 2001-09-06 US US09/947,757 patent/US20020019425A1/en not_active Abandoned
-
2003
- 2003-01-24 US US10/350,560 patent/US6982277B2/en not_active Expired - Lifetime
- 2003-01-28 US US10/352,597 patent/US7008956B2/en not_active Expired - Lifetime
-
2005
- 2005-05-24 US US11/136,231 patent/US20050222224A1/en not_active Abandoned
-
2008
- 2008-01-30 US US12/022,317 patent/US20080161426A1/en not_active Abandoned
- 2008-12-04 IL IL195723A patent/IL195723A/en not_active IP Right Cessation
-
2010
- 2010-08-23 JP JP2010185868A patent/JP2010265321A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20030144331A1 (en) | 2003-07-31 |
| US6593353B1 (en) | 2003-07-15 |
| NZ513487A (en) | 2003-02-28 |
| JP2010265321A (ja) | 2010-11-25 |
| EP1143943A2 (en) | 2001-10-17 |
| IL144294A (en) | 2010-04-15 |
| EP1143943A3 (en) | 2002-09-11 |
| WO2000044364A2 (en) | 2000-08-03 |
| DE60037394T2 (de) | 2009-01-02 |
| US7012087B2 (en) | 2006-03-14 |
| JP2002535357A (ja) | 2002-10-22 |
| US20020006941A1 (en) | 2002-01-17 |
| US7008956B2 (en) | 2006-03-07 |
| IL144294A0 (en) | 2002-05-23 |
| ATE380548T1 (de) | 2007-12-15 |
| CA2360671A1 (en) | 2000-08-03 |
| US20080161426A1 (en) | 2008-07-03 |
| EP1143943B1 (en) | 2007-12-12 |
| US20030176318A1 (en) | 2003-09-18 |
| ZA200105823B (en) | 2002-05-07 |
| US20050222224A1 (en) | 2005-10-06 |
| WO2000044364A3 (en) | 2001-08-23 |
| IL195723A (en) | 2010-12-30 |
| US20020019425A1 (en) | 2002-02-14 |
| DE60037394D1 (de) | 2008-01-24 |
| US6982277B2 (en) | 2006-01-03 |
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