AU2018368789B2 - Oxoacridinyl acetic acid derivatives and methods of use - Google Patents

Oxoacridinyl acetic acid derivatives and methods of use Download PDF

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Publication number
AU2018368789B2
AU2018368789B2 AU2018368789A AU2018368789A AU2018368789B2 AU 2018368789 B2 AU2018368789 B2 AU 2018368789B2 AU 2018368789 A AU2018368789 A AU 2018368789A AU 2018368789 A AU2018368789 A AU 2018368789A AU 2018368789 B2 AU2018368789 B2 AU 2018368789B2
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AU
Australia
Prior art keywords
cmpd
alkyl
compound
halogen
cancer
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Ceased
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AU2018368789A
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English (en)
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AU2018368789A1 (en
Inventor
Bryce K. ALLEN
Brian T. CHAMBERLAIN
Finith E. JERNIGAN III
Meghana M. KULKARNI
Zhixiong Lin
Kristen A. MARINO
James M. Rice
Sharon Shechter
Woody SHERMAN
Dazhi TAN
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Stingthera Inc
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Stingthera Inc
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Publication of AU2018368789A1 publication Critical patent/AU2018368789A1/en
Assigned to Stingthera, Inc. reassignment Stingthera, Inc. Amend patent request/document other than specification (104) Assignors: SILICON SWAT, INC.
Application granted granted Critical
Publication of AU2018368789B2 publication Critical patent/AU2018368789B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AU2018368789A 2017-11-20 2018-11-20 Oxoacridinyl acetic acid derivatives and methods of use Ceased AU2018368789B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762588820P 2017-11-20 2017-11-20
US62/588,820 2017-11-20
US201862631530P 2018-02-16 2018-02-16
US62/631,530 2018-02-16
US201862723660P 2018-08-28 2018-08-28
US62/723,660 2018-08-28
PCT/US2018/062021 WO2019100061A1 (en) 2017-11-20 2018-11-20 Oxoacridinyl acetic acid derivatives and methods of use

Publications (2)

Publication Number Publication Date
AU2018368789A1 AU2018368789A1 (en) 2020-06-11
AU2018368789B2 true AU2018368789B2 (en) 2022-06-02

Family

ID=66540425

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018368789A Ceased AU2018368789B2 (en) 2017-11-20 2018-11-20 Oxoacridinyl acetic acid derivatives and methods of use

Country Status (13)

Country Link
US (2) US10745358B2 (https=)
EP (1) EP3713920A4 (https=)
JP (1) JP7323539B2 (https=)
KR (1) KR20200100081A (https=)
CN (1) CN111630036B (https=)
AU (1) AU2018368789B2 (https=)
BR (1) BR112020009592A2 (https=)
CA (1) CA3079262A1 (https=)
IL (1) IL274796A (https=)
MX (1) MX2020004902A (https=)
PH (1) PH12020550652A1 (https=)
SG (1) SG11202004442VA (https=)
WO (1) WO2019100061A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7270608B2 (ja) 2017-08-31 2023-05-10 エフ－スター・セラピューティクス・インコーポレイテッド 化合物、組成物、及び疾患の治療方法
US20220227761A1 (en) * 2019-05-16 2022-07-21 Stingthera, Inc. Oxoacridinyl acetic acid derivatives and methods of use
WO2020249773A1 (en) * 2019-06-12 2020-12-17 Ryvu Therapeutics S.A. Next-generation modulators of stimulator of interferon genes (sting)
CN112442033A (zh) * 2019-08-28 2021-03-05 迈德欣国际有限公司 Sting通路调节剂及其用途
CN112624972A (zh) * 2019-09-24 2021-04-09 中国人民解放军军事科学院军事医学研究院 吖啶酮类化合物及医药用途
RU2730530C1 (ru) * 2019-10-29 2020-08-24 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Новое химическое соединение L-лизина 9-оксоакридинил-10-ацетат, стимулирующее продукцию интерлейкина-24 и фактора некроза опухолей - бета
CN112778336B (zh) * 2019-11-02 2023-05-05 上海凌达生物医药有限公司 一类含氮稠环类sting调节剂类化合物、制备方法和用途
CN111039849B (zh) * 2019-12-26 2021-07-06 阜阳欣奕华材料科技有限公司 一种含有咔唑环类化合物的制备方法
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0889037A1 (en) * 1996-03-13 1999-01-07 Eisai Co., Ltd. Nitrogenous tricyclic compounds and drugs comprising the same
US20050217038A1 (en) * 2004-04-06 2005-10-06 Glenn Robert W Jr Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3681360A (en) 1971-04-09 1972-08-01 Hoffmann La Roche Antiviral substituted acridanones
JPH0867873A (ja) 1994-08-29 1996-03-12 Pioneer Electron Corp 有機エレクトロルミネッセンス素子
PL322083A1 (en) 1995-03-02 1998-01-05 Yamanouchi Pharma Co Ltd Novel derivative of quinuklidine, incorporating a tricyclic system of condensed heteronuclei
AU7145396A (en) 1995-10-04 1997-04-28 Eisai Co. Ltd. Acridone compounds
RU2118532C1 (ru) * 1996-04-10 1998-09-10 Олег Викторович Травкин Противоинфекционное, противовоспалительное и противоопухолевое лекарственное средство
JPH11100373A (ja) * 1997-09-26 1999-04-13 Eisai Co Ltd 新規フェノチアジン誘導体及びその医薬
RU2197248C2 (ru) * 2001-03-20 2003-01-27 Травкин Олег Викторович Лекарственный препарат, обладающий иммуномоделирующим, иммунокоррегирующим, противопаразитарным, противосклеротическим, противовирусным, противобактериальным, противогрибковым, противовоспалительным и противоопухолевым действием, и способ его приготовления
GB0113435D0 (en) 2001-06-04 2001-07-25 Amersham Pharm Biotech Uk Ltd Acridone derivatives as labels for fluorescence detection of target materials
GB0113434D0 (en) 2001-06-04 2001-07-25 Amersham Pharm Biotech Uk Ltd Quinacridone derivatives as labels for fluorescence detection of biological materials
WO2004106923A1 (en) 2003-05-28 2004-12-09 Amersham Biosciences Uk Limited Differential analysis of cell surface proteins on closed membrane structures by labelling with dyes in the presence of an internal standard
JP2006004736A (ja) 2004-06-17 2006-01-05 Sumitomo Chemical Co Ltd 光電変換素子及び光電変換素子用色素
WO2008021745A2 (en) 2006-08-16 2008-02-21 Itherx Pharmaceuticals, Inc. Hepatitis c virus entry inhibitors
JP2008090130A (ja) 2006-10-04 2008-04-17 Konica Minolta Medical & Graphic Inc 感光性平版印刷版材料
WO2009112791A1 (en) 2008-03-14 2009-09-17 Assaymetrics Limited Fluorogenic peptides and their method of production
JP2009271403A (ja) 2008-05-09 2009-11-19 Konica Minolta Medical & Graphic Inc 感光性平版印刷版材料および平版印刷版の製造方法
JP5717959B2 (ja) 2009-11-17 2015-05-13 株式会社Adeka 芳香族スルホニウム塩化合物
US8618125B2 (en) 2011-01-14 2013-12-31 Heptiva LLC Composition comprising hepatic therapeutic active for treating liver diseases, certain cancers and liver health maintenance
WO2013022740A2 (en) 2011-08-05 2013-02-14 Corning Incorporated Gpr35 ligands and the uses thereof
WO2015046502A1 (ja) 2013-09-30 2015-04-02 富士フイルム株式会社 感光性樹脂組成物、硬化膜の製造方法、硬化膜、有機ｅｌ表示装置および液晶表示装置
CN109394752A (zh) * 2013-10-21 2019-03-01 德雷克塞尔大学 治疗慢性乙型肝炎病毒感染的sting激动剂的用途
CN103709122B (zh) 2013-11-29 2016-05-25 四川大学 用于治疗的抗肿瘤和抗真菌化合物
WO2016179702A1 (en) * 2015-05-11 2016-11-17 Ranju Ralhan Acridinone compositions for treating head and neck cancers and methods of prognosing head and neck cancers
WO2018165494A1 (en) 2017-03-10 2018-09-13 Albert Einstein College Of Medicine, Inc. Small molecule bax inhibitors and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0889037A1 (en) * 1996-03-13 1999-01-07 Eisai Co., Ltd. Nitrogenous tricyclic compounds and drugs comprising the same
US20050217038A1 (en) * 2004-04-06 2005-10-06 Glenn Robert W Jr Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CAS Registry Number 908816-64-8; STN Entry Date 27 September 2006; 10(9H)-Acridineacetic acid, 4-cyano-2,3-dimethyl-9-oxo-, ethyl ester *

Also Published As

Publication number Publication date
AU2018368789A1 (en) 2020-06-11
KR20200100081A (ko) 2020-08-25
BR112020009592A2 (pt) 2020-11-03
EP3713920A4 (en) 2021-04-14
IL274796A (en) 2020-07-30
US20230113570A1 (en) 2023-04-13
MX2020004902A (es) 2020-09-09
JP7323539B2 (ja) 2023-08-08
CN111630036A (zh) 2020-09-04
CN111630036B (zh) 2024-12-27
WO2019100061A1 (en) 2019-05-23
PH12020550652A1 (en) 2021-04-26
SG11202004442VA (en) 2020-06-29
US10745358B2 (en) 2020-08-18
CA3079262A1 (en) 2019-05-23
JP2021503501A (ja) 2021-02-12
EP3713920A1 (en) 2020-09-30
US20190161449A1 (en) 2019-05-30

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Owner name: STINGTHERA, INC.

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired