KR20200100081A - 옥소아크리디닐 아세트산 유도체 및 사용 방법 - Google Patents
옥소아크리디닐 아세트산 유도체 및 사용 방법 Download PDFInfo
- Publication number
- KR20200100081A KR20200100081A KR1020207017927A KR20207017927A KR20200100081A KR 20200100081 A KR20200100081 A KR 20200100081A KR 1020207017927 A KR1020207017927 A KR 1020207017927A KR 20207017927 A KR20207017927 A KR 20207017927A KR 20200100081 A KR20200100081 A KR 20200100081A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- compound
- halogen
- sting
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CC1(C)OB(*)OC1(C)C Chemical compound CC1(C)OB(*)OC1(C)C 0.000 description 5
- UMRFLDHHWMTAEX-UHFFFAOYSA-N CN(C)c(cc1)cc(N(CC(O)=O)c(c2ccc3Cl)c3Cl)c1C2=O Chemical compound CN(C)c(cc1)cc(N(CC(O)=O)c(c2ccc3Cl)c3Cl)c1C2=O UMRFLDHHWMTAEX-UHFFFAOYSA-N 0.000 description 1
- BWQDBWGHJCJSAK-UHFFFAOYSA-N OC(CN(c(cc(cc1)F)c1C(c1ccc2Cl)=O)c1c2Cl)=[O]=S Chemical compound OC(CN(c(cc(cc1)F)c1C(c1ccc2Cl)=O)c1c2Cl)=[O]=S BWQDBWGHJCJSAK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762588820P | 2017-11-20 | 2017-11-20 | |
| US62/588,820 | 2017-11-20 | ||
| US201862631530P | 2018-02-16 | 2018-02-16 | |
| US62/631,530 | 2018-02-16 | ||
| US201862723660P | 2018-08-28 | 2018-08-28 | |
| US62/723,660 | 2018-08-28 | ||
| PCT/US2018/062021 WO2019100061A1 (en) | 2017-11-20 | 2018-11-20 | Oxoacridinyl acetic acid derivatives and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20200100081A true KR20200100081A (ko) | 2020-08-25 |
Family
ID=66540425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207017927A Ceased KR20200100081A (ko) | 2017-11-20 | 2018-11-20 | 옥소아크리디닐 아세트산 유도체 및 사용 방법 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10745358B2 (https=) |
| EP (1) | EP3713920A4 (https=) |
| JP (1) | JP7323539B2 (https=) |
| KR (1) | KR20200100081A (https=) |
| CN (1) | CN111630036B (https=) |
| AU (1) | AU2018368789B2 (https=) |
| BR (1) | BR112020009592A2 (https=) |
| CA (1) | CA3079262A1 (https=) |
| IL (1) | IL274796A (https=) |
| MX (1) | MX2020004902A (https=) |
| PH (1) | PH12020550652A1 (https=) |
| SG (1) | SG11202004442VA (https=) |
| WO (1) | WO2019100061A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7270608B2 (ja) | 2017-08-31 | 2023-05-10 | エフ－スター・セラピューティクス・インコーポレイテッド | 化合物、組成物、及び疾患の治療方法 |
| US20220227761A1 (en) * | 2019-05-16 | 2022-07-21 | Stingthera, Inc. | Oxoacridinyl acetic acid derivatives and methods of use |
| WO2020249773A1 (en) * | 2019-06-12 | 2020-12-17 | Ryvu Therapeutics S.A. | Next-generation modulators of stimulator of interferon genes (sting) |
| CN112442033A (zh) * | 2019-08-28 | 2021-03-05 | 迈德欣国际有限公司 | Sting通路调节剂及其用途 |
| CN112624972A (zh) * | 2019-09-24 | 2021-04-09 | 中国人民解放军军事科学院军事医学研究院 | 吖啶酮类化合物及医药用途 |
| RU2730530C1 (ru) * | 2019-10-29 | 2020-08-24 | Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" | Новое химическое соединение L-лизина 9-оксоакридинил-10-ацетат, стимулирующее продукцию интерлейкина-24 и фактора некроза опухолей - бета |
| CN112778336B (zh) * | 2019-11-02 | 2023-05-05 | 上海凌达生物医药有限公司 | 一类含氮稠环类sting调节剂类化合物、制备方法和用途 |
| CN111039849B (zh) * | 2019-12-26 | 2021-07-06 | 阜阳欣奕华材料科技有限公司 | 一种含有咔唑环类化合物的制备方法 |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3681360A (en) | 1971-04-09 | 1972-08-01 | Hoffmann La Roche | Antiviral substituted acridanones |
| JPH0867873A (ja) | 1994-08-29 | 1996-03-12 | Pioneer Electron Corp | 有機エレクトロルミネッセンス素子 |
| PL322083A1 (en) | 1995-03-02 | 1998-01-05 | Yamanouchi Pharma Co Ltd | Novel derivative of quinuklidine, incorporating a tricyclic system of condensed heteronuclei |
| AU7145396A (en) | 1995-10-04 | 1997-04-28 | Eisai Co. Ltd. | Acridone compounds |
| US6333322B1 (en) * | 1996-03-13 | 2001-12-25 | Eisai Co., Ltd. | Nitrogen-containing tricyclic compounds and drugs containing the same |
| RU2118532C1 (ru) * | 1996-04-10 | 1998-09-10 | Олег Викторович Травкин | Противоинфекционное, противовоспалительное и противоопухолевое лекарственное средство |
| JPH11100373A (ja) * | 1997-09-26 | 1999-04-13 | Eisai Co Ltd | 新規フェノチアジン誘導体及びその医薬 |
| RU2197248C2 (ru) * | 2001-03-20 | 2003-01-27 | Травкин Олег Викторович | Лекарственный препарат, обладающий иммуномоделирующим, иммунокоррегирующим, противопаразитарным, противосклеротическим, противовирусным, противобактериальным, противогрибковым, противовоспалительным и противоопухолевым действием, и способ его приготовления |
| GB0113435D0 (en) | 2001-06-04 | 2001-07-25 | Amersham Pharm Biotech Uk Ltd | Acridone derivatives as labels for fluorescence detection of target materials |
| GB0113434D0 (en) | 2001-06-04 | 2001-07-25 | Amersham Pharm Biotech Uk Ltd | Quinacridone derivatives as labels for fluorescence detection of biological materials |
| WO2004106923A1 (en) | 2003-05-28 | 2004-12-09 | Amersham Biosciences Uk Limited | Differential analysis of cell surface proteins on closed membrane structures by labelling with dyes in the presence of an internal standard |
| WO2005099656A2 (en) * | 2004-04-06 | 2005-10-27 | The Procter & Gamble Company | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof |
| JP2006004736A (ja) | 2004-06-17 | 2006-01-05 | Sumitomo Chemical Co Ltd | 光電変換素子及び光電変換素子用色素 |
| WO2008021745A2 (en) | 2006-08-16 | 2008-02-21 | Itherx Pharmaceuticals, Inc. | Hepatitis c virus entry inhibitors |
| JP2008090130A (ja) | 2006-10-04 | 2008-04-17 | Konica Minolta Medical & Graphic Inc | 感光性平版印刷版材料 |
| WO2009112791A1 (en) | 2008-03-14 | 2009-09-17 | Assaymetrics Limited | Fluorogenic peptides and their method of production |
| JP2009271403A (ja) | 2008-05-09 | 2009-11-19 | Konica Minolta Medical & Graphic Inc | 感光性平版印刷版材料および平版印刷版の製造方法 |
| JP5717959B2 (ja) | 2009-11-17 | 2015-05-13 | 株式会社Adeka | 芳香族スルホニウム塩化合物 |
| US8618125B2 (en) | 2011-01-14 | 2013-12-31 | Heptiva LLC | Composition comprising hepatic therapeutic active for treating liver diseases, certain cancers and liver health maintenance |
| WO2013022740A2 (en) | 2011-08-05 | 2013-02-14 | Corning Incorporated | Gpr35 ligands and the uses thereof |
| WO2015046502A1 (ja) | 2013-09-30 | 2015-04-02 | 富士フイルム株式会社 | 感光性樹脂組成物、硬化膜の製造方法、硬化膜、有機ｅｌ表示装置および液晶表示装置 |
| CN109394752A (zh) * | 2013-10-21 | 2019-03-01 | 德雷克塞尔大学 | 治疗慢性乙型肝炎病毒感染的sting激动剂的用途 |
| CN103709122B (zh) | 2013-11-29 | 2016-05-25 | 四川大学 | 用于治疗的抗肿瘤和抗真菌化合物 |
| WO2016179702A1 (en) * | 2015-05-11 | 2016-11-17 | Ranju Ralhan | Acridinone compositions for treating head and neck cancers and methods of prognosing head and neck cancers |
| WO2018165494A1 (en) | 2017-03-10 | 2018-09-13 | Albert Einstein College Of Medicine, Inc. | Small molecule bax inhibitors and uses thereof |
-
2018
- 2018-11-20 SG SG11202004442VA patent/SG11202004442VA/en unknown
- 2018-11-20 CA CA3079262A patent/CA3079262A1/en active Pending
- 2018-11-20 MX MX2020004902A patent/MX2020004902A/es unknown
- 2018-11-20 AU AU2018368789A patent/AU2018368789B2/en not_active Ceased
- 2018-11-20 BR BR112020009592-3A patent/BR112020009592A2/pt not_active IP Right Cessation
- 2018-11-20 US US16/195,997 patent/US10745358B2/en active Active
- 2018-11-20 WO PCT/US2018/062021 patent/WO2019100061A1/en not_active Ceased
- 2018-11-20 KR KR1020207017927A patent/KR20200100081A/ko not_active Ceased
- 2018-11-20 JP JP2020545072A patent/JP7323539B2/ja active Active
- 2018-11-20 EP EP18878928.3A patent/EP3713920A4/en active Pending
- 2018-11-20 CN CN201880086600.0A patent/CN111630036B/zh active Active
-
2020
- 2020-05-15 PH PH12020550652A patent/PH12020550652A1/en unknown
- 2020-05-20 IL IL274796A patent/IL274796A/en unknown
-
2022
- 2022-07-28 US US17/875,770 patent/US20230113570A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018368789A1 (en) | 2020-06-11 |
| BR112020009592A2 (pt) | 2020-11-03 |
| EP3713920A4 (en) | 2021-04-14 |
| IL274796A (en) | 2020-07-30 |
| US20230113570A1 (en) | 2023-04-13 |
| MX2020004902A (es) | 2020-09-09 |
| JP7323539B2 (ja) | 2023-08-08 |
| CN111630036A (zh) | 2020-09-04 |
| CN111630036B (zh) | 2024-12-27 |
| WO2019100061A1 (en) | 2019-05-23 |
| PH12020550652A1 (en) | 2021-04-26 |
| SG11202004442VA (en) | 2020-06-29 |
| US10745358B2 (en) | 2020-08-18 |
| AU2018368789B2 (en) | 2022-06-02 |
| CA3079262A1 (en) | 2019-05-23 |
| JP2021503501A (ja) | 2021-02-12 |
| EP3713920A1 (en) | 2020-09-30 |
| US20190161449A1 (en) | 2019-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20200619 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20211119 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20240205 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20240412 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20240205 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |