BR112020009592A2 - derivados de ácido oxoacridinil acético e métodos de uso - Google Patents

derivados de ácido oxoacridinil acético e métodos de uso Download PDF

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Publication number
BR112020009592A2
BR112020009592A2 BR112020009592-3A BR112020009592A BR112020009592A2 BR 112020009592 A2 BR112020009592 A2 BR 112020009592A2 BR 112020009592 A BR112020009592 A BR 112020009592A BR 112020009592 A2 BR112020009592 A2 BR 112020009592A2
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BR
Brazil
Prior art keywords
alkyl
compound according
fact
halogen
cancer
Prior art date
Application number
BR112020009592-3A
Other languages
English (en)
Portuguese (pt)
Inventor
Brian T. Chamberlain
Zhixiong Lin
James M. Rice
Finith E. Jernigan Iii
Woody SHERMAN
Meghana M. KULKARNI
Sharon Shechter
Bryce K. ALLEN
Dazhi TAN
Kristen A. MARINO
Original Assignee
Silicon Swat, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Silicon Swat, Inc. filed Critical Silicon Swat, Inc.
Publication of BR112020009592A2 publication Critical patent/BR112020009592A2/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/86Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
BR112020009592-3A 2017-11-20 2018-11-20 derivados de ácido oxoacridinil acético e métodos de uso BR112020009592A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762588820P 2017-11-20 2017-11-20
US62/588,820 2017-11-20
US201862631530P 2018-02-16 2018-02-16
US62/631,530 2018-02-16
US201862723660P 2018-08-28 2018-08-28
US62/723,660 2018-08-28
PCT/US2018/062021 WO2019100061A1 (en) 2017-11-20 2018-11-20 Oxoacridinyl acetic acid derivatives and methods of use

Publications (1)

Publication Number Publication Date
BR112020009592A2 true BR112020009592A2 (pt) 2020-11-03

Family

ID=66540425

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020009592-3A BR112020009592A2 (pt) 2017-11-20 2018-11-20 derivados de ácido oxoacridinil acético e métodos de uso

Country Status (13)

Country Link
US (2) US10745358B2 (https=)
EP (1) EP3713920A4 (https=)
JP (1) JP7323539B2 (https=)
KR (1) KR20200100081A (https=)
CN (1) CN111630036B (https=)
AU (1) AU2018368789B2 (https=)
BR (1) BR112020009592A2 (https=)
CA (1) CA3079262A1 (https=)
IL (1) IL274796A (https=)
MX (1) MX2020004902A (https=)
PH (1) PH12020550652A1 (https=)
SG (1) SG11202004442VA (https=)
WO (1) WO2019100061A1 (https=)

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JP7270608B2 (ja) 2017-08-31 2023-05-10 エフ-スター・セラピューティクス・インコーポレイテッド 化合物、組成物、及び疾患の治療方法
US20220227761A1 (en) * 2019-05-16 2022-07-21 Stingthera, Inc. Oxoacridinyl acetic acid derivatives and methods of use
WO2020249773A1 (en) * 2019-06-12 2020-12-17 Ryvu Therapeutics S.A. Next-generation modulators of stimulator of interferon genes (sting)
CN112442033A (zh) * 2019-08-28 2021-03-05 迈德欣国际有限公司 Sting通路调节剂及其用途
CN112624972A (zh) * 2019-09-24 2021-04-09 中国人民解放军军事科学院军事医学研究院 吖啶酮类化合物及医药用途
RU2730530C1 (ru) * 2019-10-29 2020-08-24 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Новое химическое соединение L-лизина 9-оксоакридинил-10-ацетат, стимулирующее продукцию интерлейкина-24 и фактора некроза опухолей - бета
CN112778336B (zh) * 2019-11-02 2023-05-05 上海凌达生物医药有限公司 一类含氮稠环类sting调节剂类化合物、制备方法和用途
CN111039849B (zh) * 2019-12-26 2021-07-06 阜阳欣奕华材料科技有限公司 一种含有咔唑环类化合物的制备方法
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法

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Also Published As

Publication number Publication date
AU2018368789A1 (en) 2020-06-11
KR20200100081A (ko) 2020-08-25
EP3713920A4 (en) 2021-04-14
IL274796A (en) 2020-07-30
US20230113570A1 (en) 2023-04-13
MX2020004902A (es) 2020-09-09
JP7323539B2 (ja) 2023-08-08
CN111630036A (zh) 2020-09-04
CN111630036B (zh) 2024-12-27
WO2019100061A1 (en) 2019-05-23
PH12020550652A1 (en) 2021-04-26
SG11202004442VA (en) 2020-06-29
US10745358B2 (en) 2020-08-18
AU2018368789B2 (en) 2022-06-02
CA3079262A1 (en) 2019-05-23
JP2021503501A (ja) 2021-02-12
EP3713920A1 (en) 2020-09-30
US20190161449A1 (en) 2019-05-30

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2801 DE 10/09/2024.