AU2018254442B2 - Antigen-specific immune effector cells - Google Patents

Antigen-specific immune effector cells Download PDF

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Publication number
AU2018254442B2
AU2018254442B2 AU2018254442A AU2018254442A AU2018254442B2 AU 2018254442 B2 AU2018254442 B2 AU 2018254442B2 AU 2018254442 A AU2018254442 A AU 2018254442A AU 2018254442 A AU2018254442 A AU 2018254442A AU 2018254442 B2 AU2018254442 B2 AU 2018254442B2
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cells
cell
antigen
hla
car
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AU2018254442A1 (en
Inventor
Andrew J. Brandl
Sarah BURTON
Ethan MCLEOD
Christie MUNN
Deepika Rajesh
Bradley Swanson
Maksym A. Vodyanyk
Wen Bo Wang
Xin Zhang
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Fujifilm Cellular Dynamics Inc
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Fujifilm Cellular Dynamics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K40/42—Cancer antigens
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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AU2018254442A 2017-04-18 2018-04-18 Antigen-specific immune effector cells Active AU2018254442B2 (en)

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US201762486875P 2017-04-18 2017-04-18
US62/486,875 2017-04-18
PCT/US2018/028133 WO2018195175A1 (en) 2017-04-18 2018-04-18 Antigen-specific immune effector cells

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AU2018254442A1 AU2018254442A1 (en) 2019-10-17
AU2018254442B2 true AU2018254442B2 (en) 2024-03-28

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KR (1) KR102668891B1 (https=)
CN (1) CN110891967B (https=)
AU (1) AU2018254442B2 (https=)
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