AU2017323521B9 - Di-substituted pyrazole compounds for the treatment of diseases - Google Patents

Di-substituted pyrazole compounds for the treatment of diseases Download PDF

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Publication number
AU2017323521B9
AU2017323521B9 AU2017323521A AU2017323521A AU2017323521B9 AU 2017323521 B9 AU2017323521 B9 AU 2017323521B9 AU 2017323521 A AU2017323521 A AU 2017323521A AU 2017323521 A AU2017323521 A AU 2017323521A AU 2017323521 B9 AU2017323521 B9 AU 2017323521B9
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Prior art keywords
compound
cancer
formula
pharmaceutically acceptable
alkyl
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AU2017323521A1 (en
AU2017323521B2 (en
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Joel Huff
John Kincaid
Motonari Uesugi
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Fgh Biotech Inc
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Fgh Biotech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2017323521A 2016-09-07 2017-09-07 Di-substituted pyrazole compounds for the treatment of diseases Active AU2017323521B9 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662384661P 2016-09-07 2016-09-07
US62/384,661 2016-09-07
US201662438944P 2016-12-23 2016-12-23
US62/438,944 2016-12-23
PCT/US2017/050562 WO2018049080A1 (en) 2016-09-07 2017-09-07 Di-substituted pyrazole compounds for the treatment of diseases

Publications (3)

Publication Number Publication Date
AU2017323521A1 AU2017323521A1 (en) 2019-05-02
AU2017323521B2 AU2017323521B2 (en) 2021-11-11
AU2017323521B9 true AU2017323521B9 (en) 2022-02-17

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ID=59895438

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017323521A Active AU2017323521B9 (en) 2016-09-07 2017-09-07 Di-substituted pyrazole compounds for the treatment of diseases

Country Status (7)

Country Link
US (1) US11339142B2 (https=)
EP (1) EP3510027B1 (https=)
JP (1) JP7071981B2 (https=)
CN (1) CN110072861B (https=)
AU (1) AU2017323521B9 (https=)
ES (1) ES2932187T3 (https=)
WO (1) WO2018049080A1 (https=)

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KR102498741B1 (ko) * 2016-04-29 2023-02-10 에프지에이치 바이오테크 인코포레이티드 질환 치료용 이-치환된 피라졸 화합물
ES2932187T3 (es) 2016-09-07 2023-01-16 Fgh Biotech Inc Compuestos de pirazol disustituidos para el tratamiento de enfermedades
CN108947839A (zh) * 2018-06-28 2018-12-07 山东润博生物科技有限公司 一种苯氧羧酸类除草剂的制备方法
CN108947841A (zh) * 2018-06-28 2018-12-07 山东润博生物科技有限公司 一种苯氧羧酸酯的制备方法
CN109265352B (zh) * 2018-10-31 2021-06-04 杭州迈世腾药物科技有限公司 芳基环丙基醚及其衍生物的制备方法
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2020132700A1 (en) 2018-12-21 2020-06-25 Fgh Biotech Inc. Methods of using inhibitors of srebp in combination with niclosamide and analogs thereof
EP4096659A4 (en) * 2020-01-27 2023-10-18 Capulus Therapeutics, LLC Srebp inhibitors comprising a thiophene central ring

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Also Published As

Publication number Publication date
CN110072861A (zh) 2019-07-30
US20190194167A1 (en) 2019-06-27
US11339142B2 (en) 2022-05-24
ES2932187T3 (es) 2023-01-16
AU2017323521A1 (en) 2019-05-02
WO2018049080A1 (en) 2018-03-15
EP3510027A1 (en) 2019-07-17
AU2017323521B2 (en) 2021-11-11
CN110072861B (zh) 2022-11-11
JP7071981B2 (ja) 2022-05-19
CA3036195A1 (en) 2018-03-15
EP3510027B1 (en) 2022-11-02
JP2019530742A (ja) 2019-10-24

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