AU2016374253B2 - Targeted disruption of the MHC cell receptor - Google Patents

Targeted disruption of the MHC cell receptor Download PDF

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Publication number
AU2016374253B2
AU2016374253B2 AU2016374253A AU2016374253A AU2016374253B2 AU 2016374253 B2 AU2016374253 B2 AU 2016374253B2 AU 2016374253 A AU2016374253 A AU 2016374253A AU 2016374253 A AU2016374253 A AU 2016374253A AU 2016374253 B2 AU2016374253 B2 AU 2016374253B2
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zfp
cell
seq
gene
designated
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AU2016374253A1 (en
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Gary K. Lee
David Paschon
Lei Zhang
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Sangamo Therapeutics Inc
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Sangamo Therapeutics Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2016374253A 2015-12-18 2016-12-15 Targeted disruption of the MHC cell receptor Active AU2016374253B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022200341A AU2022200341B2 (en) 2015-12-18 2022-01-19 Targeted Disruption Of The MHC Cell Receptor

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562269410P 2015-12-18 2015-12-18
US62/269,410 2015-12-18
US201662305097P 2016-03-08 2016-03-08
US62/305,097 2016-03-08
US201662329439P 2016-04-29 2016-04-29
US62/329,439 2016-04-29
PCT/US2016/066988 WO2017106537A2 (en) 2015-12-18 2016-12-15 Targeted disruption of the mhc cell receptor

Related Child Applications (1)

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AU2022200341A Division AU2022200341B2 (en) 2015-12-18 2022-01-19 Targeted Disruption Of The MHC Cell Receptor

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AU2016374253A1 AU2016374253A1 (en) 2018-06-28
AU2016374253B2 true AU2016374253B2 (en) 2021-10-21

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AU2022200341A Active AU2022200341B2 (en) 2015-12-18 2022-01-19 Targeted Disruption Of The MHC Cell Receptor

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US (3) US10500229B2 (cg-RX-API-DMAC7.html)
EP (1) EP3390437B1 (cg-RX-API-DMAC7.html)
JP (3) JP2018537112A (cg-RX-API-DMAC7.html)
KR (1) KR20180088911A (cg-RX-API-DMAC7.html)
CN (2) CN117137947A (cg-RX-API-DMAC7.html)
AU (2) AU2016374253B2 (cg-RX-API-DMAC7.html)
BR (1) BR112018012235A2 (cg-RX-API-DMAC7.html)
CA (1) CA3008382A1 (cg-RX-API-DMAC7.html)
EA (1) EA201891212A1 (cg-RX-API-DMAC7.html)
IL (2) IL297018A (cg-RX-API-DMAC7.html)
MX (2) MX2018007519A (cg-RX-API-DMAC7.html)
NZ (1) NZ743429A (cg-RX-API-DMAC7.html)
SG (2) SG10202005640UA (cg-RX-API-DMAC7.html)
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