AU2016372159B2 - Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK - Google Patents

Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK Download PDF

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Publication number
AU2016372159B2
AU2016372159B2 AU2016372159A AU2016372159A AU2016372159B2 AU 2016372159 B2 AU2016372159 B2 AU 2016372159B2 AU 2016372159 A AU2016372159 A AU 2016372159A AU 2016372159 A AU2016372159 A AU 2016372159A AU 2016372159 B2 AU2016372159 B2 AU 2016372159B2
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hmwk
seq
peptide
glu
sample
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AU2016372159A1 (en
Inventor
Ryan Faucette
Gul M. Mustafa
Daniel J. Sexton
Mark SZEWC
Jiang Wu
Guodong Zhang
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Priority to AU2022204058A priority Critical patent/AU2022204058B2/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2016372159A 2015-12-15 2016-12-15 Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK Active AU2016372159B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2022204058A AU2022204058B2 (en) 2015-12-15 2022-06-10 Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK
AU2025200412A AU2025200412A1 (en) 2015-12-15 2025-01-22 Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562267734P 2015-12-15 2015-12-15
US62/267,734 2015-12-15
PCT/US2016/066936 WO2017106504A1 (en) 2015-12-15 2016-12-15 Peptide quantitation assay for differentiating full-length high molecular weight kininogen (hmwk) and cleaved hmwk

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022204058A Division AU2022204058B2 (en) 2015-12-15 2022-06-10 Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK

Publications (2)

Publication Number Publication Date
AU2016372159A1 AU2016372159A1 (en) 2018-07-05
AU2016372159B2 true AU2016372159B2 (en) 2022-03-24

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AU2016372159A Active AU2016372159B2 (en) 2015-12-15 2016-12-15 Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK
AU2022204058A Active AU2022204058B2 (en) 2015-12-15 2022-06-10 Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK
AU2025200412A Pending AU2025200412A1 (en) 2015-12-15 2025-01-22 Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK

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Application Number Title Priority Date Filing Date
AU2022204058A Active AU2022204058B2 (en) 2015-12-15 2022-06-10 Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK
AU2025200412A Pending AU2025200412A1 (en) 2015-12-15 2025-01-22 Peptide quantitation assay for differentiating full-length high molecular weight kininogen (HMWK) and cleaved HMWK

Country Status (13)

Country Link
US (3) US11668718B2 (enExample)
EP (2) EP3390439B1 (enExample)
JP (3) JP7092669B2 (enExample)
KR (2) KR102874711B1 (enExample)
CN (1) CN108602877A (enExample)
AU (3) AU2016372159B2 (enExample)
CA (1) CA3008621A1 (enExample)
CO (1) CO2018007216A2 (enExample)
EA (1) EA201891414A1 (enExample)
IL (4) IL297850B2 (enExample)
MX (2) MX2018007493A (enExample)
NZ (1) NZ743482A (enExample)
WO (1) WO2017106504A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3060908T (pt) 2013-10-21 2021-05-27 Dyax Corp Diagnóstico e tratamento de doenças autoimunes
KR20250066486A (ko) 2013-10-21 2025-05-13 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법
JP6903648B2 (ja) 2015-10-19 2021-07-14 ダイアックス コーポレーション 切断高分子量キニノーゲンを検出するイムノアッセイ
EP3390439B1 (en) 2015-12-15 2025-03-12 Takeda Pharmaceutical Company Limited Peptide quantitation assay for differentiating full-length high molecular weight kininogen (hmwk) and cleaved hmwk
WO2018225830A1 (ja) * 2017-06-08 2018-12-13 国立大学法人宮崎大学 肺がんの検出方法

Citations (1)

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WO2014113712A1 (en) * 2013-01-20 2014-07-24 Dyax Corp. Evaluation and treatment of bradykinin-mediated disorders

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JP2603487B2 (ja) 1987-11-26 1997-04-23 大日本製薬株式会社 ガンに罹患している疑いのあるヒトをスクリーニングする方法
JPH08208692A (ja) 1994-09-28 1996-08-13 Sumitomo Pharmaceut Co Ltd 新規な細胞接着抑制ペプチド誘導体
JP3073439B2 (ja) * 1996-02-08 2000-08-07 雪印乳業株式会社 骨形成促進及び骨吸収防止剤
AU1521500A (en) 1998-11-10 2000-05-29 W. Robert Colman Inhibition of angiogenesis by peptide analogs of high molecular weight kininogendomain
US20060154319A1 (en) 1999-04-29 2006-07-13 Flodgaard Hans J Inhibition of bradykinin release
WO2001034195A1 (en) 1999-11-12 2001-05-17 Temple University Of The Commonwealth System Of Higher Education Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5
CA2478962A1 (en) 2002-03-15 2003-09-25 Attenuon, Llc Cell surface tropomyosin as a target of angiogenesis inhibition
CN1858243A (zh) 2005-04-30 2006-11-08 安徽省生物医学研究所 一种预测血管紧张素ii受体拮抗剂类降压药药物作用的方法及其应用
EP2216651A4 (en) * 2007-10-18 2010-12-01 Miyazaki Prefectural Ind Suppo BIOMARKERS FOR THE DIAGNOSIS OF LIVER DISEASE
JP5348595B2 (ja) 2008-07-07 2013-11-20 日本臓器製薬株式会社 線維筋痛症の検査法
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KR20250066486A (ko) * 2013-10-21 2025-05-13 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법
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Publication number Publication date
JP2024026847A (ja) 2024-02-28
US12135329B2 (en) 2024-11-05
JP7758766B2 (ja) 2025-10-22
CO2018007216A2 (es) 2018-09-20
IL297850B1 (en) 2024-06-01
US20210025898A1 (en) 2021-01-28
WO2017106504A8 (en) 2017-07-13
KR20240161708A (ko) 2024-11-12
MX2023000773A (es) 2023-02-22
JP7092669B2 (ja) 2022-06-28
US11668718B2 (en) 2023-06-06
MX2018007493A (es) 2018-09-18
EP4597115A2 (en) 2025-08-06
CN108602877A (zh) 2018-09-28
KR20180134838A (ko) 2018-12-19
US20250172567A1 (en) 2025-05-29
KR102874711B1 (ko) 2025-10-23
AU2016372159A1 (en) 2018-07-05
IL259995B2 (en) 2023-05-01
EA201891414A1 (ru) 2019-02-28
IL297850B2 (en) 2024-10-01
BR112018012165A2 (pt) 2018-12-04
KR102728491B1 (ko) 2024-11-13
AU2025200412A1 (en) 2025-02-13
EP4597115A3 (en) 2025-08-13
US20230408528A1 (en) 2023-12-21
AU2022204058B2 (en) 2024-10-31
JP2019505185A (ja) 2019-02-28
IL297850A (en) 2023-01-01
IL259995B1 (en) 2023-01-01
CA3008621A1 (en) 2017-06-22
NZ743482A (en) 2023-04-28
WO2017106504A1 (en) 2017-06-22
JP2022141640A (ja) 2022-09-29
EP3390439A1 (en) 2018-10-24
JP7425117B2 (ja) 2024-01-30
IL259995A (en) 2018-07-31
IL312919B1 (en) 2025-10-01
IL322971A (en) 2025-10-01
IL312919A (en) 2024-07-01
EP3390439B1 (en) 2025-03-12
AU2022204058A1 (en) 2022-06-30

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